ES2190095T3 - Sales nitricas de inhibidores del enzima de conversion. - Google Patents

Sales nitricas de inhibidores del enzima de conversion.

Info

Publication number
ES2190095T3
ES2190095T3 ES98938668T ES98938668T ES2190095T3 ES 2190095 T3 ES2190095 T3 ES 2190095T3 ES 98938668 T ES98938668 T ES 98938668T ES 98938668 T ES98938668 T ES 98938668T ES 2190095 T3 ES2190095 T3 ES 2190095T3
Authority
ES
Spain
Prior art keywords
formula
forms
riv
riii
enzyme inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES98938668T
Other languages
English (en)
Spanish (es)
Inventor
Soldato Piero Del
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nicox SA
Original Assignee
Nicox SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nicox SA filed Critical Nicox SA
Application granted granted Critical
Publication of ES2190095T3 publication Critical patent/ES2190095T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0217—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -C(=O)-C-N-C(=O)-N-C-C(=O)-
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cosmetics (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pyrrole Compounds (AREA)
ES98938668T 1997-06-27 1998-06-24 Sales nitricas de inhibidores del enzima de conversion. Expired - Lifetime ES2190095T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT97MI001523A IT1292426B1 (it) 1997-06-27 1997-06-27 Sali nitrati di ace-inibitori

Publications (1)

Publication Number Publication Date
ES2190095T3 true ES2190095T3 (es) 2003-07-16

Family

ID=11377450

Family Applications (1)

Application Number Title Priority Date Filing Date
ES98938668T Expired - Lifetime ES2190095T3 (es) 1997-06-27 1998-06-24 Sales nitricas de inhibidores del enzima de conversion.

Country Status (17)

Country Link
US (1) US6218417B1 (enExample)
EP (1) EP1019370B1 (enExample)
JP (1) JP2002506456A (enExample)
KR (1) KR100512892B1 (enExample)
CN (1) CN1205186C (enExample)
AT (1) ATE230393T1 (enExample)
AU (1) AU740411B2 (enExample)
BR (1) BR9810459A (enExample)
CA (1) CA2292794A1 (enExample)
DE (1) DE69810498T2 (enExample)
DK (1) DK1019370T3 (enExample)
ES (1) ES2190095T3 (enExample)
HU (1) HUP0003133A3 (enExample)
IL (1) IL132691A (enExample)
IT (1) IT1292426B1 (enExample)
RU (1) RU2194037C2 (enExample)
WO (1) WO1999000361A1 (enExample)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1301759B1 (it) * 1998-06-19 2000-07-07 Nicox Sa Sali nitrati di farmaci antiipertensivi
IT1303672B1 (it) * 1998-07-28 2001-02-23 Nicox Sa Sali nitrati di farmaci attivi nei disordini ossei
EP1212053A4 (en) 1999-09-08 2004-08-11 Nitromed Inc METHODS FOR THE TREATMENT AND PROPHYLAXIS OF CONGESTIVE HEART FAILURE BY HYDRALAZIN COMPOUNDS AND ISOSORBIDE DINITRATE OR ISOSORBIDE MONONITRATE
DE60042611D1 (de) 1999-10-29 2009-09-03 Nitromed Inc Verfahren zur behandlung von gefässerkrankungen, dxid auszeichnen
US7537785B2 (en) 1999-10-29 2009-05-26 Nitromed, Inc. Composition for treating vascular diseases characterized by nitric oxide insufficiency
US7708989B2 (en) * 1999-10-29 2010-05-04 Nitromed, Inc. Methods of treating vascular diseases characterized by nitric oxide insufficiency
US7235237B2 (en) 1999-10-29 2007-06-26 Nitromed, Inc. Methods of treating vascular diseases characterized by nitric oxide insufficiency
DE60233140D1 (de) 2001-05-02 2009-09-10 Nitromed Inc Nitrosiertes und nitrosyliertes nebivolol und seine metaboliten, zusammensetzungen und anwendungsverfahren
GB0111872D0 (en) * 2001-05-15 2001-07-04 Northwick Park Inst For Medica Therapeutic agents and methods
JP2005519928A (ja) * 2002-02-04 2005-07-07 ハース，ベルナー Ｃｏ放出能力を有する化合物の投与によって哺乳動物を治療する方法と、ｃｏ放出能力を有する化合物ならびにその医薬組成物
US7968605B2 (en) * 2002-02-04 2011-06-28 ALFAMA—Investigação e Desenvolvimento de Produtos Farmacêuticos, Lda. Methods for treating inflammatory disease by administering aldehydes and derivatives thereof
US20080026984A1 (en) * 2002-02-04 2008-01-31 Alfama - Investigacao E Desenvolvimento De Productos Farmaceuticos Lda Methods for treating inflammatory disease by administering aldehydes and derivatives thereof
WO2004037843A2 (en) * 2002-10-25 2004-05-06 Yissum Research Development Company Of The Hebrew University Of Jerusalem Steroid compounds comprising superoxide dismutase mimic groups and nitric oxide donor groups, and their use in the preparation of medicaments
GB2395432B (en) * 2002-11-20 2005-09-14 Northwick Park Inst For Medica Therapeutic delivery of carbon monoxide to extracorporeal and isolated organs
US20070207217A1 (en) * 2003-02-03 2007-09-06 Alfama - Investigacao E Desenvolvimento De Productos Farmaceuticos Lda Method for treating a mammal by administration of a compound having the ability to release CO
US7169805B2 (en) * 2003-05-28 2007-01-30 Nicox S.A. Captopril derivatives
SI21704A (en) * 2004-01-14 2005-08-31 Lek Farmacevtska Druzba Dd New crystal form of perindopril, procedure of its preparation, pharmaceutical preparations containing this form and their application in treatment of hypertensia
EP1778267A4 (en) * 2004-07-16 2010-01-06 Nitromed Inc COMPOSITIONS AND METHODS ASSOCIATED WITH HEART FAILURE
ATE462703T1 (de) 2004-08-25 2010-04-15 Actelion Pharmaceuticals Ltd Bicyclononen-derivate als renin-inhibitoren
EP1679072B9 (en) * 2005-01-06 2009-09-02 IPCA Laboratories Limited Process for for synthesis of (2S,3aS,7aS)-1-(S)-alanyl-octahydro-1H-indole-2- carboxylic acid derivatives and use in the synthesis of perindopril
EP1883412A4 (en) * 2005-05-05 2008-09-03 Keryx Biopharmaceuticals Inc COMBINATION THERAPY WITH SULODEXIDE AND A BLOOD PRESSURE WRITING AGENT IN THE TREATMENT OF DIABETIC NEPHROPATHY
JP4297972B2 (ja) * 2005-05-27 2009-07-15 アクテリオン ファーマシューティカルズ リミテッド 新規なピペリジンカルボン酸アミド誘導体
GB0511686D0 (en) * 2005-06-08 2005-07-13 Novartis Ag Organic compounds
WO2007045551A2 (en) * 2005-10-18 2007-04-26 Nicox S.A. Renin inhibitors nitroderivatives
GB0601394D0 (en) 2006-01-24 2006-03-01 Hemocorm Ltd Therapeutic delivery of carbon monoxide
RU2425032C2 (ru) 2006-02-02 2011-07-27 Актелион Фармасьютикалз Лтд Вторичные амины в качестве ингибиторов ренина
AU2007217980A1 (en) * 2006-02-17 2007-08-30 Nitromed, Inc. Methods using hydralazine compounds and isosorbide dinitrate or isosorbide mononitrate
CL2007000595A1 (es) * 2006-03-08 2008-01-04 Actelion Pharmaceuticals Ltd Compuestos derivados de piperidina; composicion farmaceutica y uso para el tratamiento y/o profilaxis de enfermedades seleccionadas entre hipertension, insuficiencia cardiaca congestiva e insuficiencia renal entre otras.
CA2652135A1 (en) * 2006-05-16 2007-11-29 Nitromed, Inc. Solid dosage formulations of hydralazine compounds
PL2274295T3 (pl) * 2008-05-05 2016-01-29 Idorsia Pharmaceuticals Ltd 3,4–podstawione pochodne piperydyny jako inhibitory reniny
ES2656237T3 (es) 2011-04-19 2018-02-26 Alfama, Inc. Moléculas liberadoras de monóxido de carbono y usos de las mismas
EP2734235B1 (en) 2011-07-21 2017-03-22 Alfama, Inc. Ruthenium carbon monoxide releasing molecules and uses thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT377496B (de) * 1981-06-19 1985-03-25 Voith Gmbh J M Vorrichtung zum anwickeln einer warenbahn auf eine neu eingelegte wickelhuelse in einer doppeltragwalzen-wickelmaschine
SE463851B (sv) 1988-09-02 1991-02-04 Amsu Ltd Komposition foer behandling av erektil dysfunktion via uretra
US5352708A (en) 1992-09-21 1994-10-04 Allergan, Inc. Non-acidic cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivatives as therapeutic agents
US5328933A (en) 1992-10-28 1994-07-12 Allergan, Inc. Cyclopentane heptenylnitro and heptanylnitro-2-aliphatic or aryl aliphatic derivatives and homologues
PT719253E (pt) * 1993-09-17 2004-07-30 Pfizer Piperidinas 3-amino-5-carboxi-substituidas e pirrolidinas 3-amino-4-carboxi-substituidas como antagonistas de taquicinina
DE69512232T2 (de) 1994-05-10 2000-02-24 Nicox S.A., Paris Nitroverbindingen und ihre zubereitungen mit entzündungsremmenden, schmertzlindernden und antithrombotischen wirkungen
WO1996028423A1 (en) * 1995-03-15 1996-09-19 Sankyo Company, Limited Dipeptide compounds having ahpba structure
US5625083A (en) 1995-06-02 1997-04-29 Bezuglov; Vladimir V. Dinitroglycerol esters of unsaturated fatty acids and prostaglandins
US5645839A (en) * 1995-06-07 1997-07-08 Trustees Of Boston University Combined use of angiotensin inhibitors and nitric oxide stimulators to treat fibrosis
CN1141771A (zh) * 1995-08-02 1997-02-05 贾力 巯-亚硝基化合物及其医学用途

Also Published As

Publication number Publication date
US6218417B1 (en) 2001-04-17
IL132691A0 (en) 2001-03-19
AU740411B2 (en) 2001-11-01
IL132691A (en) 2004-06-01
ITMI971523A1 (it) 1998-12-27
ATE230393T1 (de) 2003-01-15
DK1019370T3 (da) 2003-05-05
CA2292794A1 (en) 1999-01-07
CN1205186C (zh) 2005-06-08
EP1019370A1 (en) 2000-07-19
AU8730098A (en) 1999-01-19
ITMI971523A0 (enExample) 1997-06-27
HUP0003133A3 (en) 2002-10-28
RU2194037C2 (ru) 2002-12-10
KR20010013958A (ko) 2001-02-26
WO1999000361A1 (en) 1999-01-07
JP2002506456A (ja) 2002-02-26
HUP0003133A2 (en) 2001-03-28
CN1260780A (zh) 2000-07-19
IT1292426B1 (it) 1999-02-08
BR9810459A (pt) 2006-10-03
DE69810498D1 (de) 2003-02-06
KR100512892B1 (ko) 2005-09-07
DE69810498T2 (de) 2003-10-30
EP1019370B1 (en) 2003-01-02

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