IT1206954B - Agenti terapeutici a base di un acil derivato della carnitina per la cura di vasculopatie periferiche - Google Patents

Agenti terapeutici a base di un acil derivato della carnitina per la cura di vasculopatie periferiche

Info

Publication number
IT1206954B
IT1206954B IT7947976A IT4797679A IT1206954B IT 1206954 B IT1206954 B IT 1206954B IT 7947976 A IT7947976 A IT 7947976A IT 4797679 A IT4797679 A IT 4797679A IT 1206954 B IT1206954 B IT 1206954B
Authority
IT
Italy
Prior art keywords
acil
carnitine
derivative
treatment
therapeutic agents
Prior art date
Application number
IT7947976A
Other languages
English (en)
Italian (it)
Other versions
IT7947976A0 (it
Original Assignee
Sigma Tau Ind Farmaceuti
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Ind Farmaceuti filed Critical Sigma Tau Ind Farmaceuti
Publication of IT7947976A0 publication Critical patent/IT7947976A0/it
Priority to IT7947976A priority Critical patent/IT1206954B/it
Priority to DE19792911670 priority patent/DE2911670A1/de
Priority to US06/119,075 priority patent/US4346107A/en
Priority to US06/118,835 priority patent/US4343816A/en
Priority to AU55268/80A priority patent/AU535565B2/en
Priority to NL8000741A priority patent/NL8000741A/nl
Priority to AU55267/80A priority patent/AU535518B2/en
Priority to NL8000768A priority patent/NL8000768A/nl
Priority to CH102780A priority patent/CH642848A5/it
Priority to CH102880A priority patent/CH641673A5/it
Priority to FR8003014A priority patent/FR2448347A1/fr
Priority to JP1592980A priority patent/JPS55136227A/ja
Priority to GB8004602A priority patent/GB2046593A/en
Priority to GB8004599A priority patent/GB2043443A/en
Priority to JP1593080A priority patent/JPS55136223A/ja
Priority to BE0/199369A priority patent/BE881681A/fr
Priority to DE19803005208 priority patent/DE3005208A1/de
Priority to FR8003015A priority patent/FR2448348A1/fr
Priority to BE0/199368A priority patent/BE881680A/fr
Application granted granted Critical
Publication of IT1206954B publication Critical patent/IT1206954B/it

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Psychiatry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
IT7947976A 1979-02-12 1979-02-12 Agenti terapeutici a base di un acil derivato della carnitina per la cura di vasculopatie periferiche IT1206954B (it)

Priority Applications (19)

Application Number Priority Date Filing Date Title
IT7947976A IT1206954B (it) 1979-02-12 1979-02-12 Agenti terapeutici a base di un acil derivato della carnitina per la cura di vasculopatie periferiche
DE19792911670 DE2911670A1 (de) 1979-02-12 1979-03-24 Arzneimittel zur therapeutischen behandlung von peripheren vaskularen erkrankungen
US06/119,075 US4346107A (en) 1979-02-12 1980-02-05 Pharmaceutical composition comprising acyl-carnitine for the treatment of impaired cerebral metabolism
US06/118,835 US4343816A (en) 1979-02-12 1980-02-05 Pharmaceutical composition comprising an acyl-carnitine, for treating peripheral vascular diseases
AU55268/80A AU535565B2 (en) 1979-02-12 1980-02-06 Pharmaceutical compositions of acyl-carnitine
NL8000741A NL8000741A (nl) 1979-02-12 1980-02-06 Een acylcarnitine bevattend farmaceutisch preparaat.
AU55267/80A AU535518B2 (en) 1979-02-12 1980-02-06 Pharmaceutical compositions of acyl-carnitine
NL8000768A NL8000768A (nl) 1979-02-12 1980-02-07 Een acyl-carnitine bevattend farmaceutisch preparaat.
CH102780A CH642848A5 (it) 1979-02-12 1980-02-08 Composizione farmaceutica comprendente una acil-carnitina, per il trattamento di vasculopatie periferiche.
CH102880A CH641673A5 (it) 1979-02-12 1980-02-08 Composizione farmaceutica comprendente una acil-carnitina per il trattamento del rallentato metabolismo cerebrale.
FR8003014A FR2448347A1 (fr) 1979-02-12 1980-02-12 Composition pharmaceutique comprenant une acyl-carnitine pour le traitement des maladies vasculaires peripheriques
JP1592980A JPS55136227A (en) 1979-02-12 1980-02-12 Peripheral vessel disease treating agent
GB8004602A GB2046593A (en) 1979-02-12 1980-02-12 Pharmaceutical compositions comprising acyl-carnitine for the treatment of impaired cerebral metabolism
GB8004599A GB2043443A (en) 1979-02-12 1980-02-12 Pharmaceutical compositions comprising an acyl-carnitine for treating pheripheral vascular diseases
JP1593080A JPS55136223A (en) 1979-02-12 1980-02-12 Brain metabolism obstruction treating agent
BE0/199369A BE881681A (fr) 1979-02-12 1980-02-12 Composition pharmaceutique a base d'acylcarnitine pour le traitement des maladies vasculaires peripheriques, et methode utilisee a cet effet
DE19803005208 DE3005208A1 (de) 1979-02-12 1980-02-12 Verwendung von acylcarnitin in arzneimitteln zur behandlung von stoerungen im gehirn-metabolismus
FR8003015A FR2448348A1 (fr) 1979-02-12 1980-02-12 Composition pharmaceutique comprenant une acyl-carnitine pour le traitement du metabolisme cerebral perturbe
BE0/199368A BE881680A (fr) 1979-02-12 1980-02-12 Composition pharmaceutique a base d'acylcarnitine pour le traitement d'un metabolisme cerebral altere et methode utilisee a cet effet

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT7947976A IT1206954B (it) 1979-02-12 1979-02-12 Agenti terapeutici a base di un acil derivato della carnitina per la cura di vasculopatie periferiche

Publications (2)

Publication Number Publication Date
IT7947976A0 IT7947976A0 (it) 1979-02-12
IT1206954B true IT1206954B (it) 1989-05-17

Family

ID=11263725

Family Applications (1)

Application Number Title Priority Date Filing Date
IT7947976A IT1206954B (it) 1979-02-12 1979-02-12 Agenti terapeutici a base di un acil derivato della carnitina per la cura di vasculopatie periferiche

Country Status (10)

Country Link
US (1) US4343816A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (2) JPS55136227A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AU (1) AU535565B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
BE (1) BE881681A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CH (1) CH642848A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (1) DE2911670A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FR (1) FR2448347A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
GB (1) GB2043443A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IT (1) IT1206954B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NL (1) NL8000741A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
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IT1142934B (it) * 1981-11-06 1986-10-15 Sigma Tau Ind Farmaceuti Uso della carnitina e delle acilcarnitine inferiori nel trattamento terapeutico della patologia delle vene
IT1157238B (it) * 1982-10-29 1987-02-11 Sigma Tau Ind Farmaceuti Impiego di 1-carnitina per migliorare i paramenti biochimici e comportamentali dell'eta' senile
IT1150396B (it) * 1982-12-09 1986-12-10 Sigma Tau Ind Farmaceuti Impiego di alcanoil l-carnitine per il trattamento terapeutico di miopa tie e distrofie muscolari
CH655005A5 (it) * 1983-02-16 1986-03-27 Sigma Tau Ind Farmaceuti Composizione farmaceutica ad azione metabolica ed energetica utilizzabile in terapia cardiaca e vascolare.
IT1181682B (it) * 1985-06-11 1987-09-30 Sigma Tau Ind Farmaceuti Impiego di alcanoil l-carnitine per il trattamento terapeutico del parkinsonismo idiopatico o indotto
IT1224842B (it) * 1988-12-27 1990-10-24 Sigma Tau Ind Farmaceuti Uso di derivati della l-carnitina nel trattamento terapeutico delle alterazioni degenerative del sistema nervoso
IT1230141B (it) * 1989-05-03 1991-10-14 Fidia Spa Impiego di derivati della fosfatidil carnitina per la preparazione di composizioni farmaceutiche aventi attivita' nella terapia delle patologie dell'uomo associate con un danno neuronale.
IT1231944B (it) * 1989-05-05 1992-01-16 Sigma Tau Ind Farmaceuti Composizione farmaceutica per il trattamento di protozoosi, particolarmente della tripasonomiasi comprendente d-carnitina o un alcanoilderivato della d-carnitina
IT1263004B (it) * 1992-10-08 1996-07-23 Sigma Tau Ind Farmaceuti Impiego della l-carnitina e acil l-carnitine nel trattamento a lungo termine di pazienti diabetici non insulino-dipendenti.
US5741816A (en) * 1994-06-20 1998-04-21 Tanabe Seiyaku Co., Ltd. Hair-growth agent
AU6482596A (en) * 1995-07-03 1997-02-05 Wilson T. Crandall Transdermal and oral treatment of androgenic alopecia
IT1276225B1 (it) * 1995-10-17 1997-10-27 Sigma Tau Ind Farmaceuti Composizioni farmaceutiche contenenti l-carnitina e alcanoil l- carnitine in associazione con resveratrolo o suoi derivati utili per
DE69605531T2 (de) * 1996-03-04 2000-05-31 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A., Rom/Roma Carnitinderivat als Arzneimittel zur Behandlung von Arteriosklerose obliterans
WO1998041201A1 (en) * 1997-03-17 1998-09-24 Btg International Limited Therapeutic compositions
IT1291127B1 (it) * 1997-04-01 1998-12-29 Sigma Tau Ind Farmaceuti Integratore alimentare per soggetti dediti ad intensa e prolungata attivita' fisica
WO2000027386A1 (en) * 1998-11-11 2000-05-18 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Use of propionylcarnitine for the manufacture of a medicament for inhibiting smooth muscle cell proliferation
CA2352485A1 (en) * 1998-11-26 2000-06-02 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Use of fumarate salt of l-carnitine or its alkanoyl derivatives in ischaemia
US6616942B1 (en) 1999-03-29 2003-09-09 Soft Gel Technologies, Inc. Coenzyme Q10 formulation and process methodology for soft gel capsules manufacturing
US6562869B1 (en) 1999-09-23 2003-05-13 Juvenon, Inc. Nutritional supplement for increased energy and stamina
WO2001021208A1 (en) 1999-09-23 2001-03-29 Juvenon Corporation Nutritional supplement for increased energy and stamina
US20070072927A1 (en) * 1999-09-23 2007-03-29 Vita Joseph A Nutritional supplement for increased energy and stamina
IT1307278B1 (it) * 1999-11-18 2001-10-30 Sigma Tau Healthscience Spa Composizione per la prevenzione e/o il trattamento di disturbi dovutiad un alterato metabolismo dei lipidi, che comprende propionil
US7713546B1 (en) * 2001-04-03 2010-05-11 Soft Gel Technologies, Inc. Corosolic acid formulation and its application for weight-loss management and blood sugar balance
US6964494B2 (en) 2001-01-22 2005-11-15 Eflare Corporation Pty Ltd Safety/warning device
ITRM20020620A1 (it) * 2002-12-13 2004-06-14 Sigma Tau Ind Farmaceuti Uso delle carnitine per la prevenzione e/o il trattamento dei disturbi causati dall'andropausa.
US20080089877A1 (en) * 2003-08-14 2008-04-17 Udell Ronald G Super Absorption Coenzyme Q10
US8124072B2 (en) 2003-09-29 2012-02-28 Soft Gel Technologies, Inc. Solubilized CoQ-10
US7169385B2 (en) * 2003-09-29 2007-01-30 Ronald G. Udell Solubilized CoQ-10 and carnitine
US8105583B2 (en) 2003-09-29 2012-01-31 Soft Gel Technologies, Inc. Solubilized CoQ-10
GB0323348D0 (en) * 2003-10-06 2003-11-05 Cambridge Theranostics Ltd Methods and means for modulating lipid metabolism
US20050232911A1 (en) * 2004-04-19 2005-10-20 Schreiber Brian D Prevention and treatment of metabolic abnormalities associated with excess intramyocellular lipid
US20060051435A1 (en) * 2004-08-19 2006-03-09 Udell Ronald G Nutritional supplement for body fat reduction
WO2006061341A1 (en) * 2004-12-10 2006-06-15 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Use of propionyl l-carnitine for the preparation of a high-dose medicament for the treatment of peripheral arterial disease
US7887852B2 (en) * 2005-06-03 2011-02-15 Soft Gel Technologies, Inc. Soft gel capsules containing polymethoxylated flavones and palm oil tocotrienols
US20050249803A1 (en) * 2005-06-03 2005-11-10 Udell Ronald G Soft gel capsules containing polymethoxylated flavones and palm oil tocotrienols
US20070104805A1 (en) * 2005-11-01 2007-05-10 Udell Ronald G Compositions of Hoodia Gordonii and Pinolenic Acid Derivatives
US7615324B2 (en) * 2007-03-14 2009-11-10 Fujifilm Corporation Photosensitive composition, and cured relief pattern production method and semiconductor device using the same
US8343541B2 (en) 2007-03-15 2013-01-01 Soft Gel Technologies, Inc. Ubiquinol and alpha lipoic acid compositions
US20080226696A1 (en) * 2007-03-15 2008-09-18 Ben Treadwell Methods of improving learning abilities of aged companion animals
EP2353596A1 (en) 2010-02-02 2011-08-10 SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. Combination composition, comprising as active ingredients L-carnitine or propionyl L-carnitine, for the prevention or treatment of chronic venous insufficiency
CA2801281C (en) * 2010-06-16 2018-07-10 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Acetyl-carnitine for use in a method for increasing neurogenesis in neural tissue
KR20230011999A (ko) 2020-05-15 2023-01-25 알파시그마 에스.피.에이. 메틸폴레이트를 포함하는 조성물
IT202100020729A1 (it) 2021-08-02 2023-02-02 Univ Degli Studi Di Napoli Federico Ii Preparazione combinata per il trattamento della malattia di Pompe

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Publication number Priority date Publication date Assignee Title
BE700864A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * 1967-07-03 1967-12-18
GB1256162A (en) * 1968-08-16 1971-12-08 Braun Fa B Improvements in and relating to liquid products for intravenous administration
US3810994A (en) * 1972-06-01 1974-05-14 Ethyl Corp Method and composition for treating obesity
JPS531812B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * 1972-12-07 1978-01-23
JPS5058213A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * 1973-09-26 1975-05-21
AU518617B2 (en) * 1977-04-29 1981-10-08 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Therapeutic application of acetyl-d, 1-carnitine
IT1143611B (it) * 1977-11-03 1986-10-22 Sigma Tau Ind Farmaceuti Applicazione della acetil-carnitina nella terapia delle affezioni cardiache di/tipo anossico,ischemico,cardiotossico e nelle sindromi aritmiche
FR2414914A1 (fr) * 1978-01-18 1979-08-17 Sigma Tau Ind Farmaceuti Utilisations therapeutiques nouvelles de l'acetyl-1-carnitine et d'autres derives acyles de la 1-carnitine
DE2903579A1 (de) * 1978-02-03 1979-08-09 Sigma Tau Ind Farmaceuti Verwendung von acetylcarnitin und anderen acylderivaten des carnitins zur behandlung der hyperlipoproteinaemie und hyperlimpidaemie sowie arzneimittel
IT1156741B (it) * 1978-05-15 1987-02-04 Sigma Tau Ind Farmaceuti Applicazione terapeutica della carnitina e di alcuni derivati acilati della carnitina nell'emodialisi

Also Published As

Publication number Publication date
DE2911670A1 (de) 1980-08-14
BE881681A (fr) 1980-05-30
JPS55136227A (en) 1980-10-23
AU5526880A (en) 1980-08-21
AU535565B2 (en) 1984-03-29
US4343816A (en) 1982-08-10
CH642848A5 (it) 1984-05-15
IT7947976A0 (it) 1979-02-12
NL8000741A (nl) 1980-08-14
FR2448347A1 (fr) 1980-09-05
JPH0233015B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1990-07-25
JPS55136223A (en) 1980-10-23
GB2043443A (en) 1980-10-08
JPH0233014B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1990-07-25

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Legal Events

Date Code Title Description
MEDI Supplementary protection certificate for pharmaceutical products: court of cassation

Free format text: CCP 502, 19950511; SIGMA-TAU INDUSTRIE FARMACEUTICHE R IUNITE S.P.A

TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19961216

MEDD Supplementary protection certificate for pharmaceutical products: granted

Free format text: CCP 502, 19950511; SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A