IT1200080B - Dispersione solida di un agente farmaceuticamente attivo, particolarmente diidropiridina, in una matrice cristallina solubile in acqua, composizione farmaceutica che la contiene e processo per la loro preparazione - Google Patents

Dispersione solida di un agente farmaceuticamente attivo, particolarmente diidropiridina, in una matrice cristallina solubile in acqua, composizione farmaceutica che la contiene e processo per la loro preparazione

Info

Publication number
IT1200080B
IT1200080B IT8548210A IT4821085A IT1200080B IT 1200080 B IT1200080 B IT 1200080B IT 8548210 A IT8548210 A IT 8548210A IT 4821085 A IT4821085 A IT 4821085A IT 1200080 B IT1200080 B IT 1200080B
Authority
IT
Italy
Prior art keywords
preparation
pharmaceutical composition
active agent
composition containing
water soluble
Prior art date
Application number
IT8548210A
Other languages
English (en)
Italian (it)
Other versions
IT8548210A0 (it
Inventor
Wolfgang Czarnecki
Jean Claude Gfeller
Hans Peter Bier
Original Assignee
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Ag filed Critical Sandoz Ag
Publication of IT8548210A0 publication Critical patent/IT8548210A0/it
Application granted granted Critical
Publication of IT1200080B publication Critical patent/IT1200080B/it

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
IT8548210A 1984-06-14 1985-06-13 Dispersione solida di un agente farmaceuticamente attivo, particolarmente diidropiridina, in una matrice cristallina solubile in acqua, composizione farmaceutica che la contiene e processo per la loro preparazione IT1200080B (it)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3422083 1984-06-14
DE3442566 1984-11-22

Publications (2)

Publication Number Publication Date
IT8548210A0 IT8548210A0 (it) 1985-06-13
IT1200080B true IT1200080B (it) 1989-01-05

Family

ID=25822108

Family Applications (1)

Application Number Title Priority Date Filing Date
IT8548210A IT1200080B (it) 1984-06-14 1985-06-13 Dispersione solida di un agente farmaceuticamente attivo, particolarmente diidropiridina, in una matrice cristallina solubile in acqua, composizione farmaceutica che la contiene e processo per la loro preparazione

Country Status (21)

Country Link
AT (1) AT391806B (pt)
AU (2) AU587190B2 (pt)
BE (1) BE902626A (pt)
CA (1) CA1264441A (pt)
CY (1) CY1635A (pt)
DE (1) DE3520184C2 (pt)
DK (1) DK167649B1 (pt)
ES (1) ES8702141A1 (pt)
FR (1) FR2565822B1 (pt)
GB (3) GB2160100B (pt)
GR (1) GR851430B (pt)
HK (1) HK25192A (pt)
HU (1) HU198844B (pt)
IE (1) IE58834B1 (pt)
IL (1) IL75490A0 (pt)
IT (1) IT1200080B (pt)
LU (1) LU85946A1 (pt)
NL (1) NL194389C (pt)
NZ (1) NZ212390A (pt)
PT (1) PT80635B (pt)
SE (1) SE504583C2 (pt)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1187751B (it) * 1985-10-15 1987-12-23 Eurand Spa Procedimento per la preparazione di formulazioni solidi di nifedipina ad elevata biodisponibilita' e ad effetto prolungato e formulazioni cosi' ottenute
US4816263A (en) * 1987-10-02 1989-03-28 Alza Corporation Dosage form for treating cardiovascular diseases comprising isradipine
EP0406315B1 (en) * 1988-03-24 1992-11-11 Bukh Meditec A/S Controlled release composition
GR1000270B (el) * 1988-09-30 1992-05-12 Alza Corp Μορφη δοσολογιας για θεραπεια καρδιαγγειακων ασθενειων.
DK469989D0 (da) * 1989-09-22 1989-09-22 Bukh Meditec Farmaceutisk praeparat
MX9300110A (es) * 1992-01-13 1994-07-29 Gerhard Gergely Preparacion farmaceutica en la forma de una tableta de efervescencia o de desintegracion o de un granulado de tipo instanteneo y procedimiento para su preparacion.
DE4201179A1 (de) * 1992-01-17 1993-07-22 Alfatec Pharma Gmbh Wirkstoff(e) enthaltendes granulat oder pellet mit einem geruest aus hydrophilen makromolekuelen und verfahren zu seiner herstellung
US6726930B1 (en) 1993-09-09 2004-04-27 Penwest Pharmaceuticals Co. Sustained release heterodisperse hydrogel systems for insoluble drugs
US5455046A (en) * 1993-09-09 1995-10-03 Edward Mendell Co., Inc. Sustained release heterodisperse hydrogel systems for insoluble drugs
US5773025A (en) * 1993-09-09 1998-06-30 Edward Mendell Co., Inc. Sustained release heterodisperse hydrogel systems--amorphous drugs
GB2281697A (en) * 1993-09-14 1995-03-15 Euro Celtique Sa Laxative compositions in capsules
DE69739165D1 (de) 1996-07-08 2009-01-29 Penwest Pharmaceuticals Co Matrix mit verzögerter freisetzung für hochdosierte unlösliche arzneistoffe
DE19710009A1 (de) * 1997-03-12 1998-09-24 Knoll Ag Mehrphasige wirkstoffhaltige Zubereitungsformen
US6056977A (en) 1997-10-15 2000-05-02 Edward Mendell Co., Inc. Once-a-day controlled release sulfonylurea formulation
US6787157B1 (en) 1998-03-10 2004-09-07 Abbott Laboratories Multiphase active ingredient-containing formulations
WO2000076480A2 (en) * 1999-06-11 2000-12-21 Eli Lilly And Company Pharmaceutical materials and methods for their preparation and use
US7001892B1 (en) 1999-06-11 2006-02-21 Purdue Research Foundation Pharmaceutical materials and methods for their preparation and use
KR100507400B1 (ko) * 1999-08-04 2005-08-10 아스텔라스세이야쿠 가부시키가이샤 안정한 경구용 의약 조성물
CA2352211C (en) 1999-09-30 2009-03-24 Edward Mendell Co., Inc. Sustained release matrix systems for highly soluble drugs
NZ526993A (en) * 2001-02-13 2005-01-28 Astrazeneca Ab Pharmaceutical formulation of a drug substance that has a pH-dependent solubility in water
US7135436B2 (en) 2003-05-05 2006-11-14 J.F. Daley International, Ltd. Solid algicide, preparation and usage in recirculating water
EP1690528A1 (de) 2005-02-11 2006-08-16 Abbott GmbH & Co. KG Herstellung von Dosierungsformen mit einer festen Dispersion eines mikrokristallinen Wirkstoffs
US8399007B2 (en) 2006-12-05 2013-03-19 Landec Corporation Method for formulating a controlled-release pharmaceutical formulation
EP2500015A1 (en) 2006-12-05 2012-09-19 Landec Corporation Delivery of drugs
US8114883B2 (en) 2007-12-04 2012-02-14 Landec Corporation Polymer formulations for delivery of bioactive materials
WO2010022193A2 (en) 2008-08-20 2010-02-25 Board Of Regents, The University Of Texas System Hot-melt extrusion of modified release multi-particulates

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1617362A1 (de) * 1967-11-17 1971-03-25 Beiersdorf Ag Verfahren zur Herstellung von Arzneimitteln mit verzoegerter Wirkstoffabgabe in Form von Kapseln
DE2400819C2 (de) * 1974-01-09 1982-04-22 Bayer Ag, 5090 Leverkusen Verfahren zur Herstellung fester Zubereitungen von schwerlöslichen Arzneimittelwirkstoffen in feinster Verteilung
DE2546577B2 (de) * 1975-10-17 1981-04-02 Sandoz-Patent-GmbH, 7850 Lörrach Feste Stoffe aus Polyvinylpyrrolidon und Ergotalkaloiden
GB1504553A (en) * 1975-11-17 1978-03-22 Sandoz Ltd Tablet formulations
GB1579818A (en) * 1977-06-07 1980-11-26 Yamanouchi Pharma Co Ltd Nifedipine-containing solid preparation composition
CH639659A5 (de) * 1978-12-18 1983-11-30 Sandoz Ag Neue 1,4-dihydropyridinderivate, deren herstellung und verwendung.
FI64938C (fi) * 1977-06-20 1984-02-10 Sandoz Ag Foerfarande foer framstaellning av nya terapeutiskt anvaendbara bensoxa- och bensotiadiazolyl-1,4-dihydropyridinderivat
EP0001247A1 (en) * 1977-09-14 1979-04-04 Kanebo, Ltd. Pharmaceutical preparation containing nifedipine and a method for producing the same.
FI793888A (fi) * 1978-12-21 1980-06-22 Sandoz Ag Galeniska blandningar
DE2904310A1 (de) * 1979-02-05 1980-08-07 Boehringer Mannheim Gmbh Formlinge mit retardierter wirkstofffreisetzung und verfahren zu deren herstellung
JPS56115726A (en) * 1980-02-20 1981-09-11 Kaken Pharmaceut Co Ltd Pharmaceutical containing nifedipine
DE3033919A1 (de) * 1980-09-09 1982-04-22 Bayer Ag, 5090 Leverkusen Feste arzneizubereitungen enthaltend nifedipin und verfahren zu ihrer herstellung
US4442112A (en) * 1981-09-02 1984-04-10 Sandoz Ltd. Dihydropyridine derivatives useful in treating vascular headaches
EP0078430B2 (de) * 1981-10-29 1993-02-10 Bayer Ag Verfahren zur Herstellung von festen, schnellfreisetzenden Arzneizubereitungen mit Dihydropyridinen
CA1208558A (en) * 1982-10-07 1986-07-29 Kazuo Kigasawa Soft buccal
DE3318649A1 (de) * 1983-05-21 1984-11-22 Bayer Ag, 5090 Leverkusen Zweiphasenformulierung

Also Published As

Publication number Publication date
GB8514855D0 (en) 1985-07-17
HU198844B (en) 1989-12-28
GB2196851A (en) 1988-05-11
GB2196851B (en) 1989-06-07
AU4454389A (en) 1990-03-22
IT8548210A0 (it) 1985-06-13
IL75490A0 (en) 1985-10-31
BE902626A (fr) 1985-12-10
IE58834B1 (en) 1993-11-17
AU587190B2 (en) 1989-08-10
GB8727055D0 (en) 1987-12-23
DK167649B1 (da) 1993-12-06
PT80635B (pt) 1987-10-20
NL194389C (nl) 2002-03-04
DE3520184A1 (de) 1985-12-19
GB2196852A (en) 1988-05-11
IE851460L (en) 1985-12-14
HUT40918A (en) 1987-03-30
FR2565822B1 (fr) 1989-02-17
GB8727056D0 (en) 1987-12-23
ATA174885A (de) 1990-06-15
ES544075A0 (es) 1987-01-01
DK264785D0 (da) 1985-06-12
ES8702141A1 (es) 1987-01-01
NL8501578A (nl) 1986-01-02
SE504583C2 (sv) 1997-03-10
AU4348685A (en) 1985-12-19
NL194389B (nl) 2001-11-01
DE3520184C2 (de) 1997-03-13
LU85946A1 (fr) 1986-01-24
NZ212390A (en) 1992-02-25
AT391806B (de) 1990-12-10
SE8502950D0 (sv) 1985-06-13
GB2160100A (en) 1985-12-18
FR2565822A1 (fr) 1985-12-20
CY1635A (en) 1992-11-06
PT80635A (en) 1985-07-01
DK264785A (da) 1985-12-15
GB2160100B (en) 1989-06-01
GR851430B (pt) 1985-11-25
HK25192A (en) 1992-04-10
SE8502950L (sv) 1985-12-15
GB2196852B (en) 1989-05-17
CA1264441A (en) 1990-01-16

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Legal Events

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TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19970623