IT1178457B - Derivati di 3-cefem-4-carbossilati e loro sali, esteri e solvati aventi proprieta' antibatteriche - Google Patents

Derivati di 3-cefem-4-carbossilati e loro sali, esteri e solvati aventi proprieta' antibatteriche

Info

Publication number
IT1178457B
IT1178457B IT19543/84A IT1954384A IT1178457B IT 1178457 B IT1178457 B IT 1178457B IT 19543/84 A IT19543/84 A IT 19543/84A IT 1954384 A IT1954384 A IT 1954384A IT 1178457 B IT1178457 B IT 1178457B
Authority
IT
Italy
Prior art keywords
cefem
carboxylates
solvates
esters
derivatives
Prior art date
Application number
IT19543/84A
Other languages
English (en)
Other versions
IT8419543A0 (it
Inventor
Narita Yukio
Iimura Seiji
Aburaki Shimpei
Okumura Jun
Naito Takayuki
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of IT8419543A0 publication Critical patent/IT8419543A0/it
Application granted granted Critical
Publication of IT1178457B publication Critical patent/IT1178457B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
IT19543/84A 1983-02-10 1984-02-09 Derivati di 3-cefem-4-carbossilati e loro sali, esteri e solvati aventi proprieta' antibatteriche IT1178457B (it)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/465,374 US4486586A (en) 1983-02-10 1983-02-10 Cephalosporin derivatives

Publications (2)

Publication Number Publication Date
IT8419543A0 IT8419543A0 (it) 1984-02-09
IT1178457B true IT1178457B (it) 1987-09-09

Family

ID=23847555

Family Applications (1)

Application Number Title Priority Date Filing Date
IT19543/84A IT1178457B (it) 1983-02-10 1984-02-09 Derivati di 3-cefem-4-carbossilati e loro sali, esteri e solvati aventi proprieta' antibatteriche

Country Status (9)

Country Link
US (1) US4486586A (it)
JP (2) JPS59172493A (it)
CY (2) CY1526A (it)
DE (1) DE3404615A1 (it)
FR (1) FR2540875B1 (it)
GB (2) GB2134522B (it)
HK (2) HK31990A (it)
IT (1) IT1178457B (it)
MY (1) MY101117A (it)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4751295A (en) * 1984-04-09 1988-06-14 Bristol-Myers Company Cephalosporin derivatives
CA1276929C (en) * 1984-04-09 1990-11-27 Masahisa Oka Cephalosporin antibacterial agents
US4788185A (en) * 1984-04-23 1988-11-29 Takeda Chemical Industries, Ltd. Cephalosporin compounds
GB8411954D0 (en) * 1984-05-10 1984-06-13 Glaxo Group Ltd Cephalosporin antibiotics
JPS61145186A (ja) * 1984-12-20 1986-07-02 Meiji Seika Kaisha Ltd 新規セフエム化合物及びその製造法
ATE89826T1 (de) * 1985-03-01 1993-06-15 Takeda Chemical Industries Ltd Antibakterielle verbindungen, ihre herstellung und verwendung.
US4708955A (en) * 1985-06-24 1987-11-24 Bristol-Myers Company 3-(substituted)propenyl-7-aminothiazol-ylcephalosporanic acids and esters thereof
US4874856A (en) * 1985-06-24 1989-10-17 Bristol-Myers Company 3-(substituted)propenyl-7-(aminothiazolylacetamido) ceph-3-em-4-carboxylic acids and esters thereof
DE3650157T2 (de) * 1985-12-26 1995-05-04 Eisai Co Ltd Cephalosporin-verbindungen.
US5373000A (en) * 1985-12-26 1994-12-13 Eisai Co., Ltd. 7Beta-(thiadiazolyl)-2-iminoacetamido-3cephem compounds
IL84128A (en) * 1986-10-13 1992-12-01 Eisai Co Ltd 3-propenylcephem derivatives, their preparation and pharmaceutical compositions containing them
US4929612A (en) * 1987-04-17 1990-05-29 Eisai Co., Ltd. Thiadiazolylacetamide cephem derivatives
FR2622585B1 (fr) * 1987-11-03 1991-04-19 Roussel Uclaf Nouvelles cephalosporines comportant en position 3 un radical vinyle substitue, leur procede de preparation, leur application comme medicaments, les compositions les renfermant et les nouveaux intermediaires obtenus
US5019571A (en) * 1988-01-25 1991-05-28 Eli Lilly And Company 1-carbacephalosporin antibiotics
ATE155469T1 (de) * 1988-03-16 1997-08-15 Eisai Co Ltd Verfahren zur herstellung von cephemderivaten
FR2663332B1 (fr) * 1990-06-15 1997-11-07 Roussel Uclaf Nouvelles cephalosporines comportant en position 3 un radical propenyle substitue par un ammonium quaternaire, leur procede de preparation, leur application comme medicaments, les compositions les renfermant et les nouveaux intermediaires obtenus.
FR2684995A1 (en) * 1991-12-12 1993-06-18 Roussel Uclaf Cephalosporins containing a ( alpha -carboxy-3,4-dihydroxybenzyloxyimino) group, preparation process and intermediates, application as medicaments and pharmaceutical compositions
US5143911A (en) * 1990-08-23 1992-09-01 Bristol-Myers Squibb Company Antibiotic c-3 di-hydroxyphenyl substituted cephalosporin compounds, compositions and method of use thereof
US5234920A (en) * 1990-08-23 1993-08-10 Bristol-Myers Squibb Company Antibiotic C-7 catechol-substituted cephalosporin compounds, compositions, and method of use thereof
US5126336A (en) * 1990-08-23 1992-06-30 Bristol-Myers Squibb Company Antibiotic c-3 catechol-substituted cephalosporin compounds, compositions and method of use thereof
US5095012A (en) * 1990-08-23 1992-03-10 Bristol-Myers Squibb Company Antibiotic c-7 catechol-substituted cephalosporin compounds, compositions, and method of use thereof
AT396108B (de) * 1991-08-21 1993-06-25 Biochemie Gmbh Neues verfahren und neue zwischenprodukte zur herstellung von 7-aminocephalosporansaeurederivaten
FR2696180B1 (fr) * 1992-09-28 1994-10-28 Roussel Uclaf Nouvelles céphalosporines comportant en position 7, un radical benzyloxyimino substitué, leur procédé de préparation et leur application comme médicaments.
ATE196472T1 (de) * 1991-12-12 2000-10-15 Hoechst Marion Roussel Inc Antibiotische cephalosporine einen substituierten benzyloxyimino-radikal in position 7 tragend
FR2684994B1 (fr) * 1991-12-12 1995-03-03 Roussel Uclaf Nouvelles cephalosporines comportant en position 7, un radical benzyloxyimino substitue, leur procede de preparation et leur application comme medicaments.
JPH07173168A (ja) * 1993-07-14 1995-07-11 Sumitomo Chem Co Ltd セフェム系化合物、その製法、およびそれのセフェム系抗生物質製造への利用
JPH0741484A (ja) * 1993-07-29 1995-02-10 Katayama Seiyakushiyo:Kk セフェム化合物及び抗菌剤
US5661144A (en) * 1994-08-16 1997-08-26 Meiji Seika Kabushiki Kaisha Cephem derivatives with 3-substituted bis heterocycles
US7427680B2 (en) * 2001-01-12 2008-09-23 The Regents Of The University Of California Fluorogenic substrates for BETA-lactamase gene expression
KR0164458B1 (ko) 1995-04-04 1999-01-15 김은영 암모니오세팔로스포린 계열 항생제 및 그의 제조방법
BR9911445A (pt) 1998-06-22 2001-03-20 Hoffmann La Roche Derivados de propenil cefalosporina
JP4658806B2 (ja) * 2003-09-09 2011-03-23 日本化学工業株式会社 ３−クロロメチル−３−セフェム誘導体の製造方法
US7214825B2 (en) 2003-10-17 2007-05-08 Honeywell International Inc. O-(3-chloropropenyl) hydroxylamine free base
WO2005071096A2 (en) 2004-01-21 2005-08-04 Molecular Probes, Inc. Derivatives of cephalosporin and clavulanic acid for detecting beta-lacamase in a sample

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1342241A (en) * 1970-01-23 1974-01-03 Glaxo Lab Ltd Cephalosporin compounds
GB1399086A (en) * 1971-05-14 1975-06-25 Glaxo Lab Ltd Cephalosporin compounds
GB1591439A (en) * 1976-10-01 1981-06-24 Glaxo Operations Ltd 7-syn (oxyimino -acylamido) cephalosporins
AR229883A1 (es) * 1978-05-26 1983-12-30 Glaxo Group Ltd Procedimiento para la preparacion de antibiotico(6r,7r)-7-((z)-2-(2-aminotiazol-4-il)-2-(2-carboxiprop-2-oxiimino)-acetamido)-3-(1-piridinometil)-cef-3-em-4-carboxilato
ES485433A1 (es) * 1978-10-27 1980-07-01 Glaxo Group Ltd Un procedimiento para la preparacion de antibioticos de ce- falosporina
NO801501L (no) * 1979-05-23 1980-11-24 Rhone Poulenc Ind Fremgangsmaate for fremstilling av 3-tiovinylcefalosporiner
FR2457296A1 (fr) * 1979-05-23 1980-12-19 Rhone Poulenc Ind Nouveaux derives de vinyl-3 cephalosporines et leur preparation
US4409214A (en) * 1979-11-19 1983-10-11 Fujisawa Pharmaceutical, Co., Ltd. 7-Acylamino-3-vinylcephalosporanic acid derivatives and processes for the preparation thereof
US4443444A (en) * 1980-08-11 1984-04-17 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds
FR2494280A1 (fr) * 1980-11-20 1982-05-21 Rhone Poulenc Ind Nouveaux derives de la cephalosporine et leur preparation
FR2494275A2 (fr) * 1980-11-20 1982-05-21 Rhone Poulenc Ind Nouveaux derives de vinyl-3 cephalosporines et leur preparation
FR2494276A2 (fr) * 1980-11-20 1982-05-21 Rhone Poulenc Ind Nouvelles vinyl-3 cephalosporines, et leur preparation

Also Published As

Publication number Publication date
GB2178038B (en) 1987-08-12
DE3404615C2 (it) 1989-06-15
HK31990A (en) 1990-05-04
JPH0357108B2 (it) 1991-08-30
GB8620597D0 (en) 1986-10-01
GB2134522A (en) 1984-08-15
MY101117A (en) 1991-07-16
JPS61165393A (ja) 1986-07-26
IT8419543A0 (it) 1984-02-09
CY1527A (en) 1990-11-16
HK33890A (en) 1990-05-11
GB2178038A (en) 1987-02-04
FR2540875B1 (fr) 1986-10-17
JPS59172493A (ja) 1984-09-29
JPS6220191B2 (it) 1987-05-06
FR2540875A1 (fr) 1984-08-17
DE3404615A1 (de) 1984-08-16
US4486586A (en) 1984-12-04
GB2134522B (en) 1987-02-25
GB8403474D0 (en) 1984-03-14
CY1526A (en) 1990-11-16

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