FR2540875B1 - Nouveaux derives de la cephalosporine et leur procede de preparation - Google Patents

Nouveaux derives de la cephalosporine et leur procede de preparation

Info

Publication number
FR2540875B1
FR2540875B1 FR8402017A FR8402017A FR2540875B1 FR 2540875 B1 FR2540875 B1 FR 2540875B1 FR 8402017 A FR8402017 A FR 8402017A FR 8402017 A FR8402017 A FR 8402017A FR 2540875 B1 FR2540875 B1 FR 2540875B1
Authority
FR
France
Prior art keywords
preparation process
cephalosporin derivatives
novel cephalosporin
novel
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR8402017A
Other languages
English (en)
Other versions
FR2540875A1 (fr
Inventor
Yukio Narita
Seiji Iimura
Shimpei Aburaki
Jun Okumura
Takayuki Naito
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Co
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of FR2540875A1 publication Critical patent/FR2540875A1/fr
Application granted granted Critical
Publication of FR2540875B1 publication Critical patent/FR2540875B1/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FR8402017A 1983-02-10 1984-02-09 Nouveaux derives de la cephalosporine et leur procede de preparation Expired FR2540875B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/465,374 US4486586A (en) 1983-02-10 1983-02-10 Cephalosporin derivatives

Publications (2)

Publication Number Publication Date
FR2540875A1 FR2540875A1 (fr) 1984-08-17
FR2540875B1 true FR2540875B1 (fr) 1986-10-17

Family

ID=23847555

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8402017A Expired FR2540875B1 (fr) 1983-02-10 1984-02-09 Nouveaux derives de la cephalosporine et leur procede de preparation

Country Status (9)

Country Link
US (1) US4486586A (fr)
JP (2) JPS59172493A (fr)
CY (2) CY1527A (fr)
DE (1) DE3404615A1 (fr)
FR (1) FR2540875B1 (fr)
GB (2) GB2134522B (fr)
HK (2) HK31990A (fr)
IT (1) IT1178457B (fr)
MY (1) MY101117A (fr)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4751295A (en) * 1984-04-09 1988-06-14 Bristol-Myers Company Cephalosporin derivatives
CA1276929C (fr) * 1984-04-09 1990-11-27 Masahisa Oka Agents antibacteriens de cephalosporine
US4788185A (en) * 1984-04-23 1988-11-29 Takeda Chemical Industries, Ltd. Cephalosporin compounds
GB8411954D0 (en) * 1984-05-10 1984-06-13 Glaxo Group Ltd Cephalosporin antibiotics
JPS61145186A (ja) * 1984-12-20 1986-07-02 Meiji Seika Kaisha Ltd 新規セフエム化合物及びその製造法
ATE89826T1 (de) * 1985-03-01 1993-06-15 Takeda Chemical Industries Ltd Antibakterielle verbindungen, ihre herstellung und verwendung.
US4708955A (en) * 1985-06-24 1987-11-24 Bristol-Myers Company 3-(substituted)propenyl-7-aminothiazol-ylcephalosporanic acids and esters thereof
US4874856A (en) * 1985-06-24 1989-10-17 Bristol-Myers Company 3-(substituted)propenyl-7-(aminothiazolylacetamido) ceph-3-em-4-carboxylic acids and esters thereof
US5373000A (en) * 1985-12-26 1994-12-13 Eisai Co., Ltd. 7Beta-(thiadiazolyl)-2-iminoacetamido-3cephem compounds
WO1987003875A1 (fr) * 1985-12-26 1987-07-02 Eisai Co., Ltd. Derives de cephalosporine
IL84128A (en) * 1986-10-13 1992-12-01 Eisai Co Ltd 3-propenylcephem derivatives, their preparation and pharmaceutical compositions containing them
US4929612A (en) * 1987-04-17 1990-05-29 Eisai Co., Ltd. Thiadiazolylacetamide cephem derivatives
FR2622585B1 (fr) * 1987-11-03 1991-04-19 Roussel Uclaf Nouvelles cephalosporines comportant en position 3 un radical vinyle substitue, leur procede de preparation, leur application comme medicaments, les compositions les renfermant et les nouveaux intermediaires obtenus
US5019571A (en) * 1988-01-25 1991-05-28 Eli Lilly And Company 1-carbacephalosporin antibiotics
DE68928174T2 (de) * 1988-03-16 1997-12-18 Eisai Co Ltd Verfahren zur Herstellung von Cephemderivaten
FR2663332B1 (fr) * 1990-06-15 1997-11-07 Roussel Uclaf Nouvelles cephalosporines comportant en position 3 un radical propenyle substitue par un ammonium quaternaire, leur procede de preparation, leur application comme medicaments, les compositions les renfermant et les nouveaux intermediaires obtenus.
FR2684995A1 (en) * 1991-12-12 1993-06-18 Roussel Uclaf Cephalosporins containing a ( alpha -carboxy-3,4-dihydroxybenzyloxyimino) group, preparation process and intermediates, application as medicaments and pharmaceutical compositions
US5095012A (en) * 1990-08-23 1992-03-10 Bristol-Myers Squibb Company Antibiotic c-7 catechol-substituted cephalosporin compounds, compositions, and method of use thereof
US5143911A (en) * 1990-08-23 1992-09-01 Bristol-Myers Squibb Company Antibiotic c-3 di-hydroxyphenyl substituted cephalosporin compounds, compositions and method of use thereof
US5126336A (en) * 1990-08-23 1992-06-30 Bristol-Myers Squibb Company Antibiotic c-3 catechol-substituted cephalosporin compounds, compositions and method of use thereof
US5234920A (en) * 1990-08-23 1993-08-10 Bristol-Myers Squibb Company Antibiotic C-7 catechol-substituted cephalosporin compounds, compositions, and method of use thereof
AT396108B (de) * 1991-08-21 1993-06-25 Biochemie Gmbh Neues verfahren und neue zwischenprodukte zur herstellung von 7-aminocephalosporansaeurederivaten
SG45426A1 (en) * 1991-12-12 1998-01-16 Roussel Uclaf Novel cephalosporins substituted in the 7-position by a benzylamino radical processes for their preparation and their use as medicaments
FR2696180B1 (fr) * 1992-09-28 1994-10-28 Roussel Uclaf Nouvelles céphalosporines comportant en position 7, un radical benzyloxyimino substitué, leur procédé de préparation et leur application comme médicaments.
FR2684994B1 (fr) * 1991-12-12 1995-03-03 Roussel Uclaf Nouvelles cephalosporines comportant en position 7, un radical benzyloxyimino substitue, leur procede de preparation et leur application comme medicaments.
JPH07173168A (ja) * 1993-07-14 1995-07-11 Sumitomo Chem Co Ltd セフェム系化合物、その製法、およびそれのセフェム系抗生物質製造への利用
JPH0741484A (ja) * 1993-07-29 1995-02-10 Katayama Seiyakushiyo:Kk セフェム化合物及び抗菌剤
WO1996005205A1 (fr) * 1994-08-16 1996-02-22 Meiji Seika Kabushiki Kaisha Nouveau derive de cepheme
US7427680B2 (en) * 2001-01-12 2008-09-23 The Regents Of The University Of California Fluorogenic substrates for BETA-lactamase gene expression
KR0164458B1 (ko) 1995-04-04 1999-01-15 김은영 암모니오세팔로스포린 계열 항생제 및 그의 제조방법
AU761450B2 (en) 1998-06-22 2003-06-05 Basilea Pharmaceutica Ag Propenyl cephalosporin derivatives
JP4658806B2 (ja) * 2003-09-09 2011-03-23 日本化学工業株式会社 ３−クロロメチル−３−セフェム誘導体の製造方法
US7214825B2 (en) 2003-10-17 2007-05-08 Honeywell International Inc. O-(3-chloropropenyl) hydroxylamine free base
US20050227309A1 (en) * 2004-01-21 2005-10-13 Corry Schuyler B Optically-detectable enzyme substrates and their method of use

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1342241A (en) * 1970-01-23 1974-01-03 Glaxo Lab Ltd Cephalosporin compounds
GB1399086A (en) * 1971-05-14 1975-06-25 Glaxo Lab Ltd Cephalosporin compounds
GB1591439A (en) * 1976-10-01 1981-06-24 Glaxo Operations Ltd 7-syn (oxyimino -acylamido) cephalosporins
AR228726A1 (es) * 1978-05-26 1983-04-15 Glaxo Group Ltd Procedimiento para la preparacion del antibiotico(6r,7r)-7-((z)-2-(2-aminotiazol-4-il)-2-(2-carboxiprop-2-oxiimino)acetamido)-3-(1-piridiniometil)cef-3-em-4-carboxilato
CA1131618A (fr) * 1978-10-27 1982-09-14 Cynthia H. O'callaghan Composes de cephalosporine
BE883415A (fr) * 1979-05-23 1980-11-21 Rhone Poulenc Ind Nouvelles thiovinyl-3 cephalosporines, leur preparation et les compositions qui les contiennent
FR2457296A1 (fr) * 1979-05-23 1980-12-19 Rhone Poulenc Ind Nouveaux derives de vinyl-3 cephalosporines et leur preparation
US4409214A (en) * 1979-11-19 1983-10-11 Fujisawa Pharmaceutical, Co., Ltd. 7-Acylamino-3-vinylcephalosporanic acid derivatives and processes for the preparation thereof
US4443444A (en) * 1980-08-11 1984-04-17 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds
FR2494275A2 (fr) * 1980-11-20 1982-05-21 Rhone Poulenc Ind Nouveaux derives de vinyl-3 cephalosporines et leur preparation
FR2494276A2 (fr) * 1980-11-20 1982-05-21 Rhone Poulenc Ind Nouvelles vinyl-3 cephalosporines, et leur preparation
FR2494280A1 (fr) * 1980-11-20 1982-05-21 Rhone Poulenc Ind Nouveaux derives de la cephalosporine et leur preparation

Also Published As

Publication number Publication date
DE3404615C2 (fr) 1989-06-15
GB2178038A (en) 1987-02-04
FR2540875A1 (fr) 1984-08-17
JPH0357108B2 (fr) 1991-08-30
MY101117A (en) 1991-07-16
IT8419543A0 (it) 1984-02-09
GB2134522A (en) 1984-08-15
HK33890A (en) 1990-05-11
US4486586A (en) 1984-12-04
GB8620597D0 (en) 1986-10-01
JPS59172493A (ja) 1984-09-29
JPS6220191B2 (fr) 1987-05-06
IT1178457B (it) 1987-09-09
DE3404615A1 (de) 1984-08-16
GB8403474D0 (en) 1984-03-14
GB2134522B (en) 1987-02-25
CY1527A (en) 1990-11-16
JPS61165393A (ja) 1986-07-26
GB2178038B (en) 1987-08-12
HK31990A (en) 1990-05-04
CY1526A (en) 1990-11-16

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Legal Events

Date Code Title Description
ST Notification of lapse