IT1178455B - Soluzioni di insulina stabilizzate e metodi per la loro produzione - Google Patents

Soluzioni di insulina stabilizzate e metodi per la loro produzione

Info

Publication number
IT1178455B
IT1178455B IT19420/83A IT1942083A IT1178455B IT 1178455 B IT1178455 B IT 1178455B IT 19420/83 A IT19420/83 A IT 19420/83A IT 1942083 A IT1942083 A IT 1942083A IT 1178455 B IT1178455 B IT 1178455B
Authority
IT
Italy
Prior art keywords
production
methods
insulin solutions
stabilized insulin
stabilized
Prior art date
Application number
IT19420/83A
Other languages
English (en)
Italian (it)
Other versions
IT8319420A0 (it
Inventor
Jens Jorgen Vejlgaard Brange
Svend Havelund
Original Assignee
Novo Industri As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Industri As filed Critical Novo Industri As
Publication of IT8319420A0 publication Critical patent/IT8319420A0/it
Application granted granted Critical
Publication of IT1178455B publication Critical patent/IT1178455B/it

Links

Classifications

    • H—ELECTRICITY
    • H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
    • H05K—PRINTED CIRCUITS; CASINGS OR CONSTRUCTIONAL DETAILS OF ELECTRIC APPARATUS; MANUFACTURE OF ASSEMBLAGES OF ELECTRICAL COMPONENTS
    • H05K13/00—Apparatus or processes specially adapted for manufacturing or adjusting assemblages of electric components
    • H05K13/06—Wiring by machine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Manufacturing & Machinery (AREA)
  • Microelectronics & Electronic Packaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
IT19420/83A 1982-02-05 1983-02-04 Soluzioni di insulina stabilizzate e metodi per la loro produzione IT1178455B (it)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK49182 1982-02-05

Publications (2)

Publication Number Publication Date
IT8319420A0 IT8319420A0 (it) 1983-02-04
IT1178455B true IT1178455B (it) 1987-09-09

Family

ID=8094159

Family Applications (1)

Application Number Title Priority Date Filing Date
IT19420/83A IT1178455B (it) 1982-02-05 1983-02-04 Soluzioni di insulina stabilizzate e metodi per la loro produzione

Country Status (22)

Country Link
US (1) US4476118A (cg-RX-API-DMAC7.html)
JP (1) JPS58192818A (cg-RX-API-DMAC7.html)
AT (1) AT382780B (cg-RX-API-DMAC7.html)
AU (1) AU549981B2 (cg-RX-API-DMAC7.html)
BE (1) BE895832A (cg-RX-API-DMAC7.html)
CA (1) CA1203476A (cg-RX-API-DMAC7.html)
CH (1) CH657530A5 (cg-RX-API-DMAC7.html)
DE (1) DE3303860A1 (cg-RX-API-DMAC7.html)
ES (1) ES519533A0 (cg-RX-API-DMAC7.html)
FI (1) FI78616C (cg-RX-API-DMAC7.html)
FR (1) FR2521009B1 (cg-RX-API-DMAC7.html)
GB (1) GB2114573B (cg-RX-API-DMAC7.html)
GR (1) GR77388B (cg-RX-API-DMAC7.html)
IE (1) IE54548B1 (cg-RX-API-DMAC7.html)
IT (1) IT1178455B (cg-RX-API-DMAC7.html)
LU (1) LU84632A1 (cg-RX-API-DMAC7.html)
NL (1) NL187269C (cg-RX-API-DMAC7.html)
NO (1) NO161204C (cg-RX-API-DMAC7.html)
NZ (1) NZ203189A (cg-RX-API-DMAC7.html)
PT (1) PT76195B (cg-RX-API-DMAC7.html)
SE (1) SE460948B (cg-RX-API-DMAC7.html)
ZA (1) ZA83742B (cg-RX-API-DMAC7.html)

Families Citing this family (51)

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DE3576120D1 (de) * 1984-06-09 1990-04-05 Hoechst Ag Insulinzubereitungen, verfahren zu deren herstellung und deren verwendung.
JP2520262B2 (ja) * 1987-08-21 1996-07-31 春幸 川原 パツチテスト材料
US4789660A (en) * 1987-09-10 1988-12-06 American Home Products Corporation Insulin administration using methyl and propyl paraben
US5130298A (en) * 1989-05-16 1992-07-14 Ethicon, Inc. Stabilized compositions containing epidermal growth factor
US5534488A (en) * 1993-08-13 1996-07-09 Eli Lilly And Company Insulin formulation
US5474978A (en) * 1994-06-16 1995-12-12 Eli Lilly And Company Insulin analog formulations
AR002976A1 (es) * 1995-03-31 1998-05-27 Lilly Co Eli Formulaciones farmaceuticas parenterales de efecto prolongado de insulina; cristales de dichos analogos aplicables en dichas formulaciones yprocedimiento de las formulaciones mencionadas
AU7678196A (en) * 1995-11-13 1997-06-05 Minimed, Inc. Methods and compositions for the delivery of monomeric proteins
AU2260097A (en) * 1996-03-12 1997-10-01 Life Technologies, Inc. Hematopoietic cell culture nutrient supplement
EP0821006B1 (de) * 1996-07-26 2004-04-21 Aventis Pharma Deutschland GmbH Insulinderivate mit erhöhter Zinkbindung
EP1283051B1 (en) * 1997-06-13 2006-06-14 Eli Lilly And Company Stable insulin formulations
CO4750643A1 (es) * 1997-06-13 1999-03-31 Lilly Co Eli Formulacion estable de la insulina que contiene l-arginina y protamina
DE69826705T2 (de) * 1997-11-12 2006-02-23 Alza Corp., Palo Alto Verfahren zur dermalen verabreichung von polypeptiden
DE19825447A1 (de) 1998-06-06 1999-12-09 Hoechst Marion Roussel De Gmbh Neue Insulinanaloga mit erhöhter Zinkbildung
PL197504B1 (pl) * 1998-10-16 2008-04-30 Novo Nordisk As Trwałe stężone preparaty insulinowe do podawania do płuc
DE19930676B4 (de) * 1999-07-02 2006-01-19 Sanofi-Aventis Deutschland Gmbh Verfahren zur Stabilisierung von Insulin, Insulinderivaten und/oder deren Vorläufer in komplexen Mischungen bei deren Lagerung in wäßrigen Lösungsmitteln
ES2266187T3 (es) * 2000-03-24 2007-03-01 Genentech, Inc. Uso de la insulina para el tratamiento de trastornos del cartilago.
JP4147234B2 (ja) * 2004-09-27 2008-09-10 キヤノン株式会社 吐出用液体、吐出方法、カートリッジ及び吐出装置
ATE496064T1 (de) 2002-05-07 2011-02-15 Novo Nordisk As Lösliche formulierungen, die monomeres insulin und acyliertes insulin enthalten
US20050065066A1 (en) * 2002-12-20 2005-03-24 Kaarsholm Niels Christian Stabilised insulin compositions
AU2003291972A1 (en) * 2002-12-20 2004-07-14 Novo Nordisk A/S Pharmaceutical compositions comprising insulin and legends of insulin hexamer
WO2004096266A1 (en) * 2003-05-02 2004-11-11 Novo Nordisk A/S Improved physical stability of insulin formulations
BRPI0413276B8 (pt) * 2003-08-05 2021-05-25 Novo Nordisk As derivado de insulina, complexo de zinco do mesmo, e, composição farmacêutica
KR101309770B1 (ko) * 2004-07-19 2013-09-30 바이오콘 리미티드 인슐린―올리고머 접합체，제형 및 이들의 용도
DK1969004T3 (da) * 2005-12-28 2011-11-28 Novo Nordisk As Insulinsammensætninger og metode til at lave en sammensætning
US20090136538A1 (en) * 2006-05-22 2009-05-28 Jan Jezek Stable vaccine formulation
GB0700523D0 (en) * 2007-01-11 2007-02-21 Insense Ltd The Stabilisation Of Proteins
EP2134351B1 (en) 2007-03-13 2016-04-27 Nutrition 21, Inc. Methods and compositions for the sustained release of chromium
CN101677947B (zh) * 2007-06-13 2013-07-17 诺沃-诺迪斯克有限公司 包含胰岛素衍生物的药物制剂
WO2009002867A2 (en) 2007-06-26 2008-12-31 Nutrition 21, Inc. Multiple unit dosage form having a therapeutic agents in combination with a nutritional supplement
US8937042B2 (en) 2007-11-16 2015-01-20 Novo Nordisk A/S Pharmaceutical compositions comprising GLP-1 peptides or extendin-4 and a basal insulin peptide
EP2328607A1 (en) * 2008-07-16 2011-06-08 Arecor Limited Stable formulation of a therapeutic protein
EP2341940A1 (en) * 2008-07-16 2011-07-13 Arecor Limited The stabilisation of proteins
ES2607003T3 (es) * 2008-10-30 2017-03-28 Novo Nordisk A/S Tratamiento de diabetes mellitus utilizando inyecciones de insulina con una frecuencia de inyección inferior a la diaria
US9060927B2 (en) 2009-03-03 2015-06-23 Biodel Inc. Insulin formulations for rapid uptake
JP6049625B2 (ja) 2010-10-27 2016-12-21 ノヴォ ノルディスク アー／エス 様々な注射間隔を用いて施されるインスリン注射を使用する、真性糖尿病の治療
WO2012119007A1 (en) 2011-03-01 2012-09-07 N21 Acquisition Holding, Llc Compositions of insulin and chromium for the treatment and prevention of diabetes, hypoglycemia and related disorders
EP2919804B1 (fr) 2012-11-13 2018-01-31 Adocia Formulation à action rapide d'insuline comprenant un composé anionique substitué
AU2013365945B2 (en) * 2012-12-19 2017-03-02 Wockhardt Limited A stable aqueous composition comprising human insulin or an analogue or derivative thereof
NZ707168A (en) 2012-12-26 2016-09-30 Wockhardt Ltd Pharmaceutical composition of insulins
TWI780236B (zh) * 2013-02-04 2022-10-11 法商賽諾菲公司 胰島素類似物及/或胰島素衍生物之穩定化醫藥調配物
WO2014177623A1 (en) 2013-04-30 2014-11-06 Novo Nordisk A/S Novel administration regime
EP3077414B1 (en) * 2013-12-04 2020-06-17 Merck Sharp & Dohme Corp. Method for preparing crystalline insulin
AR102869A1 (es) 2014-12-16 2017-03-29 Lilly Co Eli Composiciones de insulina de rápida acción
JO3749B1 (ar) 2015-08-27 2021-01-31 Lilly Co Eli تركيبات إنسولين سريعة المفعول
MX2018009748A (es) 2016-02-11 2019-02-07 Nutrition 21 Llc Composiciones que contienen cromo para mejorar la salud y el estado físico.
WO2018060735A1 (en) * 2016-09-29 2018-04-05 Arecor Limited Novel formulations
IL270975B2 (en) 2017-06-01 2024-02-01 Lilly Co Eli Fast-acting insulin preparations
US10335464B1 (en) 2018-06-26 2019-07-02 Novo Nordisk A/S Device for titrating basal insulin
WO2021009027A1 (en) 2019-07-12 2021-01-21 Novo Nordisk A/S High concentration insulin formulation
CN120142500B (zh) * 2025-02-28 2025-10-10 中国计量科学研究院 一种具有互换性的活性人胰岛素溶液标准物质及其制备方法和应用

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Publication number Priority date Publication date Assignee Title
US2882202A (en) * 1950-04-05 1959-04-14 Novo Terapeutisk Labor As Insulin crystal preparations and methods of producing them
US2787575A (en) * 1950-11-22 1957-04-02 Organon Zinc-glycine-insulin composition and production thereof
US2882203A (en) * 1951-06-26 1959-04-14 Novo Terapeutisk Labor As Injectable insulin preparation with protracted effect
DE1044360B (de) * 1953-08-19 1958-11-20 Roskilde Medical Company Ltd R Verfahren zur Herstellung von Zinkinsulin mit erhoehtem Zinkgehalt
DE956098C (de) * 1954-02-18 1957-01-10 Dr Dr Guenther Weitzel Verfahren zur Herstellung zinkreicher Insulin-Komplexverbindungen
US3058885A (en) * 1957-06-08 1962-10-16 Novo Terapeutisk Labor As Process for treatment of insulin crystals and for production of insulin preparationstherefrom
US3014842A (en) * 1957-08-10 1961-12-26 Novo Terapeutish Lab A S Injectable bovine insulin crystal suspensions and process of producing same
US3091573A (en) * 1958-05-12 1963-05-28 Novo Terapeutisk Labor As Quick acting insulin preparation
FR1263220A (fr) * 1958-08-01 1961-06-09 Novo Terapeutisk Labor As Procédé de production d'une préparation d'insuline à action rapide
DK116527B (da) * 1967-03-01 1970-01-19 Nordisk Insulinlab Fremgangsmåde til fremstilling af en hurtigtvirkende, holdbar, neutral opløsning af rent krystallinsk okseinsulin eller okseinsulin, der ved tilsætning af Zn er krystalliserbart i vand, eller blandinger af okseinsulin og insulin af anden oprindelse.
GB1285023A (en) * 1968-08-09 1972-08-09 Novo Terapeutisk Labor As Improvements in or relating to injectable insulin preparations
US3657425A (en) * 1969-03-12 1972-04-18 Burroughs Wellcome Co Beef insulin preparations
DE2459515C3 (de) * 1974-12-17 1982-02-11 Hoechst Ag, 6000 Frankfurt Arzneimittelzubereitungen mit antidiabetischer Wirkung
DE3064888D1 (en) * 1979-04-30 1983-10-27 Hoechst Ag Aqueous solutions of proteins stable against denaturization, process for their manufacture, and their utilization
DK80781A (da) * 1980-02-29 1981-08-30 Hospital For Sick Children Oploesninger af polypeptider
EP0102976A1 (en) * 1982-03-03 1984-03-21 Nordisk Insulinlaboratorium A process for producing an insulin preparation

Also Published As

Publication number Publication date
IE830220L (en) 1983-08-05
NO161204B (no) 1989-04-10
CA1203476A (en) 1986-04-22
NZ203189A (en) 1985-07-31
NL187269C (nl) 1991-08-01
AT382780B (de) 1987-04-10
LU84632A1 (fr) 1983-09-08
ES8500060A1 (es) 1984-10-16
GB2114573A (en) 1983-08-24
ES519533A0 (es) 1984-10-16
ZA83742B (en) 1983-11-30
FR2521009A1 (fr) 1983-08-12
DE3303860C2 (cg-RX-API-DMAC7.html) 1989-12-28
FI830375L (fi) 1983-08-06
GB2114573B (en) 1985-05-01
BE895832A (fr) 1983-08-04
AU549981B2 (en) 1986-02-20
US4476118A (en) 1984-10-09
IT8319420A0 (it) 1983-02-04
NL8300440A (nl) 1983-09-01
FI78616C (fi) 1989-09-11
SE8300598D0 (sv) 1983-02-04
PT76195B (en) 1986-01-27
FI78616B (fi) 1989-05-31
CH657530A5 (de) 1986-09-15
FR2521009B1 (fr) 1987-07-17
NO830385L (no) 1983-08-08
ATA38983A (de) 1986-09-15
NO161204C (no) 1989-07-19
DE3303860A1 (de) 1983-08-18
JPS58192818A (ja) 1983-11-10
SE8300598L (sv) 1983-08-06
AU1113683A (en) 1983-08-11
IE54548B1 (en) 1989-11-08
GR77388B (cg-RX-API-DMAC7.html) 1984-09-11
JPH0367056B2 (cg-RX-API-DMAC7.html) 1991-10-21
NL187269B (nl) 1991-03-01
PT76195A (en) 1983-03-01
SE460948B (sv) 1989-12-11
FI830375A0 (fi) 1983-02-03
GB8303133D0 (en) 1983-03-09

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Legal Events

Date Code Title Description
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19970226