IT1143942B - Picolilammide idrata di acido isoftalico ad azione antiaggregante piastrinica antitrombinica ed anticoagulante e procedimento per la sua preparazione - Google Patents

Picolilammide idrata di acido isoftalico ad azione antiaggregante piastrinica antitrombinica ed anticoagulante e procedimento per la sua preparazione

Info

Publication number
IT1143942B
IT1143942B IT48494/80A IT4849480A IT1143942B IT 1143942 B IT1143942 B IT 1143942B IT 48494/80 A IT48494/80 A IT 48494/80A IT 4849480 A IT4849480 A IT 4849480A IT 1143942 B IT1143942 B IT 1143942B
Authority
IT
Italy
Prior art keywords
thrombinic
picolylamide
agulant
aggregating
hydrated
Prior art date
Application number
IT48494/80A
Other languages
English (en)
Italian (it)
Other versions
IT8048494A0 (it
Inventor
Giovanni Orzalesi
Ivo Volpato
Original Assignee
Manetti & Roberts Italo Brit
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Manetti & Roberts Italo Brit filed Critical Manetti & Roberts Italo Brit
Publication of IT8048494A0 publication Critical patent/IT8048494A0/it
Priority to IT48494/80A priority Critical patent/IT1143942B/it
Priority to SE8101963A priority patent/SE438674B/sv
Priority to IL62509A priority patent/IL62509A/xx
Priority to NZ196677A priority patent/NZ196677A/xx
Priority to DE3113150A priority patent/DE3113150C2/de
Priority to CH2531/81A priority patent/CH649533A5/it
Priority to AU69310/81A priority patent/AU537921B2/en
Priority to ZA00812362A priority patent/ZA812362B/xx
Priority to IE808/81A priority patent/IE51218B1/en
Priority to AT0166481A priority patent/AT375645B/de
Priority to CA375,430A priority patent/CA1129419A/en
Priority to ES501470A priority patent/ES8203086A1/es
Priority to PT72899A priority patent/PT72899B/pt
Priority to DK177281A priority patent/DK155735C/da
Priority to FI811257A priority patent/FI74951C/fi
Priority to DD81229409A priority patent/DD158397A5/de
Priority to GB8112454A priority patent/GB2080288B/en
Priority to NO811360A priority patent/NO154193C/no
Priority to JP56061120A priority patent/JPS6043063B2/ja
Priority to FR8108501A priority patent/FR2481283B1/fr
Priority to NLAANVRAGE8102016,A priority patent/NL186860C/xx
Priority to OA57386A priority patent/OA06795A/xx
Priority to BE2/59122A priority patent/BE888528A/nl
Application granted granted Critical
Publication of IT1143942B publication Critical patent/IT1143942B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/40—Acylated substituent nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
IT48494/80A 1980-04-23 1980-04-23 Picolilammide idrata di acido isoftalico ad azione antiaggregante piastrinica antitrombinica ed anticoagulante e procedimento per la sua preparazione IT1143942B (it)

Priority Applications (23)

Application Number Priority Date Filing Date Title
IT48494/80A IT1143942B (it) 1980-04-23 1980-04-23 Picolilammide idrata di acido isoftalico ad azione antiaggregante piastrinica antitrombinica ed anticoagulante e procedimento per la sua preparazione
SE8101963A SE438674B (sv) 1980-04-23 1981-03-27 Monohydratet av n,n'-bis(3-pikolyl)-4-metoxi-isoftalamid, forfarande for dess framstellning samt farmaceutisk sammansettning for behandling av tromboemboliska sjukdomar
IL62509A IL62509A (en) 1980-04-23 1981-03-27 Monohydrated n,n'-bis-(3-picolyl)-4-methoxy-isophthalamide,its preparation and pharmaceutical compositions containing it
NZ196677A NZ196677A (en) 1980-04-23 1981-03-30 Monohydrated n n'-bis-(3-picolyl)-4-methoxyisophthalamide and pharmaceutical compositions
DE3113150A DE3113150C2 (de) 1980-04-23 1981-04-01 Kristallines N,N'-Bis-(3-picolyl)-4-methoxy-isophthalamid-monohydrat, Verfahren zu seiner Herstellung und dieses enthaltende, pharmazeutische Mittel
CH2531/81A CH649533A5 (it) 1980-04-23 1981-04-07 Picolilamide idrata di acido isoftalico ad azione antiaggregante piastrinica, antitrombinica ed anticoagulante e procedimento per la sua preparazione.
AU69310/81A AU537921B2 (en) 1980-04-23 1981-04-08 Monohydrated isophthalic acid picolylamide
ZA00812362A ZA812362B (en) 1980-04-23 1981-04-09 Monohydrated isophthalic acid picolylamide, process of preparation and pharmaceutical use thereof
IE808/81A IE51218B1 (en) 1980-04-23 1981-04-09 Isophthalic acid picolylamide monohydrate,process for the preparation and pharmaceutical use thereof
AT0166481A AT375645B (de) 1980-04-23 1981-04-10 Verfahren zur herstellung von isophthalsaeurepicolyamidmonohydrat
CA375,430A CA1129419A (en) 1980-04-23 1981-04-14 Monohydrated isophthalic acid picolylamide, process of preparation and pharmaceutical use thereof
ES501470A ES8203086A1 (es) 1980-04-23 1981-04-20 Un procedimiento para la produccion de n,n'-bis-(3-picolil) -4-metoxi-isoftalamida monohidratada
PT72899A PT72899B (en) 1980-04-23 1981-04-21 Monohydrated isopthalic acid picolylamide process of preparation and pharmaceutical use thereof
DK177281A DK155735C (da) 1980-04-23 1981-04-21 Fremgangsmaade til fremstilling af monohydratiseret n,n'-bis-(3-picolyl)-4-methoxy-isophthalamid
NO811360A NO154193C (no) 1980-04-23 1981-04-22 Fremgangsmaate for fremstilling av monohydratisert picotamid
DD81229409A DD158397A5 (de) 1980-04-23 1981-04-22 Verfahren zur herstellung von isophthalsaeurepicolylamidmonohydrat
GB8112454A GB2080288B (en) 1980-04-23 1981-04-22 4-methoxy-isophthalic acid picolylamide monohydrate
FI811257A FI74951C (fi) 1980-04-23 1981-04-22 Foerfarande foer framstaellning av en monohydratiserad isoftalsyrapikolylamid i stabil kristallin form.
JP56061120A JPS6043063B2 (ja) 1980-04-23 1981-04-22 血小板抗凝集作用をもつ新規化合物、それの製造法及びそれを含む医薬組成物
FR8108501A FR2481283B1 (de) 1980-04-23 1981-04-23
NLAANVRAGE8102016,A NL186860C (nl) 1980-04-23 1981-04-23 N,n'-bis-(3-picolyl)-4-methoxy-isoftalamidemonohydraat, werkwijze voor de bereiding daarvan en farmaceutische preparaten, die dit bevatten.
OA57386A OA06795A (fr) 1980-04-23 1981-04-23 N, N'-bis -(3-picolyl) -4-méthoxy-isophtalamide monohydratée et sa préparation.
BE2/59122A BE888528A (nl) 1980-04-23 1981-04-23 Isoftaalzuurpycolylamidemonohydraat, werkwijze voor de bereinding daarvan en farmaceutische toepassing,

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT48494/80A IT1143942B (it) 1980-04-23 1980-04-23 Picolilammide idrata di acido isoftalico ad azione antiaggregante piastrinica antitrombinica ed anticoagulante e procedimento per la sua preparazione

Publications (2)

Publication Number Publication Date
IT8048494A0 IT8048494A0 (it) 1980-04-23
IT1143942B true IT1143942B (it) 1986-10-29

Family

ID=11266904

Family Applications (1)

Application Number Title Priority Date Filing Date
IT48494/80A IT1143942B (it) 1980-04-23 1980-04-23 Picolilammide idrata di acido isoftalico ad azione antiaggregante piastrinica antitrombinica ed anticoagulante e procedimento per la sua preparazione

Country Status (23)

Country Link
JP (1) JPS6043063B2 (de)
AT (1) AT375645B (de)
AU (1) AU537921B2 (de)
BE (1) BE888528A (de)
CA (1) CA1129419A (de)
CH (1) CH649533A5 (de)
DD (1) DD158397A5 (de)
DE (1) DE3113150C2 (de)
DK (1) DK155735C (de)
ES (1) ES8203086A1 (de)
FI (1) FI74951C (de)
FR (1) FR2481283B1 (de)
GB (1) GB2080288B (de)
IE (1) IE51218B1 (de)
IL (1) IL62509A (de)
IT (1) IT1143942B (de)
NL (1) NL186860C (de)
NO (1) NO154193C (de)
NZ (1) NZ196677A (de)
OA (1) OA06795A (de)
PT (1) PT72899B (de)
SE (1) SE438674B (de)
ZA (1) ZA812362B (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1214915B (it) * 1985-10-10 1990-01-31 Manetti & Roberts Italo Brit Derivato dell'acido 4-metossiisoftalico con attivita'farmacologica in disordini tromboembolici e procedimento per la sua preparazione
US5227492A (en) * 1988-01-20 1993-07-13 Yamanouchi Pharmaceutical Co., Ltd. Diurea derivatives useful as medicaments and processes for the preparation thereof
AR066696A1 (es) * 2007-05-21 2009-09-09 Dybly Ag Sales de picotamida. composiciones farmaceuticas.
CN111154114A (zh) * 2019-12-31 2020-05-15 肇庆学院 一种基于5-乙氧基间苯二甲酸的锌(ⅱ)金属有机配位化合物及其制备方法
CN111154113A (zh) * 2019-12-31 2020-05-15 肇庆学院 一种基于双核钴(ⅱ)的金属有机配合物及其制备方法
CN112159347B (zh) * 2020-10-27 2022-06-07 常州工程职业技术学院 吡考他胺的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL149810B (nl) * 1969-04-21 1976-06-15 Lilly Co Eli Werkwijze ter bereiding van een farmaceutisch preparaat door kristallijn cefalexine in een voor therapeutische toediening geschikte vorm te brengen, gevormde farmaceutische preparaten, alsmede werkwijze ter bereiding van voor bovengenoemde toepassing geschikt cefalexine.
IT1016005B (it) * 1970-07-01 1977-05-30 Manetti & Roberts Italo Brit Picolilamidi dell acido 4 idrossi isoftalico e suoi derivati e relativo procedimento di prepara zione
US3973026A (en) * 1975-02-05 1976-08-03 Societa Italo-Britannica L. Manetti-H. Roberts & C. Inhibitor of blood plate aggregation

Also Published As

Publication number Publication date
SE438674B (sv) 1985-04-29
ZA812362B (en) 1982-04-28
FI811257L (fi) 1981-10-24
AU537921B2 (en) 1984-07-19
CA1129419A (en) 1982-08-10
ATA166481A (de) 1984-01-15
DE3113150A1 (de) 1982-01-28
SE8101963L (sv) 1981-10-24
NZ196677A (en) 1983-05-31
FI74951B (fi) 1987-12-31
AU6931081A (en) 1981-10-29
JPS5735566A (en) 1982-02-26
IE51218B1 (en) 1986-11-12
GB2080288A (en) 1982-02-03
JPS6043063B2 (ja) 1985-09-26
ES501470A0 (es) 1982-02-16
IL62509A0 (en) 1981-05-20
OA06795A (fr) 1982-12-31
GB2080288B (en) 1984-02-01
FR2481283B1 (de) 1985-01-04
DD158397A5 (de) 1983-01-12
NO811360L (no) 1981-10-26
DE3113150C2 (de) 1985-05-15
NL8102016A (nl) 1981-11-16
NO154193B (no) 1986-04-28
ES8203086A1 (es) 1982-02-16
DK155735C (da) 1989-10-02
NL186860C (nl) 1991-03-18
AT375645B (de) 1984-08-27
IE810808L (en) 1981-10-23
FR2481283A1 (de) 1981-10-30
PT72899A (en) 1981-05-01
CH649533A5 (it) 1985-05-31
NO154193C (no) 1986-08-06
DK177281A (da) 1981-10-24
DK155735B (da) 1989-05-08
IT8048494A0 (it) 1980-04-23
FI74951C (fi) 1988-04-11
PT72899B (en) 1982-04-05
IL62509A (en) 1984-03-30
BE888528A (nl) 1981-08-17
NL186860B (nl) 1990-10-16

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Legal Events

Date Code Title Description
ITCP Complementary protection certificate

Free format text: CCP 126

MEDD Supplementary protection certificate for pharmaceutical products: granted

Free format text: CCP 126, 19920417; SANDOZ S.A.

TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19970410