IS6766A - Pravastatínnatríum, að mestu leyti laust við pravastatínlaktón og epí-pravastatín, og blöndur sem innihalda það - Google Patents
Pravastatínnatríum, að mestu leyti laust við pravastatínlaktón og epí-pravastatín, og blöndur sem innihalda þaðInfo
- Publication number
- IS6766A IS6766A IS6766A IS6766A IS6766A IS 6766 A IS6766 A IS 6766A IS 6766 A IS6766 A IS 6766A IS 6766 A IS6766 A IS 6766A IS 6766 A IS6766 A IS 6766A
- Authority
- IS
- Iceland
- Prior art keywords
- pravastatin
- epi
- lactone
- mixtures containing
- largely free
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title 1
- 229960002965 pravastatin Drugs 0.000 title 1
- TUZYXOIXSAXUGO-PZAWKZKUSA-N pravastatin Chemical compound C1=C[C@H](C)[C@H](CC[C@@H](O)C[C@@H](O)CC(O)=O)[C@H]2[C@@H](OC(=O)[C@@H](C)CC)C[C@H](O)C=C21 TUZYXOIXSAXUGO-PZAWKZKUSA-N 0.000 title 1
- OQARDMYXSOFTLN-PZAWKZKUSA-N pravastatin lactone Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@@H](O)C[C@@H]([C@H]12)OC(=O)[C@@H](C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 OQARDMYXSOFTLN-PZAWKZKUSA-N 0.000 title 1
- 229960001495 pravastatin sodium Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F1/00—Compounds containing elements of Groups 1 or 11 of the Periodic Table
- C07F1/04—Sodium compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/34—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D309/36—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
- C07D309/38—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms one oxygen atom in position 2 or 4, e.g. pyrones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/225—Polycarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/48—Separation; Purification; Stabilisation; Use of additives
- C07C67/52—Separation; Purification; Stabilisation; Use of additives by change in the physical state, e.g. crystallisation
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Emergency Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pyrane Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23827800P | 2000-10-05 | 2000-10-05 | |
| PCT/US2001/031230 WO2002030415A1 (en) | 2000-10-05 | 2001-10-05 | Pravastatin sodium substantially free of pravastatin lactone and epi-pravastatin, and compositions containing same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IS6766A true IS6766A (is) | 2003-04-01 |
Family
ID=22897222
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IS6766A IS6766A (is) | 2000-10-05 | 2003-04-01 | Pravastatínnatríum, að mestu leyti laust við pravastatínlaktón og epí-pravastatín, og blöndur sem innihalda það |
Country Status (18)
| Country | Link |
|---|---|
| EP (1) | EP1330245A4 (enExample) |
| JP (6) | JP3737801B2 (enExample) |
| KR (1) | KR20030059173A (enExample) |
| CN (1) | CN1468098A (enExample) |
| AU (1) | AU2002211462A1 (enExample) |
| CA (1) | CA2422744A1 (enExample) |
| CZ (1) | CZ20031166A3 (enExample) |
| HR (1) | HRP20030347A2 (enExample) |
| HU (1) | HUP0400913A2 (enExample) |
| IL (1) | IL155194A0 (enExample) |
| IS (1) | IS6766A (enExample) |
| MX (1) | MXPA03002963A (enExample) |
| NO (1) | NO20031532L (enExample) |
| NZ (1) | NZ525631A (enExample) |
| PL (1) | PL361230A1 (enExample) |
| SK (1) | SK5232003A3 (enExample) |
| WO (1) | WO2002030415A1 (enExample) |
| ZA (1) | ZA200302313B (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1798214A3 (en) * | 1999-11-30 | 2007-08-01 | Teva Gyogyszergyár Zártköruen Muködo Részvenytarsaság | Process for recovering statin compounds from a fermentation broth |
| SI1265604T1 (sl) * | 1999-11-30 | 2007-04-30 | Sag Teva Gyogyszergyar Zartkoe | Postopek za ponovno pridobivanje statinskih spojin iz fermentacije brozge |
| YU39102A (sh) * | 1999-11-30 | 2006-01-16 | Biogal Gyogyszergyar Rt | Postupak dobijanja statina iz fermentacione smeše |
| JP2003516959A (ja) | 1999-12-14 | 2003-05-20 | ビオガル ジョジセルジャール アール テー． | プラバスタチンナトリウムの新規フォーム |
| JP3737801B2 (ja) * | 2000-10-05 | 2006-01-25 | テバ ジョジセルジャール レースベニュタールシャシャーグ | プラバスタチンラクトン及びエピプラバスタチンを実質的に含まないプラバスタチンナトリウム、並びにそれを含む組成物 |
| JP3236282B1 (ja) * | 2000-10-16 | 2001-12-10 | 三共株式会社 | プラバスタチンを精製する方法 |
| GB0218781D0 (en) | 2002-08-13 | 2002-09-18 | Astrazeneca Ab | Chemical process |
| EP1452519A1 (en) * | 2003-02-25 | 2004-09-01 | Balkanpharma-Razgrad AD | Method for the isolation and purification of pravastatin sodium |
| GB0312896D0 (en) | 2003-06-05 | 2003-07-09 | Astrazeneca Ab | Chemical process |
| UY28501A1 (es) | 2003-09-10 | 2005-04-29 | Astrazeneca Uk Ltd | Compuestos químicos |
| GB0324791D0 (en) | 2003-10-24 | 2003-11-26 | Astrazeneca Ab | Chemical process |
| ATE412409T1 (de) * | 2003-11-24 | 2008-11-15 | Teva Gyogyszergyar Zartkoeruee | Verfahren zur reinigung von pravastatin |
| NZ552389A (en) | 2004-08-06 | 2009-05-31 | Transform Pharmaceuticals Inc | Statin pharmaceutical compositions and related methods of treatment |
| ES2254028B1 (es) * | 2004-11-29 | 2007-03-01 | Ercros Industrial, S.A. | Procedimiento para la obtencion de pravastatina sodica purificada. |
| US20070004737A1 (en) * | 2005-02-25 | 2007-01-04 | Inbal Ornan | Process of purifying tadalafil |
| JP4813841B2 (ja) * | 2005-07-25 | 2011-11-09 | キユーピー株式会社 | プラバスタチンナトリウムの製造方法 |
| HU229260B1 (en) * | 2010-11-29 | 2013-10-28 | Egis Gyogyszergyar Nyrt | Process for preparation of rosuvastatin salts |
| CN114031496B (zh) * | 2021-11-30 | 2024-09-27 | 广东蓝宝制药有限公司 | 一种高纯度普伐他汀1,1,3,3-四甲基丁胺的制备方法 |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3378441A (en) * | 1963-10-17 | 1968-04-16 | S B Penick & Company | Tetraene antibiotic purification |
| JPS5221594B2 (enExample) * | 1973-09-29 | 1977-06-11 | ||
| YU40452B (en) * | 1975-02-07 | 1986-02-28 | Beecham Group Plc | Process for the elimination of contaminating impurities from clavulinic acid |
| US4231938A (en) * | 1979-06-15 | 1980-11-04 | Merck & Co., Inc. | Hypocholesteremic fermentation products and process of preparation |
| JPS572240A (en) * | 1980-06-06 | 1982-01-07 | Sankyo Co Ltd | Ml-236b derivative |
| DK149080C (da) * | 1980-06-06 | 1986-07-28 | Sankyo Co | Fremgangsmaade til fremstilling af derivater af ml-236b-carboxylsyre |
| JPS5889191A (ja) * | 1981-11-20 | 1983-05-27 | Sankyo Co Ltd | ３−ヒドロキシ−ｍｌ−２３６ｂ誘導体の製造法 |
| JPS5890509A (ja) * | 1981-11-25 | 1983-05-30 | Sankyo Co Ltd | 高コレステロ−ル血症治療用組成物 |
| JPH01190661A (ja) * | 1988-01-22 | 1989-07-31 | Konishi Kagaku Kogyo Kk | ４，４′−ジヒドロキシジフエニルスルホンの精製法 |
| JP2739328B2 (ja) * | 1988-09-14 | 1998-04-15 | 日本ケミファ株式会社 | ベンズイミダゾール化合物の精製方法 |
| US5202029A (en) * | 1991-03-13 | 1993-04-13 | Caron Kabushiki Kaisha | Process for purification of hmg-coa reductase inhibitors |
| NZ250609A (en) * | 1992-12-28 | 1995-07-26 | Sankyo Co | Hexahydronaphthalene esters and ring closed lactones; preparation and medicaments |
| JPH06256278A (ja) * | 1993-03-03 | 1994-09-13 | Nissan Chem Ind Ltd | 光学活性α−カルバモイルアルカン酸誘導体およびその製法 |
| CA2126365C (en) * | 1993-07-06 | 1999-08-24 | Steven W. Felman | Recovery of citric acid from impure process streams by addition of strong acids and salts thereof |
| WO1995027073A1 (en) * | 1994-03-31 | 1995-10-12 | Pfizer Inc. | Process for natamycin recovery |
| PT784605E (pt) * | 1995-08-03 | 2000-08-31 | Dsm Nv | Processo selectivo para a desacilacao de compostos acetilados campo e antecedentes da invencao |
| JPH09124655A (ja) * | 1995-11-01 | 1997-05-13 | Sankyo Co Ltd | 新規スクアレンシンターゼ阻害活性化合物 |
| EP0877089A1 (en) * | 1997-05-07 | 1998-11-11 | Gist-Brocades B.V. | HMG-CoA reductase inhibitor preparation process |
| SI20072A (sl) * | 1998-09-18 | 2000-04-30 | LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. | Postopek za pridobivanje inhibitorjev HMG-CoA reduktaze |
| SI20070A (sl) * | 1998-09-18 | 2000-04-30 | LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. | Nove soli inhibitorjev HMG-CoA reduktaze |
| JP2000229855A (ja) * | 1998-12-07 | 2000-08-22 | Satoshi Takebe | プラバスタチンナトリウム錠 |
| BR0009180A (pt) * | 1999-02-03 | 2002-03-26 | Inst Drug Res Ltd | Processo microbiológico para a preparação de pravastatin |
| HUP9902352A1 (hu) * | 1999-07-12 | 2000-09-28 | Gyógyszerkutató Intézet Kft. | Eljárás pravasztatin mikrobiológiai előállítására |
| YU39102A (sh) * | 1999-11-30 | 2006-01-16 | Biogal Gyogyszergyar Rt | Postupak dobijanja statina iz fermentacione smeše |
| JP3737801B2 (ja) * | 2000-10-05 | 2006-01-25 | テバ ジョジセルジャール レースベニュタールシャシャーグ | プラバスタチンラクトン及びエピプラバスタチンを実質的に含まないプラバスタチンナトリウム、並びにそれを含む組成物 |
-
2001
- 2001-10-05 JP JP2002533858A patent/JP3737801B2/ja not_active Expired - Fee Related
- 2001-10-05 MX MXPA03002963A patent/MXPA03002963A/es not_active Application Discontinuation
- 2001-10-05 WO PCT/US2001/031230 patent/WO2002030415A1/en not_active Ceased
- 2001-10-05 CA CA002422744A patent/CA2422744A1/en not_active Abandoned
- 2001-10-05 AU AU2002211462A patent/AU2002211462A1/en not_active Abandoned
- 2001-10-05 PL PL01361230A patent/PL361230A1/xx unknown
- 2001-10-05 SK SK523-2003A patent/SK5232003A3/sk unknown
- 2001-10-05 HR HR20030347A patent/HRP20030347A2/xx not_active Application Discontinuation
- 2001-10-05 CZ CZ20031166A patent/CZ20031166A3/cs unknown
- 2001-10-05 CN CNA018168604A patent/CN1468098A/zh active Pending
- 2001-10-05 HU HU0400913A patent/HUP0400913A2/hu not_active IP Right Cessation
- 2001-10-05 NZ NZ525631A patent/NZ525631A/en unknown
- 2001-10-05 KR KR10-2003-7004764A patent/KR20030059173A/ko not_active Abandoned
- 2001-10-05 IL IL15519401A patent/IL155194A0/xx unknown
- 2001-10-05 EP EP01979511A patent/EP1330245A4/en not_active Withdrawn
-
2003
- 2003-03-25 ZA ZA200302313A patent/ZA200302313B/en unknown
- 2003-04-01 IS IS6766A patent/IS6766A/is unknown
- 2003-04-04 NO NO20031532A patent/NO20031532L/no not_active Application Discontinuation
-
2004
- 2004-09-24 JP JP2004278522A patent/JP2005013238A/ja not_active Withdrawn
-
2005
- 2005-08-18 JP JP2005237299A patent/JP2006036781A/ja active Pending
-
2009
- 2009-08-21 JP JP2009191951A patent/JP2009268479A/ja not_active Withdrawn
-
2013
- 2013-01-25 JP JP2013011711A patent/JP2013128486A/ja not_active Withdrawn
-
2015
- 2015-07-31 JP JP2015152088A patent/JP2015212300A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP1330245A1 (en) | 2003-07-30 |
| AU2002211462A1 (en) | 2002-04-22 |
| NO20031532D0 (no) | 2003-04-04 |
| NZ525631A (en) | 2005-05-27 |
| HRP20030347A2 (en) | 2005-04-30 |
| WO2002030415A9 (en) | 2002-10-31 |
| SK5232003A3 (en) | 2004-06-08 |
| CZ20031166A3 (cs) | 2004-04-14 |
| EP1330245A4 (en) | 2004-10-20 |
| NO20031532L (no) | 2003-04-04 |
| JP2009268479A (ja) | 2009-11-19 |
| ZA200302313B (en) | 2004-03-25 |
| JP2006036781A (ja) | 2006-02-09 |
| IL155194A0 (en) | 2003-11-23 |
| JP3737801B2 (ja) | 2006-01-25 |
| KR20030059173A (ko) | 2003-07-07 |
| JP2004510817A (ja) | 2004-04-08 |
| CA2422744A1 (en) | 2002-04-18 |
| JP2015212300A (ja) | 2015-11-26 |
| MXPA03002963A (es) | 2005-01-25 |
| JP2013128486A (ja) | 2013-07-04 |
| CN1468098A (zh) | 2004-01-14 |
| PL361230A1 (en) | 2004-10-04 |
| WO2002030415A1 (en) | 2002-04-18 |
| HUP0400913A2 (en) | 2006-11-28 |
| JP2005013238A (ja) | 2005-01-20 |
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