EP1330245A4 - PRAVASTATIN SODIUM, ESSENTIALLY FREE OF PRAVASTATIN LACTONE AND EPIPRAVASTATIN, AND COMPOSITIONS CONTAINING THIS - Google Patents

PRAVASTATIN SODIUM, ESSENTIALLY FREE OF PRAVASTATIN LACTONE AND EPIPRAVASTATIN, AND COMPOSITIONS CONTAINING THIS

Info

Publication number
EP1330245A4
EP1330245A4 EP01979511A EP01979511A EP1330245A4 EP 1330245 A4 EP1330245 A4 EP 1330245A4 EP 01979511 A EP01979511 A EP 01979511A EP 01979511 A EP01979511 A EP 01979511A EP 1330245 A4 EP1330245 A4 EP 1330245A4
Authority
EP
European Patent Office
Prior art keywords
pravastatin
epi
substantially free
compositions containing
lactone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP01979511A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP1330245A1 (en
Inventor
Vilmos Keri
Lajos Deak
Ilona Forgacs
Csaba Szabo
Arvai Edit Nagyne
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teva Pharmaceutical Works PLC
Original Assignee
Biogal Gyogyszergyar Rt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22897222&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EP1330245(A4) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Biogal Gyogyszergyar Rt filed Critical Biogal Gyogyszergyar Rt
Publication of EP1330245A1 publication Critical patent/EP1330245A1/en
Publication of EP1330245A4 publication Critical patent/EP1330245A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F1/00—Compounds containing elements of Groups 1 or 11 of the Periodic Table
    • C07F1/04—Sodium compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/34—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D309/36—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
    • C07D309/38—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms one oxygen atom in position 2 or 4, e.g. pyrones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/225—Polycarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/48—Separation; Purification; Stabilisation; Use of additives
    • C07C67/52—Separation; Purification; Stabilisation; Use of additives by change in the physical state, e.g. crystallisation

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pyrane Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP01979511A 2000-10-05 2001-10-05 PRAVASTATIN SODIUM, ESSENTIALLY FREE OF PRAVASTATIN LACTONE AND EPIPRAVASTATIN, AND COMPOSITIONS CONTAINING THIS Withdrawn EP1330245A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US23827800P 2000-10-05 2000-10-05
US238278P 2000-10-05
PCT/US2001/031230 WO2002030415A1 (en) 2000-10-05 2001-10-05 Pravastatin sodium substantially free of pravastatin lactone and epi-pravastatin, and compositions containing same

Publications (2)

Publication Number Publication Date
EP1330245A1 EP1330245A1 (en) 2003-07-30
EP1330245A4 true EP1330245A4 (en) 2004-10-20

Family

ID=22897222

Family Applications (1)

Application Number Title Priority Date Filing Date
EP01979511A Withdrawn EP1330245A4 (en) 2000-10-05 2001-10-05 PRAVASTATIN SODIUM, ESSENTIALLY FREE OF PRAVASTATIN LACTONE AND EPIPRAVASTATIN, AND COMPOSITIONS CONTAINING THIS

Country Status (18)

Country Link
EP (1) EP1330245A4 (enExample)
JP (6) JP3737801B2 (enExample)
KR (1) KR20030059173A (enExample)
CN (1) CN1468098A (enExample)
AU (1) AU2002211462A1 (enExample)
CA (1) CA2422744A1 (enExample)
CZ (1) CZ20031166A3 (enExample)
HR (1) HRP20030347A2 (enExample)
HU (1) HUP0400913A2 (enExample)
IL (1) IL155194A0 (enExample)
IS (1) IS6766A (enExample)
MX (1) MXPA03002963A (enExample)
NO (1) NO20031532L (enExample)
NZ (1) NZ525631A (enExample)
PL (1) PL361230A1 (enExample)
SK (1) SK5232003A3 (enExample)
WO (1) WO2002030415A1 (enExample)
ZA (1) ZA200302313B (enExample)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1798214A3 (en) * 1999-11-30 2007-08-01 Teva Gyogyszergyár Zártköruen Muködo Részvenytarsaság Process for recovering statin compounds from a fermentation broth
EP1481674B1 (en) * 1999-11-30 2008-01-02 TEVA Gyógyszergyár Zártkörüen Müködö Részvénytársaság Process for recovering statin compounds from a fermentation broth
ES2273737T3 (es) * 1999-11-30 2007-05-16 Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag Procedimiento para la recuperacion de compuestos de estatina de un caldo de fermentacion.
IL150187A0 (en) 1999-12-14 2002-12-01 Biogal Pharmaceutical Co Ltd Novel forms of pravastatin sodium
HRP20030347A2 (en) * 2000-10-05 2005-04-30 Teva Gy�gyszergy�r R�szv�nyt�rsas�g Pravastatin sodium substantially free of pravastatin lactone and epi-pravastatin, and compositions containing same
JP3236282B1 (ja) * 2000-10-16 2001-12-10 三共株式会社 プラバスタチンを精製する方法
GB0218781D0 (en) 2002-08-13 2002-09-18 Astrazeneca Ab Chemical process
EP1452519A1 (en) * 2003-02-25 2004-09-01 Balkanpharma-Razgrad AD Method for the isolation and purification of pravastatin sodium
GB0312896D0 (en) 2003-06-05 2003-07-09 Astrazeneca Ab Chemical process
UY28501A1 (es) 2003-09-10 2005-04-29 Astrazeneca Uk Ltd Compuestos químicos
GB0324791D0 (en) 2003-10-24 2003-11-26 Astrazeneca Ab Chemical process
EP2033636A1 (en) 2003-11-24 2009-03-11 TEVA Gyógyszergyár Zártkörüen Müködö Részvénytársaság Method of purifying pravastatin
MX2007001553A (es) 2004-08-06 2008-03-07 Transform Pharmaceuticals Inc Nuevas composiciones farmaceuticas de estatina y metodos de tratamiento relacionados.
ES2254028B1 (es) * 2004-11-29 2007-03-01 Ercros Industrial, S.A. Procedimiento para la obtencion de pravastatina sodica purificada.
MX2007010431A (es) * 2005-02-25 2007-10-11 Teva Pharma Proceso para purificar tadalafil.
JP4813841B2 (ja) * 2005-07-25 2011-11-09 キユーピー株式会社 プラバスタチンナトリウムの製造方法
HU229260B1 (en) * 2010-11-29 2013-10-28 Egis Gyogyszergyar Nyrt Process for preparation of rosuvastatin salts
CN114031496B (zh) * 2021-11-30 2024-09-27 广东蓝宝制药有限公司 一种高纯度普伐他汀1,1,3,3-四甲基丁胺的制备方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000046175A1 (en) * 1999-02-03 2000-08-10 Institute For Drug Research Ltd. Microbial process for preparing pravastatin
WO2001039768A1 (en) * 1999-11-30 2001-06-07 Biogal Gyogyszergyar Rt Process for recovering statin compounds from a fermentation broth

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3378441A (en) * 1963-10-17 1968-04-16 S B Penick & Company Tetraene antibiotic purification
JPS5221594B2 (enExample) * 1973-09-29 1977-06-11
CH624956A5 (de) * 1975-02-07 1981-08-31 Glaxo Operations Ltd Verfahren zur entfernung von verunreinigungen aus clavulansaeure.
US4231938A (en) * 1979-06-15 1980-11-04 Merck & Co., Inc. Hypocholesteremic fermentation products and process of preparation
DK149080C (da) * 1980-06-06 1986-07-28 Sankyo Co Fremgangsmaade til fremstilling af derivater af ml-236b-carboxylsyre
JPS572240A (en) * 1980-06-06 1982-01-07 Sankyo Co Ltd Ml-236b derivative
JPS5889191A (ja) * 1981-11-20 1983-05-27 Sankyo Co Ltd ３−ヒドロキシ−ｍｌ−２３６ｂ誘導体の製造法
JPS5890509A (ja) * 1981-11-25 1983-05-30 Sankyo Co Ltd 高コレステロ−ル血症治療用組成物
JPH01190661A (ja) * 1988-01-22 1989-07-31 Konishi Kagaku Kogyo Kk ４，４′−ジヒドロキシジフエニルスルホンの精製法
JP2739328B2 (ja) * 1988-09-14 1998-04-15 日本ケミファ株式会社 ベンズイミダゾール化合物の精製方法
US5202029A (en) * 1991-03-13 1993-04-13 Caron Kabushiki Kaisha Process for purification of hmg-coa reductase inhibitors
NZ250609A (en) * 1992-12-28 1995-07-26 Sankyo Co Hexahydronaphthalene esters and ring closed lactones; preparation and medicaments
JPH06256278A (ja) * 1993-03-03 1994-09-13 Nissan Chem Ind Ltd 光学活性α−カルバモイルアルカン酸誘導体およびその製法
CA2126365C (en) * 1993-07-06 1999-08-24 Steven W. Felman Recovery of citric acid from impure process streams by addition of strong acids and salts thereof
DK0754239T3 (da) * 1994-03-31 1998-05-18 Cultor Oy Fremgangsmåde til indvinding af natamycin
HU221636B1 (hu) * 1995-08-03 2002-12-28 Plus Chemicals B.V. Szelektív eljárás acilezett vegyületek dezacilezésére
JPH09124655A (ja) * 1995-11-01 1997-05-13 Sankyo Co Ltd 新規スクアレンシンターゼ阻害活性化合物
EP0877089A1 (en) * 1997-05-07 1998-11-11 Gist-Brocades B.V. HMG-CoA reductase inhibitor preparation process
SI20072A (sl) * 1998-09-18 2000-04-30 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Postopek za pridobivanje inhibitorjev HMG-CoA reduktaze
SI20070A (sl) * 1998-09-18 2000-04-30 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Nove soli inhibitorjev HMG-CoA reduktaze
JP2000229855A (ja) * 1998-12-07 2000-08-22 Satoshi Takebe プラバスタチンナトリウム錠
HUP9902352A1 (hu) * 1999-07-12 2000-09-28 Gyógyszerkutató Intézet Kft. Eljárás pravasztatin mikrobiológiai előállítására
HRP20030347A2 (en) * 2000-10-05 2005-04-30 Teva Gy�gyszergy�r R�szv�nyt�rsas�g Pravastatin sodium substantially free of pravastatin lactone and epi-pravastatin, and compositions containing same

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000046175A1 (en) * 1999-02-03 2000-08-10 Institute For Drug Research Ltd. Microbial process for preparing pravastatin
WO2001039768A1 (en) * 1999-11-30 2001-06-07 Biogal Gyogyszergyar Rt Process for recovering statin compounds from a fermentation broth

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO0230415A1 *

Also Published As

Publication number Publication date
JP2015212300A (ja) 2015-11-26
NO20031532D0 (no) 2003-04-04
ZA200302313B (en) 2004-03-25
JP2013128486A (ja) 2013-07-04
IS6766A (is) 2003-04-01
IL155194A0 (en) 2003-11-23
SK5232003A3 (en) 2004-06-08
KR20030059173A (ko) 2003-07-07
WO2002030415A9 (en) 2002-10-31
NO20031532L (no) 2003-04-04
PL361230A1 (en) 2004-10-04
CN1468098A (zh) 2004-01-14
AU2002211462A1 (en) 2002-04-22
CA2422744A1 (en) 2002-04-18
JP3737801B2 (ja) 2006-01-25
MXPA03002963A (es) 2005-01-25
JP2009268479A (ja) 2009-11-19
WO2002030415A1 (en) 2002-04-18
NZ525631A (en) 2005-05-27
JP2005013238A (ja) 2005-01-20
JP2004510817A (ja) 2004-04-08
HUP0400913A2 (en) 2006-11-28
HRP20030347A2 (en) 2005-04-30
EP1330245A1 (en) 2003-07-30
CZ20031166A3 (cs) 2004-04-14
JP2006036781A (ja) 2006-02-09

Similar Documents

Publication Publication Date Title
IL155194A0 (en) Pravastatin sodium substantially free of pravastatin lactone and epi-pravastatin, and compositions containing same
AU3459702A (en) Branched primary alcohol compositions and derivatives thereof
HUP0400691A3 (en) Pyrimidineamines as angiogenesis modulators and pharmaceutical compositions containing them
HUP0302297A3 (en) Substituted thioacetamides and pharmaceutical compositions containing them
AU2001281140A1 (en) Anti-plasmodium compositions and methods of use
IL137363A0 (en) Pharmaceutical compositions containing mupirocin
HUP0303184A3 (en) Substituted c-cyclohexylmethylamine derivatives and pharmaceutical compositions containing them
GB2368014B (en) Pharmaceutical composition containing citalopram
NZ524418A (en) Highly purified simvastatin compositions
HUP0303204A3 (en) 1-methylcarbapenem derivatives and pharmaceutical compositions containing them
IL150187A0 (en) Novel forms of pravastatin sodium
GB0029847D0 (en) Preparation of spheroids
IL151715A0 (en) N-deacetylthiocolchicine derivatives and pharmaceutical compositions containing them
AU9482601A (en) Tocol-based compositions containing amiodarone
IL159614A0 (en) Benzofuran derivatives and pharmaceutical compositions containing the same
HUP0302531A3 (en) Pharmaceutical compositions containing citalopram
HK1055685A (en) Pravastatin sodium substantially free of pravastatin lactone and epi-pravastatin, and compositions containing same
AU2001272490A1 (en) Use of galiella lactone
AU2001264324A1 (en) Method of stabilizing medicinal compositions containing pravastatin
AU2001294374A1 (en) 2-acylindenes and these containing perfume compositions
AU7057701A (en) New use as antihelmintics of albofungin and analogs
GB0018502D0 (en) New compositions of matter
ZA200204500B (en) Forms of pravastatin sodium.
AU2002216388A1 (en) Benzofuran derivatives and pharmaceutical compositions containing the same
PL340617A1 (en) Derivatives of 2-acylpyridine

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20030501

AK Designated contracting states

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

AX Request for extension of the european patent

Extension state: AL LT LV MK RO SI

A4 Supplementary search report drawn up and despatched

Effective date: 20040902

RIC1 Information provided on ipc code assigned before grant

Ipc: 7A 61K 31/22 B

Ipc: 7A 61K 31/225 B

Ipc: 7A 61K 31/19 A

17Q First examination report despatched

Effective date: 20041013

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: TEVA GYOGYSZERGYAR RESZVENYTARSASAG

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: TEVA GYOGYSZERGYAR ZARTKOERUEN MUKOEDO RESZVENYTAR

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20060605

REG Reference to a national code

Ref country code: HK

Ref legal event code: WD

Ref document number: 1055685

Country of ref document: HK