IS6698A - Háhreinsaðar símvastatínblöndur - Google Patents

Háhreinsaðar símvastatínblöndur

Info

Publication number
IS6698A
IS6698A IS6698A IS6698A IS6698A IS 6698 A IS6698 A IS 6698A IS 6698 A IS6698 A IS 6698A IS 6698 A IS6698 A IS 6698A IS 6698 A IS6698 A IS 6698A
Authority
IS
Iceland
Prior art keywords
preparations
simvastatin
purity
purity simvastatin
simvastatin preparations
Prior art date
Application number
IS6698A
Other languages
English (en)
Inventor
Csaba Szabo
Korodi Ferenc
Istvan Melczer
Salyi Szabolcs
Leonov David
Original Assignee
Plus Chemicals, B.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Plus Chemicals, B.V. filed Critical Plus Chemicals, B.V.
Publication of IS6698A publication Critical patent/IS6698A/is

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pyrane Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IS6698A 2000-07-27 2003-01-24 Háhreinsaðar símvastatínblöndur IS6698A (is)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22111200P 2000-07-27 2000-07-27
PCT/US2001/023525 WO2002009697A1 (en) 2000-07-27 2001-07-26 Highly purified simvastatin compositions

Publications (1)

Publication Number Publication Date
IS6698A true IS6698A (is) 2003-01-24

Family

ID=22826406

Family Applications (1)

Application Number Title Priority Date Filing Date
IS6698A IS6698A (is) 2000-07-27 2003-01-24 Háhreinsaðar símvastatínblöndur

Country Status (20)

Country Link
US (1) US6686481B2 (is)
EP (1) EP1303268A4 (is)
JP (1) JP2004505045A (is)
KR (1) KR100542094B1 (is)
CN (1) CN1446088A (is)
AU (2) AU2001282981B2 (is)
CA (1) CA2419206A1 (is)
CZ (1) CZ2003554A3 (is)
HR (1) HRP20030109A2 (is)
HU (1) HUP0302963A3 (is)
IL (1) IL154068A0 (is)
IS (1) IS6698A (is)
MX (1) MXPA03000748A (is)
NZ (1) NZ524418A (is)
PL (1) PL365691A1 (is)
RU (1) RU2275909C2 (is)
SK (1) SK2172003A3 (is)
WO (1) WO2002009697A1 (is)
YU (1) YU101402A (is)
ZA (1) ZA200300344B (is)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100435078B1 (ko) * 2002-02-08 2004-06-09 종근당바이오 주식회사 심바스타틴의 정제방법
KR100502834B1 (ko) * 2002-03-25 2005-07-20 보령제약 주식회사 개선된 락톤화 반응에 의한 심바스타틴의 제조방법 및이의 정제방법
CA2515179A1 (en) * 2003-02-11 2004-08-26 Ferenc Korodi Process for preparing simvastatin having controlled ranges of simvastatin dimer content
EP1563837A1 (en) * 2004-02-03 2005-08-17 Ferrer Internacional, S.A. Hypocholesterolemic compositions comprising a statin and an antiflatulent agent
PL2018153T3 (pl) 2006-04-26 2012-09-28 Rosemont Pharmaceuticals Ltd Ciekłe kompozycje doustne
US8455640B2 (en) 2006-05-03 2013-06-04 Msn Laboratories Limited Process for statins and its pharmaceutically acceptable salts thereof
EP2032715B1 (en) * 2006-05-24 2012-02-01 The Regents of the University of California Methods and materials for making simvastatin and related compounds
EP2086945B1 (en) 2006-10-09 2016-01-06 MSN Laboratories Private Limited Novel process for the preparation of statins and their pharmaceutically acceptable salts thereof
JP2009114121A (ja) * 2007-11-06 2009-05-28 Kaneka Corp シンバスタチンの製造方法
EP2387561A4 (en) 2009-01-19 2012-07-25 Msn Lab Ltd IMPROVED PROCESS FOR THE PREPARATION OF HIGH-PURITY (3R, 5S) -7-β-CYCLOPROPYL-4- (4-FLUOROPHENYL) QUINOLIN-3-YL-3,5-DIHYDROXY-6 (E) -HEPTENOIC ACID, INCLUDING ITS PHARMACEUTICALLY ACCEPTABLE SALTS
WO2011086584A2 (en) 2010-01-18 2011-07-21 Msn Laboratories Limited Improved process for the preparation of amide intermediates and their use thereof
CN103864611B (zh) * 2013-12-24 2015-11-11 深圳华润九新药业有限公司 一种辛伐他汀羟基酸化物的制备方法、组合物、组合物的制备方法及其应用
CN103755562B (zh) * 2013-12-24 2015-11-18 深圳华润九新药业有限公司 一种洛伐他汀羟基酸化物的制备方法、组合物、组合物的制备方法及其应用
US10434106B2 (en) 2017-05-19 2019-10-08 Warsaw Orthopedic, Inc. Oxysterol-statin compounds for bone growth

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4444784A (en) 1980-08-05 1984-04-24 Merck & Co., Inc. Antihypercholesterolemic compounds
US4293496A (en) 1980-02-04 1981-10-06 Merck & Co., Inc. 6(R)-[2-(8-Hydroxy-2,6-dimethylpolyhydronaphthyl-1)-ethyl]-4(R)-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-ones
US4582915A (en) 1983-10-11 1986-04-15 Merck & Co., Inc. Process for C-methylation of 2-methylbutyrates
US4820850A (en) 1987-07-10 1989-04-11 Merck & Co., Inc. Process for α-C-alkylation of the 8-acyl group on mevinolin and analogs thereof
US5223415A (en) 1990-10-15 1993-06-29 Merck & Co., Inc. Biosynthetic production of 7-[1',2',6',7',8',8a'(R)-hexahydro-2'(S),6'(R)-dimethyl-8'(S)-hydroxy-1'(S)-naphthyl]-3(R),5(R)-dihydroxyheptanoic acid (triol acid)
US5159104A (en) 1991-05-01 1992-10-27 Merck & Co., Inc. Process to simvastatin ester
US5393893A (en) 1993-11-08 1995-02-28 Apotex, Inc. Process for producing simvastatin and analogs thereof
AU747219C (en) * 1997-01-28 2003-11-20 Plus Chemicals B.V. Process for the production of semi synthetic statins via novel intermediates
SI9800057A (sl) 1998-02-26 1999-08-31 Krka, Tovarna Zdravil, D.D. Postopek za pripravo simvastatina in njegovih derivatov
NO991045L (no) * 1998-03-05 1999-09-06 Synthon Bv FremgangsmÕte ved fremstilling av simvastatin og/eller dets derivater
EP0940395A1 (en) 1998-03-05 1999-09-08 Synthon B.V. Process for producing simvastatin and/or its derivatives

Also Published As

Publication number Publication date
US20020115712A1 (en) 2002-08-22
EP1303268A1 (en) 2003-04-23
AU2001282981B2 (en) 2004-08-05
HUP0302963A2 (hu) 2003-12-29
CA2419206A1 (en) 2002-02-07
PL365691A1 (en) 2005-01-10
RU2275909C2 (ru) 2006-05-10
ZA200300344B (en) 2004-01-21
JP2004505045A (ja) 2004-02-19
MXPA03000748A (es) 2004-06-25
SK2172003A3 (en) 2003-06-03
HRP20030109A2 (en) 2005-02-28
YU101402A (sh) 2006-01-16
AU8298101A (en) 2002-02-13
WO2002009697A1 (en) 2002-02-07
US6686481B2 (en) 2004-02-03
EP1303268A4 (en) 2006-08-09
KR100542094B1 (ko) 2006-01-11
HUP0302963A3 (en) 2004-03-01
KR20030047995A (ko) 2003-06-18
CN1446088A (zh) 2003-10-01
CZ2003554A3 (cs) 2003-08-13
IL154068A0 (en) 2003-07-31
NZ524418A (en) 2004-12-24

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