IN2015DN02238A - - Google Patents
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- Publication number
- IN2015DN02238A IN2015DN02238A IN2238DEN2015A IN2015DN02238A IN 2015DN02238 A IN2015DN02238 A IN 2015DN02238A IN 2238DEN2015 A IN2238DEN2015 A IN 2238DEN2015A IN 2015DN02238 A IN2015DN02238 A IN 2015DN02238A
- Authority
- IN
- India
- Prior art keywords
- formula
- nucleic acid
- salt
- oligonucleotides
- oligonucleotide
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H23/00—Compounds containing boron, silicon or a metal, e.g. chelates or vitamin B12
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2012208906 | 2012-09-21 | ||
| JP2013022360 | 2013-02-07 | ||
| PCT/JP2013/075370 WO2014046212A1 (ja) | 2012-09-21 | 2013-09-19 | グアニジン架橋を有する人工ヌクレオシドおよびオリゴヌクレオチド |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2015DN02238A true IN2015DN02238A (enrdf_load_stackoverflow) | 2015-08-21 |
Family
ID=50341516
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN2238DEN2015 IN2015DN02238A (enrdf_load_stackoverflow) | 2012-09-21 | 2013-09-19 |
Country Status (9)
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014126229A1 (ja) * | 2013-02-18 | 2014-08-21 | 塩野義製薬株式会社 | 含窒素複素環構造を有するヌクレオシド及びヌクレオチド |
| TW201718618A (zh) * | 2015-09-18 | 2017-06-01 | 田邊三菱製藥股份有限公司 | 架橋型核酸ＧｕＮＡ，其製造方法，及中間體化合物 |
| US11234995B2 (en) | 2016-01-07 | 2022-02-01 | Osaka University | α-synuclein expression inhibitor |
| WO2018155451A1 (ja) | 2017-02-21 | 2018-08-30 | 国立大学法人大阪大学 | 核酸化合物およびオリゴヌクレオチド |
| US11261440B2 (en) | 2017-02-21 | 2022-03-01 | Osaka University | Antisense oligonucleic acid |
| WO2019009298A1 (ja) * | 2017-07-05 | 2019-01-10 | 国立大学法人大阪大学 | α－シヌクレイン発現抑制剤 |
| EP3677281A4 (en) | 2017-08-31 | 2021-05-12 | Mitsubishi Tanabe Pharma Corporation | THERAPEUTIC AGENT CONTAINING AN IL-33 ANTAGONIST TO TREAT ENDOMETRIOSIS |
| US11560401B2 (en) * | 2018-05-10 | 2023-01-24 | Nippon Shinyaku Co., Ltd. | Method for preparing oligonucleic acid compound |
| EP3831837A4 (en) | 2018-07-31 | 2023-06-14 | Osaka University | OLIGONUCLEOTIDE THERAPEUTIC AGENT FOR SMALL CELL LUNG CANCER |
| EP3848460A4 (en) | 2018-09-05 | 2023-01-25 | Osaka University | Antisense oligonucleotide targeting arl4c molecule, and nucleic acid drug using antisense oligonucleotide |
| AU2019381386B2 (en) * | 2018-11-12 | 2025-06-26 | Mitsubishi Tanabe Pharma Corporation | Crosslinked artificial nucleic acid ALNA |
| CN113646007B (zh) | 2019-03-29 | 2024-08-23 | 希森美康株式会社 | 新人工核酸、其制造方法及用途 |
| MX2021011921A (es) | 2019-03-29 | 2021-10-26 | Mitsubishi Tanabe Pharma Corp | Compuesto, metodo y composicion farmaceutica para modular la expresion del doble homeobox 4 (dux4). |
| US11466274B2 (en) | 2019-05-31 | 2022-10-11 | Aligos Therapeutics, Inc. | Modified gapmer oligonucleotides and methods of use |
| JP7366160B2 (ja) * | 2019-06-20 | 2023-10-20 | エフ． ホフマン－ラ ロシュ アーゲー | 放射標識されたｍｏｅｍ型オリゴヌクレオチド及びその調製のための方法 |
| EP4151237A4 (en) | 2020-05-12 | 2024-08-14 | Mitsubishi Tanabe Pharma Corporation | Compound, method and pharmaceutical composition for regulating expression of ataxin 3 |
| EP4219517A4 (en) | 2020-09-25 | 2024-09-25 | Riken Genesis Co., Ltd. | NOVEL ARTIFICIAL NUCLEIC ACID, METHOD FOR PRODUCING THE SAME AND USE THEREOF |
| CN116507727A (zh) | 2020-11-06 | 2023-07-28 | 住友制药株式会社 | Rps25基因的表达和/或功能调节剂 |
| EP4299744A4 (en) | 2021-02-25 | 2024-10-23 | Osaka University | OLIGONUCLEOTIDE FOR INDUCING N-EXON SKIPPING DURING PROCESSING OF REST mRNA PRECURSORS |
| JP2024105742A (ja) * | 2021-05-26 | 2024-08-07 | ルクサナバイオテク株式会社 | 心疾患治療薬 |
| KR20240013202A (ko) | 2021-05-28 | 2024-01-30 | 스미토모 파마 가부시키가이샤 | 안티센스 핵산 |
| CN113552198B (zh) * | 2021-05-31 | 2024-03-26 | 武汉维尔博生物科技有限公司 | 一种基于高响应葡萄糖适配体的电化学传感器及其制备方法 |
| EP4389893A4 (en) | 2021-08-21 | 2025-09-10 | Takeda Pharmaceuticals Co | PEPTIDE-DRUG CONJUGATE BINDING HUMAN TRANSFERRIN RECEPTOR |
| WO2023093960A1 (en) * | 2021-11-26 | 2023-06-01 | Syddansk Universitet | Modified peptide-oligonucleotide conjugate |
| WO2023127857A1 (ja) | 2021-12-27 | 2023-07-06 | 株式会社理研ジェネシス | 新規人工核酸、その製造方法及び用途 |
| CN119032175A (zh) * | 2022-03-17 | 2024-11-26 | 阿利戈斯治疗公司 | 经修饰的间隔体寡聚物及其使用的方法 |
| WO2024101446A1 (ja) | 2022-11-10 | 2024-05-16 | ルクサナバイオテク株式会社 | 架橋部にグアニジノ構造を有する修飾ヌクレオシドおよびそれを用いたオリゴヌクレオチドの製造方法 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4458066A (en) * | 1980-02-29 | 1984-07-03 | University Patents, Inc. | Process for preparing polynucleotides |
| US5132418A (en) * | 1980-02-29 | 1992-07-21 | University Patents, Inc. | Process for preparing polynucleotides |
| US4500707A (en) * | 1980-02-29 | 1985-02-19 | University Patents, Inc. | Nucleosides useful in the preparation of polynucleotides |
| US4973679A (en) * | 1981-03-27 | 1990-11-27 | University Patents, Inc. | Process for oligonucleo tide synthesis using phosphormidite intermediates |
| US4668777A (en) * | 1981-03-27 | 1987-05-26 | University Patents, Inc. | Phosphoramidite nucleoside compounds |
| US5696253A (en) * | 1994-06-30 | 1997-12-09 | The Regents Of The University Of California | Polynucleoside chain with 3'→5' guanidyl linkages |
| JP3756313B2 (ja) | 1997-03-07 | 2006-03-15 | 武 今西 | 新規ビシクロヌクレオシド及びオリゴヌクレオチド類縁体 |
| JP4151751B2 (ja) * | 1999-07-22 | 2008-09-17 | 第一三共株式会社 | 新規ビシクロヌクレオシド類縁体 |
| WO2003068795A1 (fr) * | 2002-02-13 | 2003-08-21 | Takeshi Imanishi | Analogues de nucleoside et derive d'oligonucleotide comprenant un analogue nucleotidique de ces composes |
| EP1661905B9 (en) | 2003-08-28 | 2012-12-19 | IMANISHI, Takeshi | Novel artificial nucleic acids of n-o bond crosslinkage type |
| WO2007026824A1 (ja) | 2005-08-31 | 2007-03-08 | Osaka University | オリゴヌクレオチド類縁体 |
| CN102596983B (zh) * | 2009-10-29 | 2016-06-15 | 国立大学法人大阪大学 | 交联型人工核苷和核苷酸 |
| US8536323B2 (en) * | 2010-04-21 | 2013-09-17 | Pierce Biotechnology, Inc. | Modified nucleotides |
| US9206216B2 (en) * | 2010-04-21 | 2015-12-08 | Pierce Biotechnology, Inc. | Modified nucleotides methods and kits |
-
2013
- 2013-09-19 KR KR1020157010144A patent/KR101707437B1/ko active Active
- 2013-09-19 EP EP13838365.8A patent/EP2899197B1/en active Active
- 2013-09-19 WO PCT/JP2013/075370 patent/WO2014046212A1/ja active Application Filing
- 2013-09-19 CA CA2885719A patent/CA2885719C/en active Active
- 2013-09-19 JP JP2014536921A patent/JP6048982B2/ja active Active
- 2013-09-19 IN IN2238DEN2015 patent/IN2015DN02238A/en unknown
- 2013-09-19 US US14/428,646 patent/US10377789B2/en active Active
- 2013-09-19 CN CN201380057335.0A patent/CN104768964B/zh active Active
- 2013-09-19 ES ES13838365.8T patent/ES2622716T3/es active Active
Also Published As
| Publication number | Publication date |
|---|---|
| JP6048982B2 (ja) | 2016-12-21 |
| CN104768964B (zh) | 2017-03-29 |
| US20150266917A1 (en) | 2015-09-24 |
| EP2899197A4 (en) | 2016-03-09 |
| EP2899197B1 (en) | 2017-03-22 |
| WO2014046212A1 (ja) | 2014-03-27 |
| EP2899197A1 (en) | 2015-07-29 |
| CA2885719A1 (en) | 2014-03-27 |
| JPWO2014046212A1 (ja) | 2016-08-18 |
| KR101707437B1 (ko) | 2017-02-16 |
| US10377789B2 (en) | 2019-08-13 |
| CA2885719C (en) | 2017-07-11 |
| CN104768964A (zh) | 2015-07-08 |
| KR20150056647A (ko) | 2015-05-26 |
| ES2622716T3 (es) | 2017-07-07 |
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