IN2015DN02238A - - Google Patents
Download PDFInfo
- Publication number
- IN2015DN02238A IN2015DN02238A IN2238DEN2015A IN2015DN02238A IN 2015DN02238 A IN2015DN02238 A IN 2015DN02238A IN 2238DEN2015 A IN2238DEN2015 A IN 2238DEN2015A IN 2015DN02238 A IN2015DN02238 A IN 2015DN02238A
- Authority
- IN
- India
- Prior art keywords
- formula
- nucleic acid
- salt
- oligonucleotides
- oligonucleotide
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H23/00—Compounds containing boron, silicon or a metal, e.g. chelates or vitamin B12
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2012208906 | 2012-09-21 | ||
| JP2013022360 | 2013-02-07 | ||
| PCT/JP2013/075370 WO2014046212A1 (ja) | 2012-09-21 | 2013-09-19 | グアニジン架橋を有する人工ヌクレオシドおよびオリゴヌクレオチド |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2015DN02238A true IN2015DN02238A (OSRAM) | 2015-08-21 |
Family
ID=50341516
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN2238DEN2015 IN2015DN02238A (OSRAM) | 2012-09-21 | 2013-09-19 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US10377789B2 (OSRAM) |
| EP (1) | EP2899197B1 (OSRAM) |
| JP (1) | JP6048982B2 (OSRAM) |
| KR (1) | KR101707437B1 (OSRAM) |
| CN (1) | CN104768964B (OSRAM) |
| CA (1) | CA2885719C (OSRAM) |
| ES (1) | ES2622716T3 (OSRAM) |
| IN (1) | IN2015DN02238A (OSRAM) |
| WO (1) | WO2014046212A1 (OSRAM) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6292631B2 (ja) | 2013-02-18 | 2018-03-14 | 塩野義製薬株式会社 | 含窒素複素環構造を有するヌクレオシド及びヌクレオチド |
| TW201718618A (zh) * | 2015-09-18 | 2017-06-01 | 田邊三菱製藥股份有限公司 | 架橋型核酸ＧｕＮＡ，其製造方法，及中間體化合物 |
| JP6569920B2 (ja) * | 2016-01-07 | 2019-09-04 | 国立大学法人大阪大学 | α−シヌクレイン発現抑制剤 |
| US11286275B2 (en) | 2017-02-21 | 2022-03-29 | Osaka University | Nucleic acid compound and oligonucleotide |
| US11261440B2 (en) | 2017-02-21 | 2022-03-01 | Osaka University | Antisense oligonucleic acid |
| WO2019009298A1 (ja) * | 2017-07-05 | 2019-01-10 | 国立大学法人大阪大学 | α－シヌクレイン発現抑制剤 |
| EP3677281A4 (en) | 2017-08-31 | 2021-05-12 | Mitsubishi Tanabe Pharma Corporation | THERAPEUTIC AGENT CONTAINING AN IL-33 ANTAGONIST TO TREAT ENDOMETRIOSIS |
| KR102898787B1 (ko) * | 2018-05-10 | 2025-12-11 | 니뽄 신야쿠 가부시키가이샤 | 올리고 핵산 화합물의 제조 방법 |
| CN112513062B (zh) * | 2018-07-31 | 2024-05-10 | 国立大学法人大阪大学 | 含有寡聚核苷酸的小细胞肺癌治疗药 |
| EP3848460A4 (en) | 2018-09-05 | 2023-01-25 | Osaka University | ANTISENSE OLIGONUCLEOTIDE AND NUCLEIC ACID DRUG WITH ANTISENSE OLIGONUCLEOTIDE TARGETED AGAINST ARL4C MOLECULE |
| SG11202104901VA (en) | 2018-11-12 | 2021-06-29 | Mitsubishi Tanabe Pharma Corp | Crosslinked artificial nucleic acid alna |
| JP7413362B2 (ja) | 2019-03-29 | 2024-01-15 | シスメックス株式会社 | 新規人工核酸、その製造方法及び用途 |
| CN113710283B (zh) | 2019-03-29 | 2025-04-08 | 田边三菱制药株式会社 | 用于调节dux4的表达的化合物、方法和医药组合物 |
| CN113905744A (zh) | 2019-05-31 | 2022-01-07 | 阿利戈斯治疗公司 | 经修饰的间隙子寡核苷酸及其使用方法 |
| US20230087946A1 (en) * | 2019-06-20 | 2023-03-23 | Hoffmann-La Roche Inc. | Radiolabeled moem type oligonucleotides and process for their preparation |
| WO2021230286A1 (ja) | 2020-05-12 | 2021-11-18 | 田辺三菱製薬株式会社 | Ａｔａｘｉｎ ３発現を調節するための化合物、方法及び医薬組成物 |
| JP7725490B2 (ja) | 2020-09-25 | 2025-08-19 | 株式会社理研ジェネシス | 新規人工核酸、その製造方法及び用途 |
| JPWO2022097727A1 (OSRAM) | 2020-11-06 | 2022-05-12 | ||
| EP4299744A4 (en) | 2021-02-25 | 2024-10-23 | Osaka University | OLIGONUCLEOTIDE FOR INDUCING N-EXON SKIPPING DURING PROCESSING OF REST mRNA PRECURSORS |
| JP2024105742A (ja) * | 2021-05-26 | 2024-08-07 | ルクサナバイオテク株式会社 | 心疾患治療薬 |
| TW202313975A (zh) | 2021-05-28 | 2023-04-01 | 日商住友製藥股份有限公司 | 反義核酸 |
| CN113552198B (zh) * | 2021-05-31 | 2024-03-26 | 武汉维尔博生物科技有限公司 | 一种基于高响应葡萄糖适配体的电化学传感器及其制备方法 |
| WO2023026994A1 (ja) | 2021-08-21 | 2023-03-02 | 武田薬品工業株式会社 | ヒトトランスフェリンレセプター結合ペプチド－薬物コンジュゲート |
| WO2023093960A1 (en) * | 2021-11-26 | 2023-06-01 | Syddansk Universitet | Modified peptide-oligonucleotide conjugate |
| EP4458836A4 (en) | 2021-12-27 | 2025-05-21 | Riken Genesis Co., Ltd. | Novel artificial nucleic acid, method for producing same, and use of same |
| CA3255691A1 (en) * | 2022-03-17 | 2023-09-21 | Aligos Therapeutics, Inc. | MODIFIED GAPMERE OLIGOMERS AND THEIR METHODS OF USE |
| JPWO2024101446A1 (OSRAM) | 2022-11-10 | 2024-05-16 | ||
| WO2024181416A1 (ja) | 2023-02-28 | 2024-09-06 | 国立大学法人大阪大学 | オリゴヌクレオチド、ならびにそれを用いるｒｅｓｔ発現抑制剤および医薬組成物 |
| WO2024257847A1 (ja) | 2023-06-16 | 2024-12-19 | 住友ファーマ株式会社 | Ｒｐｓ２５遺伝子の発現及び／又はその機能を調節するアンチセンスオリゴヌクレオチド |
| US20250368996A1 (en) | 2024-05-14 | 2025-12-04 | Aligos Therapeutics, Inc. | Modified antisense oligonucleotides for treating hepatitis b virus |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4500707A (en) * | 1980-02-29 | 1985-02-19 | University Patents, Inc. | Nucleosides useful in the preparation of polynucleotides |
| US4458066A (en) * | 1980-02-29 | 1984-07-03 | University Patents, Inc. | Process for preparing polynucleotides |
| US5132418A (en) * | 1980-02-29 | 1992-07-21 | University Patents, Inc. | Process for preparing polynucleotides |
| US4668777A (en) * | 1981-03-27 | 1987-05-26 | University Patents, Inc. | Phosphoramidite nucleoside compounds |
| US4973679A (en) * | 1981-03-27 | 1990-11-27 | University Patents, Inc. | Process for oligonucleo tide synthesis using phosphormidite intermediates |
| US5696253A (en) * | 1994-06-30 | 1997-12-09 | The Regents Of The University Of California | Polynucleoside chain with 3'→5' guanidyl linkages |
| JP3756313B2 (ja) | 1997-03-07 | 2006-03-15 | 武 今西 | 新規ビシクロヌクレオシド及びオリゴヌクレオチド類縁体 |
| JP4151751B2 (ja) * | 1999-07-22 | 2008-09-17 | 第一三共株式会社 | 新規ビシクロヌクレオシド類縁体 |
| EP2354148B1 (en) | 2002-02-13 | 2013-09-04 | Takeshi Imanishi | Nucleoside analogues and oligonucleotide derivative comprising nucleotide analogue thereof |
| ATE555118T1 (de) | 2003-08-28 | 2012-05-15 | Takeshi Imanishi | Neue synthetische nukleidsäuren vom typ mit quervernetzter n-o-bindung |
| WO2007026824A1 (ja) * | 2005-08-31 | 2007-03-08 | Osaka University | オリゴヌクレオチド類縁体 |
| AU2010312751B2 (en) | 2009-10-29 | 2014-07-24 | Osaka University | Bridged artificial nucleoside and nucleotide |
| US9206216B2 (en) * | 2010-04-21 | 2015-12-08 | Pierce Biotechnology, Inc. | Modified nucleotides methods and kits |
| US8536323B2 (en) * | 2010-04-21 | 2013-09-17 | Pierce Biotechnology, Inc. | Modified nucleotides |
-
2013
- 2013-09-19 KR KR1020157010144A patent/KR101707437B1/ko active Active
- 2013-09-19 WO PCT/JP2013/075370 patent/WO2014046212A1/ja not_active Ceased
- 2013-09-19 IN IN2238DEN2015 patent/IN2015DN02238A/en unknown
- 2013-09-19 JP JP2014536921A patent/JP6048982B2/ja active Active
- 2013-09-19 CN CN201380057335.0A patent/CN104768964B/zh active Active
- 2013-09-19 ES ES13838365.8T patent/ES2622716T3/es active Active
- 2013-09-19 CA CA2885719A patent/CA2885719C/en active Active
- 2013-09-19 US US14/428,646 patent/US10377789B2/en active Active
- 2013-09-19 EP EP13838365.8A patent/EP2899197B1/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US10377789B2 (en) | 2019-08-13 |
| KR101707437B1 (ko) | 2017-02-16 |
| EP2899197A4 (en) | 2016-03-09 |
| JPWO2014046212A1 (ja) | 2016-08-18 |
| CA2885719C (en) | 2017-07-11 |
| CN104768964B (zh) | 2017-03-29 |
| WO2014046212A1 (ja) | 2014-03-27 |
| EP2899197B1 (en) | 2017-03-22 |
| CA2885719A1 (en) | 2014-03-27 |
| CN104768964A (zh) | 2015-07-08 |
| JP6048982B2 (ja) | 2016-12-21 |
| EP2899197A1 (en) | 2015-07-29 |
| KR20150056647A (ko) | 2015-05-26 |
| ES2622716T3 (es) | 2017-07-07 |
| US20150266917A1 (en) | 2015-09-24 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IN2015DN02238A (OSRAM) | ||
| IL272953B (en) | Nucleosides, modified nucleotides and their analogs | |
| MX356625B (es) | Oligonucleotidos para elaborar un cambio en la secuencia de una molécula de ácido ribonucleico objetivo presente en una célula viva. | |
| ZA201403783B (en) | Modified nucleoside, nucleotide, and nucleic acid compositions | |
| IL262667A (en) | Nucleosides, nucleotides and modified nucleic acids, and their uses | |
| HK1200484A1 (zh) | 多聚寡核苷酸化合物 | |
| NZ630800A (en) | Methods of preparing substituted nucleotide analogs | |
| WO2014144978A3 (en) | Improved compositions for treating muscular dystrophy | |
| LT2794629T (lt) | 2`,4`-difluor-2`-metilu pakeistieji nukleozidų dariniai, kaip hcv rnr replikacijos inhibitoriai | |
| ZA201404444B (en) | 4'-azido,3'-fluoro substituted nucleoside derivatives as inhibitors of hcv rna replication | |
| EP4279610A3 (en) | Ribonucleic acid purification | |
| PH12015500260A1 (en) | Neprilysin inhibitors | |
| AP2015008533A0 (en) | Substituted nucleosides, nucleotides and analogs thereof | |
| PH12014502733A1 (en) | Neprilysin inhibitors | |
| AP2014007943A0 (en) | Substituted nucleosides, nucleotides and analogs thereof | |
| BR112015005091A2 (pt) | polinucleotídeo antissenso isolado, composição farmacêutica, métodos para induzir salto de éxon de um rna, para melhorar distrofia muscular, para inibir a progressão de patologia distrófica, e para melhorar função muscular, e, kit. | |
| GB201204407D0 (en) | Nucleic acid molecule | |
| EP2770054A4 (en) | ACTIVATION OF FUNCTIONAL NUCLEIC ACIDS BY SPECIFIC MODIFICATION |