IN2014MN01781A - - Google Patents
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- Publication number
- IN2014MN01781A IN2014MN01781A IN1781MUN2014A IN2014MN01781A IN 2014MN01781 A IN2014MN01781 A IN 2014MN01781A IN 1781MUN2014 A IN1781MUN2014 A IN 1781MUN2014A IN 2014MN01781 A IN2014MN01781 A IN 2014MN01781A
- Authority
- IN
- India
- Prior art keywords
- cdim
- binding proteins
- cells
- well
- diagnostic assays
- Prior art date
Links
- 102000014914 Carrier Proteins Human genes 0.000 abstract 4
- 210000003719 b-lymphocyte Anatomy 0.000 abstract 4
- 108091008324 binding proteins Proteins 0.000 abstract 4
- 238000003556 assay Methods 0.000 abstract 2
- 239000000427 antigen Substances 0.000 abstract 1
- 102000025171 antigen binding proteins Human genes 0.000 abstract 1
- 108091000831 antigen binding proteins Proteins 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 230000030833 cell death Effects 0.000 abstract 1
- 230000000779 depleting effect Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 210000005170 neoplastic cell Anatomy 0.000 abstract 1
- 230000001613 neoplastic effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 102000040430 polynucleotide Human genes 0.000 abstract 1
- 108091033319 polynucleotide Proteins 0.000 abstract 1
- 239000002157 polynucleotide Substances 0.000 abstract 1
- 230000002062 proliferating effect Effects 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3061—Blood cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/734—Complement-dependent cytotoxicity [CDC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Cell Biology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Virology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Rheumatology (AREA)
- Transplantation (AREA)
- Communicable Diseases (AREA)
- Neurosurgery (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261633330P | 2012-02-08 | 2012-02-08 | |
| PCT/US2013/025430 WO2013120012A2 (en) | 2012-02-08 | 2013-02-08 | Cdim binding proteins and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2014MN01781A true IN2014MN01781A (enrdf_load_stackoverflow) | 2015-07-03 |
Family
ID=48045015
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN1781MUN2014 IN2014MN01781A (enrdf_load_stackoverflow) | 2012-02-08 | 2013-02-08 |
Country Status (14)
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
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| DK3041862T3 (da) | 2013-09-05 | 2020-07-27 | Igm Biosciences Inc | Modificerede bispecifikke, penta- og hexavalente ig-m-antistoffer med konstant kæde |
| JP6800751B2 (ja) * | 2013-12-17 | 2020-12-16 | アイム・セラピューティクス・べー・フェー | 骨髄増殖性又はリンパ球増殖性疾患に対抗するための手段及び方法 |
| EP3105250B1 (en) | 2014-02-10 | 2020-08-05 | IGM Biosciences, Inc. | Iga multi-specific binding molecules |
| SG10201909716RA (en) | 2014-04-03 | 2019-11-28 | Igm Biosciences Inc | Modified j-chain |
| CA2972990A1 (en) | 2015-01-20 | 2016-07-28 | Beatrice Tien-Yi WANG | Tumor necrosis factor (tnf) superfamily receptor binding molecules and uses thereof |
| EP3957738A1 (en) * | 2015-03-04 | 2022-02-23 | IGM Biosciences, Inc. | Cd20 binding molecules and uses thereof |
| CN107921285B (zh) | 2015-03-25 | 2022-06-07 | Igm生物科学股份有限公司 | 多价乙型肝炎病毒抗原结合分子及其应用 |
| HK1245675A1 (zh) | 2015-04-17 | 2018-08-31 | Igm Biosciences, Inc. | 多价人免疫缺陷病毒抗原结合分子及其用途 |
| WO2017059380A1 (en) | 2015-09-30 | 2017-04-06 | Igm Biosciences, Inc. | Binding molecules with modified j-chain |
| DK3356401T3 (da) | 2015-09-30 | 2020-09-07 | Igm Biosciences Inc | Bindingsmolekyler med modificeret j-kæde |
| PL3455257T3 (pl) | 2016-05-09 | 2022-01-17 | Igm Biosciences Inc. | Przeciwciała anty-pd-l1 |
| IL276890B2 (en) | 2016-08-15 | 2023-10-01 | Novartis Ag | Regimens and methods of treating multiple sclerosis using ofatumumab |
| US11834506B2 (en) | 2017-02-08 | 2023-12-05 | Dragonfly Therapeutics, Inc. | Multi-specific binding proteins that bind NKG2D, CD16, and a tumor-associated antigen for activation of natural killer cells and therapeutic uses thereof to treat cancer |
| WO2018148447A1 (en) * | 2017-02-08 | 2018-08-16 | Adimab, Llc | Antibody heavy chain variable domains targeting the nkg2d receptor |
| EP4273258A3 (en) | 2017-02-20 | 2024-01-17 | Dragonfly Therapeutics, Inc. | Proteins binding her2, nkg2d and cd16 |
| CN110536900B (zh) | 2017-04-07 | 2024-06-11 | Igm生物科学股份有限公司 | 调节补体依赖性细胞溶解效应子功能的修饰的人igm恒定区 |
| ES2986967T3 (es) | 2018-02-08 | 2024-11-13 | Dragonfly Therapeutics Inc | Combinaciones de dominios variables de anticuerpos dirigidas al receptor NKG2D |
| SG11202007579TA (en) | 2018-02-08 | 2020-09-29 | Dragonfly Therapeutics Inc | Combination therapy of cancer involving multi-specific binding proteins that activate natural killer cells |
| KR102832460B1 (ko) | 2018-02-20 | 2025-07-11 | 드래곤플라이 쎄라퓨틱스, 인크. | Cd33, nkg2d, 및 cd16에 결합하는 다중-특이적 결합 단백질, 및 이의 사용 방법 |
| KR102745232B1 (ko) | 2018-03-01 | 2024-12-26 | 아이쥐엠 바이오사이언스 인코포레이티드 | IgM 혈청 반감기에 영향을 미치는 IgM Fc 및 J-쇄 돌연변이 |
| WO2020033630A1 (en) | 2018-08-08 | 2020-02-13 | Dragonfly Therapeutics, Inc. | Multi-specific binding proteins that bind bcma, nkg2d and cd16, and methods of use |
| EA202091888A1 (ru) | 2018-08-08 | 2020-10-23 | Драгонфлай Терапьютикс, Инк. | Вариабельные домены антител, нацеленные на рецептор nkg2d |
| CA3108646A1 (en) | 2018-08-08 | 2020-02-13 | Dragonfly Therapeutics, Inc. | Proteins binding nkg2d, cd16 and a tumor-associated antigen |
| JP7627216B2 (ja) * | 2018-11-16 | 2025-02-05 | メモリアル スローン ケタリング キャンサー センター | ムチン－１６に対する抗体およびそれを使用する方法 |
| BR112022002780A2 (pt) | 2019-08-15 | 2022-05-10 | Igm Biosciences Inc | Moléculas de ligação multiméricas imunoestimulatórias |
| CA3177024A1 (en) | 2020-05-06 | 2021-11-11 | Dragonfly Therapeutics, Inc. | Proteins binding nkg2d, cd16 and clec12a |
| AR124414A1 (es) | 2020-12-18 | 2023-03-22 | Century Therapeutics Inc | Sistema de receptor de antígeno quimérico con especificidad de receptor adaptable |
| CN117222663A (zh) | 2021-03-03 | 2023-12-12 | 蜻蜓疗法股份有限公司 | 使用结合nkg2d、cd16和肿瘤相关抗原的多特异性结合蛋白治疗癌症的方法 |
| CN114181318B (zh) * | 2021-11-08 | 2023-08-01 | 四川大学 | 一种组织特异性表达穿透血脑屏障的idua融合蛋白的重组腺相关病毒及应用 |
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| US4399216A (en) | 1980-02-25 | 1983-08-16 | The Trustees Of Columbia University | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
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| US4959455A (en) | 1986-07-14 | 1990-09-25 | Genetics Institute, Inc. | Primate hematopoietic growth factors IL-3 and pharmaceutical compositions |
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| PA8775101A1 (es) * | 2007-04-02 | 2008-11-19 | Pfizer | Anticuerpos anti-ige |
-
2013
- 2013-02-08 CA CA2863714A patent/CA2863714C/en active Active
- 2013-02-08 AU AU2013200903A patent/AU2013200903B2/en active Active
- 2013-02-08 CN CN201380008515.XA patent/CN104254544B/zh active Active
- 2013-02-08 TW TW102105337A patent/TWI606064B/zh active
- 2013-02-08 WO PCT/US2013/025430 patent/WO2013120012A2/en active Application Filing
- 2013-02-08 DK DK13713588.5T patent/DK2812356T3/da active
- 2013-02-08 KR KR1020147025110A patent/KR102102111B1/ko active Active
- 2013-02-08 MX MX2014009628A patent/MX363819B/es active IP Right Grant
- 2013-02-08 US US13/763,398 patent/US9409976B2/en active Active
- 2013-02-08 EP EP13713588.5A patent/EP2812356B1/en active Active
- 2013-02-08 JP JP2014556751A patent/JP6335796B2/ja active Active
- 2013-02-08 BR BR112014019459-9A patent/BR112014019459B1/pt active IP Right Grant
- 2013-02-08 ES ES13713588T patent/ES2735289T3/es active Active
- 2013-02-08 IN IN1781MUN2014 patent/IN2014MN01781A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HK1205136A1 (en) | 2015-12-11 |
| US9409976B2 (en) | 2016-08-09 |
| WO2013120012A2 (en) | 2013-08-15 |
| CN104254544B (zh) | 2017-04-26 |
| BR112014019459A8 (pt) | 2023-01-10 |
| KR102102111B1 (ko) | 2020-04-20 |
| MX2014009628A (es) | 2015-03-19 |
| AU2013200903B2 (en) | 2015-05-14 |
| JP2015511817A (ja) | 2015-04-23 |
| ES2735289T3 (es) | 2019-12-17 |
| CA2863714C (en) | 2022-07-05 |
| WO2013120012A3 (en) | 2013-11-07 |
| TWI606064B (zh) | 2017-11-21 |
| EP2812356A2 (en) | 2014-12-17 |
| BR112014019459B1 (pt) | 2023-04-18 |
| US20140044739A1 (en) | 2014-02-13 |
| TW201345921A (zh) | 2013-11-16 |
| EP2812356B1 (en) | 2019-03-27 |
| MX363819B (es) | 2019-04-03 |
| DK2812356T3 (da) | 2019-07-08 |
| BR112014019459A2 (pt) | 2017-06-27 |
| KR20150001728A (ko) | 2015-01-06 |
| CA2863714A1 (en) | 2013-08-15 |
| JP6335796B2 (ja) | 2018-06-06 |
| CN104254544A (zh) | 2014-12-31 |
| AU2013200903A1 (en) | 2013-08-22 |
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