IN2014CN04590A - - Google Patents
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- Publication number
- IN2014CN04590A IN2014CN04590A IN4590CHN2014A IN2014CN04590A IN 2014CN04590 A IN2014CN04590 A IN 2014CN04590A IN 4590CHN2014 A IN4590CHN2014 A IN 4590CHN2014A IN 2014CN04590 A IN2014CN04590 A IN 2014CN04590A
- Authority
- IN
- India
- Prior art keywords
- nucleic acid
- acid strand
- nucleotides
- nucleotide analogs
- transcription product
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/111—General methods applicable to biologically active non-coding nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/15—Nucleic acids forming more than 2 strands, e.g. TFOs
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/318—Chemical structure of the backbone where the PO2 is completely replaced, e.g. MMI or formacetal
- C12N2310/3181—Peptide nucleic acid, PNA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/323—Chemical structure of the sugar modified ring structure
- C12N2310/3231—Chemical structure of the sugar modified ring structure having an additional ring, e.g. LNA, ENA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/34—Spatial arrangement of the modifications
- C12N2310/341—Gapmers, i.e. of the type ===---===
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/351—Conjugate
- C12N2310/3513—Protein; Peptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/351—Conjugate
- C12N2310/3515—Lipophilic moiety, e.g. cholesterol
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/50—Physical structure
- C12N2310/53—Physical structure partially self-complementary or closed
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/50—Methods for regulating/modulating their activity
- C12N2320/52—Methods for regulating/modulating their activity modulating the physical stability, e.g. GC-content
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2011275488 | 2011-12-16 | ||
PCT/JP2012/083180 WO2013089283A1 (fr) | 2011-12-16 | 2012-12-17 | Acide nucléique double brin chimérique |
Publications (1)
Publication Number | Publication Date |
---|---|
IN2014CN04590A true IN2014CN04590A (fr) | 2015-09-18 |
Family
ID=47559626
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IN4590CHN2014 IN2014CN04590A (fr) | 2011-12-16 | 2012-12-17 |
Country Status (9)
Country | Link |
---|---|
US (5) | US9816089B2 (fr) |
EP (1) | EP2791335B1 (fr) |
JP (7) | JP6112569B2 (fr) |
CN (2) | CN104126010B (fr) |
AU (1) | AU2012353330B2 (fr) |
CA (2) | CA2859581C (fr) |
ES (1) | ES2707232T3 (fr) |
IN (1) | IN2014CN04590A (fr) |
WO (1) | WO2013089283A1 (fr) |
Families Citing this family (45)
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US9744183B2 (en) | 2009-07-06 | 2017-08-29 | Wave Life Sciences Ltd. | Nucleic acid prodrugs and methods of use thereof |
JP5868324B2 (ja) | 2010-09-24 | 2016-02-24 | 株式会社Wave Life Sciences Japan | 不斉補助基 |
SG10201700554VA (en) | 2011-07-19 | 2017-03-30 | Wave Life Sciences Pte Ltd | Methods for the synthesis of functionalized nucleic acids |
IN2014CN04590A (fr) | 2011-12-16 | 2015-09-18 | Nat Univ Corp Tokyo Med & Dent | |
AU2013288048A1 (en) | 2012-07-13 | 2015-01-22 | Wave Life Sciences Ltd. | Asymmetric auxiliary group |
CA2901983A1 (fr) * | 2013-03-01 | 2014-09-04 | National University Corporation Tokyo Medical And Dental University | Polynucleotides antisens monocatenaires chimeres et agent antisens bicatenaire |
JP6300212B2 (ja) * | 2013-03-21 | 2018-03-28 | 国立大学法人 東京医科歯科大学 | 二重鎖核酸結合剤、当該結合剤−二重鎖核酸複合体、当該複合体を含有する医薬品組成物、及び、当該複合体の製造方法 |
CA2915443A1 (fr) * | 2013-06-16 | 2014-12-24 | National University Corporation Tokyo Medical And Dental University | Acide nucleique antisens a double brin ayant un effet de saut d'exon |
WO2015105083A1 (fr) * | 2014-01-07 | 2015-07-16 | 塩野義製薬株式会社 | Oligonucléotide double brin contenant un oligonucléotide antisens et un dérivé de sucre |
US9714288B2 (en) | 2014-09-30 | 2017-07-25 | The Regents Of The University Of California | Antisense compounds and uses thereof |
US11116843B2 (en) | 2015-09-25 | 2021-09-14 | Ionis Pharmaceuticals, Inc. | Conjugated antisense compounds and their use |
WO2017068791A1 (fr) * | 2015-10-23 | 2017-04-27 | レナセラピューティクス株式会社 | Complexe d'acide nucléique présentant au moins une structure renflée |
EP3366773A4 (fr) * | 2015-10-23 | 2019-06-12 | Rena Therapeutics Inc. | Complexe d'acides nucléiques |
JP6950958B2 (ja) * | 2015-12-01 | 2021-10-13 | 国立大学法人 東京医科歯科大学 | 核酸を含む経腸投与用組成物 |
US11530409B2 (en) * | 2016-01-26 | 2022-12-20 | Nissan Chemical Corporation | Single-stranded oligonucleotide |
MA45328A (fr) * | 2016-04-01 | 2019-02-06 | Avidity Biosciences Llc | Compositions acide nucléique-polypeptide et utilisations de celles-ci |
JP7043078B2 (ja) * | 2016-09-23 | 2022-03-29 | 国立大学法人 東京医科歯科大学 | 血液脳関門通過型ヘテロ2本鎖核酸 |
JP7129702B2 (ja) | 2016-09-29 | 2022-09-02 | 国立大学法人 東京医科歯科大学 | オーバーハングを有する二本鎖核酸複合体 |
US11572558B2 (en) | 2017-02-06 | 2023-02-07 | Nissan Chemical Corporation | Single-stranded oligonucleotide |
JP7190794B2 (ja) | 2017-03-29 | 2022-12-16 | 塩野義製薬株式会社 | 核酸医薬及び多分岐脂質の複合体 |
WO2018180005A1 (fr) * | 2017-03-31 | 2018-10-04 | 国立研究開発法人日本医療研究開発機構 | Acide nucléique antisens pour l'inhibition de la biosynthèse de sulfate de chondroïtine |
JP6974872B2 (ja) * | 2017-06-30 | 2021-12-01 | 国立大学法人 東京医科歯科大学 | ヘテロ二本鎖型antimiR |
TW201920671A (zh) | 2017-07-26 | 2019-06-01 | 日商日產化學股份有限公司 | 單股寡核苷酸 |
JP7360170B2 (ja) | 2018-02-28 | 2023-10-12 | 国立大学法人 東京医科歯科大学 | 虚血病変部位特異的な遺伝子治療法 |
EP3769769A4 (fr) * | 2018-03-19 | 2022-05-04 | National University Corporation Tokyo Medical and Dental University | Acide nucléique à toxicité réduite |
KR20190110043A (ko) * | 2018-03-19 | 2019-09-27 | 주식회사 케이티 | 비디오 신호 처리 방법 및 장치 |
JPWO2019182037A1 (ja) | 2018-03-20 | 2021-03-11 | 国立大学法人東京工業大学 | 毒性が低減されたアンチセンスオリゴヌクレオチド |
WO2019182109A1 (fr) * | 2018-03-22 | 2019-09-26 | 国立大学法人東京医科歯科大学 | Ligand lipidique franchissant la barrière hémato-encéphalique (bbb) à base d'un acide hétéronucléique |
EP3911747A4 (fr) * | 2019-01-18 | 2023-05-24 | University Of Massachusetts | Ancres de modification pharmacocinétique dynamique |
US20220175817A1 (en) * | 2019-04-08 | 2022-06-09 | National University Corporation Tokyo Medical And Dental University | Pharmaceutical Composition for Treating Muscle Disease |
US20220267778A1 (en) | 2019-07-30 | 2022-08-25 | Shionogi & Co., Ltd. | Nucleic acid drug targeting murf1 |
US20240117346A1 (en) * | 2019-10-11 | 2024-04-11 | National University Corporation Tokyo Medical And Dental University | Modified hetero nucleic acids |
US20230061751A1 (en) * | 2020-01-17 | 2023-03-02 | University Of Massachusetts | Universal dynamic pharmacokinetic-modifying anchors |
CN114929876A (zh) | 2020-01-31 | 2022-08-19 | 株式会社三和化学研究所 | Atn1的反义寡核苷酸 |
JPWO2021177418A1 (fr) | 2020-03-04 | 2021-09-10 | ||
WO2021187392A1 (fr) * | 2020-03-16 | 2021-09-23 | 国立大学法人東京医科歯科大学 | Acide hétéro-nucléique contenant un acide nucléique morpholino |
JPWO2021256297A1 (fr) | 2020-06-15 | 2021-12-23 | ||
EP4247949A1 (fr) | 2020-11-23 | 2023-09-27 | Alpha Anomeric SAS | Duplex d'acides nucléiques |
WO2022183102A1 (fr) * | 2021-02-26 | 2022-09-01 | Northwestern University | Biocapteurs acellulaires avec circuits de deplacement de brins d'adn |
WO2022250050A1 (fr) | 2021-05-25 | 2022-12-01 | 国立大学法人東京医科歯科大学 | Acide hétéro-nucléique à teneur en scpbna ou amna |
AU2022285344A1 (en) | 2021-05-31 | 2023-12-14 | Rena Therapeutics Inc. | Ligand-bound nucleic acid complex |
WO2023022229A1 (fr) | 2021-08-19 | 2023-02-23 | 国立大学法人東京医科歯科大学 | Acide héteronucléique modifié contenant de l'acide nucléique morpholino |
WO2023026994A1 (fr) | 2021-08-21 | 2023-03-02 | 武田薬品工業株式会社 | Conjugué peptide-médicament liant le récepteur de la transferrine humaine |
WO2023042876A1 (fr) * | 2021-09-15 | 2023-03-23 | 国立大学法人東京医科歯科大学 | Acide hétéronucléique comprenant un nucléoside 2'-modifié |
WO2023105898A1 (fr) * | 2021-12-07 | 2023-06-15 | リードファーマ株式会社 | Complexe d'oligonucléotide antisens |
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JPH09110894A (ja) * | 1995-10-17 | 1997-04-28 | Soyaku Gijutsu Kenkyusho:Kk | ハイブリッドdna/rnaオリゴヌクレオチド及び抗ウイルス剤 |
US5898031A (en) * | 1996-06-06 | 1999-04-27 | Isis Pharmaceuticals, Inc. | Oligoribonucleotides for cleaving RNA |
JP3781879B2 (ja) | 1996-11-18 | 2006-05-31 | 武 今西 | 新規ヌクレオチド類縁体 |
JP3756313B2 (ja) | 1997-03-07 | 2006-03-15 | 武 今西 | 新規ビシクロヌクレオシド及びオリゴヌクレオチド類縁体 |
US6794499B2 (en) | 1997-09-12 | 2004-09-21 | Exiqon A/S | Oligonucleotide analogues |
JP4236812B2 (ja) | 1997-09-12 | 2009-03-11 | エクシコン エ/エス | オリゴヌクレオチド類似体 |
US20060074034A1 (en) * | 2001-09-17 | 2006-04-06 | Collins Douglas A | Cobalamin mediated delivery of nucleic acids, analogs and derivatives thereof |
FR2832154B1 (fr) * | 2001-11-09 | 2007-03-16 | Centre Nat Rech Scient | Oligonucleotides inhibiteurs et leur utilisation pour reprimer specifiquement un gene |
AU2002249967A1 (en) * | 2001-11-12 | 2003-05-26 | Epiclone, Inc. | Gene silencing using sense dna and antisense rna hybrid constructs |
DE10240417A1 (de) | 2002-09-02 | 2004-03-11 | Avontec Gmbh | Decoy-Oligonukleotid-Hemmung der CD40-Expression |
US20040137471A1 (en) * | 2002-09-18 | 2004-07-15 | Timothy Vickers | Efficient reduction of target RNA's by single-and double-stranded oligomeric compounds |
CA2505801A1 (fr) | 2002-11-13 | 2004-05-27 | Rosanne Crooke | Modulation antisens de l'expression d'apolipoproteine b |
JP4731324B2 (ja) | 2003-08-28 | 2011-07-20 | 武 今西 | N−o結合性架橋構造型新規人工核酸 |
EP2256201A3 (fr) * | 2003-09-18 | 2012-07-04 | Isis Pharmaceuticals, Inc. | Modulation de l'expression de eIF4E |
US20050244869A1 (en) * | 2004-04-05 | 2005-11-03 | Brown-Driver Vickie L | Modulation of transthyretin expression |
WO2005113571A2 (fr) * | 2004-05-13 | 2005-12-01 | The University Of North Carolina At Chapel Hill | Methodes de delivrance de composes d'oligomeres |
CN101124339A (zh) | 2004-12-30 | 2008-02-13 | 托德·M·豪泽 | 使用自我保护寡核苷酸调节基因表达的组合物和方法 |
CA3044969A1 (fr) | 2006-05-05 | 2007-12-21 | Ionis Pharmaceuticals, Inc. | Composes et procedes de modulation de l'expression genique |
SG174071A1 (en) | 2006-08-10 | 2011-09-29 | Oncotherapy Science Inc | Genes and polypeptides relating to breast cancers |
WO2008029619A1 (fr) | 2006-09-07 | 2008-03-13 | Daiichi Sankyo Company, Limited | Oligonucléotide antisens ena ayant une action spécifique de la séquence |
JP2010505432A (ja) | 2006-10-09 | 2010-02-25 | サンタリス ファーマ アー/エス | Pcsk9を調節するためのrnaアンタゴニスト化合物 |
US8093222B2 (en) * | 2006-11-27 | 2012-01-10 | Isis Pharmaceuticals, Inc. | Methods for treating hypercholesterolemia |
US7858592B2 (en) * | 2007-02-26 | 2010-12-28 | The Board Of Regents Of The University Of Texas System | Interfering RNAs against the promoter region of P53 |
EP2134736A4 (fr) * | 2007-03-15 | 2013-05-29 | Jyoti Chattopadhyaya | Ribothymidines carbocycliques 2', 4' à conformation verrouillée à 5 et 6 éléments destinées à traiter des infections et le cancer |
EP2133425A1 (fr) * | 2008-06-13 | 2009-12-16 | Karin Mölling | Procédé et composé de thérapie antivirale (VIH) |
US8541569B2 (en) * | 2008-09-06 | 2013-09-24 | Chemgenes Corporation | Phosphoramidites for synthetic RNA in the reverse direction, efficient RNA synthesis and convenient introduction of 3'-end ligands, chromophores and modifications of synthetic RNA |
EP3252068A3 (fr) * | 2009-10-12 | 2018-03-14 | Larry J. Smith | Procédés et compositions permettant de moduler l'expression génique à l'aide de médicaments à base d'oligonucléotides administrés in vivo ou in vitro |
IN2014CN04590A (fr) | 2011-12-16 | 2015-09-18 | Nat Univ Corp Tokyo Med & Dent |
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2012
- 2012-12-17 IN IN4590CHN2014 patent/IN2014CN04590A/en unknown
- 2012-12-17 CN CN201280062110.XA patent/CN104126010B/zh active Active
- 2012-12-17 CN CN202011292547.5A patent/CN112386605A/zh active Pending
- 2012-12-17 EP EP12815856.5A patent/EP2791335B1/fr active Active
- 2012-12-17 AU AU2012353330A patent/AU2012353330B2/en active Active
- 2012-12-17 CA CA2859581A patent/CA2859581C/fr active Active
- 2012-12-17 WO PCT/JP2012/083180 patent/WO2013089283A1/fr active Application Filing
- 2012-12-17 JP JP2014528740A patent/JP6112569B2/ja active Active
- 2012-12-17 CA CA3106312A patent/CA3106312A1/fr active Pending
- 2012-12-17 ES ES12815856T patent/ES2707232T3/es active Active
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2014
- 2014-06-13 US US14/303,989 patent/US9816089B2/en active Active
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2017
- 2017-03-08 JP JP2017044034A patent/JP6416301B2/ja active Active
- 2017-10-05 US US15/725,845 patent/US10337006B2/en active Active
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2018
- 2018-06-28 US US16/021,165 patent/US10329567B2/en active Active
- 2018-10-03 JP JP2018188022A patent/JP6638923B2/ja active Active
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2019
- 2019-05-13 US US16/410,803 patent/US11034955B2/en active Active
- 2019-12-12 JP JP2019224279A patent/JP6960123B2/ja active Active
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2020
- 2020-10-27 JP JP2020179738A patent/JP7174384B2/ja active Active
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2021
- 2021-05-27 US US17/332,249 patent/US20210340540A1/en active Pending
- 2021-08-24 JP JP2021136038A patent/JP2022000426A/ja active Pending
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2022
- 2022-09-15 JP JP2022146970A patent/JP7423015B2/ja active Active
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