IN2012DN01968A - - Google Patents
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- Publication number
- IN2012DN01968A IN2012DN01968A IN1968DEN2012A IN2012DN01968A IN 2012DN01968 A IN2012DN01968 A IN 2012DN01968A IN 1968DEN2012 A IN1968DEN2012 A IN 1968DEN2012A IN 2012DN01968 A IN2012DN01968 A IN 2012DN01968A
- Authority
- IN
- India
- Prior art keywords
- novel process
- novel
- nep
- inhibitors
- synthesis
- Prior art date
Links
- 0 *C(OC1=O)=NC1=Cc(cc1)ccc1-c1ccccc1 Chemical compound *C(OC1=O)=NC1=Cc(cc1)ccc1-c1ccccc1 0.000 description 1
- ISDBWOPVZKNQDW-UHFFFAOYSA-N O=Cc(cc1)ccc1-c1ccccc1 Chemical compound O=Cc(cc1)ccc1-c1ccccc1 ISDBWOPVZKNQDW-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/47—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/51—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/81—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/82—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/83—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of an acyclic saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/81—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/82—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/87—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/CN2009/074125 WO2010034236A1 (en) | 2008-09-24 | 2009-09-23 | Process for the manufacture of n-acylbiphenyl alanine |
PCT/CN2010/071243 WO2011035569A1 (en) | 2009-09-23 | 2010-03-23 | Process for manufacture of n-acylbphenyl alanine |
Publications (1)
Publication Number | Publication Date |
---|---|
IN2012DN01968A true IN2012DN01968A (ar) | 2015-08-21 |
Family
ID=43796233
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IN1968DEN2012 IN2012DN01968A (ar) | 2009-09-23 | 2010-03-23 |
Country Status (11)
Country | Link |
---|---|
US (1) | US20160115118A1 (ar) |
EP (1) | EP2480523B1 (ar) |
JP (1) | JP5894531B2 (ar) |
KR (2) | KR20120093227A (ar) |
CN (1) | CN102639486B (ar) |
AU (1) | AU2010297892B2 (ar) |
BR (1) | BR112012006406A2 (ar) |
CA (1) | CA2772681C (ar) |
IN (1) | IN2012DN01968A (ar) |
RU (1) | RU2534619C2 (ar) |
WO (1) | WO2011035569A1 (ar) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2594557B1 (en) | 2009-05-28 | 2016-08-10 | Novartis AG | Substituted aminopropionic derivatives as neprilysin inhibitors |
MX2011012627A (es) | 2009-05-28 | 2011-12-14 | Novartis Ag | Derivados aminobutiricos sustituidos como inhibidores de nepralisina. |
JO2967B1 (ar) | 2009-11-20 | 2016-03-15 | نوفارتس ايه جي | مشتقات حمض أسيتيك كربامويل مثيل أمينو مستبدلة كمثبطات nep جديدة |
EA026989B1 (ru) | 2013-02-14 | 2017-06-30 | Новартис Аг | Производные замещенной бисфенилбутановой кислоты в качестве ингибиторов nep с улучшенной in vivo эффективностью |
CN105073762B (zh) | 2013-02-14 | 2017-03-08 | 诺华股份有限公司 | 作为nep(中性内肽酶)抑制剂的取代的联苯丁酰膦酸衍生物 |
TW201632493A (zh) | 2015-02-13 | 2016-09-16 | 諾華公司 | 新穎方法 |
WO2017051326A1 (en) | 2015-09-23 | 2017-03-30 | Novartis Ag | New processes and intermediates useful in synthesis of nep inhibitors |
JP7001597B2 (ja) | 2015-12-10 | 2022-01-19 | ノバルティス アーゲー | 新規なプロセスおよび中間体 |
WO2018007919A1 (en) | 2016-07-05 | 2018-01-11 | Novartis Ag | New process for early sacubitril intermediates |
JP6945619B2 (ja) | 2016-08-17 | 2021-10-06 | ノバルティス アーゲー | Nep阻害剤合成のための新規な方法および中間体 |
CN107778192A (zh) * | 2016-08-26 | 2018-03-09 | 浙江九洲药业股份有限公司 | 一种n‑烷氧或苄氧羰基手性氨酸的制备方法 |
US10774036B2 (en) | 2016-12-23 | 2020-09-15 | Novartis Ag | Process for early sacubitril intermediates |
UY38072A (es) | 2018-02-07 | 2019-10-01 | Novartis Ag | Compuestos derivados de éster butanoico sustituido con bisfenilo como inhibidores de nep, composiciones y combinaciones de los mismos |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS60185752A (ja) * | 1984-03-05 | 1985-09-21 | Mitsui Toatsu Chem Inc | α−アセトアミド桂皮酸類の製造法 |
JPS60215657A (ja) * | 1984-04-10 | 1985-10-29 | Mitsui Toatsu Chem Inc | N−アシルフエニルアラニン類の製造法 |
CA1325222C (en) * | 1985-08-23 | 1993-12-14 | Lederle (Japan), Ltd. | Process for producing 4-biphenylylacetic acid |
JPS6245554A (ja) * | 1985-08-23 | 1987-02-27 | Nippon Redarii Kk | 4−ビフエニリル酢酸の簡易製造法 |
FR2662440B1 (fr) * | 1990-05-22 | 1992-07-31 | Rhone Poulenc Sante | Procede de preparation stereoselective de derives de la phenylisoserine. |
IL123986A (en) * | 1997-04-24 | 2011-10-31 | Organon Nv | Medicinal compounds |
GB2354440A (en) * | 1999-07-20 | 2001-03-28 | Merck & Co Inc | Aryl amides as cell adhesion inhibitors |
JP4270484B2 (ja) * | 2002-03-08 | 2009-06-03 | 第一ファインケミカル株式会社 | 光学活性フェニルアラニン誘導体の製造方法 |
US7041690B2 (en) * | 2002-07-01 | 2006-05-09 | Pharmacia & Upjohn Company, Llc | Inhibitors of HCV NS5B polymerase |
US20040180943A1 (en) * | 2002-07-23 | 2004-09-16 | Augelli-Szafran Corinne Elizabeth | Oxazolone analogs as amyloid aggregation inhibitors and for the treatment of alzheimer's disease and disorders related to amyloidosis |
AR070176A1 (es) | 2008-01-17 | 2010-03-17 | Novartis Ag | Procesos de sintesis de inhibidores de nep, compuestos intermediarios y uso de los mismos en la sintesis |
CN101684077B (zh) * | 2008-09-24 | 2013-01-02 | 浙江九洲药业股份有限公司 | N-酰基联苯丙氨酸的制备方法 |
CN101774941A (zh) * | 2009-01-13 | 2010-07-14 | 浙江九洲药业股份有限公司 | 2-酰基氨基-3-联苯基丙酸的制备及拆分方法 |
CN101555211B (zh) * | 2009-05-13 | 2012-01-25 | 浙江九洲药业股份有限公司 | 2-酰基氨基-3-联苯基丙酸的化学合成方法 |
-
2010
- 2010-03-23 EP EP10818263.5A patent/EP2480523B1/en active Active
- 2010-03-23 BR BR112012006406A patent/BR112012006406A2/pt not_active Application Discontinuation
- 2010-03-23 AU AU2010297892A patent/AU2010297892B2/en not_active Ceased
- 2010-03-23 KR KR1020127010180A patent/KR20120093227A/ko active Application Filing
- 2010-03-23 WO PCT/CN2010/071243 patent/WO2011035569A1/en active Application Filing
- 2010-03-23 KR KR1020167036201A patent/KR101821090B1/ko active IP Right Grant
- 2010-03-23 CN CN201080042243.1A patent/CN102639486B/zh active Active
- 2010-03-23 RU RU2012116208/04A patent/RU2534619C2/ru not_active IP Right Cessation
- 2010-03-23 JP JP2012530106A patent/JP5894531B2/ja active Active
- 2010-03-23 IN IN1968DEN2012 patent/IN2012DN01968A/en unknown
- 2010-03-23 CA CA2772681A patent/CA2772681C/en not_active Expired - Fee Related
-
2016
- 2016-01-08 US US14/990,832 patent/US20160115118A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
KR20170002681A (ko) | 2017-01-06 |
EP2480523A4 (en) | 2013-06-26 |
AU2010297892B2 (en) | 2014-02-06 |
RU2534619C2 (ru) | 2014-11-27 |
KR101821090B1 (ko) | 2018-01-22 |
CA2772681C (en) | 2017-01-03 |
CA2772681A1 (en) | 2011-03-31 |
BR112012006406A2 (pt) | 2016-04-12 |
CN102639486B (zh) | 2014-12-31 |
JP2013505273A (ja) | 2013-02-14 |
CN102639486A (zh) | 2012-08-15 |
EP2480523B1 (en) | 2017-03-01 |
JP5894531B2 (ja) | 2016-03-30 |
EP2480523A1 (en) | 2012-08-01 |
US20160115118A1 (en) | 2016-04-28 |
WO2011035569A1 (en) | 2011-03-31 |
KR20120093227A (ko) | 2012-08-22 |
RU2012116208A (ru) | 2013-11-10 |
AU2010297892A1 (en) | 2012-03-22 |
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