MX2012001875A - Proceso para la preparación de inhibidores de la catepsina s. - Google Patents

Proceso para la preparación de inhibidores de la catepsina s.

Info

Publication number
MX2012001875A
MX2012001875A MX2012001875A MX2012001875A MX2012001875A MX 2012001875 A MX2012001875 A MX 2012001875A MX 2012001875 A MX2012001875 A MX 2012001875A MX 2012001875 A MX2012001875 A MX 2012001875A MX 2012001875 A MX2012001875 A MX 2012001875A
Authority
MX
Mexico
Prior art keywords
cathepsin
inhibitors
preparation
enzyme
synthetic processes
Prior art date
Application number
MX2012001875A
Other languages
English (en)
Inventor
Jimmy T Liang
Neelakandha S Mani
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of MX2012001875A publication Critical patent/MX2012001875A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Epoxy Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Inhibidores de la enzima de Catepsina S y sus procesos sintéticos.
MX2012001875A 2009-08-12 2010-08-11 Proceso para la preparación de inhibidores de la catepsina s. MX2012001875A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US23323109P 2009-08-12 2009-08-12
PCT/US2010/045204 WO2011019842A1 (en) 2009-08-12 2010-08-11 Process for the preparation of cathepsin s inhibitors

Publications (1)

Publication Number Publication Date
MX2012001875A true MX2012001875A (es) 2012-07-20

Family

ID=42954808

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2012001875A MX2012001875A (es) 2009-08-12 2010-08-11 Proceso para la preparación de inhibidores de la catepsina s.

Country Status (16)

Country Link
US (2) US20120142928A1 (es)
EP (1) EP2464646B1 (es)
JP (1) JP2013501804A (es)
KR (1) KR20120062752A (es)
CN (1) CN102574850A (es)
AU (1) AU2010282506A1 (es)
BR (1) BR112012003270A2 (es)
CA (1) CA2770904A1 (es)
CL (1) CL2012000353A1 (es)
IL (1) IL217997A0 (es)
MX (1) MX2012001875A (es)
NZ (1) NZ598129A (es)
RU (1) RU2012108619A (es)
SG (1) SG178319A1 (es)
WO (1) WO2011019842A1 (es)
ZA (1) ZA201201740B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2972434A1 (en) * 2014-12-30 2016-07-07 Novira Therapeutics, Inc. Derivatives and methods of treating hepatitis b infections
CN110128288B (zh) * 2018-02-02 2023-07-28 浙江九洲药业股份有限公司 一种氨基取代的环戊烷甲酸烷基酯衍生物的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3989707A (en) * 1974-06-21 1976-11-02 Janssen Pharmaceutica N.V. Benzimidazolinone derivatives
US6432980B1 (en) * 1999-11-12 2002-08-13 Merck & Co., Inc. Aliphatic amine substituted piperidyl diaryl pyrrole derivatives as antiprotozoal agents
CN1294130C (zh) * 2000-08-10 2007-01-10 奥索-麦克尼尔药品公司 取代的吡唑
RU2317988C2 (ru) * 2000-08-14 2008-02-27 Орто-Макнейл Фармасьютикал, Инк. Замещенные пиразолы, фармацевтическая композиция на их основе, применение фармацевтической композиции и способ ингибирования активности катепсина s

Also Published As

Publication number Publication date
IL217997A0 (en) 2012-03-29
EP2464646A1 (en) 2012-06-20
ZA201201740B (en) 2013-10-28
EP2464646B1 (en) 2014-05-07
JP2013501804A (ja) 2013-01-17
US20140179924A1 (en) 2014-06-26
RU2012108619A (ru) 2013-09-20
US20120142928A1 (en) 2012-06-07
NZ598129A (en) 2013-05-31
SG178319A1 (en) 2012-03-29
CN102574850A (zh) 2012-07-11
BR112012003270A2 (pt) 2019-09-24
CL2012000353A1 (es) 2013-01-25
KR20120062752A (ko) 2012-06-14
AU2010282506A1 (en) 2012-03-08
WO2011019842A1 (en) 2011-02-17
CA2770904A1 (en) 2011-02-17

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