IN192874B - - Google Patents
Info
- Publication number
- IN192874B IN192874B IN601DE1997A IN192874B IN 192874 B IN192874 B IN 192874B IN 601DE1997 A IN601DE1997 A IN 601DE1997A IN 192874 B IN192874 B IN 192874B
- Authority
- IN
- India
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8114—Kunitz type inhibitors
- C07K14/8117—Bovine/basic pancreatic trypsin inhibitor (BPTI, aprotinin)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
- A61K38/57—Protease inhibitors from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8114—Kunitz type inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Diabetes (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Zoology (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Wood Science & Technology (AREA)
- Cardiology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Vascular Medicine (AREA)
- Communicable Diseases (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN39DE2001 IN189770B (pm) | 1996-03-11 | 2001-01-19 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1310696P | 1996-03-11 | 1996-03-11 | |
| US1979396P | 1996-06-14 | 1996-06-14 | |
| US72525196A | 1996-10-04 | 1996-10-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN192874B true IN192874B (pm) | 2004-05-29 |
Family
ID=27359773
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN601DE1997 IN192874B (pm) | 1996-03-11 | 1997-03-11 |
Country Status (27)
| Country | Link |
|---|---|
| US (3) | US6583108B1 (pm) |
| EP (1) | EP0891426B1 (pm) |
| JP (2) | JP3469584B2 (pm) |
| KR (1) | KR100356956B1 (pm) |
| AR (3) | AR006188A1 (pm) |
| AT (1) | ATE328083T1 (pm) |
| AU (1) | AU716923B2 (pm) |
| BR (1) | BR9708021A (pm) |
| CA (1) | CA2247888A1 (pm) |
| CO (1) | CO4600683A1 (pm) |
| DE (1) | DE69735996T2 (pm) |
| DK (1) | DK0891426T3 (pm) |
| ES (1) | ES2263174T3 (pm) |
| HR (1) | HRP970144B1 (pm) |
| HU (1) | HU226419B1 (pm) |
| ID (1) | ID16224A (pm) |
| IL (1) | IL126115A (pm) |
| IN (1) | IN192874B (pm) |
| MY (1) | MY120693A (pm) |
| NZ (1) | NZ331540A (pm) |
| PA (1) | PA8426301A1 (pm) |
| PL (1) | PL188387B1 (pm) |
| PT (1) | PT891426E (pm) |
| SV (1) | SV1997000018A (pm) |
| TR (1) | TR199801794T2 (pm) |
| WO (1) | WO1997033996A2 (pm) |
| YU (1) | YU8997A (pm) |
Families Citing this family (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6057287A (en) | 1994-01-11 | 2000-05-02 | Dyax Corp. | Kallikrein-binding "Kunitz domain" proteins and analogues thereof |
| EP0758682B1 (en) * | 1995-07-24 | 2004-05-12 | Mitsubishi Chemical Corporation | Hepatocyte growth factor activator inhibitor |
| ES2263174T3 (es) | 1996-03-11 | 2006-12-01 | Bayer Corporation | Bikunina humana. |
| US6262233B1 (en) * | 1997-01-31 | 2001-07-17 | Human Genome Sciences, Inc. | Tissue factor pathway inhibitor-3 |
| CN1229138C (zh) * | 1998-12-22 | 2005-11-30 | 拜尔公开股份有限公司 | 加速粘液纤毛的清除速率的方法 |
| WO2000051623A2 (en) | 1999-03-05 | 2000-09-08 | The Trustees Of University Technology Corporation | Inhibitors of serine protease activity, methods and compositions for treatment of nitric oxide-induced clinical conditions |
| AU3731400A (en) | 1999-03-05 | 2000-09-21 | Trustees Of University Technology Corporation, The | Methods and compositions useful in inhibiting apoptosis |
| US20040235715A1 (en) * | 1999-11-12 | 2004-11-25 | Bayer Corporation | Method of producing glycosylated bikunin |
| IL140994A (en) * | 2000-05-15 | 2005-12-18 | Bayer Ag | Urinary trypsin inhibitor assay containing a chelating agent |
| IL140993A0 (en) | 2000-05-15 | 2002-02-10 | Bayer Ag | Trypsin substrate and diagnostic device, and method of using same |
| US6955921B2 (en) * | 2001-04-30 | 2005-10-18 | Bayer Corporation | Trypsin substrate and diagnostic device, and method of using same |
| WO2003040330A2 (en) * | 2001-11-05 | 2003-05-15 | Curagen Corporation | Therapeutic polypeptides, nucleic acids encoding same, and methods of use |
| US7153829B2 (en) | 2002-06-07 | 2006-12-26 | Dyax Corp. | Kallikrein-inhibitor therapies |
| ES2528254T3 (es) | 2002-06-07 | 2015-02-05 | Dyax Corp. | Polipéptidos de dominio Kunitz modificado y su uso para reducir la isquemia o el inicio de una respuesta inflamatoria sistémica asociada con un procedimiento quirúrgico |
| AU2004203682B2 (en) | 2003-01-06 | 2009-10-01 | Angiochem Inc. | Aprotinin and analogs as carriers across the blood-brain barrier |
| US8460243B2 (en) | 2003-06-10 | 2013-06-11 | Abbott Diabetes Care Inc. | Glucose measuring module and insulin pump combination |
| US7244616B2 (en) | 2003-06-27 | 2007-07-17 | Bayer Pharmaceuticals Corporation | Use of molecular chaperones for the enhanced production of secreted, recombinant proteins in mammalian cells |
| US7722536B2 (en) | 2003-07-15 | 2010-05-25 | Abbott Diabetes Care Inc. | Glucose measuring device integrated into a holster for a personal area network device |
| JP2007504144A (ja) | 2003-08-26 | 2007-03-01 | ザ リージェンツ オブ ザ ユニバーシティー オブ コロラド ア ボディー コーポレイト | セリンプロテアーゼ活性阻害因子、ならびに細菌感染の治療法および組成物におけるその使用方法 |
| WO2005034876A2 (en) * | 2003-10-10 | 2005-04-21 | Multicell Technologies, Inc. | Use of cell lines to produce active therapeutic proteins |
| JP2007536206A (ja) * | 2003-10-16 | 2007-12-13 | バイエル・ヘルスケア・エルエルシー | 尿中トリプシンインヒビターを検出するためのモノクローナル抗体 |
| EP1586587A1 (en) * | 2004-04-16 | 2005-10-19 | Exonhit Therapeutics SA | Compositions and methods for detecting angiogenesis |
| EP1810185A4 (en) | 2004-06-04 | 2010-01-06 | Therasense Inc | DIABETES SUPPLY HOST CLIENT ARCHITECTURE AND DATA MANAGEMENT SYSTEM |
| US7235530B2 (en) | 2004-09-27 | 2007-06-26 | Dyax Corporation | Kallikrein inhibitors and anti-thrombolytic agents and uses thereof |
| MX2007010113A (es) | 2005-02-18 | 2007-12-07 | Angiochem Inc | Polipeptidos de aprotinina para transportar un compuesto a traves de la barrera hematoencefalica. |
| US20090016959A1 (en) * | 2005-02-18 | 2009-01-15 | Richard Beliveau | Delivery of antibodies to the central nervous system |
| WO2007011693A2 (en) * | 2005-07-14 | 2007-01-25 | Medistem Laboratories, Inc. | Compositions of placentally-derived stem cells for the treatment of cancer |
| EP2233156B1 (en) | 2005-07-15 | 2013-05-01 | Angiochem Inc. | Use of aprotinin polypeptides as carriers in pharmaceutical conjugates |
| US8093017B2 (en) * | 2005-12-07 | 2012-01-10 | Siemens Heathcare Diagnostics Inc. | Detection of soluble adiponectin receptor peptides and use in diagnostics and therapeutics |
| EP1981519B1 (en) | 2005-12-29 | 2017-12-27 | Dyax Corp. | Protease inhibition |
| CA2663545A1 (en) * | 2006-09-19 | 2008-03-27 | Phylogica Limited | Neuroprotective peptide inhibitors of ap-1 signaling and uses thereof |
| WO2008058167A2 (en) * | 2006-11-07 | 2008-05-15 | Case Western Reserve University | Method for treating disorders associated with complement activation |
| WO2008077478A1 (en) * | 2006-12-22 | 2008-07-03 | Bayer Schering Pharma Aktiengesellschaft | Preparation and use of variants of the kunitz domain 2 of the human placental bikunin gene |
| US9365634B2 (en) | 2007-05-29 | 2016-06-14 | Angiochem Inc. | Aprotinin-like polypeptides for delivering agents conjugated thereto to tissues |
| EP2170932A4 (en) * | 2007-06-20 | 2012-10-10 | Phylogica Ltd | COMPOSITIONS AND APPLICATIONS THEREOF IN THE TREATMENT OF ACUTE ATOMIC SYNDROME (ARDS) AND ASSOCIATED CLINICAL ILLNESSES |
| AU2008289005A1 (en) * | 2007-08-21 | 2009-02-26 | Genzyme Corporation | Treatment with kallikrein inhibitors |
| DE102007056231A1 (de) | 2007-09-08 | 2009-03-12 | Bayer Healthcare Ag | Herstellung und Verwendung von Varianten humander Kunitz-Typ Protease-Inhibitoren (hKTPI) |
| JP5860698B2 (ja) * | 2008-04-18 | 2016-02-16 | アンジオケム，インコーポレーテッド | パクリタキセル、パクリタキセル類似体またはパクリタキセルコンジュゲートの医薬組成物ならびに関連する調製方法および使用方法 |
| RU2531591C2 (ru) | 2008-10-15 | 2014-10-20 | Ангиокем Инк. | Конъюгаты этопозида и доксорубицина для доставки лекарственных средств |
| BRPI0920209A2 (pt) | 2008-10-15 | 2015-12-22 | Angiochem Inc | conjugados de agonistas de glp-1 e usos dos mesmos |
| EP2370471B1 (en) | 2008-12-05 | 2017-02-22 | Angiochem Inc. | Neurotensin conjugate and uses thereof |
| CN102300987A (zh) | 2008-12-17 | 2011-12-28 | 安吉奥开米公司 | 膜型-1基质金属蛋白抑制剂及其用途 |
| AU2010203712A1 (en) | 2009-01-06 | 2010-07-15 | Dyax Corp. | Treatment of mucositis with kallikrein inhibitors |
| US9173891B2 (en) | 2009-04-20 | 2015-11-03 | Angiochem, Inc. | Treatment of ovarian cancer using an anticancer agent conjugated to an angiopep-2 analog |
| BRPI1015918A2 (pt) | 2009-07-02 | 2019-09-24 | Angiochem Inc | conjugados de peptídeo multiméricos e usos dos mesmos |
| WO2011085103A2 (en) | 2010-01-06 | 2011-07-14 | Dyax Corp. | Plasma kallikrein binding proteins |
| EP2371857A1 (en) * | 2010-04-01 | 2011-10-05 | CSL Behring GmbH | Factor XII inhibitors for treating interstitial lung disease |
| KR102502293B1 (ko) | 2011-01-06 | 2023-02-21 | 다케다 파머수티컬 컴패니 리미티드 | 혈장 칼리크레인 결합 단백질 |
| US10136845B2 (en) | 2011-02-28 | 2018-11-27 | Abbott Diabetes Care Inc. | Devices, systems, and methods associated with analyte monitoring devices and devices incorporating the same |
| KR20200044138A (ko) | 2011-06-24 | 2020-04-28 | 더 리젠츠 오브 더 유니버시티 오브 콜로라도, 어 바디 코포레이트 | 알파-1 안티트립신 융합 분자용 조성물, 방법 및 용도 |
| JP2015504675A (ja) | 2012-01-10 | 2015-02-16 | ザ リージェンツ オブ ザ ユニバーシティ オブ コロラド，ア ボディー コーポレイトＴＨＥ ＲＥＧＥＮＴＳ ＯＦ ＴＨＥ ＵＮＩＶＥＲＳＩＴＹ ＯＦ ＣＯＬＯＲＡＤＯ，ａ ｂｏｄｙ ｃｏｒｐｏｒａｔｅ | アルファ−１アンチトリプシン融合分子の組成物、方法、及び使用 |
| US9687561B2 (en) | 2012-08-14 | 2017-06-27 | Angiochem Inc. | Peptide-dendrimer conjugates and uses thereof |
| EP3443978A1 (en) | 2014-02-24 | 2019-02-20 | Takeda GmbH | Uti fusion proteins |
| CA2942713A1 (en) | 2014-03-27 | 2015-10-01 | Dyax Corp. | Compositions and methods for treatment of diabetic macular edema |
| DK3307326T3 (da) | 2015-06-15 | 2020-10-19 | Angiochem Inc | Fremgangsmåder til behandling af leptomeningeal karcinomatose |
| WO2017100679A1 (en) | 2015-12-11 | 2017-06-15 | Dyax Corp. | Plasma kallikrein inhibitors and uses thereof for treating hereditary angioedema attack |
| TWI888497B (zh) | 2020-03-05 | 2025-07-01 | 美商迪亞醫藥美國公司 | 烏司他丁多肽 |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5223482A (en) | 1986-11-17 | 1993-06-29 | Scios Nova Inc. | Recombinant Alzheimer's protease inhibitory amyloid protein and method of use |
| US5106833A (en) | 1987-07-23 | 1992-04-21 | Washington University | Coagulation inhibitors |
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| US5663143A (en) | 1988-09-02 | 1997-09-02 | Dyax Corp. | Engineered human-derived kunitz domains that inhibit human neutrophil elastase |
| DE59007737D1 (de) | 1989-05-13 | 1995-01-05 | Bayer Ag | Proteinaseninhibitoren, Verfahren zu ihrer Herstellung sowie diese enthaltende Arzneimittel. |
| DK408089D0 (da) | 1989-08-18 | 1989-08-18 | Novo Nordisk As | Proteiner |
| ATE135044T1 (de) | 1990-01-25 | 1996-03-15 | Univ Washington | Faktor x-laci-hybridprotein |
| JP3819931B2 (ja) | 1991-03-01 | 2006-09-13 | ダイアックス コープ． | 人体の好中球エラステーゼと人体カテプシンｇの抑制因子 |
| RU2054180C1 (ru) | 1991-08-21 | 1996-02-10 | Жирнов Олег Петрович (н/п) | Способ лечения вирусных респираторных инфекций |
| IL104325A (en) | 1992-01-07 | 2000-10-31 | Novo Nordisk As | Variants of human kunitz-type protease inhibitor domain II of tissue factor pathway inhibitor (TFPI) pharmaceutical compositions containing them a DNA construct encoding them their expression vectors a cell containing said DNA constructs and methods for the production of all the above |
| IL104326A0 (en) | 1992-01-07 | 1993-05-13 | Novo Nordisk As | Variant of human kunitz-type protease inhibitor |
| EP0651766A4 (en) | 1992-07-13 | 1996-07-31 | Corvas Int Inc | INHIBITORS OF FACTOR Xa, DERIVED FROM THE INHIBITOR OF THE PANCREATIC TRYPSON FROM BEEF. |
| US5436153A (en) | 1992-12-02 | 1995-07-25 | Sprecher; Cindy A. | Human amyloid protein precursor homolog and Kunitz-type inhibitor |
| WO1994012637A2 (en) | 1992-12-02 | 1994-06-09 | Zymogenetics, Inc. | Novel human amyloid protein precursor homologue and kunitz-type inhibitors |
| JP2769083B2 (ja) | 1993-02-22 | 1998-06-25 | 日清食品株式会社 | エラスターゼ阻害活性を有する新規ペプチドおよびその製造方法 |
| US5455338A (en) | 1993-11-05 | 1995-10-03 | Zymogenetics, Inc. | DNA encoding novel human kunitz-type inhibitors and methods relating thereto |
| ATE277081T1 (de) | 1994-01-11 | 2004-10-15 | Dyax Corp | Inhibitoren des humanplasmins, die sich von den kunitz domänen ableiten |
| CA2180950C (en) | 1994-01-11 | 2005-03-29 | William Markland | Kallikrein-inhibiting "kunitz domain" proteins and analogues thereof |
| US5795954A (en) | 1994-03-04 | 1998-08-18 | Genentech, Inc. | Factor VIIa inhibitors from Kunitz domain proteins |
| WO1996003503A1 (en) | 1994-07-21 | 1996-02-08 | The Green Cross Corporation | Process for producing urinary trypsin inhibitor and domains thereof, novel polypeptide related to the both, and process for producing the polypeptide |
| US5541228A (en) * | 1994-10-14 | 1996-07-30 | Bristol-Myers Squibb Co. | Melatonergic agents |
| CA2220497A1 (en) | 1995-05-08 | 1996-11-14 | Scios, Inc. | Kunitz type protease inhibitors |
| US5786328A (en) | 1995-06-05 | 1998-07-28 | Genentech, Inc. | Use of kunitz type plasma kallikrein inhibitors |
| EP0758682B1 (en) * | 1995-07-24 | 2004-05-12 | Mitsubishi Chemical Corporation | Hepatocyte growth factor activator inhibitor |
| US5736364A (en) | 1995-12-04 | 1998-04-07 | Genentech, Inc. | Factor viia inhibitors |
| ES2263174T3 (es) | 1996-03-11 | 2006-12-01 | Bayer Corporation | Bikunina humana. |
| US6262233B1 (en) | 1997-01-31 | 2001-07-17 | Human Genome Sciences, Inc. | Tissue factor pathway inhibitor-3 |
| US6294648B1 (en) * | 1999-07-20 | 2001-09-25 | Bayer Corporation | Protein having proteinase inhibitor activity |
-
1997
- 1997-03-10 ES ES97915029T patent/ES2263174T3/es not_active Expired - Lifetime
- 1997-03-10 AU AU22077/97A patent/AU716923B2/en not_active Ceased
- 1997-03-10 PT PT97915029T patent/PT891426E/pt unknown
- 1997-03-10 HU HU9902698A patent/HU226419B1/hu not_active IP Right Cessation
- 1997-03-10 DE DE69735996T patent/DE69735996T2/de not_active Expired - Fee Related
- 1997-03-10 TR TR1998/01794T patent/TR199801794T2/xx unknown
- 1997-03-10 NZ NZ331540A patent/NZ331540A/en unknown
- 1997-03-10 PL PL97328822A patent/PL188387B1/pl not_active IP Right Cessation
- 1997-03-10 BR BR9708021A patent/BR9708021A/pt not_active Application Discontinuation
- 1997-03-10 AT AT97915029T patent/ATE328083T1/de not_active IP Right Cessation
- 1997-03-10 WO PCT/US1997/003894 patent/WO1997033996A2/en active IP Right Grant
- 1997-03-10 JP JP53280497A patent/JP3469584B2/ja not_active Expired - Fee Related
- 1997-03-10 KR KR10-1998-0707163A patent/KR100356956B1/ko not_active Expired - Fee Related
- 1997-03-10 CA CA002247888A patent/CA2247888A1/en not_active Abandoned
- 1997-03-10 YU YU8997A patent/YU8997A/sh unknown
- 1997-03-10 DK DK97915029T patent/DK0891426T3/da active
- 1997-03-10 IL IL126115A patent/IL126115A/en not_active IP Right Cessation
- 1997-03-10 EP EP97915029A patent/EP0891426B1/en not_active Expired - Lifetime
- 1997-03-11 MY MYPI97001015A patent/MY120693A/en unknown
- 1997-03-11 PA PA19978426301A patent/PA8426301A1/es unknown
- 1997-03-11 AR ARP970100967A patent/AR006188A1/es active IP Right Grant
- 1997-03-11 ID IDP970779A patent/ID16224A/id unknown
- 1997-03-11 IN IN601DE1997 patent/IN192874B/en unknown
- 1997-03-11 CO CO97013175A patent/CO4600683A1/es unknown
- 1997-03-11 SV SV1997000018A patent/SV1997000018A/es not_active Application Discontinuation
- 1997-03-11 HR HR970144A patent/HRP970144B1/xx not_active IP Right Cessation
-
1998
- 1998-08-31 US US09/144,428 patent/US6583108B1/en not_active Expired - Fee Related
-
2001
- 2001-10-10 US US09/974,026 patent/US7019123B2/en not_active Expired - Fee Related
-
2003
- 2003-04-23 JP JP2003119118A patent/JP2004000208A/ja active Pending
-
2006
- 2006-03-27 US US11/390,775 patent/US7452859B2/en not_active Expired - Fee Related
- 2006-04-20 AR ARP060101562A patent/AR053063A2/es unknown
-
2007
- 2007-01-11 AR ARP070100116A patent/AR058982A1/es unknown