IL97313A - אינדולים מותמרים, תהליכים להכין אותם, ותכשירים המכילים אותם, להפחתתלחץ תוך עיניים, ולהקלת כאבים ומחלותשיגרוניות ודלקתיות - Google Patents

אינדולים מותמרים, תהליכים להכין אותם, ותכשירים המכילים אותם, להפחתתלחץ תוך עיניים, ולהקלת כאבים ומחלותשיגרוניות ודלקתיות

Info

Publication number
IL97313A
IL97313A IL9731391A IL9731391A IL97313A IL 97313 A IL97313 A IL 97313A IL 9731391 A IL9731391 A IL 9731391A IL 9731391 A IL9731391 A IL 9731391A IL 97313 A IL97313 A IL 97313A
Authority
IL
Israel
Prior art keywords
alkyl
methyl
indole
substituted
pyrrolidinyl
Prior art date
Application number
IL9731391A
Other languages
English (en)
Other versions
IL97313A0 (en
Original Assignee
Sterling Drug Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sterling Drug Inc filed Critical Sterling Drug Inc
Priority to IL11044791A priority Critical patent/IL110447A/he
Publication of IL97313A0 publication Critical patent/IL97313A0/xx
Priority to IL11044794A priority patent/IL110447A0/xx
Publication of IL97313A publication Critical patent/IL97313A/he

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
IL9731391A 1990-02-26 1991-02-20 אינדולים מותמרים, תהליכים להכין אותם, ותכשירים המכילים אותם, להפחתתלחץ תוך עיניים, ולהקלת כאבים ומחלותשיגרוניות ודלקתיות IL97313A (he)

Priority Applications (2)

Application Number Priority Date Filing Date Title
IL11044791A IL110447A (he) 1990-02-26 1991-02-20 אינדולים מותמרים
IL11044794A IL110447A0 (en) 1990-02-26 1994-07-25 Substituted indoles

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/484,759 US5068234A (en) 1990-02-26 1990-02-26 3-arylcarbonyl-1-(c-attached-n-heteryl)-1h-indoles

Publications (2)

Publication Number Publication Date
IL97313A0 IL97313A0 (en) 1992-05-25
IL97313A true IL97313A (he) 1995-07-31

Family

ID=23925489

Family Applications (1)

Application Number Title Priority Date Filing Date
IL9731391A IL97313A (he) 1990-02-26 1991-02-20 אינדולים מותמרים, תהליכים להכין אותם, ותכשירים המכילים אותם, להפחתתלחץ תוך עיניים, ולהקלת כאבים ומחלותשיגרוניות ודלקתיות

Country Status (17)

Country Link
US (4) US5068234A (he)
EP (1) EP0444451A3 (he)
JP (1) JPH0741475A (he)
KR (1) KR100191258B1 (he)
AU (1) AU638795B2 (he)
CA (1) CA2035711A1 (he)
FI (1) FI910851A (he)
HU (1) HU208132B (he)
IE (1) IE910492A1 (he)
IL (1) IL97313A (he)
MX (1) MX24568A (he)
MY (1) MY107158A (he)
NO (1) NO177006C (he)
NZ (1) NZ237041A (he)
PT (1) PT96871B (he)
RU (1) RU2052457C1 (he)
SG (1) SG55090A1 (he)

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US5538973A (en) * 1992-03-27 1996-07-23 Kyoto Pharmaceutical Industries, Ltd. Imidazole derivative, pharmaceutical use thereof, and intermediate therefor
AU684878B2 (en) * 1993-11-24 1998-01-08 Merck & Co., Inc. Compounds and the use thereof to promote the release of growth hormone(s)
US5486525A (en) * 1993-12-16 1996-01-23 Abbott Laboratories Platelet activating factor antagonists: imidazopyridine indoles
US5532237A (en) * 1995-02-15 1996-07-02 Merck Frosst Canada, Inc. Indole derivatives with affinity for the cannabinoid receptor
FR2735774B1 (fr) * 1995-06-21 1997-09-12 Sanofi Sa Utilisation de composes agonistes du recepteur cb2 humain pour la preparation de medicaments immunomodulateurs, nouveaux composes agonistes du recepteur cb2 et les compositions pharmaceutiques les contenant
GB2308362A (en) * 1995-12-19 1997-06-25 Lilly Industries Ltd Pharmaceutical indole derivatives
DE69717148T2 (de) * 1996-12-10 2003-10-02 Abbott Laboratories, Abbott Park 3-pyridylenantiomere und ihre verwendung als analgetika
US6132762A (en) * 1997-05-05 2000-10-17 Cristobal; Walter Transcutaneous application of marijuana
DE69910373T2 (de) * 1998-05-04 2004-04-01 The University Of Connecticut, Farmington Analgetische und immunomodulierende cannabinoiden
US6166069A (en) * 1998-05-12 2000-12-26 American Home Products Corporation Phenyl oxo-acetic acids useful in the treatment of insulin resistance and hyperglycemia
US6479535B1 (en) * 1998-05-15 2002-11-12 Wyeth 2-phenyl-1-[4-(2-aminoethoxy)-benzyl]-indole and estrogen formulations
US7589220B2 (en) * 1998-06-09 2009-09-15 University Of Connecticut Inhibitors of the anandamide transporter
US7897598B2 (en) * 1998-06-09 2011-03-01 Alexandros Makriyannis Inhibitors of the anandamide transporter
US7161016B1 (en) 1998-11-24 2007-01-09 University Of Connecticut Cannabimimetic lipid amides as useful medications
US7276613B1 (en) 1998-11-24 2007-10-02 University Of Connecticut Retro-anandamides, high affinity and stability cannabinoid receptor ligands
US6566560B2 (en) 1999-03-22 2003-05-20 Immugen Pharmaceuticals, Inc. Resorcinolic compounds
US7119108B1 (en) 1999-10-18 2006-10-10 University Of Connecticut Pyrazole derivatives as cannabinoid receptor antagonists
US6943266B1 (en) * 1999-10-18 2005-09-13 University Of Connecticut Bicyclic cannabinoid agonists for the cannabinoid receptor
WO2001028329A1 (en) 1999-10-18 2001-04-26 University Of Connecticut Peripheral cannabinoid receptor (cb2) selective ligands
US8084467B2 (en) * 1999-10-18 2011-12-27 University Of Connecticut Pyrazole derivatives as cannabinoid receptor antagonists
EP1702617A1 (en) * 1999-10-18 2006-09-20 The University Of Connecticut Cannabimimetic indole derivatives
US7741365B2 (en) * 1999-10-18 2010-06-22 University Of Connecticut Peripheral cannabinoid receptor (CB2) selective ligands
US6900236B1 (en) * 1999-10-18 2005-05-31 University Of Connecticut Cannabimimetic indole derivatives
US7393842B2 (en) * 2001-08-31 2008-07-01 University Of Connecticut Pyrazole analogs acting on cannabinoid receptors
AU2042301A (en) * 1999-12-03 2001-06-12 Alcon Universal Limited 1-aminoalkyl-1H-indoles for treating glaucoma
AU2002213429A1 (en) * 2000-09-28 2002-04-08 Immugen Pharmaceuticals, Inc. Antiviral methods and compounds
AU2001296402A1 (en) * 2000-09-28 2002-04-08 Immugen Pharmaceuticals, Inc. Methods and compounds for inhibiting eicosanoid metabolism and platelet aggregation
AUPR118000A0 (en) * 2000-11-02 2000-11-23 Amrad Operations Pty. Limited Therapeutic molecules and methods
WO2002058636A2 (en) * 2001-01-26 2002-08-01 University Of Connecticut Novel cannabimimetic ligands
WO2002060447A1 (en) 2001-01-29 2002-08-08 University Of Connecticut Receptor selective cannabimimetic aminoalkylindoles
EP1414775B1 (en) * 2001-07-13 2012-12-19 The University of Connecticut Bicyclic cannabinoid
JP2003040866A (ja) * 2001-07-31 2003-02-13 Nippon Kayaku Co Ltd Ｎ置換インドール誘導体、その製造法及びそれを有効成分とする害虫防除剤
CA2464333C (en) * 2001-10-26 2011-07-26 University Of Connecticut Heteroindanes: a new class of potent cannabimimetic ligands
US20030232101A1 (en) * 2002-03-18 2003-12-18 Immugen Pharmaceuticals, Inc. Topical formulations of resorcinols and cannibinoids and methods of use
WO2004103410A1 (en) 2002-06-06 2004-12-02 Yissum Research Development Company Of The Hebrew University Of Jerusalem Methods compositions and articles of manufacture for modulating bone growth
US7183313B2 (en) 2002-08-23 2007-02-27 University Of Connecticut Keto cannabinoids with therapeutic indications
WO2005007111A2 (en) 2003-07-11 2005-01-27 Bristol-Myers Squibb Company Tetrahydroquinoline derivatives as cannabinoid receptor modulators
US7326706B2 (en) 2003-08-15 2008-02-05 Bristol-Myers Squibb Company Pyrazine modulators of cannabinoid receptors
IL160420A0 (en) 2004-02-16 2004-07-25 Yissum Res Dev Co Treating or preventing diabetes with cannabidiol
KR20070112383A (ko) * 2005-03-12 2007-11-23 유니레버 엔.브이. 테르페노이드 화합물을 포함하는 모발 및/또는 두피 관리조성물
AU2006225152B2 (en) * 2005-03-12 2009-10-08 Unilever Plc Hair and/or scalp care compositions incorporating flavonoid compounds
CN101175533B (zh) * 2005-03-12 2010-12-22 荷兰联合利华有限公司 掺入氨基-氧代-吲哚-亚基化合物的头发和/或头皮护理组合物
DE102009056426A1 (de) 2009-09-03 2011-03-10 Liebherr-Hausgeräte Ochsenhausen GmbH Unterbaugruppenelement für ein Kühl- und/oder Gefriergerät, Kühl- und/oder Gefriergerät sowie Verfahren zur Montage eines Kühl- und/oder Gefriergerätes
CN102838525A (zh) * 2012-09-04 2012-12-26 江苏昊华精细化工有限公司 1-戊基-3-(1萘甲酰基)吲哚的合成方法

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US3361759A (en) * 1963-10-07 1968-01-02 Upjohn Co 3-(2-pyrrolidinyl)-indoles and method of preparation
BR6570394D0 (pt) * 1964-07-02 1973-08-14 Merck & Co Inc Processo para a preparacao de compostos da serie indolica
US3462440A (en) * 1965-12-03 1969-08-19 American Home Prod 1,4-bis(2-indol-3-ylethyl)piperidines
US3481953A (en) * 1967-12-18 1969-12-02 American Home Prod 1-arylsulfonyl-3-(2-substituted ethyl) indoles
GB1374414A (en) * 1972-06-12 1974-11-20 Sterling Drug Inc 1-acyl-3-amino-alkyl-indoles and their preparation
GB1436771A (en) * 1973-02-16 1976-05-26 Labaz Indole derivatives and process for preparing the same
FR2354766A1 (fr) * 1976-06-17 1978-01-13 Labaz Derives n-aminoalkyles d'indole et procedes pour les preparer
US4581354A (en) * 1984-08-06 1986-04-08 Sterling Drug Inc. 3-arylcarbonyl- and 3-cycloalkylcarbonyl-1-aminoalkyl-1H-indoles, compositions and use
PH23498A (en) * 1984-08-06 1989-08-16 Sterling Drug Inc 3-carbonyl-1-aminoalkyl-1h-indoles,composition and use thereof
USRE32761E (en) * 1984-08-06 1988-10-04 Sterling Drug Inc. 3-arylcarbonyl and 3-cycloalkylcarbonyl-1-aminoalkyl-1H-indoles, compositions and use
US4634776A (en) * 1984-08-06 1987-01-06 Sterling Drug, Inc. 3-arylcarbonyl-and 3-cycloalkylcarbonyl-1-aminoalkyl-1H-indoles
US4774243A (en) * 1985-12-24 1988-09-27 Merck & Co., Inc. Dopamine agonists for treating elevated intraocular pressure
ES2059570T3 (es) * 1988-01-15 1994-11-16 Abbott Lab 1-aminometil-1,2,3,4-tetrahidronaftalenos e -indanos.
DE3907974A1 (de) * 1989-03-11 1990-09-13 Merck Patent Gmbh Indolderivate
CA2036307C (en) * 1990-03-08 2002-07-09 Susan Jean Ward 3-arylcarbonyl-1-aminoalkyl-1h-indole-containing antiglaucoma compositions and method
US4973587A (en) * 1990-03-08 1990-11-27 Sterling Drug Inc. 3-arylcarbonyl-1-aminoalkyl-1H-indole-containing antiglaucoma method
ATE130002T1 (de) * 1990-08-13 1995-11-15 Hoechst Roussel Pharma 1-(pyridinylalkyl)-1h-indole, -indoline und analoge.

Also Published As

Publication number Publication date
AU638795B2 (en) 1993-07-08
FI910851A0 (fi) 1991-02-22
EP0444451A2 (en) 1991-09-04
HU208132B (en) 1993-08-30
IL97313A0 (en) 1992-05-25
KR100191258B1 (ko) 1999-06-15
HUT56565A (en) 1991-09-30
PT96871A (pt) 1991-10-31
NZ237041A (en) 1992-11-25
NO910731L (no) 1991-08-27
IE910492A1 (en) 1991-08-28
US5817651A (en) 1998-10-06
NO177006B (no) 1995-03-27
SG55090A1 (en) 1998-12-21
RU2052457C1 (ru) 1996-01-20
EP0444451A3 (en) 1992-04-08
AU7122291A (en) 1991-08-29
JPH0741475A (ja) 1995-02-10
US5324737A (en) 1994-06-28
US5068234A (en) 1991-11-26
MX24568A (es) 1993-09-01
NO177006C (no) 1995-07-05
KR910021399A (ko) 1991-12-20
HU910400D0 (en) 1991-08-28
PT96871B (pt) 1998-07-31
MY107158A (en) 1995-09-30
FI910851A (fi) 1991-08-27
US5607933A (en) 1997-03-04
NO910731D0 (no) 1991-02-25
CA2035711A1 (en) 1991-08-27

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Legal Events

Date Code Title Description
HP Change in proprietorship
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees