ES2059570T3 - 1-aminometil-1,2,3,4-tetrahidronaftalenos e -indanos. - Google Patents

1-aminometil-1,2,3,4-tetrahidronaftalenos e -indanos.

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Publication number
ES2059570T3
ES2059570T3 ES89100538T ES89100538T ES2059570T3 ES 2059570 T3 ES2059570 T3 ES 2059570T3 ES 89100538 T ES89100538 T ES 89100538T ES 89100538 T ES89100538 T ES 89100538T ES 2059570 T3 ES2059570 T3 ES 2059570T3
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Prior art keywords
hydrogen
formula
lower alkyl
tornado
ring
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ES89100538T
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English (en)
Inventor
Bernardis John Francis De
Robert Edward Zelle
Fatima Zehra Basha
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Abbott Laboratories
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Abbott Laboratories
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    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
    • C07C211/30—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring the six-membered aromatic ring being part of a condensed ring system formed by two rings
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    • C07C215/48—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups
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    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Furan Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)

Abstract

LA PRESENTE INVENCION INCLUYE COMPONENTES REPRESENTADOS POR LA FORMULA (I): EN DONDE N ES 0 O 1; R1, R2, R3 Y R4 SON ELEGIDOS INDEPENDIENTEMENTE DE HIDROGENO, HIDROXIDO, AMINO, ALQUILAMINO, ALQUILSULFONILAMINO, ALQUILO INFERIOR, ALCOXI INFERIOR, HALO Y TIOALCOXI; O R1 Y R2 O R2 Y R3 TORNADOS JUNTOS PUEDEN FORMAR UN PUENTE METILENODIOXI O ETILENODIOXI; R10 ES ELEGIDO INDEPENDIENTEMENTE DE HIDROGENO, ALQUILO INFERIOR, FENIL Y FENIL SUSTITUIDO; R5 ES ALQUILO INFERIOR; R9 ES HIDROGENO O ALQUILO INFERIOR; R6 Y R8 SON HIDROGENO; Y R7 ES FORMULA (II): EN DONDE M ES 0, 1 O 2; X ES CH2, O, S O N CH3; O R7 ES FORMULA (III): EN DONDE S ES 0, 1 O 2; Z ES C O N; Y R11 Y R12 SON ELEGIDOS SELECTIVAMENTE DE HIDROGENO, HALO HIDROXIDO, METOXIDO, TIOMETOXIDO, AMINO Y ALQUILO INFERIOR O R11 Y R12 TORNADOS JUNTOS PUEDEN FORMAR UN PUENTE METILENODIOXI O DE ETILENODIOXI; O R17 ES FORMULA (IV); EN DONDE T ES 0 O 1; Y R9 TORNADOS JUNTOS FORMAN UN ANILLO DE PIRROLIDINA Y ENTONCES R6 Y R8 SON HIDROGENO Y R7 ES COMOSE DESCRIBE ANTES; O R5 Y R9 TORNADOS JUNTOS FORMAN UN ANILLO DE PIRROLIDINA Y ENTONCES R6 ES HIDROGENO, R7 Y R8 TORNADOS JUNTOS O UN ANILLO FUSIL DE PIRROLIDINA Y EN TONCES R9 Y R6 SON HIDROGENO Y R7 ES FENIL, FENIL SUBSTITUIDO, TIENIL O FURIL; O R7 Y R9 SON HIDROGENO Y R6 ES BENCIL, BENCIL SUSTITUIDO, TIENILMETIL O FUNILMETIL; O UNA SAL ACEPTABLE FARMACEUTICAMENTE DE ELLO.
ES89100538T 1988-01-15 1989-01-13 1-aminometil-1,2,3,4-tetrahidronaftalenos e -indanos. Expired - Lifetime ES2059570T3 (es)

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JP (1) JP2693843B2 (es)
CA (1) CA1337425C (es)
DE (1) DE68909253T2 (es)
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WO (1) WO1989006645A1 (es)

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Publication number Priority date Publication date Assignee Title
US4963568A (en) * 1989-05-31 1990-10-16 Abbott Laboratories Dopamine agonists
AU655898B2 (en) * 1989-05-31 1995-01-12 Abbott Laboratories Dopamine agonists
FR2656607B1 (fr) * 1989-12-29 1994-03-11 Midy Spa Phenylethanolaminomethyltetralines.
IE65511B1 (en) * 1989-12-29 1995-11-01 Sanofi Sa New phenylethanolaminomethyltetralins
US5068234A (en) * 1990-02-26 1991-11-26 Sterling Drug Inc. 3-arylcarbonyl-1-(c-attached-n-heteryl)-1h-indoles
FR2664592B1 (fr) * 1990-07-10 1994-09-02 Adir Nouveaux derives de la piperidine, de la tetrahydropyridine et de la pyrrolidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
DK148292D0 (da) * 1992-12-09 1992-12-09 Lundbeck & Co As H Forbindelser
US5792767A (en) * 1995-01-27 1998-08-11 Abbott Laboratories Bicyclic substituted hexahydrobenz e! isoindole alpha-1 adrenergic antagonists
PE20020690A1 (es) * 2000-11-03 2002-08-23 Upjohn Co Metodo y tratamiento y prevencion de los dolores de cabeza de migranas
SE0201938D0 (sv) * 2002-06-20 2002-06-20 Astrazeneca Ab New process
EP1856126A2 (en) 2005-02-17 2007-11-21 Wyeth a Corporation of the State of Delaware Cycloalkylfused indole, benzothiophene, benzofuran and indene derivatives
AR097950A1 (es) * 2013-10-08 2016-04-20 Bayer Cropscience Ag N-hetaril(tio)carbonil-2-(benzocicloalquen-1-il)ciclaminas

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US3553093A (en) * 1965-03-19 1971-01-05 Xerox Corp Color photoelectrophoretic imaging process
US3704323A (en) * 1969-12-23 1972-11-28 Squibb & Sons Inc Indane derivatives
BE786748A (fr) * 1971-07-26 1973-01-26 Basf Ag 1-aminomethyl-indanes-n-substitues
JPS535146A (en) * 1976-07-02 1978-01-18 Tanabe Seiyaku Co Ltd Indane derivatives and their preparation
GB2093938B (en) * 1981-02-27 1985-02-20 Davies & Metcalfe Quick take-up and release of brakes
IT1150211B (it) * 1981-03-02 1986-12-10 Abbott Lab 1,2,3,4-tetraidronaftaleni sostituiti con amminoalchili adazione farmaceutica
GB8704572D0 (en) * 1987-02-26 1987-04-01 Lundbeck & Co As H Organic compounds

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EP0325963B1 (en) 1993-09-22
JP2693843B2 (ja) 1997-12-24
EP0325963A1 (en) 1989-08-02
EP0395734A1 (en) 1990-11-07
EP0395734A4 (en) 1991-01-02
WO1989006645A1 (en) 1989-07-27
CA1337425C (en) 1995-10-24
JPH04500356A (ja) 1992-01-23
DE68909253D1 (de) 1993-10-28
DE68909253T2 (de) 1994-02-24

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