EP0395734A4 - 1-aminomethyl-1,2,3,4-tetrahydronaphthalenes - Google Patents

1-aminomethyl-1,2,3,4-tetrahydronaphthalenes

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Publication number
EP0395734A4
EP0395734A4 EP19890902122 EP89902122A EP0395734A4 EP 0395734 A4 EP0395734 A4 EP 0395734A4 EP 19890902122 EP19890902122 EP 19890902122 EP 89902122 A EP89902122 A EP 89902122A EP 0395734 A4 EP0395734 A4 EP 0395734A4
Authority
EP
European Patent Office
Prior art keywords
tetrahydronaphthalenes
aminomethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP19890902122
Other versions
EP0395734A1 (en
Inventor
John Francis Debernardis
Robert Edward Zelle
Fatima Zehra Basha
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Publication of EP0395734A1 publication Critical patent/EP0395734A1/en
Publication of EP0395734A4 publication Critical patent/EP0395734A4/en
Pending legal-status Critical Current

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    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
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    • C07C211/30—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring the six-membered aromatic ring being part of a condensed ring system formed by two rings
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    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

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EP19890902122 1988-01-15 1989-01-13 1-aminomethyl-1,2,3,4-tetrahydronaphthalenes Pending EP0395734A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14436488A 1988-01-15 1988-01-15
US144364 1988-01-15

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EP0395734A1 EP0395734A1 (en) 1990-11-07
EP0395734A4 true EP0395734A4 (en) 1991-01-02

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EP89100538A Expired - Lifetime EP0325963B1 (en) 1988-01-15 1989-01-13 1-aminomethyl-1,2,3,4-tetrahydronaphthalenes and -indanes
EP19890902122 Pending EP0395734A4 (en) 1988-01-15 1989-01-13 1-aminomethyl-1,2,3,4-tetrahydronaphthalenes

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EP (2) EP0325963B1 (en)
JP (1) JP2693843B2 (en)
CA (1) CA1337425C (en)
DE (1) DE68909253T2 (en)
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WO (1) WO1989006645A1 (en)

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US4963568A (en) * 1989-05-31 1990-10-16 Abbott Laboratories Dopamine agonists
AU655898B2 (en) * 1989-05-31 1995-01-12 Abbott Laboratories Dopamine agonists
IE65511B1 (en) * 1989-12-29 1995-11-01 Sanofi Sa New phenylethanolaminomethyltetralins
FR2656607B1 (en) * 1989-12-29 1994-03-11 Midy Spa PHENYLETHANOLAMINOMETHYLTETRALINES.
US5068234A (en) * 1990-02-26 1991-11-26 Sterling Drug Inc. 3-arylcarbonyl-1-(c-attached-n-heteryl)-1h-indoles
FR2664592B1 (en) * 1990-07-10 1994-09-02 Adir NOVEL DERIVATIVES OF PIPERIDINE, TETRAHYDROPYRIDINE AND PYRROLIDINE, PROCESS FOR THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
DK148292D0 (en) * 1992-12-09 1992-12-09 Lundbeck & Co As H RELATIONS
US5792767A (en) * 1995-01-27 1998-08-11 Abbott Laboratories Bicyclic substituted hexahydrobenz e! isoindole alpha-1 adrenergic antagonists
PE20020690A1 (en) * 2000-11-03 2002-08-23 Upjohn Co METHOD AND TREATMENT AND PREVENTION OF THE HEADACHES OF MIGRANS
SE0201938D0 (en) * 2002-06-20 2002-06-20 Astrazeneca Ab New process
AR052674A1 (en) 2005-02-17 2007-03-28 Wyeth Corp DERIVATIVES OF INDOL, BENZOTIOFEN, BENZOFURAN AND INDENO CICLOALQUILCONDENSADOS
CN105636947B (en) 2013-10-08 2019-05-07 拜耳作物科学股份公司 N- heteroaryl (thio) carbonyl -2- (Benzocycloalkene -1- base) cyclammonium and its purposes as fungicide

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2137276A1 (en) * 1971-07-26 1973-02-08 Basf Ag N-SUBSTITUTED 1-AMINOMETHYLINDANES
FR2500823A1 (en) * 1981-03-02 1982-09-03 Abbott Lab 1-Aminoalkyl- tetra:hydro-naphthalene derivs. - useful as adrenergic and dopaminergic stimulants and inhibitors
EP0281261A2 (en) * 1987-02-26 1988-09-07 H. Lundbeck A/S 3-Aminomethyl derivatives of indane, indoline and dihydrobenzofurane and dihydrobenzothiophene

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3553093A (en) * 1965-03-19 1971-01-05 Xerox Corp Color photoelectrophoretic imaging process
US3704323A (en) * 1969-12-23 1972-11-28 Squibb & Sons Inc Indane derivatives
JPS535146A (en) * 1976-07-02 1978-01-18 Tanabe Seiyaku Co Ltd Indane derivatives and their preparation
GB2093938B (en) * 1981-02-27 1985-02-20 Davies & Metcalfe Quick take-up and release of brakes

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2137276A1 (en) * 1971-07-26 1973-02-08 Basf Ag N-SUBSTITUTED 1-AMINOMETHYLINDANES
FR2500823A1 (en) * 1981-03-02 1982-09-03 Abbott Lab 1-Aminoalkyl- tetra:hydro-naphthalene derivs. - useful as adrenergic and dopaminergic stimulants and inhibitors
EP0281261A2 (en) * 1987-02-26 1988-09-07 H. Lundbeck A/S 3-Aminomethyl derivatives of indane, indoline and dihydrobenzofurane and dihydrobenzothiophene

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
PATENT ABSTRACTS OF JAPAN. vol. 2, no. 48, 31st March 1978, page 52C78; & JP-A-53 005 146 (TANABE SEIYAKU) 18-01-1978 *
See also references of WO8906645A1 *

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EP0325963A1 (en) 1989-08-02
DE68909253D1 (en) 1993-10-28
ES2059570T3 (en) 1994-11-16
EP0325963B1 (en) 1993-09-22
JPH04500356A (en) 1992-01-23
JP2693843B2 (en) 1997-12-24
WO1989006645A1 (en) 1989-07-27
CA1337425C (en) 1995-10-24
DE68909253T2 (en) 1994-02-24
EP0395734A1 (en) 1990-11-07

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