IL96907A - Proteins produced by human lymphocytes a dna sequence coding for said proteins and their pharmaceutical and biological application - Google Patents

Proteins produced by human lymphocytes a dna sequence coding for said proteins and their pharmaceutical and biological application

Info

Publication number
IL96907A
IL96907A IL9690791A IL9690791A IL96907A IL 96907 A IL96907 A IL 96907A IL 9690791 A IL9690791 A IL 9690791A IL 9690791 A IL9690791 A IL 9690791A IL 96907 A IL96907 A IL 96907A
Authority
IL
Israel
Prior art keywords
protein
sequence
leu
pro
arg
Prior art date
Application number
IL9690791A
Other languages
English (en)
Other versions
IL96907A0 (en
Original Assignee
Inst Nat Sante Rech Med
Roussy Inst Gustave
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inst Nat Sante Rech Med, Roussy Inst Gustave filed Critical Inst Nat Sante Rech Med
Publication of IL96907A0 publication Critical patent/IL96907A0/xx
Publication of IL96907A publication Critical patent/IL96907A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/026—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a baculovirus
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/868—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof involving autoimmunity, allergy, immediate hypersensitivity, delayed hypersensitivity, immunosuppression, or immunotolerance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IL9690791A 1990-01-08 1991-01-08 Proteins produced by human lymphocytes a dna sequence coding for said proteins and their pharmaceutical and biological application IL96907A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9000126A FR2656800B1 (fr) 1990-01-08 1990-01-08 Nouvelles proteines produits par les lymphocytes humains, sequence d'adn codant pour ces proteines et applications pharmaceutiques et biologiques.

Publications (2)

Publication Number Publication Date
IL96907A0 IL96907A0 (en) 1992-03-29
IL96907A true IL96907A (en) 1998-10-30

Family

ID=9392569

Family Applications (1)

Application Number Title Priority Date Filing Date
IL9690791A IL96907A (en) 1990-01-08 1991-01-08 Proteins produced by human lymphocytes a dna sequence coding for said proteins and their pharmaceutical and biological application

Country Status (13)

Country Link
US (2) US5773578A (de)
EP (1) EP0510079B1 (de)
JP (1) JP2997053B2 (de)
AT (1) ATE180261T1 (de)
DE (1) DE69131249T2 (de)
DK (1) DK0510079T3 (de)
ES (1) ES2134770T3 (de)
FR (1) FR2656800B1 (de)
GR (1) GR3030811T3 (de)
IL (1) IL96907A (de)
MX (1) MX9203379A (de)
WO (1) WO1991010682A1 (de)
ZA (1) ZA91134B (de)

Families Citing this family (79)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5316920A (en) * 1992-04-17 1994-05-31 Dana-Faber Cancer Institute, Inc. Lymphocyte activation antigen HB15, a member of the immunoglobulin superfamily
JP3700859B2 (ja) 1994-05-06 2005-09-28 アンスティテュ ギュスタブ ルシ Ｌａｇ−３タンパク質の可溶性ポリペプチドフラクション；製造方法、治療用製剤、抗イディオタイプ抗体
AU755030B2 (en) * 1994-05-06 2002-11-28 Institut Gustave Roussy LAG-3 protein soluble polypeptide fractions, method of production, therapeutic composition and anti-idiotype antibody
PT843557E (pt) * 1995-07-21 2003-03-31 Applied Research Systems Metodos para detectar indentificar isolar e etiquetar e abordar selectivamente linfocitos th1 por intermedio da proteina lag-3
DE69632967T2 (de) * 1996-11-29 2005-08-11 Applied Research Systems Ars Holding N.V. Verfahren zur Verhinderung der Transplantabstoßung bei einer Transplantation und zur Herstellung einer universalen Gentherapie-Wirtszelle unter Anwendung von Lymphocyten-Aktivierungsgen (LAG-3)
EP0900841A1 (de) * 1997-06-18 1999-03-10 Institut National De La Sante Et De La Recherche Medicale (Inserm) Spleissvarianten von LAG-3
EP0893507A1 (de) 1997-07-25 1999-01-27 Institut Gustave Roussy Verwendung von MHC Klass II Liganden (CD4 und LAG-3) als Adjuvanz für Impfungen und von LAG-3 in der Behandlung von Krebs
EP1141288A2 (de) * 1998-12-18 2001-10-10 Incyte Pharmaceuticals, Inc. Lymphozytische membranproteine
SE0103423D0 (sv) * 2001-10-12 2001-10-12 Astrazeneca Ab Polymorphism
US20040258678A1 (en) * 2002-02-22 2004-12-23 Genentech, Inc. Compositions and methods for the treatment of immune related diseases
US20060240024A1 (en) 2003-02-28 2006-10-26 The Johns Hopkins University T cell regulation
KR100808925B1 (ko) 2006-09-29 2008-03-03 고려대학교 산학협력단 돼지 ｌａｇ-3 융합 이뮤노글로블린
EP2044949A1 (de) * 2007-10-05 2009-04-08 Immutep Verwendung von rekombinantem LAG-3 oder Derivaten daraus zur Auslösung einer Monozyten-Immunreaktion
AR072999A1 (es) 2008-08-11 2010-10-06 Medarex Inc Anticuerpos humanos que se unen al gen 3 de activacion linfocitaria (lag-3) y los usos de estos
AR091649A1 (es) 2012-07-02 2015-02-18 Bristol Myers Squibb Co Optimizacion de anticuerpos que se fijan al gen de activacion de linfocitos 3 (lag-3) y sus usos
RS64268B1 (sr) 2013-09-20 2023-07-31 Bristol Myers Squibb Co Kombinacija anti-lag-3 antitela i anti-pd-1 antitela za lečenje tumora
GB201322626D0 (en) 2013-12-19 2014-02-05 Immutep S A Combined preparations for the treatment of cancer
UA122479C2 (uk) 2014-01-24 2020-11-25 Дана-Фарбер Кенсер Інстітьют, Інк. Виділена молекула антитіла, яка зв’язується з людським білком програмованої смерті-1 (pd-1)
EA201691765A1 (ru) 2014-03-14 2016-12-30 Новартис Аг Молекулы антител против lag-3 и их применения
TWI693232B (zh) 2014-06-26 2020-05-11 美商宏觀基因股份有限公司 與pd-1和lag-3具有免疫反應性的共價結合的雙抗體和其使用方法
DK3552615T3 (da) 2014-07-16 2022-02-14 Transgene Onkolytisk virus til ekspression af immun-checkpoint-modulatorer
ES2833425T3 (es) 2014-07-16 2021-06-15 Roussy Inst Gustave Combinación de virus oncolítico con moduladores de punto de control inmunitario
JO3663B1 (ar) * 2014-08-19 2020-08-27 Merck Sharp & Dohme الأجسام المضادة لمضاد lag3 وأجزاء ربط الأنتيجين
GB201500374D0 (en) 2015-01-09 2015-02-25 Immutep S A Combined preparations for the treatment of cancer
TWI773646B (zh) 2015-06-08 2022-08-11 美商宏觀基因股份有限公司 結合lag-3的分子和其使用方法
US20180340025A1 (en) 2015-07-29 2018-11-29 Novartis Ag Combination therapies comprising antibody molecules to lag-3
PE20231958A1 (es) 2015-07-30 2023-12-06 Macrogenics Inc Moleculas de union a pd-1 y metodos de uso de las mismas
TWI756187B (zh) 2015-10-09 2022-03-01 美商再生元醫藥公司 抗ｌａｇ３抗體及其用途
CN108367069B (zh) 2015-12-14 2022-08-23 宏观基因有限公司 对于pd-1和ctla-4具有免疫反应性的双特异性分子及其使用方法
BR112018012352A2 (pt) 2015-12-16 2018-12-11 Merck Sharp & Dohme Corp. anticorpos anti-lag3 e fragmentos de ligação ao antígeno
CN108495651A (zh) 2015-12-17 2018-09-04 诺华股份有限公司 抗pd-1的抗体分子及其用途
US11497781B2 (en) 2016-03-10 2022-11-15 Cg Oncology, Inc. Methods of treating bladder cancer by combination therapy comprising the oncolytic adenovirus CG0070 and an immune checkpoint inhibitor
BR112019016336A2 (pt) 2017-02-10 2020-03-31 Regeneron Pharmaceuticals, Inc. Conjugado de anticorpo radiorrotulado, método para imageamento de um tecido que expressa lag3 e para tratar um tumor, e, composto.
CN118892540A (zh) 2017-04-21 2024-11-05 新罗杰股份有限公司 溶瘤痘苗病毒与免疫检查点抑制剂联合疗法
JP7301002B2 (ja) 2017-05-30 2023-06-30 ブリストル－マイヤーズ スクイブ カンパニー 抗ｌａｇ－３抗体または抗ｌａｇ－３抗体および抗ｐｄ－１もしくは抗ｐｄ－ｌ１抗体を含む組成物
WO2018222718A1 (en) 2017-05-30 2018-12-06 Bristol-Myers Squibb Company Treatment of lag-3 positive tumors
WO2020183011A1 (en) 2019-03-14 2020-09-17 Institut Curie Htr1d inhibitors and uses thereof in the treatment of cancer
CN119350468A (zh) 2019-03-29 2025-01-24 居里研究所 具有经修饰的生物活性的白介素-2变体
CA3136568A1 (en) 2019-05-13 2020-11-19 Regeneron Pharmaceuticals, Inc. Combination of pd-1 inhibitors and lag-3 inhibitors for enhanced efficacy in treating cancer
US20220401539A1 (en) 2019-10-22 2022-12-22 Institut Curie Immunotherapy Targeting Tumor Neoantigenic Peptides
EP3824954A1 (de) 2019-11-22 2021-05-26 Centre National de la Recherche Scientifique Vorrichtung, einrichtung und verfahren zur ministrahl-strahlentherapie
WO2021224186A1 (en) 2020-05-04 2021-11-11 Institut Curie New pyridine derivatives as radiosensitizers
AU2021275489A1 (en) 2020-05-20 2022-12-01 Centre National De La Recherche Scientifique - Cnrs - Single domain antibodies and their use in cancer therapies
WO2022079270A1 (en) 2020-10-16 2022-04-21 Université D'aix-Marseille Anti-gpc4 single domain antibodies
EP4232453A1 (de) 2020-10-20 2023-08-30 Institut Curie Metallische trans-(n-heterocyclische carben)-amin-platin-komplexe und verwendungen davon zur behandlung von krebs
CA3196496A1 (en) 2020-10-23 2022-04-28 Laurence David TOMS Lag-3 antagonist therapy for lung cancer
EP4247352A1 (de) 2020-11-18 2023-09-27 Institut Curie Dimere von biguanidinen und ihre therapeutischen verwendungen
EP4277934A1 (de) 2021-01-14 2023-11-22 Institut Curie Her2-einzeldomänenantikörpervarianten und cars davon
WO2022189618A1 (en) 2021-03-12 2022-09-15 Institut Curie Nitrogen-containing heterocycles as radiosensitizers
US20240269282A1 (en) 2021-05-10 2024-08-15 Institut Curie Methods for the Treatment of Cancer, Inflammatory Diseases and Autoimmune Diseases
EP4380682A1 (de) 2021-08-05 2024-06-12 Institut Curie Dynamische abtastvorrichtung zur ministrahlerzeugung
US20240316061A1 (en) 2021-09-17 2024-09-26 Institut Curie Bet inhibitors for treating pab1 deficient cancer
WO2023089032A1 (en) 2021-11-19 2023-05-25 Institut Curie Methods for the treatment of hrd cancer and brca-associated cancer
WO2023099763A1 (en) 2021-12-03 2023-06-08 Institut Curie Sirt6 inhibitors for use in treating resistant hrd cancer
CN119816320A (zh) 2022-03-24 2025-04-11 居里研究所 靶向胶质母细胞瘤中肿瘤转座元件衍生的新抗原肽的免疫疗法
EP4499677A1 (de) 2022-03-31 2025-02-05 Institut Curie Modifiziertes rela-protein zur induktion der interferonexpression und manipulierte immunzellen mit verbesserter interferonexpression
EP4504245A1 (de) 2022-04-07 2025-02-12 Institut Curie Durch chimären antigenrezeptor modifizierte myeloidzellen und verwendungen davon zur antikrebstherapie
US20250222106A1 (en) 2022-04-07 2025-07-10 Institut Curie Myeloid cells modified by chimeric antigen receptor with cd40 and uses thereof for anti-cancer therapy
EP4593868A1 (de) 2022-09-26 2025-08-06 Institut Curie Myeloidzellen zur expression von il-2 und verwendungen davon zur schnellen antikrebstherapie
CN121127264A (zh) 2023-03-13 2025-12-12 瑞泽恩制药公司 用于在治疗黑素瘤中增强疗效的pd-1抑制剂和lag-3抑制剂组合
EP4683630A1 (de) 2023-03-21 2026-01-28 Institut Curie Vps4b-inhibitor zur verwendung in verfahren zur behandlung von hrd-krebs
WO2024194402A1 (en) 2023-03-21 2024-09-26 Institut Curie Farnesyl transferase inhibitor for use in methods for the treatment of hrd cancer
WO2024194673A1 (en) 2023-03-21 2024-09-26 Institut Curie Methods for the treatment of dedifferentiated liposarcoma
EP4695290A1 (de) 2023-04-13 2026-02-18 Institut Curie Verfahren zur behandlung von akuter lymphoblastischer t-zell-leukämie
WO2025068393A1 (en) 2023-09-27 2025-04-03 Institut Curie Methods for the treatment of fibrotic related diseases
CN122180519A (zh) 2023-11-15 2026-06-09 瑞泽恩制药公司 用于增强在治疗肺癌中的功效的pd-1抑制剂和lag-3抑制剂的组合
EP4574165A1 (de) 2023-12-21 2025-06-25 Egle Therapeutics Immunozytokine zur krebsbehandlung
AU2024405515A1 (en) 2023-12-21 2026-07-02 Egle Therapeutics Immunocytokine for cancer treatment
AU2025213523A1 (en) 2024-01-26 2026-07-16 Centre National De La Recherche Scientifique Lipid degraders to trigger ferroptosis in cancer
WO2025202450A1 (en) 2024-03-28 2025-10-02 Institut Curie Myeloid cells modified by cytokine chimeric receptor and uses thereof
EP4624494A1 (de) 2024-03-29 2025-10-01 Institut Curie Her2-einzeldomänenantikörper und verwendungen davon
WO2025210252A1 (en) 2024-04-05 2025-10-09 Institut Curie Modulators of fam118b protein for use in therapy
EP4681780A1 (de) 2024-07-18 2026-01-21 Egle Therapeutics Immunozytokine zur krebsbehandlung
WO2026017820A1 (en) 2024-07-18 2026-01-22 Egle Therapeutics Fusion protein for cancer treatment
WO2026035866A1 (en) 2024-08-07 2026-02-12 Iovance Biotherapeutics, Inc. Treatment of cancer patients with tumor infiltrating lymphocyte therapies in combination with a lag-3 inhibitor and a pd-1 inhibitor
EP4707295A1 (de) 2024-09-05 2026-03-11 Egle Therapeutics Interleukin-2-varianten mit modifizierter biologischer aktivität
EP4707296A1 (de) 2024-09-05 2026-03-11 Egle Therapeutics Interleukin-2-varianten mit modifizierter biologischer aktivität
WO2026093520A1 (en) 2024-10-31 2026-05-07 Institut Curie Short-csf1-associated extracellular vesicles and uses thereof
WO2026154125A2 (en) 2025-01-17 2026-07-23 Institut Curie A tumor-specific hla-bound neoantigenic peptide encoded by ewsr1::fli1-induced neogenes

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5109123A (en) * 1988-06-14 1992-04-28 Dana Farber Cancer Institute Alteration of ability of soluble CD4 fragments to bind HIV
US4994369A (en) * 1987-12-15 1991-02-19 The Board Of Trustees Of The Leland Stanford Jr. Univ. T-cell activation related gene
US5001230A (en) * 1988-02-18 1991-03-19 Schering Corporation T cell activation markers

Also Published As

Publication number Publication date
DE69131249D1 (de) 1999-06-24
JPH05503520A (ja) 1993-06-10
DK0510079T3 (da) 1999-11-29
FR2656800A1 (fr) 1991-07-12
US5773578A (en) 1998-06-30
IL96907A0 (en) 1992-03-29
JP2997053B2 (ja) 2000-01-11
ZA91134B (en) 1992-08-26
GR3030811T3 (en) 1999-11-30
MX9203379A (es) 1992-09-01
WO1991010682A1 (fr) 1991-07-25
ATE180261T1 (de) 1999-06-15
FR2656800B1 (fr) 1992-05-15
EP0510079A1 (de) 1992-10-28
DE69131249T2 (de) 1999-12-30
US5874250A (en) 1999-02-23
EP0510079B1 (de) 1999-05-19
ES2134770T3 (es) 1999-10-16

Similar Documents

Publication Publication Date Title
US5874250A (en) DNA encoding for a protein containing the extracellular domain of lymphocyte activation gene 3
CA2143491C (en) A novel peptide related to human programmed cell death and dna encoding it
JP3253064B2 (ja) ウイルスの感染性を阻止するヒトライノウイルス受容体タンパク質
Jones et al. Isolation of complementary DNA clones encoding the human lymphocyte glycoprotein T1/Leu-1
US5976877A (en) Proteins produced by human lymphocytes DNA sequence encoding these proteins and their pharmaceutical and biological uses
US4956281A (en) DNA sequences, recombinant DNA molecules and processes for producing lymphocyte function associated antigen-3
AU641134B2 (en) A soluble molecule related to but distinct from ICAM-1
US5849699A (en) Soluble molecule related to but distinct from ICAM-1
JP3534406B2 (ja) 免疫グロブリンＥの高アフィニティレセプタのヒトβサブユニットの分離，特性化および用法
JP2001505407A (ja) 腫瘍壊死因子関連リガンド
NZ226475A (en) Soluble hcd4 (t4) t-lymphocyte surface glycoprotein that binds hiv gp120 envelope protein
AU642130B2 (en) DNA sequences, recombinant DNA molecules and processes for producing PI-linked lymphocyte function associated antigen-3
AU673810B2 (en) Secreted Mac-2-binding glycoprotein
US5891434A (en) Monoclonal antibodies to the APO-1 antigen
AU662545B2 (en) DNAs encoding proteins active in lymphocyte-mediated cytotoxicity
US5683696A (en) Cloning of duffy blood group antigen, gpD
EP0702725B1 (de) Verfahren zur herstellung rekombinanter, biologisch aktiver polypeptide
US5874264A (en) Gibbon ape leukemia virus receptor
JP2005200422A (ja) インターフェロンα／β結合タンパク質およびその製造法
US5786168A (en) Method for recombinant production of antigen non-specific glycosylation inhibiting factor (GIF)
WO1995004756A1 (en) Complement inhibitor proteins of non-human primates
AU697868C (en) The cloning of Duffy blood group antigen
JP2001523102A (ja) アポトーシス細胞死経路の細胞内変調因子
JPH1072495A (ja) 免疫関連因子

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed
KB Patent renewed
KB Patent renewed
EXP Patent expired