ES2134770T3 - Proteinas producidas por los linfocitos humanos, secuencia de adn codante para estas proteinas y aplicaciones farmaceuticas y biologicas. - Google Patents
Proteinas producidas por los linfocitos humanos, secuencia de adn codante para estas proteinas y aplicaciones farmaceuticas y biologicas.Info
- Publication number
- ES2134770T3 ES2134770T3 ES91903010T ES91903010T ES2134770T3 ES 2134770 T3 ES2134770 T3 ES 2134770T3 ES 91903010 T ES91903010 T ES 91903010T ES 91903010 T ES91903010 T ES 91903010T ES 2134770 T3 ES2134770 T3 ES 2134770T3
- Authority
- ES
- Spain
- Prior art keywords
- proteins
- pharmaceutical
- codant
- dna sequence
- human lymphocytes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
- C12N2799/026—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a baculovirus
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/868—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof involving autoimmunity, allergy, immediate hypersensitivity, delayed hypersensitivity, immunosuppression, or immunotolerance
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Cell Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Virology (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
LA PRESENTE INVENCION SE REFIERE A PROTEINAS PRODUCIDAS POR LINFOCITOS HUMANOS Y, EN PARTICULAR, UNA PROTEINA EXPRESADA EN LA SUPERFICIE DE ESTOS, SECUENCIAS DE ADN QUE CODIFICAN ESTAS PROTEINAS Y LAS APLICACIONES FARMACEUTICAS Y BIOLOGICAS DE ESTAS PROTEINAS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9000126A FR2656800B1 (fr) | 1990-01-08 | 1990-01-08 | Nouvelles proteines produits par les lymphocytes humains, sequence d'adn codant pour ces proteines et applications pharmaceutiques et biologiques. |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2134770T3 true ES2134770T3 (es) | 1999-10-16 |
Family
ID=9392569
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES91903010T Expired - Lifetime ES2134770T3 (es) | 1990-01-08 | 1991-01-08 | Proteinas producidas por los linfocitos humanos, secuencia de adn codante para estas proteinas y aplicaciones farmaceuticas y biologicas. |
Country Status (13)
Country | Link |
---|---|
US (2) | US5773578A (es) |
EP (1) | EP0510079B1 (es) |
JP (1) | JP2997053B2 (es) |
AT (1) | ATE180261T1 (es) |
DE (1) | DE69131249T2 (es) |
DK (1) | DK0510079T3 (es) |
ES (1) | ES2134770T3 (es) |
FR (1) | FR2656800B1 (es) |
GR (1) | GR3030811T3 (es) |
IL (1) | IL96907A (es) |
MX (1) | MX9203379A (es) |
WO (1) | WO1991010682A1 (es) |
ZA (1) | ZA91134B (es) |
Families Citing this family (56)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5316920A (en) * | 1992-04-17 | 1994-05-31 | Dana-Faber Cancer Institute, Inc. | Lymphocyte activation antigen HB15, a member of the immunoglobulin superfamily |
AU755030B2 (en) * | 1994-05-06 | 2002-11-28 | Institut Gustave Roussy | LAG-3 protein soluble polypeptide fractions, method of production, therapeutic composition and anti-idiotype antibody |
USRE38313E1 (en) * | 1994-05-06 | 2003-11-11 | Institut Gustave Roussy | Soluble polypeptide fractions of the LAG-3 protein, production method, therapeutic composition, anti-idiotype antibodies |
PT843557E (pt) | 1995-07-21 | 2003-03-31 | Applied Research Systems | Metodos para detectar indentificar isolar e etiquetar e abordar selectivamente linfocitos th1 por intermedio da proteina lag-3 |
ATE271607T1 (de) * | 1996-11-29 | 2004-08-15 | Applied Research Systems | Vorbeugen des graftsabstosses in transplantaten und zur herstellung von universalen gentherapie wirtszell, unter anwendung von lymphozytenaktivierungsgen-3 (lag-3) |
EP0900841A1 (en) * | 1997-06-18 | 1999-03-10 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | LAG-3 splice variants |
EP0893507A1 (en) * | 1997-07-25 | 1999-01-27 | Institut Gustave Roussy | Use of MHC class II ligands (CD4 and LAG-3) as adjuvant for vaccination and of LAG-3 in cancer treatment |
JP2002534961A (ja) * | 1998-12-18 | 2002-10-22 | インサイト・ファーマスーティカルズ・インコーポレイテッド | リンパ球膜タンパク質 |
SE0103423D0 (sv) * | 2001-10-12 | 2001-10-12 | Astrazeneca Ab | Polymorphism |
EP2388265A1 (en) * | 2002-02-22 | 2011-11-23 | Genentech, Inc. | Compositions and methods for the treatment of immune related diseases |
PT1897548E (pt) | 2003-02-28 | 2013-11-19 | Univ Johns Hopkins | Regulação de células t |
KR100808925B1 (ko) | 2006-09-29 | 2008-03-03 | 고려대학교 산학협력단 | 돼지 lag-3 융합 이뮤노글로블린 |
EP2044949A1 (en) * | 2007-10-05 | 2009-04-08 | Immutep | Use of recombinant lag-3 or the derivatives thereof for eliciting monocyte immune response |
AR072999A1 (es) * | 2008-08-11 | 2010-10-06 | Medarex Inc | Anticuerpos humanos que se unen al gen 3 de activacion linfocitaria (lag-3) y los usos de estos |
UY34887A (es) | 2012-07-02 | 2013-12-31 | Bristol Myers Squibb Company Una Corporacion Del Estado De Delaware | Optimización de anticuerpos que se fijan al gen de activación de linfocitos 3 (lag-3) y sus usos |
ES2728578T3 (es) | 2013-09-20 | 2019-10-25 | Bristol Myers Squibb Co | Combinación de anticuerpos anti-LAG-3 y anticuerpos anti-PD-1 para tratar tumores |
GB201322626D0 (en) | 2013-12-19 | 2014-02-05 | Immutep S A | Combined preparations for the treatment of cancer |
JOP20200094A1 (ar) | 2014-01-24 | 2017-06-16 | Dana Farber Cancer Inst Inc | جزيئات جسم مضاد لـ pd-1 واستخداماتها |
WO2015138920A1 (en) | 2014-03-14 | 2015-09-17 | Novartis Ag | Antibody molecules to lag-3 and uses thereof |
TWI693232B (zh) | 2014-06-26 | 2020-05-11 | 美商宏觀基因股份有限公司 | 與pd-1和lag-3具有免疫反應性的共價結合的雙抗體和其使用方法 |
EP3169341B1 (en) | 2014-07-16 | 2019-06-05 | Transgene SA | Oncolytic virus for expression of immune checkpoint modulators |
DK3169340T3 (da) | 2014-07-16 | 2020-11-09 | Roussy Inst Gustave | Kombination af onkolytisk virus med immun-checkpoint-modulatorer |
JO3663B1 (ar) * | 2014-08-19 | 2020-08-27 | Merck Sharp & Dohme | الأجسام المضادة لمضاد lag3 وأجزاء ربط الأنتيجين |
GB201500374D0 (en) | 2015-01-09 | 2015-02-25 | Immutep S A | Combined preparations for the treatment of cancer |
TWI773646B (zh) | 2015-06-08 | 2022-08-11 | 美商宏觀基因股份有限公司 | 結合lag-3的分子和其使用方法 |
MX2018001227A (es) | 2015-07-30 | 2018-03-26 | Macrogenics Inc | Moleculas de union a pd-1 y metodos de uso de las mismas. |
TWI756187B (zh) | 2015-10-09 | 2022-03-01 | 美商再生元醫藥公司 | 抗lag3抗體及其用途 |
UA125611C2 (uk) | 2015-12-14 | 2022-05-04 | Макродженікс, Інк. | Біспецифічні молекули, що мають імунореактивність відносно pd-1 і ctla-4, і способи їх застосування |
AU2016371639A1 (en) | 2015-12-16 | 2018-06-28 | Merck Sharp & Dohme Llc | Anti-LAG3 antibodies and antigen-binding fragments |
WO2017156349A1 (en) | 2016-03-10 | 2017-09-14 | Cold Genesys, Inc. | Methods of treating solid or lymphatic tumors by combination therapy |
MA46814B2 (fr) | 2017-02-10 | 2022-09-30 | Regeneron Pharma | Anticorps anti-lag3 radiomarqués pour imagerie immuno-pet |
KR20190137911A (ko) | 2017-04-21 | 2019-12-11 | 신라젠(주) | 항암 백시니아 바이러스와 관문 저해제 병용 요법 |
CN110678200B (zh) | 2017-05-30 | 2024-05-17 | 百时美施贵宝公司 | 包含抗lag-3抗体或抗lag-3抗体和抗pd-1或抗pd-l1抗体的组合物 |
HRP20231457T1 (hr) | 2017-05-30 | 2024-05-10 | Bristol-Myers Squibb Company | Liječenje lag-3-pozitivnih tumora |
WO2020183011A1 (en) | 2019-03-14 | 2020-09-17 | Institut Curie | Htr1d inhibitors and uses thereof in the treatment of cancer |
CN118388628A (zh) | 2019-03-29 | 2024-07-26 | 居里研究所 | 具有经修饰的生物活性的白介素-2变体 |
KR20220007593A (ko) | 2019-05-13 | 2022-01-18 | 리제너론 파마슈티칼스 인코포레이티드 | 암 치료에서의 효능 강화를 위한 pd-1 억제제와 lag-3 억제제의 병용 |
EP4048304A1 (en) | 2019-10-22 | 2022-08-31 | Institut Curie | Immunotherapy targeting tumor neoantigenic peptides |
EP3824954A1 (en) | 2019-11-22 | 2021-05-26 | Centre National de la Recherche Scientifique | Device, apparatus and method for minibeam radiation therapy |
WO2021224186A1 (en) | 2020-05-04 | 2021-11-11 | Institut Curie | New pyridine derivatives as radiosensitizers |
WO2021234110A1 (en) | 2020-05-20 | 2021-11-25 | Institut Curie | Single domain antibodies and their use in cancer therapies |
WO2022079270A1 (en) | 2020-10-16 | 2022-04-21 | Université D'aix-Marseille | Anti-gpc4 single domain antibodies |
EP4232453A1 (en) | 2020-10-20 | 2023-08-30 | Institut Curie | Metallic trans-(n-heterocyclic carbene)-amine-platinum complexes and uses thereof for treating cancer |
JP2023550402A (ja) | 2020-11-18 | 2023-12-01 | アンスティテュ・クリー | ビグアニジンの二量体及びその治療的使用 |
CN117916271A (zh) | 2021-01-14 | 2024-04-19 | 居里研究所 | Her2单域抗体变体及其car |
WO2022189618A1 (en) | 2021-03-12 | 2022-09-15 | Institut Curie | Nitrogen-containing heterocycles as radiosensitizers |
EP4337763A1 (en) | 2021-05-10 | 2024-03-20 | Institut Curie | Methods for the treatment of cancer, inflammatory diseases and autoimmune diseases |
WO2023011879A1 (en) | 2021-08-05 | 2023-02-09 | Institut Curie | Scanning dynamic device for minibeams production |
EP4401715A1 (en) | 2021-09-17 | 2024-07-24 | Institut Curie | Bet inhibitors for treating pab1 deficient cancer |
WO2023089032A1 (en) | 2021-11-19 | 2023-05-25 | Institut Curie | Methods for the treatment of hrd cancer and brca-associated cancer |
WO2023099763A1 (en) | 2021-12-03 | 2023-06-08 | Institut Curie | Sirt6 inhibitors for use in treating resistant hrd cancer |
WO2023180552A1 (en) | 2022-03-24 | 2023-09-28 | Institut Curie | Immunotherapy targeting tumor transposable element derived neoantigenic peptides in glioblastoma |
WO2023187024A1 (en) | 2022-03-31 | 2023-10-05 | Institut Curie | Modified rela protein for inducing interferon expression and engineered immune cells with improved interferon expression |
WO2023194607A1 (en) | 2022-04-07 | 2023-10-12 | Institut Curie | Myeloid cells modified by chimeric antigen receptor with cd40 and uses thereof for anti-cancer therapy |
WO2023194608A1 (en) | 2022-04-07 | 2023-10-12 | Institut Curie | Myeloid cells modified by chimeric antigen receptor and uses thereof for anti-cancer therapy |
WO2024068617A1 (en) | 2022-09-26 | 2024-04-04 | Institut Curie | Myeloid cells expressing il-2 and uses thereof for quick anticancer therapy |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5109123A (en) * | 1988-06-14 | 1992-04-28 | Dana Farber Cancer Institute | Alteration of ability of soluble CD4 fragments to bind HIV |
US4994369A (en) * | 1987-12-15 | 1991-02-19 | The Board Of Trustees Of The Leland Stanford Jr. Univ. | T-cell activation related gene |
US5001230A (en) * | 1988-02-18 | 1991-03-19 | Schering Corporation | T cell activation markers |
-
1990
- 1990-01-08 FR FR9000126A patent/FR2656800B1/fr not_active Expired - Fee Related
-
1991
- 1991-01-08 ZA ZA91134A patent/ZA91134B/xx unknown
- 1991-01-08 MX MX9203379A patent/MX9203379A/es unknown
- 1991-01-08 DE DE69131249T patent/DE69131249T2/de not_active Expired - Fee Related
- 1991-01-08 EP EP91903010A patent/EP0510079B1/fr not_active Expired - Lifetime
- 1991-01-08 DK DK91903010T patent/DK0510079T3/da active
- 1991-01-08 ES ES91903010T patent/ES2134770T3/es not_active Expired - Lifetime
- 1991-01-08 AT AT91903010T patent/ATE180261T1/de not_active IP Right Cessation
- 1991-01-08 WO PCT/FR1991/000009 patent/WO1991010682A1/fr active IP Right Grant
- 1991-01-08 JP JP3503112A patent/JP2997053B2/ja not_active Expired - Fee Related
- 1991-01-08 IL IL9690791A patent/IL96907A/en not_active IP Right Cessation
-
1995
- 1995-04-04 US US08/416,478 patent/US5773578A/en not_active Expired - Lifetime
- 1995-06-07 US US08/474,988 patent/US5874250A/en not_active Expired - Lifetime
-
1999
- 1999-07-20 GR GR990401899T patent/GR3030811T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
IL96907A (en) | 1998-10-30 |
FR2656800B1 (fr) | 1992-05-15 |
US5874250A (en) | 1999-02-23 |
IL96907A0 (en) | 1992-03-29 |
JP2997053B2 (ja) | 2000-01-11 |
EP0510079A1 (fr) | 1992-10-28 |
GR3030811T3 (en) | 1999-11-30 |
DE69131249D1 (de) | 1999-06-24 |
DK0510079T3 (da) | 1999-11-29 |
DE69131249T2 (de) | 1999-12-30 |
EP0510079B1 (fr) | 1999-05-19 |
WO1991010682A1 (fr) | 1991-07-25 |
FR2656800A1 (fr) | 1991-07-12 |
US5773578A (en) | 1998-06-30 |
MX9203379A (es) | 1992-09-01 |
JPH05503520A (ja) | 1993-06-10 |
ATE180261T1 (de) | 1999-06-15 |
ZA91134B (en) | 1992-08-26 |
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