IL95359A - B-71) Cyclopropylphoxy (Androst-5-AN-B-3-ol and similar compounds, 4-transducts used as inhibitors of C71-02-Liaz - Google Patents

B-71) Cyclopropylphoxy (Androst-5-AN-B-3-ol and similar compounds, 4-transducts used as inhibitors of C71-02-Liaz

Info

Publication number
IL95359A
IL95359A IL9535990A IL9535990A IL95359A IL 95359 A IL95359 A IL 95359A IL 9535990 A IL9535990 A IL 9535990A IL 9535990 A IL9535990 A IL 9535990A IL 95359 A IL95359 A IL 95359A
Authority
IL
Israel
Prior art keywords
androst
cyclopropyloxy
substituted
compound
halogen
Prior art date
Application number
IL9535990A
Other languages
English (en)
Hebrew (he)
Other versions
IL95359A0 (en
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of IL95359A0 publication Critical patent/IL95359A0/xx
Publication of IL95359A publication Critical patent/IL95359A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0018—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa
    • C07J1/0022—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
    • C07J1/0029—Ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0033—Androstane derivatives substituted in position 17 alfa and 17 beta
    • C07J1/0037—Androstane derivatives substituted in position 17 alfa and 17 beta the substituent in position 17 alfa being a saturated hydrocarbon group

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
IL9535990A 1989-08-15 1990-08-13 B-71) Cyclopropylphoxy (Androst-5-AN-B-3-ol and similar compounds, 4-transducts used as inhibitors of C71-02-Liaz IL95359A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/394,026 US4966897A (en) 1989-08-15 1989-08-15 4-substituted 17β-(cyclopropyloxy)androst-5-en-3β-ol and related compounds useful as C17-20 lyase inhibitors

Publications (2)

Publication Number Publication Date
IL95359A0 IL95359A0 (en) 1991-06-30
IL95359A true IL95359A (en) 1995-08-31

Family

ID=23557245

Family Applications (1)

Application Number Title Priority Date Filing Date
IL9535990A IL95359A (en) 1989-08-15 1990-08-13 B-71) Cyclopropylphoxy (Androst-5-AN-B-3-ol and similar compounds, 4-transducts used as inhibitors of C71-02-Liaz

Country Status (22)

Country Link
US (1) US4966897A (fr)
EP (1) EP0413269B1 (fr)
JP (1) JP2879702B2 (fr)
KR (1) KR910004650A (fr)
CN (1) CN1050195A (fr)
AT (1) ATE138930T1 (fr)
AU (1) AU628210B2 (fr)
CA (1) CA2023008C (fr)
DD (1) DD298106A5 (fr)
DE (1) DE69027262T2 (fr)
DK (1) DK0413269T3 (fr)
ES (1) ES2090064T3 (fr)
FI (1) FI95711C (fr)
GR (1) GR3020797T3 (fr)
HU (1) HUT55030A (fr)
IE (1) IE902941A1 (fr)
IL (1) IL95359A (fr)
NO (1) NO903565L (fr)
NZ (1) NZ234855A (fr)
PH (1) PH27549A (fr)
PT (1) PT94994B (fr)
ZA (1) ZA906307B (fr)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4966898A (en) * 1989-08-15 1990-10-30 Merrell Dow Pharmaceuticals Inc. 4-substituted 17β-(cyclopropylamino)androst-5-en-3β-ol and related compounds useful as C17-20 lyase inhibitors
ES2123133T3 (es) * 1993-03-10 1999-01-01 Magainin Pharma Derivados esteroidianos, composiciones farmaceuticas que contienen estos derivados esteroidianos y utilizacion de estos ultimos como antibioticos o desinfectantes.
US5486511A (en) * 1993-05-25 1996-01-23 Merrell Dow Pharmaceuticals Inc. 4-amino-17β-(cyclopropyloxy)androst-4-en-3-one, 4-amino-17β-(cyclopropylamino)androst-4-en-3-one and related compounds as C17-20 lyase and 5α-reductase
TW369521B (en) * 1993-09-17 1999-09-11 Smithkline Beecham Corp Androstenone derivative
US5856535A (en) * 1994-08-18 1999-01-05 Magainin Pharmaceuticals, Inc. Aminosterol ester compounds
US5840740A (en) * 1995-06-07 1998-11-24 Magainin Pharmaceuticals Inc. Aminosterol compounds and a method of treating infection using the aminosterol compounds
US5541322A (en) * 1994-10-14 1996-07-30 Glaxo Wellcome Inc. Synthesis of 6-azaandrostenones
US5661141A (en) * 1995-03-27 1997-08-26 Petrow; Vladimir 19-oxygenated steroids as therapeutic agents
US5795885A (en) * 1995-06-07 1998-08-18 Magainin Pharmaceuticals Inc. Method of inhibiting profileration of cells by administering an aminosterol compound
US5874597A (en) * 1995-06-07 1999-02-23 Magainin Pharmaceuticals, Inc. Certain aminosterol compounds and pharmaceutical compositions including these compounds
US5840936A (en) * 1995-06-07 1998-11-24 Magainin Pharmaceuticals Inc. Aminosterol compounds useful as inhibitors of the sodium/proton exchanger (NHE)
US5994336A (en) * 1995-06-07 1999-11-30 Magainin Pharmaceuticals Inc. Method of inhibiting proliferation of cells by administering an aminosterol compound
US5792635A (en) * 1995-06-07 1998-08-11 Magainin Pharmaceuticals, Inc. Method of inhibiting the sodium/proton exchanger NHE3 and method of inhibiting growth by administering squalamine
US5763430A (en) * 1995-06-07 1998-06-09 Magainin Pharmaceuticals Inc. Method of treating a viral infection by administering a steroid compound
US5847172A (en) * 1995-06-07 1998-12-08 Magainin Pharmaceuticals Inc. Certain aminosterol compounds and pharmaceutical compositions including these compounds
US6143738A (en) * 1995-06-07 2000-11-07 Magainin Pharmaceuticals, Inc. Therapeutic uses for an aminosterol compound
US6365597B1 (en) 1996-02-14 2002-04-02 Aventis Pharmaceuticals Inc. 4-aza steroids
CA2252584C (fr) * 1996-04-26 2008-06-10 Magainin Pharmaceuticals Inc. Traitement des carcinomes par la squalamine en association avec d'autres agents anticancereux
US6596712B2 (en) 1996-04-26 2003-07-22 Genaera Corporation Treatment of carcinomas using squalamine in combination with other anti-cancer agents or modalities
US6262283B1 (en) 1996-12-06 2001-07-17 Magainin Pharmaceuticals Inc. Stereoselective synthesis of 24-hydroxylated compounds useful for the preparation of aminosterols, vitamin D analogs, and other compounds
CA2406847C (fr) * 2000-04-12 2009-11-17 Genaera Corporation Oxydation stereoselective de systemes a cycles fusionnes pour la preparation d'aminosterols
JP2007297879A (ja) * 2006-05-02 2007-11-15 Central Glass Co Ltd 電磁波吸収板

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3475464A (en) * 1966-11-07 1969-10-28 Syntex Corp Process for the preparation of steroids and novel intermediates thereof
US4139617A (en) * 1974-05-13 1979-02-13 Richardson-Merrell Inc. 19-Oxygenated-androst-5-enes for the enhancement of libido
US4891367A (en) * 1987-04-22 1990-01-02 Merrell Dow Pharmaceuticals Inc. 17β-(cyclopropyloxy)androst-5-en-3β-ol and related compounds useful as C17-20 lyase inhibitors
US4966898A (en) * 1989-08-15 1990-10-30 Merrell Dow Pharmaceuticals Inc. 4-substituted 17β-(cyclopropylamino)androst-5-en-3β-ol and related compounds useful as C17-20 lyase inhibitors

Also Published As

Publication number Publication date
PT94994B (pt) 1997-05-28
CN1050195A (zh) 1991-03-27
IL95359A0 (en) 1991-06-30
NZ234855A (en) 1992-11-25
DE69027262D1 (de) 1996-07-11
EP0413269B1 (fr) 1996-06-05
DE69027262T2 (de) 1996-10-02
FI95711C (fi) 1996-03-11
IE902941A1 (en) 1991-02-27
NO903565D0 (no) 1990-08-14
JPH0383996A (ja) 1991-04-09
AU628210B2 (en) 1992-09-10
PH27549A (en) 1993-08-18
DK0413269T3 (da) 1996-06-24
NO903565L (no) 1991-02-18
AU6087890A (en) 1991-02-21
FI904036A0 (fi) 1990-08-15
CA2023008A1 (fr) 1991-02-16
JP2879702B2 (ja) 1999-04-05
DD298106A5 (de) 1992-02-06
ATE138930T1 (de) 1996-06-15
HUT55030A (en) 1991-04-29
GR3020797T3 (en) 1996-11-30
ZA906307B (en) 1991-06-26
PT94994A (pt) 1991-04-18
HU905005D0 (en) 1991-01-28
US4966897A (en) 1990-10-30
EP0413269A3 (en) 1992-05-20
CA2023008C (fr) 2001-05-15
ES2090064T3 (es) 1996-10-16
FI95711B (fi) 1995-11-30
KR910004650A (ko) 1991-03-29
EP0413269A2 (fr) 1991-02-20

Similar Documents

Publication Publication Date Title
US4966897A (en) 4-substituted 17β-(cyclopropyloxy)androst-5-en-3β-ol and related compounds useful as C17-20 lyase inhibitors
KR100235135B1 (ko) 암치료에 유용한 17-치환된 스테로이드
US6011025A (en) 11-(substituted phenyl)-estra-4,9-diene derivatives
JPS6069096A (ja) 新規ステロイド
US4966898A (en) 4-substituted 17β-(cyclopropylamino)androst-5-en-3β-ol and related compounds useful as C17-20 lyase inhibitors
JPH021159B2 (fr)
US4139617A (en) 19-Oxygenated-androst-5-enes for the enhancement of libido
IE43742B1 (en) 15 steroids
US4071624A (en) Androst-4-en-19-ones for the enhancement of libido
US4087524A (en) Androst-4-en-19-ols for the enhancement of libido
JPH0121158B2 (fr)
EP0291717B1 (fr) 17-Bêta-(cyclopropyloxy)androst-5-ène-3bêta-ol et composés apparentés utiles comme inhibiteurs de C17-20 lyase
US4052421A (en) 13-ethinyl-steroids and processes for their manufacture
US3505364A (en) 17alpha-cyanoethynyl steroids
JPS617294A (ja) １，２β‐メチレン‐４‐アンドロステン‐および４，６‐アンドロスタジエン‐３，１７‐ジオン、その製法およびこれを含有するエストロゲン生合成抑制作用を有する医薬調剤
EP1409512A1 (fr) Stero des 20-fluoro-17(20)-vinyliques convenant comme inhibiteurs ce la c17-20-lyase et de la 5-alpha reductase
JPH0248597A (ja) １９‐ヒドロキシラーゼ阻害剤として有用な１９‐フルオロ又はシアノ‐２１‐ヒドロキシプロゲステロン誘導体

Legal Events

Date Code Title Description
KB Patent renewed
RH Patent void