IL95118A - History of polypeptide, their preparation and the pharmaceutical preparations containing them - Google Patents

History of polypeptide, their preparation and the pharmaceutical preparations containing them

Info

Publication number
IL95118A
IL95118A IL9511890A IL9511890A IL95118A IL 95118 A IL95118 A IL 95118A IL 9511890 A IL9511890 A IL 9511890A IL 9511890 A IL9511890 A IL 9511890A IL 95118 A IL95118 A IL 95118A
Authority
IL
Israel
Prior art keywords
group
peptide
peptide according
formula
chelating
Prior art date
Application number
IL9511890A
Other languages
English (en)
Hebrew (he)
Other versions
IL95118A0 (en
Original Assignee
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB898916597A external-priority patent/GB8916597D0/en
Priority claimed from GB909004258A external-priority patent/GB9004258D0/en
Priority claimed from GB909005295A external-priority patent/GB9005295D0/en
Application filed by Sandoz Ag filed Critical Sandoz Ag
Publication of IL95118A0 publication Critical patent/IL95118A0/xx
Publication of IL95118A publication Critical patent/IL95118A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/6425—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the peptide or protein in the drug conjugate being a receptor, e.g. CD4, a cell surface antigen, i.e. not a peptide ligand targeting the antigen, or a cell surface determinant, i.e. a part of the surface of a cell
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
IL9511890A 1989-07-20 1990-07-18 History of polypeptide, their preparation and the pharmaceutical preparations containing them IL95118A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB898916597A GB8916597D0 (en) 1989-07-20 1989-07-20 Improvements in or relating to organic compounds
GB909004258A GB9004258D0 (en) 1990-02-26 1990-02-26 Improvements in or relating to organic compounds
GB909005295A GB9005295D0 (en) 1990-03-09 1990-03-09 Improvements in or relating to organic compounds

Publications (2)

Publication Number Publication Date
IL95118A0 IL95118A0 (en) 1991-06-10
IL95118A true IL95118A (en) 1995-01-24

Family

ID=27264588

Family Applications (1)

Application Number Title Priority Date Filing Date
IL9511890A IL95118A (en) 1989-07-20 1990-07-18 History of polypeptide, their preparation and the pharmaceutical preparations containing them

Country Status (13)

Country Link
EP (1) EP0436005B1 (fr)
JP (1) JPH04500823A (fr)
AT (1) ATE120374T1 (fr)
AU (1) AU638043B2 (fr)
CA (1) CA2032499C (fr)
DE (1) DE69018226T2 (fr)
DK (1) DK0436005T3 (fr)
ES (1) ES2070329T3 (fr)
FI (1) FI101938B1 (fr)
HU (1) HU219336B (fr)
IE (1) IE67637B1 (fr)
IL (1) IL95118A (fr)
WO (1) WO1991001144A1 (fr)

Families Citing this family (79)

* Cited by examiner, † Cited by third party
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US5700444A (en) * 1992-02-20 1997-12-23 Rhomed Incorporated Chemotactic peptide pharmaceutical applications
US5443816A (en) * 1990-08-08 1995-08-22 Rhomed Incorporated Peptide-metal ion pharmaceutical preparation and method
US5460785A (en) * 1989-08-09 1995-10-24 Rhomed Incorporated Direct labeling of antibodies and other protein with metal ions
US5948384A (en) * 1990-09-14 1999-09-07 Syngenix Limited Particulate agents
GB9020075D0 (en) 1990-09-14 1990-10-24 Filler Aaron G Contrast agents for magnetic resonance imaging of axonal transport
US5443815A (en) * 1991-11-27 1995-08-22 Diatech, Inc. Technetium-99m labeled peptides for imaging
US5965107A (en) * 1992-03-13 1999-10-12 Diatide, Inc. Technetium-99m labeled peptides for imaging
US7238340B1 (en) 1991-11-27 2007-07-03 Cis Bio International Monoamine, diamide, thiol-containing metal chelating agents
US5849261A (en) * 1991-02-08 1998-12-15 Diatide, Inc. Radiolabeled vasoactive intestinal peptides for diagnosis and therapy
US5997844A (en) * 1991-02-08 1999-12-07 Diatide, Inc. Technetium-99m labeled peptides for imaging
GB9115375D0 (en) * 1991-07-17 1991-09-04 Salutar Inc Compounds
US5225180A (en) * 1991-09-10 1993-07-06 Diatech, Inc. Technetium-99m labeled somatostatin-derived peptides for imaging
US6919067B2 (en) 1991-09-13 2005-07-19 Syngenix Limited Compositions comprising a tissue glue and therapeutic agents
WO1993009816A1 (fr) * 1991-11-14 1993-05-27 Battelle Memorial Institute Procede de diagnostic et de traitement du cancer
US5783170A (en) * 1991-11-27 1998-07-21 Diatide, Inc. Peptide-metal chelate conjugates
CA2127284C (fr) * 1992-01-03 2002-02-05 Buck A. Rhodes Applications pharmaceutiques a base de proteines et de peptides comportant un ion metallique
US5556609A (en) * 1992-02-20 1996-09-17 Rhomed Incorporated YIGSR peptide radiopharmaceutical applications
US5738838A (en) * 1992-02-20 1998-04-14 Rhomed Incorporated IKVAV peptide radiopharmaceutical applications
US5371184A (en) * 1992-02-05 1994-12-06 Mallinckrodt Medical, Inc. Radiolabelled peptide compounds
US5643549A (en) * 1992-02-20 1997-07-01 Rhomed Incorporated Leukostimulatory agent for in vivo leukocyte tagging
EP0636032A1 (fr) * 1992-03-25 1995-02-01 Mallinckrodt Medical, Inc. Procede pour detecter et localiser de fa on peroperatoire des tissus tumoraux
US5508020A (en) * 1992-06-05 1996-04-16 Diatech, Inc. Technetium-99M labeled peptides for imaging
CA2094785A1 (fr) * 1992-05-08 1993-11-09 Jean Gariepy Peptide chelatant le metal
US5620675A (en) 1992-06-23 1997-04-15 Diatech, Inc. Radioactive peptides
US6017512A (en) * 1992-06-23 2000-01-25 Diatide, Inc. Radiolabeled peptides
US5716596A (en) * 1992-06-23 1998-02-10 Diatide, Inc. Radioactively labeled somatostatin-derived peptides for imaging and therapeutic uses
US5871711A (en) * 1992-06-23 1999-02-16 Diatide, Inc. Radioactively-labeled somatostatin-derived peptides for imaging and therapeutic uses
US5346686A (en) * 1992-10-05 1994-09-13 Mallinckrodt Medical, Inc. Labelled interleukin-8 and medical uses thereof
US5449761A (en) * 1993-09-28 1995-09-12 Cytogen Corporation Metal-binding targeted polypeptide constructs
JPH07149668A (ja) * 1993-11-30 1995-06-13 Kanegafuchi Chem Ind Co Ltd アミロイド沈着検出用物質
US6051206A (en) * 1994-06-03 2000-04-18 Diatide, Inc Radiolabeled somatostatin-derived peptides for imaging and therapeutic uses
US6531572B1 (en) 1994-07-25 2003-03-11 Roche Diagnostics Gmbh Metal chelate-labelled peptides
DE19505960A1 (de) 1995-02-21 1996-08-22 Deutsches Krebsforsch Konjugat zur individuellen Dosierung von Arzneimitteln
US5597894A (en) * 1995-06-05 1997-01-28 The Louisiana State University Medical Center Foundation Multi-tyrosinated somatostatin analogs
US5753206A (en) * 1995-06-07 1998-05-19 Immunomedics, Inc. Radiometal-binding analogues of luteinizing hormone releasing hormone
AU725827B2 (en) * 1996-07-12 2000-10-19 Immunomedics Inc. Radiometal-binding peptide analogues
GB9708265D0 (en) * 1997-04-24 1997-06-18 Nycomed Imaging As Contrast agents
CA2273946A1 (fr) * 1996-12-02 1998-06-11 Raymond M. Reilly Ligand radiomarque servant a introduire selectivement un radionucleide emetteur d'electrons auger dans le noyau d'une cellule cancereuse
US7060247B2 (en) 1997-04-22 2006-06-13 The Curators Of The University Of Missouri Gastrin receptor-avid peptide conjugates
CA2283854A1 (fr) 1997-04-22 1998-10-29 The Curators Of The University Of Missouri Conjugues de peptides avides d'un recepteur de la gastrine
US6180082B1 (en) 1997-11-24 2001-01-30 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Method to enhance tissue accumulation of radiolabeled compounds
NZ336727A (en) * 1997-11-24 2001-10-26 Univ Louisiana State Administering a radiolabelled compound by infusion over 2-12 hours to increase the maximum radioactivity accumulated in target tissues
US6524553B2 (en) 1998-03-31 2003-02-25 Bristol-Myers Squibb Pharma Company Quinolone vitronectin receptor antagonist pharmaceuticals
US6537520B1 (en) 1998-03-31 2003-03-25 Bristol-Myers Squibb Pharma Company Pharmaceuticals for the imaging of angiogenic disorders
PL343804A1 (en) 1998-03-31 2001-09-10 Du Pont Pharm Co Pharmaceuticals for the imaging of angiogenic disorders
US6548663B1 (en) 1998-03-31 2003-04-15 Bristol-Myers Squibb Pharma Company Benzodiazepine vitronectin receptor antagonist pharmaceuticals
US6866837B2 (en) 1998-06-05 2005-03-15 Mallinckrodt Inc. Radiolabeled peptides for the diagnosis and treatment of breast and prostate tumors and metastases of such tumors
DK1001977T3 (da) * 1998-06-05 2005-12-27 Mallinckrodt Inc Radioaktivt mærkede peptider til diagnosen og behandlingen af bryst- og prostatatumorer samt metastaser af sådanne tumorer
US6465613B1 (en) 1998-11-19 2002-10-15 Tulane University Hydrophilic somatostatin analogs
US6794518B1 (en) 1998-12-18 2004-09-21 Bristol-Myers Squibb Pharma Company Vitronectin receptor antagonist pharmaceuticals
US6569402B1 (en) 1998-12-18 2003-05-27 Bristol-Myers Squibb Pharma Company Vitronectin receptor antagonist pharmaceuticals
US6511649B1 (en) 1998-12-18 2003-01-28 Thomas D. Harris Vitronectin receptor antagonist pharmaceuticals
CN1356913A (zh) 1998-12-18 2002-07-03 杜邦药品公司 玻连蛋白受体拮抗剂药物
TR200101757T2 (tr) 1998-12-18 2001-12-21 Dupont Pharmaceuticais Company Vitronektin reseptör antagonisti farmasötikler
DE19905094C1 (de) * 1999-02-01 2000-10-12 Schering Ag Gadolinium (III)-Komplexe sowie ihre Verwendung für Zweischritt Strahlentherapieformen und diese enthaltende pharmazeutische Mittel
WO2001060863A1 (fr) * 2000-02-18 2001-08-23 Dabur Research Foundation Analogues radiomarques de peptide intestinal vasoactif destines au diagnostic et a la radiotherapie
GR1003661B (el) * 2000-05-25 2001-09-05 Εθνικο Κεντρο Ερευνας Φυσικων Επιστημων (Εκεφε) "Δημοκριτος"... ΣΥΝΘΕΣΗ, ΒΙΟΛΟΓΙΚΗ ΚΑΙ ΠΡΟΚΛΙΝΙΚΗ ΑΞΙΟΛΟΓΗΣΗ ΑΝΑΛΟΓΩΝ ΤΗΣ (D-Phe6, Leu-NHEt13, des-Met14)-ΒΟΜΒΕΣΙΝΗΣ (6-14)ΤΡΟΠΟΠΟΙΗΜΕΝΩΝ ΜΕ ΠΑ ΡΑΓΩΓΑ ΤΟΥ 1,4,8,11-ΤΕΤΡΑΑΖΑΕΝΔΕΚΑΝΙΟΥ(1,4,8,11-TETRAAZAUNDECAN E)ΚΑΙ ΕΠΙΣΗΜΑΣΜΕΝΩΝ ΜΕ ΤΕΧΝΗΤΙΟ-99M- ΓΙΑ ΕΦΑΡΜΟΓΗ ΣΤΗΝ ΟΓΚΟΛΟΓ
WO2002054088A2 (fr) * 2001-01-05 2002-07-11 Duke University Agent ameliorateur de contraste en imagerie par resonance magnetique
US7893223B2 (en) 2001-07-17 2011-02-22 Bracco Imaging S.P.A. Multidentate AZA ligands able to complex metal ions and the use thereof in diagnostics and therapy
BR0212897A (pt) 2001-09-21 2004-08-24 Univ Tulane Conjugados de análogos de somatostatina ou bombesina diagnóstica ou terapêutica e usos dos mesmos
US7906102B2 (en) 2001-10-03 2011-03-15 Vanderbilt University Ligands to radiation-induced molecules
PL373567A1 (en) 2002-03-01 2005-09-05 The Administrators Of The Tulane Educational Fund Conjugates of therapeutic or cytotoxic agents and biologically active peptides
US7611692B2 (en) 2003-01-13 2009-11-03 Bracco Imaging S.P.A. Gastrin releasing peptide compounds
US8420050B2 (en) 2003-01-13 2013-04-16 Bracco Imaging S.P.A. Gastrin releasing peptide compounds
US7922998B2 (en) 2003-01-13 2011-04-12 Bracco Imaging S.P.A. Gastrin releasing peptide compounds
US7850947B2 (en) 2003-01-13 2010-12-14 Bracco Imaging S.P.A. Gastrin releasing peptide compounds
US7226577B2 (en) 2003-01-13 2007-06-05 Bracco Imaging, S. P. A. Gastrin releasing peptide compounds
ATE435035T1 (de) 2003-01-13 2009-07-15 Bracco Imaging Spa Verbesserte linker für radiopharmazeutische verbindungen
DE102004043153B4 (de) * 2004-09-03 2013-11-21 Philipps-Universität Marburg Erfindung betreffend GLP-1 und Exendin
AU2012202855B2 (en) * 2004-09-03 2015-02-26 Philipps-Universitat Marburg GLP-1 and exendin related invention
RU2007131538A (ru) * 2005-02-22 2009-03-27 Джи-И Хелткер Лимитед (GB) Радиоактивно меченые комплексы галлия, способы синтеза и применение для визуализации путем позитронно-эмиссионной томографии (пэт) экспресии рецептора эпидермального фактора роста (egfr) в злокачественных опухолях
GB0524987D0 (en) 2005-12-08 2006-01-18 Ge Healthcare Ltd Novel imaging agents for fibrosis
EP2100900A1 (fr) * 2008-03-07 2009-09-16 Universitätsspital Basel Conjugués d'antagoniste de peptide analogue de bombésine
KR20110008086A (ko) 2008-04-11 2011-01-25 메리맥 파마슈티컬즈, 인크. 인간 혈청 알부민 링커 및 그 콘쥬게이트
GB0922014D0 (en) 2009-12-17 2010-02-03 Ge Healthcare Ltd Novel integrin binders
GB201017088D0 (en) 2010-08-20 2010-11-24 Ge Healthcare Ltd Imaging tuberculosis
WO2013048832A1 (fr) 2011-09-29 2013-04-04 Ge Healthcare Limited 6-(2-fluroéthoxy)-2-naphtaldéhyde marqué au 18f pour détecter des cellules souches cancéreuses
WO2014122228A1 (fr) 2013-02-07 2014-08-14 Westfaelische Wilhelms-Universitaet Muenster Composés marqués qui se lient à l'intégrine alpha v bêta 3
US10449261B2 (en) 2014-07-24 2019-10-22 Washington University Compositions targeting radiation-induced molecules and methods of use thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE454115B (sv) * 1982-09-13 1988-03-28 Wallac Oy Homogenfasanalys med lantanidkelat som merksubstans
GB8610551D0 (en) * 1986-04-30 1986-06-04 Hoffmann La Roche Polypeptide & protein derivatives
IN165717B (fr) * 1986-08-07 1989-12-23 Battelle Memorial Institute
CA1335725C (fr) * 1987-09-25 1995-05-30 Stephen W. Hadley Methode de detection de caillots sanguins a l'aide de proteines se liant a la fibrine
DE68913753T2 (de) * 1988-10-04 1994-08-11 Cancer Res Campaign Tech Zielmittel.

Also Published As

Publication number Publication date
FI101938B (fi) 1998-09-30
FI911319A0 (fi) 1991-03-18
FI101938B1 (fi) 1998-09-30
DE69018226T2 (de) 1995-09-21
WO1991001144A1 (fr) 1991-02-07
CA2032499C (fr) 2002-05-14
AU6070990A (en) 1991-02-22
IE902619A1 (en) 1991-02-27
CA2032499A1 (fr) 1991-01-21
HU219336B (en) 2001-03-28
EP0436005A1 (fr) 1991-07-10
IL95118A0 (en) 1991-06-10
ES2070329T3 (es) 1995-06-01
ATE120374T1 (de) 1995-04-15
HUT56583A (en) 1991-09-30
JPH04500823A (ja) 1992-02-13
EP0436005B1 (fr) 1995-03-29
IE67637B1 (en) 1996-04-17
DE69018226D1 (de) 1995-05-04
HU906177D0 (en) 1991-08-28
AU638043B2 (en) 1993-06-17
DK0436005T3 (da) 1995-07-03

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