IL95118A - תולדות פוליפטיד, הכנתן ותכשירי רוקחות המכילים אותן - Google Patents

תולדות פוליפטיד, הכנתן ותכשירי רוקחות המכילים אותן

Info

Publication number
IL95118A
IL95118A IL9511890A IL9511890A IL95118A IL 95118 A IL95118 A IL 95118A IL 9511890 A IL9511890 A IL 9511890A IL 9511890 A IL9511890 A IL 9511890A IL 95118 A IL95118 A IL 95118A
Authority
IL
Israel
Prior art keywords
group
peptide
peptide according
formula
chelating
Prior art date
Application number
IL9511890A
Other languages
English (en)
Other versions
IL95118A0 (en
Original Assignee
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB898916597A external-priority patent/GB8916597D0/en
Priority claimed from GB909004258A external-priority patent/GB9004258D0/en
Priority claimed from GB909005295A external-priority patent/GB9005295D0/en
Application filed by Sandoz Ag filed Critical Sandoz Ag
Publication of IL95118A0 publication Critical patent/IL95118A0/xx
Publication of IL95118A publication Critical patent/IL95118A/he

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/6425—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the peptide or protein in the drug conjugate being a receptor, e.g. CD4, a cell surface antigen, i.e. not a peptide ligand targeting the antigen, or a cell surface determinant, i.e. a part of the surface of a cell
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
IL9511890A 1989-07-20 1990-07-18 תולדות פוליפטיד, הכנתן ותכשירי רוקחות המכילים אותן IL95118A (he)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB898916597A GB8916597D0 (en) 1989-07-20 1989-07-20 Improvements in or relating to organic compounds
GB909004258A GB9004258D0 (en) 1990-02-26 1990-02-26 Improvements in or relating to organic compounds
GB909005295A GB9005295D0 (en) 1990-03-09 1990-03-09 Improvements in or relating to organic compounds

Publications (2)

Publication Number Publication Date
IL95118A0 IL95118A0 (en) 1991-06-10
IL95118A true IL95118A (he) 1995-01-24

Family

ID=27264588

Family Applications (1)

Application Number Title Priority Date Filing Date
IL9511890A IL95118A (he) 1989-07-20 1990-07-18 תולדות פוליפטיד, הכנתן ותכשירי רוקחות המכילים אותן

Country Status (13)

Country Link
EP (1) EP0436005B1 (he)
JP (1) JPH04500823A (he)
AT (1) ATE120374T1 (he)
AU (1) AU638043B2 (he)
CA (1) CA2032499C (he)
DE (1) DE69018226T2 (he)
DK (1) DK0436005T3 (he)
ES (1) ES2070329T3 (he)
FI (1) FI101938B (he)
HU (1) HU219336B (he)
IE (1) IE67637B1 (he)
IL (1) IL95118A (he)
WO (1) WO1991001144A1 (he)

Families Citing this family (79)

* Cited by examiner, † Cited by third party
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US5460785A (en) * 1989-08-09 1995-10-24 Rhomed Incorporated Direct labeling of antibodies and other protein with metal ions
US5443816A (en) * 1990-08-08 1995-08-22 Rhomed Incorporated Peptide-metal ion pharmaceutical preparation and method
US5700444A (en) * 1992-02-20 1997-12-23 Rhomed Incorporated Chemotactic peptide pharmaceutical applications
US5948384A (en) * 1990-09-14 1999-09-07 Syngenix Limited Particulate agents
GB9020075D0 (en) 1990-09-14 1990-10-24 Filler Aaron G Contrast agents for magnetic resonance imaging of axonal transport
US5965107A (en) * 1992-03-13 1999-10-12 Diatide, Inc. Technetium-99m labeled peptides for imaging
US5443815A (en) * 1991-11-27 1995-08-22 Diatech, Inc. Technetium-99m labeled peptides for imaging
US7238340B1 (en) 1991-11-27 2007-07-03 Cis Bio International Monoamine, diamide, thiol-containing metal chelating agents
US5849261A (en) * 1991-02-08 1998-12-15 Diatide, Inc. Radiolabeled vasoactive intestinal peptides for diagnosis and therapy
US5997844A (en) * 1991-02-08 1999-12-07 Diatide, Inc. Technetium-99m labeled peptides for imaging
GB9115375D0 (en) * 1991-07-17 1991-09-04 Salutar Inc Compounds
US5225180A (en) * 1991-09-10 1993-07-06 Diatech, Inc. Technetium-99m labeled somatostatin-derived peptides for imaging
US6919067B2 (en) 1991-09-13 2005-07-19 Syngenix Limited Compositions comprising a tissue glue and therapeutic agents
WO1993009816A1 (en) * 1991-11-14 1993-05-27 Battelle Memorial Institute Method for diagnosing and treating cancer
US5783170A (en) * 1991-11-27 1998-07-21 Diatide, Inc. Peptide-metal chelate conjugates
CA2127284C (en) * 1992-01-03 2002-02-05 Buck A. Rhodes Protein- and peptide-metal ion pharmaceutical applications
US5738838A (en) * 1992-02-20 1998-04-14 Rhomed Incorporated IKVAV peptide radiopharmaceutical applications
US5556609A (en) * 1992-02-20 1996-09-17 Rhomed Incorporated YIGSR peptide radiopharmaceutical applications
US5371184A (en) * 1992-02-05 1994-12-06 Mallinckrodt Medical, Inc. Radiolabelled peptide compounds
US5643549A (en) * 1992-02-20 1997-07-01 Rhomed Incorporated Leukostimulatory agent for in vivo leukocyte tagging
JPH07505621A (ja) * 1992-03-25 1995-06-22 マリンクロッド・インコーポレイテッド 外科手術中における腫瘍組織の検出および探知法
US5508020A (en) 1992-06-05 1996-04-16 Diatech, Inc. Technetium-99M labeled peptides for imaging
CA2094785A1 (en) * 1992-05-08 1993-11-09 Jean Gariepy Metal chelating peptide
US5620675A (en) 1992-06-23 1997-04-15 Diatech, Inc. Radioactive peptides
US5716596A (en) * 1992-06-23 1998-02-10 Diatide, Inc. Radioactively labeled somatostatin-derived peptides for imaging and therapeutic uses
US5871711A (en) * 1992-06-23 1999-02-16 Diatide, Inc. Radioactively-labeled somatostatin-derived peptides for imaging and therapeutic uses
US6017512A (en) * 1992-06-23 2000-01-25 Diatide, Inc. Radiolabeled peptides
US5346686A (en) * 1992-10-05 1994-09-13 Mallinckrodt Medical, Inc. Labelled interleukin-8 and medical uses thereof
US5449761A (en) * 1993-09-28 1995-09-12 Cytogen Corporation Metal-binding targeted polypeptide constructs
JPH07149668A (ja) * 1993-11-30 1995-06-13 Kanegafuchi Chem Ind Co Ltd アミロイド沈着検出用物質
US6051206A (en) * 1994-06-03 2000-04-18 Diatide, Inc Radiolabeled somatostatin-derived peptides for imaging and therapeutic uses
AU689626B2 (en) 1994-07-25 1998-04-02 Boehringer Mannheim Gmbh Peptides marked with metal chelates
DE19505960A1 (de) * 1995-02-21 1996-08-22 Deutsches Krebsforsch Konjugat zur individuellen Dosierung von Arzneimitteln
US5597894A (en) * 1995-06-05 1997-01-28 The Louisiana State University Medical Center Foundation Multi-tyrosinated somatostatin analogs
US5753206A (en) * 1995-06-07 1998-05-19 Immunomedics, Inc. Radiometal-binding analogues of luteinizing hormone releasing hormone
AU725827B2 (en) * 1996-07-12 2000-10-19 Immunomedics Inc. Radiometal-binding peptide analogues
GB9708265D0 (en) * 1997-04-24 1997-06-18 Nycomed Imaging As Contrast agents
CA2273946A1 (en) * 1996-12-02 1998-06-11 Raymond M. Reilly A radiolabelled ligand for selectively introducing an auger electron emitting radionuclide into the nucleus of a cancer cell
WO1998047524A1 (en) 1997-04-22 1998-10-29 Curators Of The University Of Missouri Gastrin receptor-avid peptide conjugates
US7060247B2 (en) 1997-04-22 2006-06-13 The Curators Of The University Of Missouri Gastrin receptor-avid peptide conjugates
ATE395002T1 (de) * 1997-11-24 2008-05-15 Univ Louisiana State Verfahren zum verbessern der anhäufung von radioaktiven verbindungen in gewebe
US6180082B1 (en) 1997-11-24 2001-01-30 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Method to enhance tissue accumulation of radiolabeled compounds
US6537520B1 (en) 1998-03-31 2003-03-25 Bristol-Myers Squibb Pharma Company Pharmaceuticals for the imaging of angiogenic disorders
US6548663B1 (en) 1998-03-31 2003-04-15 Bristol-Myers Squibb Pharma Company Benzodiazepine vitronectin receptor antagonist pharmaceuticals
HUP0101468A2 (hu) 1998-03-31 2001-08-28 Du Pont Pharmaceuticals Company Angiogenetikus rendellenességek leképzésére alkalmas szerek
US6524553B2 (en) 1998-03-31 2003-02-25 Bristol-Myers Squibb Pharma Company Quinolone vitronectin receptor antagonist pharmaceuticals
US6866837B2 (en) 1998-06-05 2005-03-15 Mallinckrodt Inc. Radiolabeled peptides for the diagnosis and treatment of breast and prostate tumors and metastases of such tumors
JP4295921B2 (ja) * 1998-06-05 2009-07-15 マリンクロッド・インコーポレイテッド 乳癌および前立腺癌、並びにそのような腫瘍の転移の診断および処置用放射能標識化ペプチド
US6465613B1 (en) 1998-11-19 2002-10-15 Tulane University Hydrophilic somatostatin analogs
US6511649B1 (en) 1998-12-18 2003-01-28 Thomas D. Harris Vitronectin receptor antagonist pharmaceuticals
BR9917079A (pt) 1998-12-18 2001-10-30 Du Pont Pharm Co Compostos antagonistas de receptor devitronectina, kit, composição metalofarmacêuticade diagnóstico ou terapêutica, composição deagente de contraste para ultra-som, composiçãoradiofarmacêutica terapêutica, composiçãofarmacêutica de diagnóstico, método detratamento da artrite reumatóide, do cancêr e darestenose em um paciente, método de formação deimagem da angiogênese terapêutica, do câncer, denovos vasos sanguìneos, da arteriosclerose, darestenose, da isquemia e da lesão por reperfusãodo miocárdio em um paciente
AU2371400A (en) 1998-12-18 2000-07-03 Du Pont Pharmaceuticals Company Vitronectin receptor antagonist pharmaceuticals
US6569402B1 (en) 1998-12-18 2003-05-27 Bristol-Myers Squibb Pharma Company Vitronectin receptor antagonist pharmaceuticals
US6794518B1 (en) 1998-12-18 2004-09-21 Bristol-Myers Squibb Pharma Company Vitronectin receptor antagonist pharmaceuticals
DE19905094C1 (de) * 1999-02-01 2000-10-12 Schering Ag Gadolinium (III)-Komplexe sowie ihre Verwendung für Zweischritt Strahlentherapieformen und diese enthaltende pharmazeutische Mittel
DE60033697D1 (de) * 2000-02-18 2007-04-12 Dabur Res Foundation Sahibabad Radiomarkierte vip-analoge zur diagnose und therapie
GR1003661B (el) * 2000-05-25 2001-09-05 Εθνικο Κεντρο Ερευνας Φυσικων Επιστημων (Εκεφε) "Δημοκριτος"... ΣΥΝΘΕΣΗ, ΒΙΟΛΟΓΙΚΗ ΚΑΙ ΠΡΟΚΛΙΝΙΚΗ ΑΞΙΟΛΟΓΗΣΗ ΑΝΑΛΟΓΩΝ ΤΗΣ (D-Phe6, Leu-NHEt13, des-Met14)-ΒΟΜΒΕΣΙΝΗΣ (6-14)ΤΡΟΠΟΠΟΙΗΜΕΝΩΝ ΜΕ ΠΑ ΡΑΓΩΓΑ ΤΟΥ 1,4,8,11-ΤΕΤΡΑΑΖΑΕΝΔΕΚΑΝΙΟΥ(1,4,8,11-TETRAAZAUNDECAN E)ΚΑΙ ΕΠΙΣΗΜΑΣΜΕΝΩΝ ΜΕ ΤΕΧΝΗΤΙΟ-99M- ΓΙΑ ΕΦΑΡΜΟΓΗ ΣΤΗΝ ΟΓΚΟΛΟΓ
US6972122B2 (en) * 2001-01-05 2005-12-06 Duke University Contrast enhancement agent for magnetic resonance imaging
US7893223B2 (en) 2001-07-17 2011-02-22 Bracco Imaging S.P.A. Multidentate AZA ligands able to complex metal ions and the use thereof in diagnostics and therapy
KR20040047846A (ko) 2001-09-21 2004-06-05 더 어드미니스트레이터 오브 더 튜레인 에듀케이셔널 펀드 진단 또는 치료용 소마토스타틴 또는 봄베신 유사체콘쥬게이트 및 이들의 용도
US7906102B2 (en) 2001-10-03 2011-03-15 Vanderbilt University Ligands to radiation-induced molecules
ES2339934T3 (es) 2002-03-01 2010-05-27 The Administrators Of The Tulane Educational Fund Conjugados de agentes citotoxicos y peptidos biologicamente activos.
US7850947B2 (en) 2003-01-13 2010-12-14 Bracco Imaging S.P.A. Gastrin releasing peptide compounds
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ATE435035T1 (de) 2003-01-13 2009-07-15 Bracco Imaging Spa Verbesserte linker für radiopharmazeutische verbindungen
US7611692B2 (en) 2003-01-13 2009-11-03 Bracco Imaging S.P.A. Gastrin releasing peptide compounds
US8420050B2 (en) 2003-01-13 2013-04-16 Bracco Imaging S.P.A. Gastrin releasing peptide compounds
US7922998B2 (en) 2003-01-13 2011-04-12 Bracco Imaging S.P.A. Gastrin releasing peptide compounds
AU2012202855B2 (en) * 2004-09-03 2015-02-26 Philipps-Universitat Marburg GLP-1 and exendin related invention
DE102004043153B4 (de) * 2004-09-03 2013-11-21 Philipps-Universität Marburg Erfindung betreffend GLP-1 und Exendin
CA2598863A1 (en) * 2005-02-22 2006-08-31 Ge Healthcare Limited Radiolabeled gallium complexes, methods for synthesis and use for pet imaging of egfr epxression in malignant tumors
GB0524987D0 (en) 2005-12-08 2006-01-18 Ge Healthcare Ltd Novel imaging agents for fibrosis
EP2100900A1 (en) * 2008-03-07 2009-09-16 Universitätsspital Basel Bombesin analog peptide antagonist conjugates
CA2721093A1 (en) 2008-04-11 2009-10-15 Merrimack Pharmaceuticals, Inc. Human serum albumin linkers and conjugates thereof
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WO2013048832A1 (en) 2011-09-29 2013-04-04 Ge Healthcare Limited 18 f - labelled 6 - ( 2 - fluoroethoxy) - 2 - naphthaldehyde for detecting cancer stem cells
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GB8610551D0 (en) * 1986-04-30 1986-06-04 Hoffmann La Roche Polypeptide & protein derivatives
IN165717B (he) * 1986-08-07 1989-12-23 Battelle Memorial Institute
CA1335725C (en) * 1987-09-25 1995-05-30 Stephen W. Hadley Method of diagnosing blood clots using fibrin-binding proteins
WO1990003798A2 (en) * 1988-10-04 1990-04-19 Cancer Research Campaign Technology Limited Targetting agents

Also Published As

Publication number Publication date
CA2032499C (en) 2002-05-14
EP0436005A1 (en) 1991-07-10
AU6070990A (en) 1991-02-22
FI911319A0 (fi) 1991-03-18
ATE120374T1 (de) 1995-04-15
AU638043B2 (en) 1993-06-17
HUT56583A (en) 1991-09-30
IE67637B1 (en) 1996-04-17
IL95118A0 (en) 1991-06-10
DK0436005T3 (da) 1995-07-03
IE902619A1 (en) 1991-02-27
DE69018226D1 (de) 1995-05-04
FI101938B1 (fi) 1998-09-30
CA2032499A1 (en) 1991-01-21
DE69018226T2 (de) 1995-09-21
FI101938B (fi) 1998-09-30
HU219336B (en) 2001-03-28
EP0436005B1 (en) 1995-03-29
HU906177D0 (en) 1991-08-28
JPH04500823A (ja) 1992-02-13
ES2070329T3 (es) 1995-06-01
WO1991001144A1 (en) 1991-02-07

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