CA1335725C - Methode de detection de caillots sanguins a l'aide de proteines se liant a la fibrine - Google Patents

Methode de detection de caillots sanguins a l'aide de proteines se liant a la fibrine

Info

Publication number
CA1335725C
CA1335725C CA 578453 CA578453A CA1335725C CA 1335725 C CA1335725 C CA 1335725C CA 578453 CA578453 CA 578453 CA 578453 A CA578453 A CA 578453A CA 1335725 C CA1335725 C CA 1335725C
Authority
CA
Canada
Prior art keywords
protein
fibrin
linker
compound
thrombolytic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA 578453
Other languages
English (en)
Inventor
Stephen W. Hadley
Marjorie A. Mohler
John M. Reno
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genentech Inc
Poniard Pharmaceuticals Inc
Original Assignee
Genentech Inc
Poniard Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc, Poniard Pharmaceuticals Inc filed Critical Genentech Inc
Application granted granted Critical
Publication of CA1335725C publication Critical patent/CA1335725C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Optics & Photonics (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CA 578453 1987-09-25 1988-09-26 Methode de detection de caillots sanguins a l'aide de proteines se liant a la fibrine Expired - Fee Related CA1335725C (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10132987A 1987-09-25 1987-09-25
US07/101,329 1987-09-25

Publications (1)

Publication Number Publication Date
CA1335725C true CA1335725C (fr) 1995-05-30

Family

ID=22284078

Family Applications (1)

Application Number Title Priority Date Filing Date
CA 578453 Expired - Fee Related CA1335725C (fr) 1987-09-25 1988-09-26 Methode de detection de caillots sanguins a l'aide de proteines se liant a la fibrine

Country Status (2)

Country Link
CA (1) CA1335725C (fr)
WO (1) WO1989002752A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012072819A1 (fr) * 2010-12-03 2012-06-07 INSERM (Institut National de la Santé et de la Recherche Médicale) Agents pour l'imagerie moléculaire de sérine protéases dans des pathologies humaines

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5059541A (en) * 1988-04-29 1991-10-22 Neorx Corporation Minimal derivatization of proteins
WO1991001144A1 (fr) * 1989-07-20 1991-02-07 Sandoz Ltd Derives de polypeptide etiquetes
US5997844A (en) * 1991-02-08 1999-12-07 Diatide, Inc. Technetium-99m labeled peptides for imaging
US5645815A (en) * 1991-02-08 1997-07-08 Diatide, Inc. Radiolabled compounds for thrombus imaging
DK0570493T3 (da) * 1991-02-08 2000-06-26 Diatide Inc Technetium-99m-mærkede polypeptider til billeddannelse.
US6019958A (en) * 1991-02-08 2000-02-01 Diatide, Inc. Technetium-99m labeled peptides for imaging inflammation
US5965107A (en) * 1992-03-13 1999-10-12 Diatide, Inc. Technetium-99m labeled peptides for imaging
US5736122A (en) * 1991-02-08 1998-04-07 Diatide, Inc. Technetium-99m labeled peptides for thrombus imaging
US5508020A (en) 1992-06-05 1996-04-16 Diatech, Inc. Technetium-99M labeled peptides for imaging
AU677208B2 (en) * 1992-05-21 1997-04-17 Cis Bio International Technetium-99m labeled peptides for thrombus imaging
US5968476A (en) * 1992-05-21 1999-10-19 Diatide, Inc. Technetium-99m labeled peptides for thrombus imaging
US5879657A (en) * 1993-03-30 1999-03-09 The Dupont Merck Pharmaceutical Company Radiolabeled platelet GPIIb/IIIa receptor antagonists as imaging agents for the diagnosis of thromboembolic disorders
DK0693941T3 (da) * 1993-04-08 2002-10-14 Diatide Inc Radiomærkede forbindelser til trombe-billeddannelse
US6866837B2 (en) 1998-06-05 2005-03-15 Mallinckrodt Inc. Radiolabeled peptides for the diagnosis and treatment of breast and prostate tumors and metastases of such tumors
AU2002367022A1 (en) * 2001-12-21 2003-07-30 Immunochemistry Technologies, Llc Novel affinity labels

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4416865A (en) * 1973-02-20 1983-11-22 Research Corporation Radiopharmaceuticals for localization of thromboembolic disease
JPS56125317A (en) * 1980-03-08 1981-10-01 Nippon Mejifuijitsukusu Kk Stable radioactive diagnosticum with radioactive metallic mark
US4418052A (en) * 1980-08-12 1983-11-29 Wong Dennis W Diagnostic compositions and method for radiologic imaging of fibrinogen deposition in the body
US4861869A (en) * 1986-05-29 1989-08-29 Mallinckrodt, Inc. Coupling agents for joining radionuclide metal ions with biologically useful proteins

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012072819A1 (fr) * 2010-12-03 2012-06-07 INSERM (Institut National de la Santé et de la Recherche Médicale) Agents pour l'imagerie moléculaire de sérine protéases dans des pathologies humaines
US9272054B2 (en) 2010-12-03 2016-03-01 Institut National De La Sante Et De La Recherche Medicale (Inserm) Agents for the molecular imaging of serine-protease in human pathologies

Also Published As

Publication number Publication date
WO1989002752A1 (fr) 1989-04-06

Similar Documents

Publication Publication Date Title
EP0342215B1 (fr) Procede de diagnostic de caillots sanguins utilisant des proteines liant la fibrine
CA1335725C (fr) Methode de detection de caillots sanguins a l'aide de proteines se liant a la fibrine
US5180816A (en) One vial method for labeling protein/linker conjugates with technetium-99M
US5925331A (en) Technetium-99m labeled peptides for thrombus imaging
US5094848A (en) Cleavable diphosphate and amidated diphosphate linkers
CA1338721C (fr) Squelette de chelates polysubstitues utilise pour l'obtention d'un conjugue de proteine et de chelate metallique
US5656600A (en) α-ketoamide derivatives as inhibitors of thrombosis
KR100235137B1 (ko) 모노아민, 다아민, 티올-함유 금속 킬레이트제
KR100235136B1 (ko) 영상화용 테크네튬-99m 표지화 펩티드
US5202451A (en) Anchimeric radiometal chelating compounds
US5371184A (en) Radiolabelled peptide compounds
JPH08502240A (ja) 二官能性キレート剤としての置換チオ尿素
JP2954355B2 (ja) 血栓イメージング用の放射性同位体標識化合物
EP0308757A1 (fr) Agents chélateurs à plusieurs liaisons coordonnées à base d'unités de l'hydroxy-8 quinoléine
US5746996A (en) Thiolation of peptides for radionuclide-based radiodetection and radiotherapy
AU762736B2 (en) Labelled glutamine and lysine analogues
WO1992018536A2 (fr) Procede de detection et de localisation de tissus comprenant des recepteurs de neurokinine 1
EP0994730B1 (fr) SUBSTRATS DE FACTEUR XIIIa MARQUES
EP0857071A1 (fr) Composes de biotine (radio) marques
CA2222966C (fr) Thiolation de peptides aux fins d'une radiodetection et d'une radiopherapie utilisant des radionuclides
US5968476A (en) Technetium-99m labeled peptides for thrombus imaging
US6028056A (en) Pharmaceutical compositions for imaging and treating thrombi
CA2141739A1 (fr) Methode de preparation d'une proteine marquee par un radionucleide metallique
WO1997047329A9 (fr) Compositions radiopharmaceutiques capables de se localiser en des sites de thrombus
CA2257856A1 (fr) Compositions radiopharmaceutiques capables de se localiser en des sites de thrombus

Legal Events

Date Code Title Description
MKLA Lapsed