WO1989002752A1 - Procede de diagnostic de caillots sanguins utilisant des proteines liant la fibrine - Google Patents

Procede de diagnostic de caillots sanguins utilisant des proteines liant la fibrine Download PDF

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Publication number
WO1989002752A1
WO1989002752A1 PCT/US1988/003318 US8803318W WO8902752A1 WO 1989002752 A1 WO1989002752 A1 WO 1989002752A1 US 8803318 W US8803318 W US 8803318W WO 8902752 A1 WO8902752 A1 WO 8902752A1
Authority
WO
WIPO (PCT)
Prior art keywords
protein
fibrin
compound
linker
thrombolytic
Prior art date
Application number
PCT/US1988/003318
Other languages
English (en)
Inventor
Stephen W. Hadley
Marjorie A. Mohler
John M. Reno
Original Assignee
Genentech, Inc.
Neorx Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech, Inc., Neorx Corporation filed Critical Genentech, Inc.
Priority to DE88909689T priority Critical patent/DE3883522T2/de
Priority to AT88909689T priority patent/ATE93396T1/de
Publication of WO1989002752A1 publication Critical patent/WO1989002752A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Optics & Photonics (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

On marque une protéine liant la fibrine telle qu'un t-PA (activation de plasminogène de type tissulaire), avec une substance détectable telle qu'un radionuclide, puis on l'administre à un patient pour diagnostiquer des caillots sanguins et contrôler leur dissolution pendant la thérapie. La substance détectable est de préférence fixée au t-PA par des liaisons se liant spécifiquement à la partie de la protéine de t-PA responsable de l'activité enzymatique, diminuant ainsi cette activité tout en laissant intacte la propriété qu'a la protéine de lier la fibrine.
PCT/US1988/003318 1987-09-25 1988-09-26 Procede de diagnostic de caillots sanguins utilisant des proteines liant la fibrine WO1989002752A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
DE88909689T DE3883522T2 (de) 1987-09-25 1988-09-26 Verfahren zum diagnostizieren von blutpfropfen mit fibrin-bindenden proteinen.
AT88909689T ATE93396T1 (de) 1987-09-25 1988-09-26 Verfahren zum diagnostizieren von blutpfropfen mit fibrin-bindenden proteinen.

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10132987A 1987-09-25 1987-09-25
US101,329 1987-09-25
US247,973 1988-09-22

Publications (1)

Publication Number Publication Date
WO1989002752A1 true WO1989002752A1 (fr) 1989-04-06

Family

ID=22284078

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1988/003318 WO1989002752A1 (fr) 1987-09-25 1988-09-26 Procede de diagnostic de caillots sanguins utilisant des proteines liant la fibrine

Country Status (2)

Country Link
CA (1) CA1335725C (fr)
WO (1) WO1989002752A1 (fr)

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0339684A2 (fr) * 1988-04-29 1989-11-02 Neorx Corporation Dérivation minimale de protéines
WO1991001144A1 (fr) * 1989-07-20 1991-02-07 Sandoz Ltd Derives de polypeptide etiquetes
WO1993023085A1 (fr) * 1992-05-21 1993-11-25 Diatech, Inc. PEPTIDES MARQUES AU TECHNETIUM-99m DESTINES A L'IMAGERIE DE THROMBUS
US5645815A (en) * 1991-02-08 1997-07-08 Diatide, Inc. Radiolabled compounds for thrombus imaging
US5736122A (en) * 1991-02-08 1998-04-07 Diatide, Inc. Technetium-99m labeled peptides for thrombus imaging
US5776428A (en) * 1992-04-30 1998-07-07 Diatide, Inc. Technetium-99m labeled peptides for imaging
US5849260A (en) * 1991-02-08 1998-12-15 Diatide, Inc. Technetium-99M labeled peptides for thrombus imaging
US5879657A (en) * 1993-03-30 1999-03-09 The Dupont Merck Pharmaceutical Company Radiolabeled platelet GPIIb/IIIa receptor antagonists as imaging agents for the diagnosis of thromboembolic disorders
US5968476A (en) * 1992-05-21 1999-10-19 Diatide, Inc. Technetium-99m labeled peptides for thrombus imaging
US5976494A (en) * 1992-06-05 1999-11-02 Diatide, Inc. Technetium-99m labeled peptides for imaging
US5997844A (en) * 1991-02-08 1999-12-07 Diatide, Inc. Technetium-99m labeled peptides for imaging
US6019958A (en) * 1991-02-08 2000-02-01 Diatide, Inc. Technetium-99m labeled peptides for imaging inflammation
US6056940A (en) * 1993-04-08 2000-05-02 Diatide, Inc. Radiolabeled compounds for thrombus imaging
WO2003059877A2 (fr) * 2001-12-21 2003-07-24 Immunochemistry Technologies, Llc Nouveaux marqueurs d'affinite
US6866837B2 (en) 1998-06-05 2005-03-15 Mallinckrodt Inc. Radiolabeled peptides for the diagnosis and treatment of breast and prostate tumors and metastases of such tumors

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012072819A1 (fr) * 2010-12-03 2012-06-07 INSERM (Institut National de la Santé et de la Recherche Médicale) Agents pour l'imagerie moléculaire de sérine protéases dans des pathologies humaines

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4416865A (en) * 1973-02-20 1983-11-22 Research Corporation Radiopharmaceuticals for localization of thromboembolic disease
US4418052A (en) * 1980-08-12 1983-11-29 Wong Dennis W Diagnostic compositions and method for radiologic imaging of fibrinogen deposition in the body
US4425319A (en) * 1980-03-08 1984-01-10 Nihon Medi-Physics Co., Ltd. Radioactive diagnostic agent and non-radioactive carrier therefor
EP0247866A1 (fr) * 1986-05-29 1987-12-02 Mallinckrodt, Inc. (a Delaware corporation) Agents de couplage pour la préparation de protéines marquées par la radioactivité

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4416865A (en) * 1973-02-20 1983-11-22 Research Corporation Radiopharmaceuticals for localization of thromboembolic disease
US4425319A (en) * 1980-03-08 1984-01-10 Nihon Medi-Physics Co., Ltd. Radioactive diagnostic agent and non-radioactive carrier therefor
US4418052A (en) * 1980-08-12 1983-11-29 Wong Dennis W Diagnostic compositions and method for radiologic imaging of fibrinogen deposition in the body
EP0247866A1 (fr) * 1986-05-29 1987-12-02 Mallinckrodt, Inc. (a Delaware corporation) Agents de couplage pour la préparation de protéines marquées par la radioactivité

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DIALOG INFORMATION SERVICES, File 154, Medline 83-89, Dialog Accession No. 05587996, BAKER R.J., "Studies of 99mTc-Acylplasmins as Agents for Thrombus Detection"; & EUR. J. NUCL. MED., 10 (3-4), p. 155-9. *
DIALOG INFORMATION SERVICES, File 154, Medline 83-89, Dialog Accession No. 06507050, HNATOWICH D.J., "Characterization of Indium-111 Labelad Recombinant Tissue Plasminogen Activator for the Imaging of Thrombi"; & EUR. J. NUCL. MED., (GERMANY, WEST), 1987, 13(9), p. 467-73. *
METHODS IN ENZYMOLOGY, Vol. 80, 1981, CHARLES KETTNER, "Inactivation of Trypsin-Like Enzymes with Peptides of Arginine Chloromethyl Ketone", pages 826-842. *

Cited By (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0339684A3 (fr) * 1988-04-29 1992-04-08 Neorx Corporation Dérivation minimale de protéines
EP0339684A2 (fr) * 1988-04-29 1989-11-02 Neorx Corporation Dérivation minimale de protéines
WO1991001144A1 (fr) * 1989-07-20 1991-02-07 Sandoz Ltd Derives de polypeptide etiquetes
US6248304B1 (en) 1991-02-08 2001-06-19 Berlex Laboratories, Inc. Scintigraphic imaging agents
US5645815A (en) * 1991-02-08 1997-07-08 Diatide, Inc. Radiolabled compounds for thrombus imaging
US5736122A (en) * 1991-02-08 1998-04-07 Diatide, Inc. Technetium-99m labeled peptides for thrombus imaging
US6019958A (en) * 1991-02-08 2000-02-01 Diatide, Inc. Technetium-99m labeled peptides for imaging inflammation
US5849260A (en) * 1991-02-08 1998-12-15 Diatide, Inc. Technetium-99M labeled peptides for thrombus imaging
US5997844A (en) * 1991-02-08 1999-12-07 Diatide, Inc. Technetium-99m labeled peptides for imaging
US5879658A (en) * 1991-02-08 1999-03-09 Diatide, Inc. Technetium-99m labeled peptides for thrombus imaging
US5965107A (en) * 1992-03-13 1999-10-12 Diatide, Inc. Technetium-99m labeled peptides for imaging
US6086849A (en) * 1992-04-30 2000-07-11 Diatide, Inc. Technetium-99m labeled peptides for imaging
US5922303A (en) * 1992-04-30 1999-07-13 Diatide, Inc. Technetium-99M labeled peptides for imaging
US5780007A (en) * 1992-04-30 1998-07-14 Diatide, Inc. Technetium-99m labeled peptides for imaging
US5776428A (en) * 1992-04-30 1998-07-07 Diatide, Inc. Technetium-99m labeled peptides for imaging
US6093383A (en) * 1992-04-30 2000-07-25 Diatide, Inc. Bisamine bisthiol radiolabel binding moieties
WO1993023085A1 (fr) * 1992-05-21 1993-11-25 Diatech, Inc. PEPTIDES MARQUES AU TECHNETIUM-99m DESTINES A L'IMAGERIE DE THROMBUS
US5968476A (en) * 1992-05-21 1999-10-19 Diatide, Inc. Technetium-99m labeled peptides for thrombus imaging
US5925331A (en) * 1992-05-21 1999-07-20 Diatide, Inc. Technetium-99m labeled peptides for thrombus imaging
EP1004322A3 (fr) * 1992-05-21 2003-12-03 Diatide, Inc. Peptides marqués au Technetium-99M destinés a l'imagerie de thrombus
EP1004322A2 (fr) * 1992-05-21 2000-05-31 Diatide, Inc. Peptides marqués au Technetium-99M destinés a l'imagerie de thrombus
US5976494A (en) * 1992-06-05 1999-11-02 Diatide, Inc. Technetium-99m labeled peptides for imaging
US6667389B1 (en) 1992-06-05 2003-12-23 Diatide, Inc. Technetium-99m labeled peptides for imaging
US5879657A (en) * 1993-03-30 1999-03-09 The Dupont Merck Pharmaceutical Company Radiolabeled platelet GPIIb/IIIa receptor antagonists as imaging agents for the diagnosis of thromboembolic disorders
US6022523A (en) * 1993-03-30 2000-02-08 Dupont Pharmaceuticals Company Radiolabeled platelet GPIIb/IIIa receptor antagonists as imaging agents for the diagnosis of thromboembolic disorders
US6056940A (en) * 1993-04-08 2000-05-02 Diatide, Inc. Radiolabeled compounds for thrombus imaging
US6866837B2 (en) 1998-06-05 2005-03-15 Mallinckrodt Inc. Radiolabeled peptides for the diagnosis and treatment of breast and prostate tumors and metastases of such tumors
WO2003059877A2 (fr) * 2001-12-21 2003-07-24 Immunochemistry Technologies, Llc Nouveaux marqueurs d'affinite
WO2003059877A3 (fr) * 2001-12-21 2003-12-11 Immunochemistry Technologies L Nouveaux marqueurs d'affinite

Also Published As

Publication number Publication date
CA1335725C (fr) 1995-05-30

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