IL94903A0 - N-substituted cycloalkyl and polycycloalkyl alpha-substituted trp-phe-and phenethylamine derivatives and pharmaceutical compositions containing them - Google Patents

N-substituted cycloalkyl and polycycloalkyl alpha-substituted trp-phe-and phenethylamine derivatives and pharmaceutical compositions containing them

Info

Publication number
IL94903A0
IL94903A0 IL94903A IL9490390A IL94903A0 IL 94903 A0 IL94903 A0 IL 94903A0 IL 94903 A IL94903 A IL 94903A IL 9490390 A IL9490390 A IL 9490390A IL 94903 A0 IL94903 A0 IL 94903A0
Authority
IL
Israel
Prior art keywords
agents
substituted
alpha
pharmaceutical compositions
phe
Prior art date
Application number
IL94903A
Other languages
English (en)
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of IL94903A0 publication Critical patent/IL94903A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C07K5/06156—Dipeptides with the first amino acid being heterocyclic and Trp-amino acid; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Anesthesiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Indole Compounds (AREA)
IL94903A 1989-06-29 1990-06-28 N-substituted cycloalkyl and polycycloalkyl alpha-substituted trp-phe-and phenethylamine derivatives and pharmaceutical compositions containing them IL94903A0 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US37432789A 1989-06-29 1989-06-29
US42248689A 1989-10-16 1989-10-16
US53081190A 1990-06-05 1990-06-05

Publications (1)

Publication Number Publication Date
IL94903A0 true IL94903A0 (en) 1991-04-15

Family

ID=27409174

Family Applications (1)

Application Number Title Priority Date Filing Date
IL94903A IL94903A0 (en) 1989-06-29 1990-06-28 N-substituted cycloalkyl and polycycloalkyl alpha-substituted trp-phe-and phenethylamine derivatives and pharmaceutical compositions containing them

Country Status (17)

Country Link
EP (2) EP0479910A1 (xx)
JP (1) JP2972331B2 (xx)
KR (2) KR0167315B1 (xx)
CN (1) CN1049165A (xx)
AT (1) ATE275546T1 (xx)
AU (1) AU644088B2 (xx)
CA (2) CA2060652C (xx)
DE (1) DE69034162T2 (xx)
DK (1) DK0405537T3 (xx)
ES (1) ES2229202T3 (xx)
FI (1) FI106197B (xx)
IE (1) IE902347A1 (xx)
IL (1) IL94903A0 (xx)
NO (1) NO301831B1 (xx)
NZ (1) NZ234264A (xx)
PT (1) PT94543B (xx)
WO (1) WO1991000274A1 (xx)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5162336A (en) * 1990-06-21 1992-11-10 Rhone-Poulenc Rorer Pharmaceuticals Inc. Tetrahydro-pyrido-indoles as cholecystokinin and gastrin antagonists
US5340825A (en) * 1990-08-31 1994-08-23 Warner-Lambert Company Pro drugs for CCK antagonists
US5244915A (en) * 1990-08-31 1993-09-14 Warner-Lambert Company Amico acid derivatives cyclized at the c-terminal
JP3356431B2 (ja) * 1990-08-31 2002-12-16 ワーナー―ランバート・コンパニー Ｃｃｋアンタゴニストに対するプロ―ドラッグ
JPH06502627A (ja) * 1990-08-31 1994-03-24 ワーナー―ランバート・コンパニー 新規コレシストキニンアンタゴニスト、その製造および治療用使用
US5593967A (en) * 1990-08-31 1997-01-14 Warner-Lambert Company Cholecystokinin antagonists, their preparation and therapeutic use
US5264420A (en) * 1990-09-27 1993-11-23 Merck & Co., Inc. Fibrinogen receptor antagonists
AU1907292A (en) * 1991-04-24 1992-12-21 Warner-Lambert Company Alpha-substituted polypeptides having therapeutic activity
HUT68769A (en) * 1991-05-07 1995-07-28 Merck & Co Inc FIBRINOGéN RECEPTOR ANTAGONIST COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM AS EFFECTIVE SUBSTANCE
CA2110986A1 (en) * 1991-07-12 1993-01-21 Geoffrey Neil Woodruff Cholecystokinin antagonists useful in the treatment of panic attacks
US5153191A (en) * 1991-08-20 1992-10-06 Warner-Lambert Company Cholecystokinin antagonists useful for treating depression
US5217957A (en) * 1991-08-20 1993-06-08 Warner-Lambert Company Cholecystokinin antagonists useful for treating depression
US5272158A (en) * 1991-10-29 1993-12-21 Merck & Co., Inc. Fibrinogen receptor antagonists
US5389631A (en) * 1991-10-29 1995-02-14 Merck & Co., Inc. Fibrinogen receptor antagonists
DE4137490A1 (de) * 1991-11-14 1993-05-19 Goedecke Ag Synthese von tricyclo(3.3.1.13,7)dec-2.yl(r-(r*,r*))-3- (1h-indol-3-yl-methyl)-3-methyl-4,9-dioxo- 7,11-diphenyl-10-oxa-2,5,8-triaza-undecanat
US6492531B1 (en) 1992-02-18 2002-12-10 Warner-Lambert Company Method of treating cognitive disorders
US5514683A (en) * 1992-02-20 1996-05-07 James Black Foundation Limited Bicyclo 2,2,2!octane derivatives
JPH07504184A (ja) * 1992-02-20 1995-05-11 ジェイムズ・ブラック・ファウンデーション・リミテッド コレストシストキニン抑制剤としてのビシクロ［２，２，２］オクタン誘導体
GB9316722D0 (en) * 1993-08-12 1993-09-29 Black James Foundation Bicyclo (2.2.2)octane derivatives
US5227490A (en) * 1992-02-21 1993-07-13 Merck & Co., Inc. Fibrinogen receptor antagonists
WO1994000421A1 (en) * 1992-06-19 1994-01-06 James Black Foundation Limited Bicyclooctane and bicycloheptane derivatives
US5380872A (en) * 1992-07-14 1995-01-10 Glaxo Inc. Modulators of cholecystokinin
US5922681A (en) * 1992-09-14 1999-07-13 Warner-Lambert Company Endothelin antagonists
US5340798A (en) * 1992-10-14 1994-08-23 Merck & Co., Inc. Fibrinogen receptor antagonists
WO1994008577A1 (en) * 1992-10-14 1994-04-28 Merck & Co., Inc. Fibrinogen receptor antagonists
DE69327536T2 (de) * 1992-10-14 2000-07-06 Merck & Co Inc Fibrinogenrezeptor-antagonisten
US5358956A (en) * 1992-10-14 1994-10-25 Merck & Co., Inc. Fibrinogen receptor antagonists
CA2150550A1 (en) * 1992-12-01 1994-06-09 Melissa S. Egbertson Fibrinogen receptor antagonists
FR2700540B1 (fr) * 1993-01-15 1995-02-17 Irj alpha-méthyl-(R)-tryptophyl-arylcycloalkylalkylamides ligands aux récepteurs des gastrines, leur préparation et leur utilisation en thérapeutique.
US5441952A (en) * 1993-04-05 1995-08-15 Merck & Co., Inc. Fibrinogen receptor antagonists
US5334596A (en) * 1993-05-11 1994-08-02 Merck & Co., Inc. Fibrinogen receptor antagonists
US5397791A (en) * 1993-08-09 1995-03-14 Merck & Co., Inc. Fibrinogen receptor antagonists
US5821241A (en) * 1994-02-22 1998-10-13 Merck & Co., Inc. Fibrinogen receptor antagonists
EP0763026B1 (en) * 1994-05-27 2003-03-26 James Black Foundation Limited Gastrin and cck antagonists
US5719144A (en) * 1995-02-22 1998-02-17 Merck & Co., Inc. Fibrinogen receptor antagonists
US5852045A (en) * 1995-10-19 1998-12-22 Merck & Co., Inc. Fibrinogen receptor antagonists
US5789421A (en) * 1995-10-26 1998-08-04 Merck & Co., Inc. Fibrinogen receptor antagonist
US5780480A (en) * 1996-02-28 1998-07-14 Merck & Co., Inc. Fibrinogen receptor antagonists
US5889023A (en) * 1996-05-10 1999-03-30 Merck & Co., Inc. Fibrinogen receptor antagonist
US5981584A (en) * 1997-02-06 1999-11-09 Merck & Co., Inc. Fibrinogen receptor antagonist prodrugs
US7375093B2 (en) 2002-07-05 2008-05-20 Intrexon Corporation Ketone ligands for modulating the expression of exogenous genes via an ecdysone receptor complex
US8415354B2 (en) 2004-04-29 2013-04-09 Abbott Laboratories Methods of use of inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme
US7880001B2 (en) 2004-04-29 2011-02-01 Abbott Laboratories Inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme
US20100222316A1 (en) 2004-04-29 2010-09-02 Abbott Laboratories Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme
US20090192198A1 (en) 2005-01-05 2009-07-30 Abbott Laboratories Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme
KR101496206B1 (ko) 2005-01-05 2015-02-27 애브비 인코포레이티드 11-베타-하이드록시스테로이드 데하이드로게나제 타입 1 효소의 억제제로서의 아다만틸 유도체
WO2006074330A2 (en) 2005-01-05 2006-07-13 Abbott Laboratories Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme
US8198331B2 (en) 2005-01-05 2012-06-12 Abbott Laboratories Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme
JP5736098B2 (ja) 2007-08-21 2015-06-17 アッヴィ・インコーポレイテッド 中枢神経系障害を治療するための医薬組成物
RU2602742C2 (ru) * 2013-12-13 2016-11-20 Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт фармакологии имен В.В. Закусова" Фармацевтическая композиция амида n-(6-фенилгексаноил)глицил-l-триптофана, выполненная в твердой лекарственной форме
CN110740996B (zh) * 2017-04-10 2024-01-09 密执安大学评议会 共价小分子dcn1抑制剂和使用其的治疗方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4482567A (en) * 1982-10-07 1984-11-13 Research Foundation For Mental Hygiene, Inc. N-hexanoyl to n-heptadecanoyl 5-hydroxy tryptophan-5-hydroxytryptophanamides and use as analgesics
US4757151A (en) * 1985-11-14 1988-07-12 Warner-Lambert Company 2-substituted-[2-substituted-amino]-N-arylalkyl-3-[indol-3-yl]
US4814463A (en) * 1985-12-31 1989-03-21 Biomeasure, Inc. CCK antagonists

Also Published As

Publication number Publication date
EP0479910A1 (en) 1992-04-15
CA2060652C (en) 2001-08-21
NZ234264A (en) 1993-05-26
AU644088B2 (en) 1993-12-02
ES2229202T3 (es) 2005-04-16
NO301831B1 (no) 1997-12-15
IE902347L (en) 1990-12-29
EP0405537B1 (en) 2004-09-08
FI916060A0 (fi) 1991-12-20
PT94543B (pt) 1997-04-30
CA2060652A1 (en) 1990-12-30
DK0405537T3 (da) 2005-01-10
AU5962890A (en) 1991-01-17
CA2344707C (en) 2002-07-30
KR0167315B1 (ko) 1999-01-15
EP0405537A1 (en) 1991-01-02
DE69034162T2 (de) 2005-09-22
WO1991000274A1 (en) 1991-01-10
JPH04506079A (ja) 1992-10-22
NO915122D0 (no) 1991-12-27
IE902347A1 (en) 1991-01-16
CA2344707A1 (en) 1991-01-10
KR920702678A (ko) 1992-10-06
FI106197B (fi) 2000-12-15
KR0180539B1 (en) 1999-05-01
PT94543A (pt) 1991-03-20
DE69034162D1 (de) 2004-10-14
NO915122L (no) 1992-02-27
CN1049165A (zh) 1991-02-13
JP2972331B2 (ja) 1999-11-08
ATE275546T1 (de) 2004-09-15

Similar Documents

Publication Publication Date Title
KR0180539B1 (en) N-substituted cycloalkyl and polycycloalkyl alpha-substituted trp-phe-and phenethylamine derivatives
HUT48455A (en) Process for producing stabilized pharmaceutical compositions containing dipeptide derivatives
EP0546108A4 (en) Pro-drugs for cck antagonists
HUT52040A (en) Process for producing diaryl-derivatives and pharmaceutical compositions containing them
EG19302A (en) Compound with gastric acid inhibitory effect and process for its preparation
FR2655043B1 (fr) Nouveaux derives du thiophene, leur procede de preparation et les compositions pharmaceutiques les renfermant.
HK1011356A1 (en) Alkylidene analogs of 1'-aminospiro-isoquinoline-4(1H),3'-pyrrolidineù-1,2',3,5'(2H)-tetrones useful as aldose reductase inhibitors in vivo
ZA891769B (en) Heterocyclic compounds
ZA903111B (en) 2-hydroxy-3-phenoxypropylamino compounds and pharmaceutical compositions containing them
HUT59827A (en) Process for producing pharmaceutical compositions containing pafantagonistic thieno-triazolo-diazepines for treating heart diseases produced by diminished beta-receptor-stimulant
ZA885520B (en) Beta-lactam compound,process for preparing the same intermediate for synthesis of the same and medicinal composition for bacterially infectious disease therapy containing the same
HUT46909A (en) Process for production of substituated quinoxanileimidasoline-2,4-dions and medical preparatives containing such compositions
RU93005013A (ru) 1-аминоспиро[изохинолин-4(1н)3-пирролидин-1,2,3,5'(2н)-тетроны] и их аналоги, способ их получения и фармацевтическая композиция
KR890000479A (ko) 8α-아실아미노 에르고린, 그것의 제법 및 그것을 함유하는 약학적 조성물
DE3461926D1 (en) Cycloaliphatic aminosulphonic-acid derivatives, process for their production and pharmaceutical preparations for combating heart and vascular diseases
TH20165A (th) องค์ประกอบทางเภสัชกรรมเพื่อการลดความดันเลือดและกระบวนการสำหรับการเตรียม