IL94650A - Process for sythesis of tigogenin betacellobioside and certain novel cellobioside intermediates therefor - Google Patents

Process for sythesis of tigogenin betacellobioside and certain novel cellobioside intermediates therefor

Info

Publication number
IL94650A
IL94650A IL9465090A IL9465090A IL94650A IL 94650 A IL94650 A IL 94650A IL 9465090 A IL9465090 A IL 9465090A IL 9465090 A IL9465090 A IL 9465090A IL 94650 A IL94650 A IL 94650A
Authority
IL
Israel
Prior art keywords
tigogenin
cellobioside
formula
beta
inert solvent
Prior art date
Application number
IL9465090A
Other languages
English (en)
Other versions
IL94650A0 (en
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of IL94650A0 publication Critical patent/IL94650A0/xx
Publication of IL94650A publication Critical patent/IL94650A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/12—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by acids having the group -X-C(=X)-X-, or halides thereof, in which each X means nitrogen, oxygen, sulfur, selenium or tellurium, e.g. carbonic acid, carbamic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Saccharide Compounds (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Catalysts (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Mechanical Treatment Of Semiconductor (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
IL9465090A 1989-06-13 1990-06-06 Process for sythesis of tigogenin betacellobioside and certain novel cellobioside intermediates therefor IL94650A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/365,588 US5010185A (en) 1989-06-13 1989-06-13 Processes for tigogenin beta-cellobioside

Publications (2)

Publication Number Publication Date
IL94650A0 IL94650A0 (en) 1991-04-15
IL94650A true IL94650A (en) 1994-11-11

Family

ID=23439483

Family Applications (1)

Application Number Title Priority Date Filing Date
IL9465090A IL94650A (en) 1989-06-13 1990-06-06 Process for sythesis of tigogenin betacellobioside and certain novel cellobioside intermediates therefor

Country Status (23)

Country Link
US (1) US5010185A (cs)
EP (1) EP0403150B1 (cs)
JP (1) JPH0637514B2 (cs)
KR (1) KR920002146B1 (cs)
AT (1) ATE114155T1 (cs)
AU (1) AU619986B2 (cs)
CA (1) CA2018722A1 (cs)
CZ (1) CZ279909B6 (cs)
DD (1) DD295164A5 (cs)
DE (1) DE69014152T2 (cs)
DK (1) DK0403150T3 (cs)
ES (1) ES2063269T3 (cs)
FI (1) FI902937A7 (cs)
HU (1) HU210689B (cs)
IE (1) IE64057B1 (cs)
IL (1) IL94650A (cs)
NO (1) NO902600L (cs)
NZ (1) NZ234028A (cs)
PL (3) PL163259B1 (cs)
PT (1) PT94337A (cs)
RU (1) RU2042688C1 (cs)
YU (1) YU47515B (cs)
ZA (1) ZA904527B (cs)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5294703A (en) * 1992-05-01 1994-03-15 Eastman Kodak Company Process for preparing α-D-cellobiose octaacetate
JP2578399B2 (ja) * 1992-06-26 1997-02-05 ファイザー インク． ステロイド−β−Ｏ−セロビオシドヘプタアルカノエートの製造方法
DE69314031T2 (de) * 1992-06-26 1998-01-22 Pfizer Verfahren zur herstellung von per-acylierten glykosiden
CA2139104A1 (en) * 1992-06-26 1994-01-06 Michael P. Deninno Steroidal glycosides for treating hypercholesterolemia
US5530107A (en) * 1992-10-15 1996-06-25 Pfizer Inc. Method for making steroidal peracyl glycosides
CZ280195A3 (en) * 1993-04-28 1996-02-14 Pfizer Crystalline spirostanyl glycoside, monohydrate thereof, pharmaceutical composition based thereon and process for preparing crystalline steroidal glycoside
US5502038A (en) * 1993-06-21 1996-03-26 Medical Research Foundation Of Oregon Cholesterol sequestrant glycosides that inhibit intestinal cholesterol absorption
ES2074006B1 (es) * 1993-07-05 1996-03-16 Pfizer Glicosidos esteroidales para tratar hipercolesterolemia.
GB9806513D0 (en) * 1998-03-26 1998-05-27 Phytopharm Ltd Membrane-bound receptors
JP4589869B2 (ja) * 2002-07-12 2010-12-01 塩野義製薬株式会社 酸触媒として機能するゼオライト類似体の簡易な製造法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4602003A (en) * 1982-05-17 1986-07-22 Medical Research Foundation Of Oregon Synthetic compounds to inhibit intestinal absorption of cholesterol in the treatment of hypercholesterolemia
US4602005A (en) * 1982-05-17 1986-07-22 Medical Research Foundation Of Oregon Tigogenin cellobioside for treating hypercholesterolemia and atherosclerosis

Also Published As

Publication number Publication date
ZA904527B (en) 1992-01-29
EP0403150B1 (en) 1994-11-17
NO902600L (no) 1990-12-14
PL163259B1 (pl) 1994-02-28
FI902937A0 (fi) 1990-06-12
HU903816D0 (en) 1990-11-28
KR910000779A (ko) 1991-01-30
PL285593A1 (en) 1991-07-01
DE69014152T2 (de) 1995-03-23
RU2042688C1 (ru) 1995-08-27
EP0403150A3 (en) 1992-06-17
IE902101A1 (en) 1991-01-02
FI902937A7 (fi) 1990-12-14
IE902101L (en) 1990-12-13
KR920002146B1 (ko) 1992-03-12
PL289135A1 (en) 1992-02-24
ES2063269T3 (es) 1995-01-01
IE64057B1 (en) 1995-07-12
PT94337A (pt) 1991-02-08
DK0403150T3 (da) 1995-01-16
JPH0637514B2 (ja) 1994-05-18
EP0403150A2 (en) 1990-12-19
CZ279909B6 (cs) 1995-08-16
PL163258B1 (pl) 1994-02-28
AU619986B2 (en) 1992-02-06
NZ234028A (en) 1991-10-25
YU114590A (en) 1991-10-31
YU47515B (sh) 1995-10-03
AU5707990A (en) 1991-08-01
HU210689B (en) 1995-06-28
PL289136A1 (en) 1992-02-24
DD295164A5 (de) 1991-10-24
US5010185A (en) 1991-04-23
HUT54708A (en) 1991-03-28
PL163219B1 (pl) 1994-02-28
DE69014152D1 (de) 1994-12-22
ATE114155T1 (de) 1994-12-15
CA2018722A1 (en) 1990-12-13
NO902600D0 (no) 1990-06-12
IL94650A0 (en) 1991-04-15
CZ289090A3 (en) 1995-04-12
JPH0331297A (ja) 1991-02-12

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