DK0403150T3 - Fremgangsmåde til fremstilling af tigogenin-beta-cellobiosid - Google Patents
Fremgangsmåde til fremstilling af tigogenin-beta-cellobiosidInfo
- Publication number
- DK0403150T3 DK0403150T3 DK90306143.0T DK90306143T DK0403150T3 DK 0403150 T3 DK0403150 T3 DK 0403150T3 DK 90306143 T DK90306143 T DK 90306143T DK 0403150 T3 DK0403150 T3 DK 0403150T3
- Authority
- DK
- Denmark
- Prior art keywords
- tigogenin
- cellobioside
- beta
- preparation
- synthesis
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- GMBQZIIUCVWOCD-WWASVFFGSA-N Sarsapogenine Chemical compound O([C@@H]1[C@@H]([C@]2(CC[C@@H]3[C@@]4(C)CC[C@H](O)C[C@H]4CC[C@H]3[C@@H]2C1)C)[C@@H]1C)[C@]11CC[C@H](C)CO1 GMBQZIIUCVWOCD-WWASVFFGSA-N 0.000 abstract 2
- RTMWIZOXNKJHRE-UHFFFAOYSA-N Tigogenin Natural products CC1COC2CC(C)(OC12)C3CCC4C5CCC6CC(O)CCC6(C)C5CCC34C RTMWIZOXNKJHRE-UHFFFAOYSA-N 0.000 abstract 2
- GUBGYTABKSRVRQ-CUHNMECISA-N D-Cellobiose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-CUHNMECISA-N 0.000 abstract 1
- 239000003529 anticholesteremic agent Substances 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/12—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by acids having the group -X-C(=X)-X-, or halides thereof, in which each X means nitrogen, oxygen, sulfur, selenium or tellurium, e.g. carbonic acid, carbamic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Urology & Nephrology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Medicinal Chemistry (AREA)
- Saccharide Compounds (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Compounds Of Unknown Constitution (AREA)
- Catalysts (AREA)
- Mechanical Treatment Of Semiconductor (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/365,588 US5010185A (en) | 1989-06-13 | 1989-06-13 | Processes for tigogenin beta-cellobioside |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0403150T3 true DK0403150T3 (da) | 1995-01-16 |
Family
ID=23439483
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK90306143.0T DK0403150T3 (da) | 1989-06-13 | 1990-06-06 | Fremgangsmåde til fremstilling af tigogenin-beta-cellobiosid |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US5010185A (cs) |
| EP (1) | EP0403150B1 (cs) |
| JP (1) | JPH0637514B2 (cs) |
| KR (1) | KR920002146B1 (cs) |
| AT (1) | ATE114155T1 (cs) |
| AU (1) | AU619986B2 (cs) |
| CA (1) | CA2018722A1 (cs) |
| CZ (1) | CZ279909B6 (cs) |
| DD (1) | DD295164A5 (cs) |
| DE (1) | DE69014152T2 (cs) |
| DK (1) | DK0403150T3 (cs) |
| ES (1) | ES2063269T3 (cs) |
| FI (1) | FI902937A7 (cs) |
| HU (1) | HU210689B (cs) |
| IE (1) | IE64057B1 (cs) |
| IL (1) | IL94650A (cs) |
| NO (1) | NO902600L (cs) |
| NZ (1) | NZ234028A (cs) |
| PL (3) | PL163258B1 (cs) |
| PT (1) | PT94337A (cs) |
| RU (1) | RU2042688C1 (cs) |
| YU (1) | YU47515B (cs) |
| ZA (1) | ZA904527B (cs) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5294703A (en) * | 1992-05-01 | 1994-03-15 | Eastman Kodak Company | Process for preparing α-D-cellobiose octaacetate |
| JPH07504921A (ja) * | 1992-06-26 | 1995-06-01 | フアイザー・インコーポレイテツド | 高コレステロール血症を治療するためのステロイドグリコシド |
| CA2138016A1 (en) * | 1992-06-26 | 1994-01-06 | Kathleen D. Goggin | Steroidal beta-o-cellobioside heptaalkanoate process |
| ATE158299T1 (de) * | 1992-06-26 | 1997-10-15 | Pfizer | Verfahren zur herstellung von per-acylierten glykosiden |
| US5530107A (en) * | 1992-10-15 | 1996-06-25 | Pfizer Inc. | Method for making steroidal peracyl glycosides |
| PL311278A1 (en) * | 1993-04-28 | 1996-02-05 | Pfizer | Crystalline glycosidal spirostantil monohydrate |
| US5502038A (en) * | 1993-06-21 | 1996-03-26 | Medical Research Foundation Of Oregon | Cholesterol sequestrant glycosides that inhibit intestinal cholesterol absorption |
| ES2074006B1 (es) * | 1993-07-05 | 1996-03-16 | Pfizer | Glicosidos esteroidales para tratar hipercolesterolemia. |
| GB9806513D0 (en) * | 1998-03-26 | 1998-05-27 | Phytopharm Ltd | Membrane-bound receptors |
| JP4589869B2 (ja) * | 2002-07-12 | 2010-12-01 | 塩野義製薬株式会社 | 酸触媒として機能するゼオライト類似体の簡易な製造法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4602003A (en) * | 1982-05-17 | 1986-07-22 | Medical Research Foundation Of Oregon | Synthetic compounds to inhibit intestinal absorption of cholesterol in the treatment of hypercholesterolemia |
| US4602005A (en) * | 1982-05-17 | 1986-07-22 | Medical Research Foundation Of Oregon | Tigogenin cellobioside for treating hypercholesterolemia and atherosclerosis |
-
1989
- 1989-06-13 US US07/365,588 patent/US5010185A/en not_active Expired - Fee Related
-
1990
- 1990-06-06 DE DE69014152T patent/DE69014152T2/de not_active Expired - Fee Related
- 1990-06-06 IL IL9465090A patent/IL94650A/en not_active IP Right Cessation
- 1990-06-06 AT AT90306143T patent/ATE114155T1/de not_active IP Right Cessation
- 1990-06-06 ES ES90306143T patent/ES2063269T3/es not_active Expired - Lifetime
- 1990-06-06 DK DK90306143.0T patent/DK0403150T3/da active
- 1990-06-06 JP JP2148456A patent/JPH0637514B2/ja not_active Expired - Lifetime
- 1990-06-06 EP EP90306143A patent/EP0403150B1/en not_active Expired - Lifetime
- 1990-06-11 PT PT94337A patent/PT94337A/pt not_active Application Discontinuation
- 1990-06-11 CZ CS902890A patent/CZ279909B6/cs not_active IP Right Cessation
- 1990-06-11 CA CA002018722A patent/CA2018722A1/en not_active Abandoned
- 1990-06-12 PL PL90289135A patent/PL163258B1/pl unknown
- 1990-06-12 YU YU114590A patent/YU47515B/sh unknown
- 1990-06-12 FI FI902937A patent/FI902937A7/fi not_active IP Right Cessation
- 1990-06-12 PL PL90289136A patent/PL163259B1/pl unknown
- 1990-06-12 HU HU903816A patent/HU210689B/hu not_active IP Right Cessation
- 1990-06-12 NO NO90902600A patent/NO902600L/no unknown
- 1990-06-12 IE IE210190A patent/IE64057B1/en not_active IP Right Cessation
- 1990-06-12 RU SU904830049A patent/RU2042688C1/ru active
- 1990-06-12 ZA ZA904527A patent/ZA904527B/xx unknown
- 1990-06-12 AU AU57079/90A patent/AU619986B2/en not_active Ceased
- 1990-06-12 KR KR1019900008599A patent/KR920002146B1/ko not_active Expired
- 1990-06-12 DD DD90341563A patent/DD295164A5/de not_active IP Right Cessation
- 1990-06-12 PL PL90285593A patent/PL163219B1/pl unknown
- 1990-06-12 NZ NZ234028A patent/NZ234028A/xx unknown
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