DE69014152T2 - Verfahren zur Herstellung von Tigogenin-beta-Cellobioside. - Google Patents

Verfahren zur Herstellung von Tigogenin-beta-Cellobioside.

Info

Publication number
DE69014152T2
DE69014152T2 DE69014152T DE69014152T DE69014152T2 DE 69014152 T2 DE69014152 T2 DE 69014152T2 DE 69014152 T DE69014152 T DE 69014152T DE 69014152 T DE69014152 T DE 69014152T DE 69014152 T2 DE69014152 T2 DE 69014152T2
Authority
DE
Germany
Prior art keywords
cellobiosides
preparation
tigogenin
beta
tigogenin beta
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69014152T
Other languages
English (en)
Other versions
DE69014152D1 (de
Inventor
Frank John Urban
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Publication of DE69014152D1 publication Critical patent/DE69014152D1/de
Application granted granted Critical
Publication of DE69014152T2 publication Critical patent/DE69014152T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/12—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by acids having the group -X-C(=X)-X-, or halides thereof, in which each X means nitrogen, oxygen, sulfur, selenium or tellurium, e.g. carbonic acid, carbamic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Vascular Medicine (AREA)
  • Saccharide Compounds (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Catalysts (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Mechanical Treatment Of Semiconductor (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DE69014152T 1989-06-13 1990-06-06 Verfahren zur Herstellung von Tigogenin-beta-Cellobioside. Expired - Fee Related DE69014152T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/365,588 US5010185A (en) 1989-06-13 1989-06-13 Processes for tigogenin beta-cellobioside

Publications (2)

Publication Number Publication Date
DE69014152D1 DE69014152D1 (de) 1994-12-22
DE69014152T2 true DE69014152T2 (de) 1995-03-23

Family

ID=23439483

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69014152T Expired - Fee Related DE69014152T2 (de) 1989-06-13 1990-06-06 Verfahren zur Herstellung von Tigogenin-beta-Cellobioside.

Country Status (23)

Country Link
US (1) US5010185A (de)
EP (1) EP0403150B1 (de)
JP (1) JPH0637514B2 (de)
KR (1) KR920002146B1 (de)
AT (1) ATE114155T1 (de)
AU (1) AU619986B2 (de)
CA (1) CA2018722A1 (de)
CZ (1) CZ279909B6 (de)
DD (1) DD295164A5 (de)
DE (1) DE69014152T2 (de)
DK (1) DK0403150T3 (de)
ES (1) ES2063269T3 (de)
FI (1) FI902937A0 (de)
HU (1) HU210689B (de)
IE (1) IE64057B1 (de)
IL (1) IL94650A (de)
NO (1) NO902600L (de)
NZ (1) NZ234028A (de)
PL (3) PL163259B1 (de)
PT (1) PT94337A (de)
RU (1) RU2042688C1 (de)
YU (1) YU47515B (de)
ZA (1) ZA904527B (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5294703A (en) * 1992-05-01 1994-03-15 Eastman Kodak Company Process for preparing α-D-cellobiose octaacetate
JP2566384B2 (ja) * 1992-06-26 1996-12-25 ファイザー・インコーポレーテッド ステロイダルペルアシル配糖体の合成法
WO1994000480A1 (en) * 1992-06-26 1994-01-06 Pfizer Inc. Steroidal glycosides for treating hypercholesterolemia
EP0647233A1 (de) * 1992-06-26 1995-04-12 Pfizer Inc. Verfahren zur herstellung von beta-o-cellobiosid-heptaalkanoaten
US5530107A (en) * 1992-10-15 1996-06-25 Pfizer Inc. Method for making steroidal peracyl glycosides
CZ280195A3 (en) * 1993-04-28 1996-02-14 Pfizer Crystalline spirostanyl glycoside, monohydrate thereof, pharmaceutical composition based thereon and process for preparing crystalline steroidal glycoside
US5502038A (en) * 1993-06-21 1996-03-26 Medical Research Foundation Of Oregon Cholesterol sequestrant glycosides that inhibit intestinal cholesterol absorption
ES2074006B1 (es) * 1993-07-05 1996-03-16 Pfizer Glicosidos esteroidales para tratar hipercolesterolemia.
AU2003248057A1 (en) * 2002-07-12 2004-02-02 Shinichiro Nishimura Simple process for production of zeolite analogues functioning as acid catalysts

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4602003A (en) * 1982-05-17 1986-07-22 Medical Research Foundation Of Oregon Synthetic compounds to inhibit intestinal absorption of cholesterol in the treatment of hypercholesterolemia
US4602005A (en) * 1982-05-17 1986-07-22 Medical Research Foundation Of Oregon Tigogenin cellobioside for treating hypercholesterolemia and atherosclerosis

Also Published As

Publication number Publication date
PT94337A (pt) 1991-02-08
PL289135A1 (en) 1992-02-24
ZA904527B (en) 1992-01-29
IL94650A0 (en) 1991-04-15
EP0403150A2 (de) 1990-12-19
PL163258B1 (pl) 1994-02-28
JPH0331297A (ja) 1991-02-12
YU47515B (sh) 1995-10-03
NO902600L (no) 1990-12-14
AU619986B2 (en) 1992-02-06
EP0403150B1 (de) 1994-11-17
PL285593A1 (en) 1991-07-01
EP0403150A3 (de) 1992-06-17
DE69014152D1 (de) 1994-12-22
RU2042688C1 (ru) 1995-08-27
NZ234028A (en) 1991-10-25
PL163219B1 (pl) 1994-02-28
IL94650A (en) 1994-11-11
CZ289090A3 (en) 1995-04-12
IE902101L (en) 1990-12-13
US5010185A (en) 1991-04-23
IE902101A1 (en) 1991-01-02
HU210689B (en) 1995-06-28
YU114590A (en) 1991-10-31
HU903816D0 (en) 1990-11-28
FI902937A0 (fi) 1990-06-12
PL289136A1 (en) 1992-02-24
ES2063269T3 (es) 1995-01-01
DD295164A5 (de) 1991-10-24
JPH0637514B2 (ja) 1994-05-18
ATE114155T1 (de) 1994-12-15
NO902600D0 (no) 1990-06-12
KR910000779A (ko) 1991-01-30
HUT54708A (en) 1991-03-28
CA2018722A1 (en) 1990-12-13
AU5707990A (en) 1991-08-01
DK0403150T3 (da) 1995-01-16
CZ279909B6 (cs) 1995-08-16
KR920002146B1 (ko) 1992-03-12
IE64057B1 (en) 1995-07-12
PL163259B1 (pl) 1994-02-28

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee