IL90092A - Antiviral or antibacterial composition comprising a lysozyme dimer and/or a ribonuclease dimer and use thereof - Google Patents
Antiviral or antibacterial composition comprising a lysozyme dimer and/or a ribonuclease dimer and use thereofInfo
- Publication number
- IL90092A IL90092A IL9009289A IL9009289A IL90092A IL 90092 A IL90092 A IL 90092A IL 9009289 A IL9009289 A IL 9009289A IL 9009289 A IL9009289 A IL 9009289A IL 90092 A IL90092 A IL 90092A
- Authority
- IL
- Israel
- Prior art keywords
- dimer
- lysozyme
- use according
- ribonuclease
- pharmaceutically acceptable
- Prior art date
Links
- 235000010335 lysozyme Nutrition 0.000 title claims abstract description 103
- 102000016943 Muramidase Human genes 0.000 title claims abstract description 102
- 108010014251 Muramidase Proteins 0.000 title claims abstract description 102
- 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 title claims abstract description 102
- 229960000274 lysozyme Drugs 0.000 title claims abstract description 102
- 239000004325 lysozyme Substances 0.000 title claims abstract description 102
- 239000000203 mixture Substances 0.000 title claims abstract description 44
- 230000000840 anti-viral effect Effects 0.000 title claims abstract description 12
- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 11
- 239000000539 dimer Substances 0.000 title claims description 100
- 108010015937 ribonuclease dimer Proteins 0.000 title claims description 11
- 230000001472 cytotoxic effect Effects 0.000 claims abstract description 24
- 231100000433 cytotoxic Toxicity 0.000 claims abstract description 22
- 239000003937 drug carrier Substances 0.000 claims abstract description 13
- 108020002230 Pancreatic Ribonuclease Proteins 0.000 claims description 24
- 102000005891 Pancreatic ribonuclease Human genes 0.000 claims description 24
- 239000000243 solution Substances 0.000 claims description 19
- 239000002674 ointment Substances 0.000 claims description 15
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 12
- 208000015181 infectious disease Diseases 0.000 claims description 12
- 230000003612 virological effect Effects 0.000 claims description 12
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 7
- 208000004396 mastitis Diseases 0.000 claims description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 7
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- 208000022362 bacterial infectious disease Diseases 0.000 claims description 4
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- XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 claims description 3
- 206010046914 Vaginal infection Diseases 0.000 claims description 3
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- 239000000829 suppository Substances 0.000 claims description 3
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- 102000004190 Enzymes Human genes 0.000 abstract description 32
- 108090000790 Enzymes Proteins 0.000 abstract description 32
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- 229920001214 Polysorbate 60 Polymers 0.000 description 2
- HVUMOYIDDBPOLL-XWVZOOPGSA-N Sorbitan monostearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O HVUMOYIDDBPOLL-XWVZOOPGSA-N 0.000 description 2
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- 241000194042 Streptococcus dysgalactiae Species 0.000 description 2
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- -1 Acetylstearoyloxy alcohol Chemical compound 0.000 description 1
- 208000002874 Acne Vulgaris Diseases 0.000 description 1
- 206010002942 Apathy Diseases 0.000 description 1
- 208000031462 Bovine Mastitis Diseases 0.000 description 1
- 241000224483 Coccidia Species 0.000 description 1
- 208000005156 Dehydration Diseases 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 101001013832 Homo sapiens Mitochondrial peptide methionine sulfoxide reductase Proteins 0.000 description 1
- 206010021531 Impetigo Diseases 0.000 description 1
- 241001313288 Labia Species 0.000 description 1
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- FRTGEIHSCHXMTI-UHFFFAOYSA-N dimethyl octanediimidate Chemical compound COC(=N)CCCCCCC(=N)OC FRTGEIHSCHXMTI-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Virology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US17858888A | 1988-05-26 | 1988-05-26 | |
PCT/US1988/001785 WO1989011294A1 (en) | 1988-05-26 | 1988-05-26 | Antiviral or antibacterial compound and method of use |
OA59731A OA09785A (en) | 1988-05-26 | 1990-01-26 | Antiviral or antibacterial compound and method of use |
Publications (1)
Publication Number | Publication Date |
---|---|
IL90092A true IL90092A (en) | 1995-03-30 |
Family
ID=33162813
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL9009289A IL90092A (en) | 1988-05-26 | 1989-04-27 | Antiviral or antibacterial composition comprising a lysozyme dimer and/or a ribonuclease dimer and use thereof |
Country Status (23)
Country | Link |
---|---|
US (3) | US5200182A (ja) |
EP (1) | EP0380484B1 (ja) |
JP (1) | JPH0649659B2 (ja) |
AT (1) | ATE93143T1 (ja) |
AU (1) | AU624331B2 (ja) |
BG (1) | BG60544B1 (ja) |
CA (1) | CA1335425C (ja) |
CS (1) | CS277030B6 (ja) |
DK (1) | DK173078B1 (ja) |
ES (1) | ES2011577A6 (ja) |
FI (1) | FI900412A0 (ja) |
HK (1) | HK42394A (ja) |
HU (1) | HU204710B (ja) |
IL (1) | IL90092A (ja) |
LV (1) | LV10054B (ja) |
MA (1) | MA21560A1 (ja) |
MW (1) | MW390A1 (ja) |
OA (1) | OA09785A (ja) |
PH (1) | PH26284A (ja) |
RU (1) | RU2092183C1 (ja) |
WO (1) | WO1989011294A1 (ja) |
YU (1) | YU109289A (ja) |
ZA (1) | ZA893382B (ja) |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU624331B2 (en) * | 1988-05-26 | 1992-06-11 | Nika Health Products Ltd. | A composition having as its active ingredient lysozyme or ribonuclease dimer in a pharmaceutically acceptable carrier |
KR0142172B1 (ko) * | 1990-01-08 | 1998-07-01 | 카를하인츠 리터 | 리보뉴클레아제 이량체를 만드는 개량된 방법 |
US5989880A (en) * | 1990-01-08 | 1999-11-23 | Nika Health Products Ltd. | Method of preparing lysozyme dimers |
PL173978B1 (pl) * | 1992-07-13 | 1998-05-29 | Nika Health Products Ltd | Sposób oddziaływania na wydzielanie cytokin w hodowli limfocytów krwi obwodowej |
CH682541A5 (de) * | 1992-06-23 | 1993-10-15 | Urs Viktor Dr Wirth | Biochemische Inaktivierung von RNA-Viren. |
US6183742B1 (en) | 1992-07-13 | 2001-02-06 | Nika Health Products, Limited | Applications of lysozyme dimer |
DZ1964A1 (fr) * | 1995-01-13 | 2002-10-15 | Nika Health Products Ltd | Nouvelle applications d'un dimère de lysozyme. |
GB2304048A (en) * | 1995-08-12 | 1997-03-12 | John William Carson | Medicament containing saliva extract |
US6123937A (en) * | 1997-03-14 | 2000-09-26 | Nika Health Products, Limited | Applications of lysozyme dimer |
US7338936B2 (en) * | 2000-11-28 | 2008-03-04 | House Ear Institute | Use of antimicrobial proteins and peptides for the treatment of otitis media and paranasal sinusitis |
US6716813B2 (en) * | 2000-11-28 | 2004-04-06 | House Ear Institute | Use of antimicrobial proteins and peptides for the treatment of otitis media and paranasal sinusitis |
JP2002187853A (ja) * | 2000-12-21 | 2002-07-05 | Shinei Ferumentekku:Kk | 動物の乳頭除菌剤および菌環境改善方法 |
DE10210285A1 (de) * | 2002-03-08 | 2003-11-13 | Medigene Ag | Reversibles Toxin und seine Verwendung |
WO2005115477A2 (en) | 2004-04-13 | 2005-12-08 | Quintessence Biosciences, Inc. | Non-natural ribonuclease conjugates as cytotoxic agents |
US20050244402A1 (en) * | 2004-04-30 | 2005-11-03 | Villanueva Julie M | Absorption of pain-causing agents |
US7348301B2 (en) * | 2006-02-16 | 2008-03-25 | Buckman Laboratories International, Inc. | Lysozyme-based method and composition to control the growth of microorganisms in aqueous systems |
US8840882B2 (en) * | 2006-06-23 | 2014-09-23 | Quintessence Biosciences, Inc. | Modified ribonucleases |
JP2009543868A (ja) | 2006-07-17 | 2009-12-10 | クインテセンス バイオサイエンシーズ インコーポレーティッド | 癌治療に関する方法および組成物 |
WO2008109401A2 (en) * | 2007-03-02 | 2008-09-12 | Saint Simeon Lda | Composition and method for treating papilloma virus and equine sarcoids |
WO2009036000A2 (en) * | 2007-09-11 | 2009-03-19 | University Of Maryland, Baltimore | Methods of treating a microbial infection by modulating rnase-l expression and/or activity |
US8697062B2 (en) * | 2007-10-08 | 2014-04-15 | Quintessence Biosciences, Inc. | Compositions and methods for ribonuclease-based therapeutics |
JP2012504423A (ja) | 2008-10-01 | 2012-02-23 | クインテッセンス バイオサイエンシズ,インコーポレーテッド | 治療用リボヌクレアーゼ |
WO2010099182A1 (en) * | 2009-02-25 | 2010-09-02 | Board Of Regents Of The University Of Nebraska | Activated creatinine and precursors as antibacterial agents, compositions and products containing such agents and uses thereof |
NZ600269A (en) | 2009-05-20 | 2014-02-28 | Dec Int Nz Ltd | Delivery device for treatment of mastitis |
EP2457576B1 (en) | 2010-11-29 | 2020-07-08 | Eurochit Danuta Kruszewska | Lactobacillus reuteri strain for use in the medical and veterinary prophylaxis and treatment of metabolic syndrome or infections |
RU2548803C2 (ru) * | 2011-11-28 | 2015-04-20 | Общество с ограниченной ответственностью " Фарматренд" | ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ ДЛЯ ЛЕЧЕНИЯ ГЛАЗНЫХ ИНФЕКЦИЙ P. Aeruginosa, СОДЕРЖАЩАЯ РЕКОМБИНАНТНЫЙ ЛИЗОЦИМ |
RU2509801C2 (ru) * | 2012-03-22 | 2014-03-20 | Борис Михайлович Куриненко | СПОСОБ ИСПОЛЬЗОВАНИЯ РИБОНУКЛЕАЗЫ Bacillus intermedius |
WO2013180585A1 (en) | 2012-05-29 | 2013-12-05 | Danuta Kruszewska | Nanoproduct comprising lactobacillus reuteri dan080 useful in prophylaxis and medicine, both human and veterinary and medical use of the same |
EP2674162A1 (en) | 2012-05-29 | 2013-12-18 | Danuta Kruszewska | Nanoproduct comprising lactobacillus reuteri dan080 useful in prophylaxis and medicine, both human and veterinary and medical use of the same |
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US9950075B2 (en) | 2013-03-15 | 2018-04-24 | The University Of Massachusetts | Compositions and methods for delivering agents to the central nervous system |
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CN106659165B (zh) * | 2014-07-31 | 2021-06-01 | 丘比株式会社 | 含水流动状组合物及其制造方法、以及溶菌酶加工品和/或其盐、及其制造方法 |
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FR1268M (fr) * | 1961-06-29 | 1962-04-24 | Puiseux | Médicament antimitotique et antiviral. |
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DE1517751C3 (de) * | 1965-07-08 | 1975-02-27 | Eisai Co., Ltd., Tokio | Verfahren zum Verhindern der Bildung von flockigen Lysozym- und/oder Lysozymsalzniederschlägen in wässrigen Lösungen, die Lysozym und/oder Lysozymsalze enthalten |
DE1545644A1 (de) * | 1965-12-06 | 1969-08-07 | Boehringer Sohn Ingelheim | Verfahren zur Herstellung von neuen quaternaeren Scopolammoniumsalzen |
GB1110504A (en) * | 1966-03-18 | 1968-04-18 | Prodotti Antibiotici Spa | Pharmaceutical compositions |
US4221794A (en) * | 1979-06-21 | 1980-09-09 | Newport Pharmaceuticals International, Inc. | Method of imparting immunomodulating and antiviral activity |
US4510144A (en) * | 1981-08-26 | 1985-04-09 | Newport Pharmaceuticals International | Methods of imparting immunomodulating activity with dihydrothiazolo purine derivatives |
EP0187705A3 (en) * | 1985-01-08 | 1988-05-11 | Norwich Eaton Pharmaceuticals, Inc. | Imidazo(4,5-f)quinolines useful as immunomodulating agents |
US4739046A (en) * | 1985-08-19 | 1988-04-19 | Luzio Nicholas R Di | Soluble phosphorylated glucan |
US4744984A (en) * | 1985-10-08 | 1988-05-17 | Vetrepharm Research, Inc. | Antiviral immunotherapeutic agent and preparation thereof |
AU624331B2 (en) * | 1988-05-26 | 1992-06-11 | Nika Health Products Ltd. | A composition having as its active ingredient lysozyme or ribonuclease dimer in a pharmaceutically acceptable carrier |
-
1988
- 1988-05-26 AU AU19408/88A patent/AU624331B2/en not_active Expired
- 1988-05-26 AT AT88905146T patent/ATE93143T1/de not_active IP Right Cessation
- 1988-05-26 EP EP88905146A patent/EP0380484B1/en not_active Expired - Lifetime
- 1988-05-26 HU HU883981A patent/HU204710B/hu unknown
- 1988-05-26 RU SU884743095A patent/RU2092183C1/ru active
- 1988-05-26 US US07/459,738 patent/US5200182A/en not_active Expired - Lifetime
- 1988-05-26 WO PCT/US1988/001785 patent/WO1989011294A1/en active IP Right Grant
- 1988-05-26 JP JP63504463A patent/JPH0649659B2/ja not_active Expired - Fee Related
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1989
- 1989-04-20 CA CA000597341A patent/CA1335425C/en not_active Expired - Fee Related
- 1989-04-27 IL IL9009289A patent/IL90092A/en not_active IP Right Cessation
- 1989-05-08 ZA ZA893382A patent/ZA893382B/xx unknown
- 1989-05-16 ES ES8901637A patent/ES2011577A6/es not_active Expired - Fee Related
- 1989-05-23 PH PH38684A patent/PH26284A/en unknown
- 1989-05-24 MA MA21811A patent/MA21560A1/fr unknown
- 1989-05-26 YU YU01092/89A patent/YU109289A/xx unknown
- 1989-05-26 CS CS893180A patent/CS277030B6/cs not_active IP Right Cessation
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1990
- 1990-01-22 MW MW3/90A patent/MW390A1/xx unknown
- 1990-01-22 DK DK199000168A patent/DK173078B1/da not_active IP Right Cessation
- 1990-01-25 FI FI900412A patent/FI900412A0/fi not_active IP Right Cessation
- 1990-01-26 OA OA59731A patent/OA09785A/en unknown
- 1990-02-22 BG BG91270A patent/BG60544B1/bg unknown
-
1992
- 1992-04-08 US US07/865,002 patent/US5466449A/en not_active Expired - Lifetime
- 1992-12-28 LV LVP-92-508A patent/LV10054B/en unknown
-
1994
- 1994-05-05 HK HK42394A patent/HK42394A/xx not_active IP Right Cessation
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1995
- 1995-06-07 US US08/474,663 patent/US6099835A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
YU109289A (en) | 1991-08-31 |
US5200182A (en) | 1993-04-06 |
BG91270A (bg) | 1993-12-24 |
RU2092183C1 (ru) | 1997-10-10 |
DK16890D0 (da) | 1990-01-22 |
OA09785A (en) | 1994-04-15 |
AU1940888A (en) | 1989-12-12 |
US5466449A (en) | 1995-11-14 |
HU883981D0 (en) | 1990-12-28 |
DK16890A (da) | 1990-01-22 |
DK173078B1 (da) | 1999-12-20 |
EP0380484A1 (en) | 1990-08-08 |
CS318089A3 (en) | 1992-05-13 |
HK42394A (en) | 1994-05-13 |
HU204710B (en) | 1992-02-28 |
US6099835A (en) | 2000-08-08 |
CA1335425C (en) | 1995-05-02 |
JPH03504121A (ja) | 1991-09-12 |
LV10054B (en) | 1995-02-20 |
EP0380484B1 (en) | 1993-08-18 |
HUT54060A (en) | 1991-01-28 |
AU624331B2 (en) | 1992-06-11 |
CS277030B6 (en) | 1992-11-18 |
WO1989011294A1 (en) | 1989-11-30 |
ATE93143T1 (de) | 1993-09-15 |
LV10054A (lv) | 1994-05-10 |
ES2011577A6 (es) | 1990-01-16 |
BG60544B1 (en) | 1995-08-28 |
MW390A1 (en) | 1990-11-14 |
PH26284A (en) | 1992-04-10 |
JPH0649659B2 (ja) | 1994-06-29 |
ZA893382B (en) | 1991-01-30 |
MA21560A1 (fr) | 1989-12-31 |
FI900412A0 (fi) | 1990-01-25 |
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