IL86450A - Process for making a history of 5-acylamino-2,4,6-triiodo and tribromo-benzoic acid, and some such new compounds - Google Patents

Process for making a history of 5-acylamino-2,4,6-triiodo and tribromo-benzoic acid, and some such new compounds

Info

Publication number
IL86450A
IL86450A IL8645088A IL8645088A IL86450A IL 86450 A IL86450 A IL 86450A IL 8645088 A IL8645088 A IL 8645088A IL 8645088 A IL8645088 A IL 8645088A IL 86450 A IL86450 A IL 86450A
Authority
IL
Israel
Prior art keywords
bis
formula
alkyl
group
iodo
Prior art date
Application number
IL8645088A
Other languages
English (en)
Hebrew (he)
Other versions
IL86450A0 (en
Original Assignee
Bracco Int Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IT20647/87A external-priority patent/IT1205029B/it
Priority claimed from IT8847935A external-priority patent/IT1219934B/it
Application filed by Bracco Int Bv filed Critical Bracco Int Bv
Publication of IL86450A0 publication Critical patent/IL86450A0/xx
Publication of IL86450A publication Critical patent/IL86450A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C235/16—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/12—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/65—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
IL8645088A 1987-05-22 1988-05-20 Process for making a history of 5-acylamino-2,4,6-triiodo and tribromo-benzoic acid, and some such new compounds IL86450A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT20647/87A IT1205029B (it) 1987-05-22 1987-05-22 Processo per la preparazione di derivati dell'acido 5-acilamino-2,4,6-triiodo o tribromo-benzoico e corrispondenti nuovi derivati dell'acido 5-acilamino-2,4,6-triioco o tribromo-benzzoico,ottenuti con tale processo
IT8847935A IT1219934B (it) 1988-05-05 1988-05-05 Processo per la preparazione di derivati dell' acido 5-acilamino-2,4,6-triiodo o tribromo-brenzoico e corrispondenti derivati dell' acido 5-acilamino-2,4,6-triiodo o tribromo-benzoico,ottenuti con tale processo

Publications (2)

Publication Number Publication Date
IL86450A0 IL86450A0 (en) 1988-11-15
IL86450A true IL86450A (en) 1994-05-30

Family

ID=26327605

Family Applications (1)

Application Number Title Priority Date Filing Date
IL8645088A IL86450A (en) 1987-05-22 1988-05-20 Process for making a history of 5-acylamino-2,4,6-triiodo and tribromo-benzoic acid, and some such new compounds

Country Status (13)

Country Link
US (1) US5066823A (ja)
EP (1) EP0365541B1 (ja)
JP (1) JP2585087B2 (ja)
KR (1) KR960016747B1 (ja)
AT (1) ATE79368T1 (ja)
AU (1) AU618535B2 (ja)
CA (1) CA1327600C (ja)
DE (1) DE3873766T2 (ja)
ES (1) ES2006951A6 (ja)
IE (1) IE63232B1 (ja)
IL (1) IL86450A (ja)
NZ (1) NZ224743A (ja)
WO (1) WO1988009328A1 (ja)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8717625D0 (en) * 1987-07-24 1987-09-03 Nycomed As Chemical compounds
EP0410974A4 (en) * 1988-03-01 1991-09-11 Mallinckrodt, Inc. Nonionic x-ray contrast agents, compositions and methods
AU623403B2 (en) * 1988-04-06 1992-05-14 Mallinckrodt, Inc. Process for the preparation of 2,4,6-triiodo-5-amino-n-alkylisophthalamic acid
IL90326A (en) * 1988-06-02 1993-05-13 Guerbet Sa Non-ionic triiodobenzene compounds and contrast media containing them
FR2643077B1 (fr) * 1989-01-23 1991-10-31 Guerbet Sa Nouveaux composes non ioniques iodes et produits de contraste les contenant
US5614638A (en) * 1989-11-29 1997-03-25 Bracco International B.V. Nonionic radiographic contrast agents
US5075502A (en) * 1989-12-13 1991-12-24 Mallinckrodt, Inc. Nonionic x-ray contrast agents, compositions and methods
US5191120A (en) * 1989-12-13 1993-03-02 Mallinckrodt Medical, Inc. Process for preparing nonionic X-ray contrast agents
US5019371A (en) * 1990-11-21 1991-05-28 Mallinckrodt Medical, Inc. Novel x-ray contrast agents, compositions and methods
US5356613A (en) * 1991-03-18 1994-10-18 Mallinckrodt Medical, Inc. X-ray contrast agents, compositions and methods
DE4109169A1 (de) * 1991-03-20 1992-09-24 Koehler Chemie Dr Franz Wasserloesliche nicht ionische roentgenkontrastmittel sowie mittel und verfahren zu ihrer herstellung
IL110391A (en) * 1993-07-30 1998-12-06 Zambon Spa Process for the formation of infamidol
IT1274027B (it) * 1994-03-03 1997-07-14 Zambon Spa Processo per la preparazione e purificazione di mezzi di contrasto iodurati
GB9419203D0 (en) * 1994-09-23 1994-11-09 Nycomed Innovation Ab Contrast media
GB9419206D0 (en) * 1994-09-23 1994-11-09 Nycomed Innovation Ab Contrast media
IT1271134B (it) * 1994-12-01 1997-05-26 Bracco Spa Derivati iodurati del bifenile e loro impiego diagnostico
AU6516196A (en) * 1995-07-04 1997-02-05 Recordati S.A. A process for preparing iopamidol by using a c1-c5 monoalkylether of a c2-c10 alkylene-glycol
IT1277339B1 (it) * 1995-07-25 1997-11-10 Bracco Spa Processo per la produzione di agenti contrastografici iodurati
IT1303797B1 (it) * 1998-11-27 2001-02-23 Bracco Spa Processo per la preparazione di n,n'-bis(2,3-diidrossipropil)-5-((idrossiacetil)metilammino)-2,4,6-triiodo-1,3-benzendicarbossammide.
EP1186305A1 (en) * 2000-09-07 2002-03-13 Schering Aktiengesellschaft New brominated compounds as contrast media for X-ray mammography
WO2002034712A1 (fr) * 2000-10-27 2002-05-02 Takeda Chemical Industries, Ltd. Procede de preparation de composes aromatiques substitues et produits intermediaires associes
US8920780B2 (en) * 2007-07-12 2014-12-30 Ge Healthcare As Contrast agents
EP2093206A1 (en) 2008-02-20 2009-08-26 BRACCO IMAGING S.p.A. Process for the iodination of aromatic compounds
EP2243767A1 (en) 2009-04-21 2010-10-27 Bracco Imaging S.p.A Process for the iodination of aromatic compounds
PL2451994T3 (pl) 2009-07-07 2014-04-30 Bracco Imaging Spa Proces wytwarzania środka jodującego
EP2394984A1 (en) 2010-06-10 2011-12-14 Bracco Imaging S.p.A Process for the iodination of phenolic derivatives
CN107253918A (zh) * 2017-07-27 2017-10-17 成都丽璟科技有限公司 一种制备碘美普尔的新方法
KR102128423B1 (ko) * 2018-09-17 2020-07-01 (주)유케이케미팜 조영제 이오메프롤의 제조방법
WO2023209165A1 (en) 2022-04-29 2023-11-02 Bracco Imaging Spa Process for the preparation of 2,4,6-triiodophenol derivatives

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3701771A (en) * 1969-06-27 1972-10-31 Nyegaard & Co As N-(2,4,6-triiodobenzoyl)-sugar amines
US3660464A (en) * 1970-06-19 1972-05-02 Squibb & Sons Inc Tri-iodinated diaminobenzoic acid derivatives
BE787669A (fr) * 1971-08-17 1973-02-19 Schering Ag Anilides d'acide n-methyl-dicarboxylique triiodes, et leur procede de preparation
DD104193A5 (ja) * 1972-12-22 1974-03-05
CH583562A5 (ja) * 1973-07-17 1977-01-14 Bracco Ind Chimica Spa
US4065553A (en) * 1974-05-31 1977-12-27 Laboratoires Andre Guerbet X-Ray contrast media
CH608189A5 (ja) * 1974-12-13 1978-12-29 Savac Ag
US4321368A (en) * 1975-10-20 1982-03-23 Mallinckrodt, Inc. Glycosyl triidobenzoic acid derivatives
DE2629228C2 (de) * 1976-06-25 1984-10-18 Schering AG, 1000 Berlin und 4709 Bergkamen Jodierte Isophthalamsäure-Derivate Verfahren zu deren Herstellung sowie deren Verwendung
US4191775A (en) * 1977-12-15 1980-03-04 Imperial Chemical Industries Limited Amide derivatives
DE2852094A1 (de) * 1978-11-30 1980-06-12 Schering Ag Neue roentgenkontrastmittel
IT1193211B (it) * 1979-08-09 1988-06-15 Bracco Ind Chimica Spa Derivati dell'acido 2,4,6-triiodo-isoftalico,metodo per la loro preparazione e mezzi di contrasto che li contengono
IT1207226B (it) * 1979-08-09 1989-05-17 Bracco Ind Chimica Spa Derivati dell'acido 2,4,6-triiodo-isoftalico, metodo per la loro preparazione e mezzi di contrasto che li contengono.
DE3150916A1 (de) * 1981-12-18 1983-06-30 Schering Ag, 1000 Berlin Und 4619 Bergkamen N-hydroxyaethylierte 2,4,6-trijodaminoisiophthalsaeure-bis- trihydroxybutylamide, deren herstellung und diese enthaltende roentgenkontrastmittel"
US4396598A (en) * 1982-01-11 1983-08-02 Mallinckrodt, Inc. Triiodoisophthalamide X-ray contrast agent
FR2541272A1 (fr) * 1983-02-23 1984-08-24 Guerbet Sa Composes bromes et produits opacifiants en contenant
DE3429949A1 (de) * 1984-08-10 1986-02-20 Schering AG, 1000 Berlin und 4709 Bergkamen Neue nicht -ionische 2,4,6-trijod-isophthalsaeure-bis-amide, verfahren zu ihrer herstellung und ihre verwendung als roentgenkontrastmittel
US4567034A (en) * 1984-09-07 1986-01-28 E. R. Squibb & Sons, Inc. Esters of diatrizoic acid as X-ray contrast agents

Also Published As

Publication number Publication date
EP0365541A1 (en) 1990-05-02
CA1327600C (en) 1994-03-08
IL86450A0 (en) 1988-11-15
AU1797888A (en) 1988-12-21
DE3873766T2 (de) 1993-02-11
JP2585087B2 (ja) 1997-02-26
NZ224743A (en) 1991-07-26
AU618535B2 (en) 1992-01-02
ES2006951A6 (es) 1989-05-16
JPH02503556A (ja) 1990-10-25
US5066823A (en) 1991-11-19
IE63232B1 (en) 1995-04-05
KR890701547A (ko) 1989-12-20
KR960016747B1 (ko) 1996-12-20
ATE79368T1 (de) 1992-08-15
IE881518L (en) 1988-11-22
WO1988009328A1 (en) 1988-12-01
DE3873766D1 (de) 1992-09-17
EP0365541B1 (en) 1992-08-12

Similar Documents

Publication Publication Date Title
IL86450A (en) Process for making a history of 5-acylamino-2,4,6-triiodo and tribromo-benzoic acid, and some such new compounds
EP0582790B1 (en) Novel method of producing 7-(substituted)-9-[(substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
US5043152A (en) Novel iodinated non-ionic triiodobenzene compounds and contrast media containing them
AU654341B2 (en) New polyiodated compounds, method of preparation, contrast product containing them
US5191119A (en) Process for producing non-ionic radiographic contrast media utilizing N-allylation
US9096495B2 (en) Process for the preparation of triiodinated carboxylic aromatic derivatives
AU617810B2 (en) Novel iodinated non-ionic triiodobenzene compounds and contrast media containing them
CS277109B6 (en) Nonionic contrast means and process for preparing thereof
NO853953L (no) R¯ntgenkontrastmidler.
NO840688L (no) Roentgenkontrastmidler
CA2142986A1 (en) New polyiodinated compounds, process of preparation, and contrast agent containing them
NO180297B (no) Ikke-ioniske joderte forbindelser og kontrastmidler inneholdende de samme
DE4329727C2 (de) Verfahren zur Herstellung von Hydroxyalkylaminonitrobenzol-Derivaten
KR0157422B1 (ko) 6-(3-디메틸아미노프로피오닐)포르스콜린 제조방법
USRE30798E (en) Process for preparing nitro-p-phenylenediamines
US2551013A (en) Benzodioxan amino alcohols
IE891800L (en) Novel iodinated non-ionic triiodobenzene compounds and¹contrast media containing them
CS219314B2 (en) Method of making the n-/1-allyl-2-pyrrolidinylmethyl/-2-methoxy-4,5-azi,idobenzamide

Legal Events

Date Code Title Description
KB Patent renewed
KB Patent renewed
EXP Patent expired