IL82946A - 1-t-butyl-6-methylergoline-8-methanol derivatives,their preparation and pharmaceutical compositions containing them - Google Patents
1-t-butyl-6-methylergoline-8-methanol derivatives,their preparation and pharmaceutical compositions containing themInfo
- Publication number
- IL82946A IL82946A IL82946A IL8294687A IL82946A IL 82946 A IL82946 A IL 82946A IL 82946 A IL82946 A IL 82946A IL 8294687 A IL8294687 A IL 8294687A IL 82946 A IL82946 A IL 82946A
- Authority
- IL
- Israel
- Prior art keywords
- methylergoline
- hydrogen atom
- butyl
- preparation
- pharmaceutical compositions
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/02—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hydrocarbon or substituted hydrocarbon radicals, attached in position 8
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Liquid Developers In Electrophotography (AREA)
- Graft Or Block Polymers (AREA)
- Developing Agents For Electrophotography (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB868615471A GB8615471D0 (en) | 1986-06-25 | 1986-06-25 | T-butyl ergoline derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL82946A0 IL82946A0 (en) | 1987-12-20 |
| IL82946A true IL82946A (en) | 1991-04-15 |
Family
ID=10600059
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL82946A IL82946A (en) | 1986-06-25 | 1987-06-22 | 1-t-butyl-6-methylergoline-8-methanol derivatives,their preparation and pharmaceutical compositions containing them |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US4843073A (ko) |
| EP (1) | EP0251652B1 (ko) |
| JP (1) | JPH0745498B2 (ko) |
| KR (1) | KR950008970B1 (ko) |
| AT (1) | ATE76407T1 (ko) |
| AU (1) | AU597672B2 (ko) |
| CA (1) | CA1339533C (ko) |
| DE (1) | DE3779190D1 (ko) |
| DK (1) | DK170099B1 (ko) |
| ES (1) | ES2042567T3 (ko) |
| FI (1) | FI85702C (ko) |
| GB (1) | GB8615471D0 (ko) |
| GR (1) | GR3005115T3 (ko) |
| HU (1) | HU196201B (ko) |
| IE (1) | IE61319B1 (ko) |
| IL (1) | IL82946A (ko) |
| NZ (1) | NZ220543A (ko) |
| PT (1) | PT85152B (ko) |
| SU (1) | SU1547708A3 (ko) |
| ZA (1) | ZA874569B (ko) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61245164A (ja) * | 1985-04-23 | 1986-10-31 | Seiko Instr & Electronics Ltd | パタ−ン修正装置 |
| HU193782B (en) * | 1985-06-21 | 1987-11-30 | Richter Gedeon Vegyeszet | Process for producing 2-halogeno-nicergoline derivatives and acid additional salts thereof |
| US6060483A (en) * | 1996-06-27 | 2000-05-09 | Pharmacia & Upjohn S.P.A. | Antineurodegenerative ergoline derivatives |
| WO2014195849A2 (en) * | 2013-06-03 | 2014-12-11 | Mahesh Kandula | Compositions and methods for the treatment of cerebrovascular diseases |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3228941A (en) * | 1966-01-11 | Methyl and i,g-dimethyl-ergoline i derivatives | ||
| US3228942A (en) * | 1966-01-11 | Methyl and i,g-dimeti-iyl ergoline i compounds | ||
| US3228945A (en) * | 1966-01-11 | Methyl and i,g-dimethyl-b-(a-hydroxy- alkyl)-ergoline i derivatives | ||
| DE203721C (ko) * | 1908-05-05 | |||
| US3232942A (en) * | 1964-06-02 | 1966-02-01 | Sandoz Ltd | 1-substituted (+)-lysergol |
| US3879554A (en) * | 1970-03-20 | 1975-04-22 | Farmaceutici Italia | Use of 1,6-dimethyl-8-{62 -(5-bromonicotinoyloxymethyl)-10 {60 -methoxyergoline in treating cerebral and peripheral metabolic vascular disorders |
| USRE30218E (en) * | 1974-12-06 | 1980-02-19 | Eli Lilly And Company | 8,8-Disubstituted-6-methylergolines and related compounds |
| US3959288A (en) * | 1974-12-13 | 1976-05-25 | Eli Lilly And Company | 8-Oxymethylergolines and process therefor |
| US4199579A (en) * | 1975-03-14 | 1980-04-22 | Siphar S. A. | Carbamates of 2-haloergolines and 2-haloergolenes and process for the preparation thereof |
| DE2656344A1 (de) * | 1975-12-23 | 1977-07-07 | Sandoz Ag | Ergolinderivate, ihre verwendung und herstellung |
| IT1192260B (it) * | 1977-07-05 | 1988-03-31 | Simes | Derivati di ergoline-2-tioeteri e loro solfossidi |
| GB2056437A (en) * | 1979-08-07 | 1981-03-18 | Erba Farmitalia | Secoergoline derivatives |
| US4382940A (en) * | 1979-12-06 | 1983-05-10 | Farmitalia Carlo Erba S.P.A. | Ercoline derivatives and therapeutic compositions having CNS affecting activity |
| DE3403067A1 (de) * | 1984-01-30 | 1985-08-14 | Eckart Prof. Dr. 6500 Mainz Eich | Ergolin-derivate, verfahren zu ihrer herstellung, sie enthaltende arzneimittel und deren verwendung |
| IT1213206B (it) * | 1984-08-07 | 1989-12-14 | Inverni Della Beffa Spa | Procedimento per la preparazione di derivati del lisergolo. |
| GB8612366D0 (en) * | 1986-05-21 | 1986-06-25 | Erba Farmitalia | Ergoline esters |
| AU7914587A (en) * | 1987-08-24 | 1989-03-31 | Molecular Control Corporation | Liquid crystal micelles, display, having concentric spheres |
-
1986
- 1986-06-25 GB GB868615471A patent/GB8615471D0/en active Pending
-
1987
- 1987-06-03 NZ NZ220543A patent/NZ220543A/xx unknown
- 1987-06-22 FI FI872752A patent/FI85702C/fi not_active IP Right Cessation
- 1987-06-22 JP JP62155265A patent/JPH0745498B2/ja not_active Expired - Lifetime
- 1987-06-22 IE IE165287A patent/IE61319B1/en not_active IP Right Cessation
- 1987-06-22 IL IL82946A patent/IL82946A/xx not_active IP Right Cessation
- 1987-06-23 EP EP87305570A patent/EP0251652B1/en not_active Expired - Lifetime
- 1987-06-23 ES ES87305570T patent/ES2042567T3/es not_active Expired - Lifetime
- 1987-06-23 KR KR1019870006362A patent/KR950008970B1/ko not_active IP Right Cessation
- 1987-06-23 PT PT85152A patent/PT85152B/pt not_active IP Right Cessation
- 1987-06-23 CA CA000540338A patent/CA1339533C/en not_active Expired - Fee Related
- 1987-06-23 AU AU74632/87A patent/AU597672B2/en not_active Ceased
- 1987-06-23 AT AT87305570T patent/ATE76407T1/de not_active IP Right Cessation
- 1987-06-23 US US07/065,597 patent/US4843073A/en not_active Expired - Fee Related
- 1987-06-23 DE DE8787305570T patent/DE3779190D1/de not_active Expired - Fee Related
- 1987-06-24 SU SU874202786A patent/SU1547708A3/ru active
- 1987-06-24 HU HU872871A patent/HU196201B/hu not_active IP Right Cessation
- 1987-06-24 DK DK322587A patent/DK170099B1/da not_active IP Right Cessation
- 1987-06-24 ZA ZA874569A patent/ZA874569B/xx unknown
-
1989
- 1989-03-24 US US07/328,518 patent/US5079364A/en not_active Expired - Fee Related
-
1992
- 1992-07-08 GR GR920401458T patent/GR3005115T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IE61319B1 (en) | 1994-11-02 |
| EP0251652B1 (en) | 1992-05-20 |
| US5079364A (en) | 1992-01-07 |
| FI85702C (fi) | 1992-05-25 |
| NZ220543A (en) | 1989-06-28 |
| FI872752A (fi) | 1987-12-26 |
| SU1547708A3 (ru) | 1990-02-28 |
| ATE76407T1 (de) | 1992-06-15 |
| GB8615471D0 (en) | 1986-07-30 |
| KR950008970B1 (ko) | 1995-08-10 |
| ES2042567T3 (es) | 1993-12-16 |
| EP0251652A2 (en) | 1988-01-07 |
| GR3005115T3 (ko) | 1993-05-24 |
| DE3779190D1 (de) | 1992-06-25 |
| ZA874569B (en) | 1988-02-24 |
| IL82946A0 (en) | 1987-12-20 |
| DK322587D0 (da) | 1987-06-24 |
| IE871652L (en) | 1987-12-25 |
| CA1339533C (en) | 1997-11-11 |
| PT85152B (pt) | 1990-03-30 |
| HU196201B (en) | 1988-10-28 |
| AU597672B2 (en) | 1990-06-07 |
| FI85702B (fi) | 1992-02-14 |
| JPH0745498B2 (ja) | 1995-05-17 |
| HUT44543A (en) | 1988-03-28 |
| DK322587A (da) | 1987-12-26 |
| DK170099B1 (da) | 1995-05-22 |
| FI872752A0 (fi) | 1987-06-22 |
| AU7463287A (en) | 1988-01-07 |
| PT85152A (en) | 1987-07-01 |
| JPS6322577A (ja) | 1988-01-30 |
| KR880000429A (ko) | 1988-03-25 |
| EP0251652A3 (en) | 1989-04-05 |
| US4843073A (en) | 1989-06-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| KB | Patent renewed | ||
| MM9K | Patent not in force due to non-payment of renewal fees |