IL80267A0 - Alpha tocopherol-based vesicles - Google Patents

Alpha tocopherol-based vesicles

Info

Publication number
IL80267A0
IL80267A0 IL80267A IL8026786A IL80267A0 IL 80267 A0 IL80267 A0 IL 80267A0 IL 80267 A IL80267 A IL 80267A IL 8026786 A IL8026786 A IL 8026786A IL 80267 A0 IL80267 A0 IL 80267A0
Authority
IL
Israel
Prior art keywords
alpha tocopherol
based vesicles
optionally
filter unit
vesicles
Prior art date
Application number
IL80267A
Other languages
English (en)
Original Assignee
Liposome Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27120576&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL80267(A0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Liposome Co Inc filed Critical Liposome Co Inc
Publication of IL80267A0 publication Critical patent/IL80267A0/xx
Priority to IL101274A priority Critical patent/IL101274A0/xx

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/127Liposomes
    • A61K9/1277Processes for preparing; Proliposomes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/3533,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A61K31/355Tocopherols, e.g. vitamin E
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/127Liposomes
    • A61K9/1271Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A61K9/1272Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10Antimycotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/10Anthelmintics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00Chemistry: analytical and immunological testing
    • Y10S436/829Liposomes, e.g. encapsulation
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00Stock material or miscellaneous articles
    • Y10T428/29Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984Microcapsule with fluid core [includes liposome]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dispersion Chemistry (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Virology (AREA)
  • Transplantation (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IL80267A 1985-10-15 1986-10-09 Alpha tocopherol-based vesicles IL80267A0 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
IL101274A IL101274A0 (en) 1985-10-15 1992-03-18 Methods and apparatus for extruding liposomes

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US78674085A 1985-10-15 1985-10-15
US06/911,138 US4861580A (en) 1985-10-15 1986-09-24 Composition using salt form of organic acid derivative of alpha-tocopheral

Publications (1)

Publication Number Publication Date
IL80267A0 true IL80267A0 (en) 1987-01-30

Family

ID=27120576

Family Applications (1)

Application Number Title Priority Date Filing Date
IL80267A IL80267A0 (en) 1985-10-15 1986-10-09 Alpha tocopherol-based vesicles

Country Status (9)

Country Link
US (1) US4861580A (xx)
EP (2) EP0243446B1 (xx)
JP (1) JP2848583B2 (xx)
AT (2) ATE141156T1 (xx)
AU (1) AU6543786A (xx)
CA (1) CA1315678C (xx)
DE (2) DE3650556T2 (xx)
IL (1) IL80267A0 (xx)
WO (1) WO1987002219A1 (xx)

Families Citing this family (85)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX9203291A (es) * 1985-06-26 1992-08-01 Liposome Co Inc Metodo para acoplamiento de liposomas.
US5059421A (en) * 1985-07-26 1991-10-22 The Liposome Company, Inc. Preparation of targeted liposome systems of a defined size distribution
US5041278A (en) * 1985-10-15 1991-08-20 The Liposome Company, Inc. Alpha tocopherol-based vesicles
US6759057B1 (en) 1986-06-12 2004-07-06 The Liposome Company, Inc. Methods and compositions using liposome-encapsulated non-steroidal anti-inflammatory drugs
US5204112A (en) * 1986-06-16 1993-04-20 The Liposome Company, Inc. Induction of asymmetry in vesicles
US5252263A (en) * 1986-06-16 1993-10-12 The Liposome Company, Inc. Induction of asymmetry in vesicles
US5616334A (en) * 1987-03-05 1997-04-01 The Liposome Company, Inc. Low toxicity drug-lipid systems
US5154930A (en) * 1987-03-05 1992-10-13 The Liposome Company, Inc. Pharmacological agent-lipid solution preparation
MX9203808A (es) * 1987-03-05 1992-07-01 Liposome Co Inc Formulaciones de alto contenido de medicamento: lipido, de agentes liposomicos-antineoplasticos.
US6406713B1 (en) 1987-03-05 2002-06-18 The Liposome Company, Inc. Methods of preparing low-toxicity drug-lipid complexes
WO1988007850A1 (en) * 1987-04-16 1988-10-20 The Liposome Company, Inc. Liposome continuous size reduction method and apparatus
ATE109970T1 (de) * 1987-09-03 1994-09-15 Univ Georgia Res Found Cyclosporin-augenmittel.
CA1333360C (en) * 1987-10-19 1994-12-06 Andrew S. Janoff Tocopherol-based pharmaceutical systems
MX9203804A (es) * 1987-10-19 1992-07-01 Liposome Co Inc Sistemas farmaceuticos a base de tocoferol.
US5009819A (en) * 1987-11-12 1991-04-23 The Liposome Company, Inc. Taste moderating composition
US5948441A (en) * 1988-03-07 1999-09-07 The Liposome Company, Inc. Method for size separation of particles
US5049392A (en) * 1989-01-18 1991-09-17 The Liposome Company, Inc. Osmotically dependent vesicles
DK0382271T3 (da) * 1989-02-04 1995-05-01 Akzo Nobel Nv Tocoler som adjuvanser i vacciner
ES2089011T3 (es) * 1989-02-17 1996-10-01 Liposome Co Inc Excipiente lipidico de administracion nasal y aplicacion topica.
EP0472639A4 (en) * 1989-05-15 1992-07-01 The Liposome Company, Inc. Accumulation of drugs into liposomes by a proton gradient
FR2657526B1 (fr) * 1990-01-31 1994-10-28 Lvmh Rech Utilisation d'un phosphate d'alpha-tocopherol, ou de l'un de ses derives, pour la preparation de compositions cosmetiques, dermatologiques, ou pharmaceutiques; compositions ainsi obtenues.
NZ237084A (en) * 1990-02-12 1993-10-26 Lucky Ltd Composition for the prolonged release of somatotropin comprising the somatotropin, a tocopherol component, and an assistant delaying agent
US5525232A (en) * 1990-03-02 1996-06-11 The Liposome Company, Inc. Method for entrapment of cationic species in lemellar vesicles
IT1240354B (it) * 1990-03-30 1993-12-07 Poli Ind Chimica Spa Formulazioni liposomiali di farmaci antimicotici,antibatterici e/o antantiflogistici per applicazione locale e vaginale
ATE138803T1 (de) * 1990-07-31 1996-06-15 Liposome Co Inc Anhäufung von aminosäuren und peptiden in liposomen
US5346703A (en) 1990-08-07 1994-09-13 Mediventures, Inc. Body cavity drug delivery with thermo-irreversible polyoxyalkylene and ionic polysaccharide gels
CA2047969A1 (en) * 1990-08-17 1992-02-18 Thomas D. Madden Benzoporphyrin vesicles
US5091111A (en) * 1990-09-19 1992-02-25 S. C. Johnson & Son, Inc. Aqueous emulsion and aersol delivery system using same
US5145604A (en) * 1990-09-19 1992-09-08 S. C. Johnson & Son, Inc. Aqueous emulsion and aerosol delivery system using same
GB9111611D0 (en) * 1991-05-30 1991-07-24 Sandoz Ltd Liposomes
US5318780A (en) * 1991-10-30 1994-06-07 Mediventures Inc. Medical uses of in situ formed gels
EP0665756A1 (de) * 1992-10-16 1995-08-09 SACHSE, Andreas Verfahren und vorrichtung zur herstellung flüssiger, disperser systeme
KR940011013A (ko) * 1992-11-27 1994-06-20 최근선 서방성 소마트로핀 제제의 제조방법
CA2159596C (en) * 1993-04-02 2002-06-11 Royden Coe Method of producing liposomes
EP1118326A3 (en) * 1993-05-21 2002-07-31 The Liposome Company, Inc. Reduction of liposome-induced adverse physiological reactions
ES2154680T3 (es) 1993-07-08 2001-04-16 Liposome Co Inc Metodo para controlar el tamaño de los liposomas.
DE10199039I2 (de) * 1993-10-22 2008-08-07 Hexal Ag Ind 25 Pharmazeutische zusammensetzung mit cyclosporin a, einen vitamin e derivat und einen emulgator
US5716526A (en) * 1994-01-14 1998-02-10 The Liposome Company, Inc. Method of separating materials from liposomes or lipid complexes
US6051573A (en) * 1994-06-28 2000-04-18 Alcon Laboratories, Inc. Treatment of GLC1A glaucoma with non-steroidal glucocorticoid antagonists
HU215966B (hu) * 1994-11-21 1999-07-28 BIOGAL Gyógyszergyár Rt. Orálisan alkalmazható, ciklosporint tartalmazó, összetett emulzió-előkoncentrátum
US6696413B2 (en) 1995-06-16 2004-02-24 Hexal Ag Pharmaceutical preparation with cyclosporin A
JPH10508322A (ja) 1995-10-12 1998-08-18 スーパーゲン,インコーポレイティド 5βステロイドのリポソーム配合物
US5763423A (en) * 1996-01-04 1998-06-09 Clarion Pharmaeuticals Inc. Pharmaceutical compositions, novel uses, and novel form of tocopherylphosphocholine
US6139872A (en) * 1996-08-14 2000-10-31 Henkel Corporation Method of producing a vitamin product
US6022560A (en) * 1996-08-27 2000-02-08 Clarion Pharmaceuticals Inc. Pharmaceutical compositions, novel uses, and novel form of α-tocopherylphosphocholine
DE69732308T2 (de) * 1996-09-27 2005-06-02 Jagotec Ag Arzneistoffverabreichungssystem mit hyaluronsäure
KR19990071255A (ko) 1998-02-28 1999-09-15 성재갑 소마토트로핀과 비타민의 합제 조성물
US6228385B1 (en) 1999-03-15 2001-05-08 Kimberly-Clark Worldwide Inc. Liquid antimicrobial, skin moisturizing formulation
US7314637B1 (en) 1999-06-29 2008-01-01 Neopharm, Inc. Method of administering liposomal encapsulated taxane
US6146659A (en) * 1998-07-01 2000-11-14 Neopharm, Inc. Method of administering liposomal encapsulated taxane
US6203778B1 (en) * 1998-12-08 2001-03-20 The Regents Of The University Of California Particulate radiopaque contrast agent for diagnostic imaging and microvascular characterization
IL143604A0 (en) 1998-12-30 2002-04-21 Dexcel Ltd Dispersable concentrate for the delivery of cyclosporin
EP1169033A2 (en) * 1999-04-02 2002-01-09 Washington State University Research Foundation Enhanced tissue and subcellular delivery of vitamin e compounds
US7732404B2 (en) 1999-12-30 2010-06-08 Dexcel Ltd Pro-nanodispersion for the delivery of cyclosporin
FR2840614B1 (fr) 2002-06-07 2004-08-27 Flamel Tech Sa Polyaminoacides fonctionnalises par de l'alpha-tocopherol et leurs applications notamment therapeutiques
US20040115271A1 (en) * 2002-06-21 2004-06-17 Alex Sacharoff Hydration compositions for corneal pre-surgery treatment
US7718189B2 (en) 2002-10-29 2010-05-18 Transave, Inc. Sustained release of antiinfectives
BRPI0407096A (pt) * 2003-02-03 2006-01-24 Neopharm Inc Taxano encapsulado em lipossomo estável, estéril e filtrável e outros fármacos antineoplásicos
FR2855521B1 (fr) 2003-05-28 2005-08-05 Flamel Tech Sa Polyaminoacides fonctionnalises par au moins un groupement h ydrophobe et leurs applications notamment therapeutiques.
EP1547674A1 (en) * 2003-12-23 2005-06-29 MediGene Oncology GmbH Method for producing colloidal nanoparticles
US9107824B2 (en) 2005-11-08 2015-08-18 Insmed Incorporated Methods of treating cancer with high potency lipid-based platinum compound formulations administered intraperitoneally
CA2838111C (en) 2005-12-08 2016-01-19 Insmed Incorporated Lipid-based compositions of antiinfectives for treating pulmonary infections and methods of use thereof
US20070134277A1 (en) * 2005-12-09 2007-06-14 Children's Medical Center Corporation Pharmaceutical formulation for sulfur-containing drugs in liquid dosage forms
US9211286B2 (en) * 2006-09-12 2015-12-15 Curatek Pharmaceuticals Holding, Inc. Terconazole composition and method
US8258164B2 (en) * 2006-09-12 2012-09-04 Curatek Pharmaceuticals Holding, Inc. Nitroimidazole composition and method
US20100196455A1 (en) 2007-05-04 2010-08-05 Transave, Inc. Compositions of Multicationic Drugs for Reducing Interactions with Polyanionic Biomolecules and Methods of Use Thereof
US9333214B2 (en) 2007-05-07 2016-05-10 Insmed Incorporated Method for treating pulmonary disorders with liposomal amikacin formulations
US9114081B2 (en) 2007-05-07 2015-08-25 Insmed Incorporated Methods of treating pulmonary disorders with liposomal amikacin formulations
US9119783B2 (en) 2007-05-07 2015-09-01 Insmed Incorporated Method of treating pulmonary disorders with liposomal amikacin formulations
US20110076261A1 (en) * 2007-06-19 2011-03-31 Bhiku Patel Antifungal Drug Delivery System
US20110082118A1 (en) * 2007-06-19 2011-04-07 Bhiku Patel Onychomycosis Treatment Delivery System
WO2008156798A1 (en) * 2007-06-19 2008-12-24 Prugen, Inc. Drug combination for the treatment of skin disorders
FR2921259B1 (fr) * 2007-09-26 2015-02-13 Lvmh Rech Utilisation cosmetique du phosphate de tocopherol comme agent anti-vieillissement de la peau
KR102277921B1 (ko) 2012-05-21 2021-07-14 인스메드 인코포레이티드 폐 감염을 치료하기 위한 시스템
JP2015530387A (ja) 2012-09-04 2015-10-15 エライゾン ファーマシューティカルズ, エルエルシー 脂質複合体化シスプラチンによる肺癌の再発防止
EP3581186A1 (en) 2012-11-29 2019-12-18 Insmed Incorporated Stabilized vancomycin formulations
CA2922375C (en) 2013-09-06 2021-06-15 Research Development Foundation Alpha-tea salt forms: compositions and uses for treating disease
HUP1300621A2 (hu) 2013-10-31 2015-05-28 Richter Gedeon Nyrt Steril, tetszõleges részecskeméretû, liposzómák elõállítása zárt rendszerû folyamatos extrúzióval
PL3142643T3 (pl) 2014-05-15 2019-12-31 Insmed Incorporated Sposoby leczenia zakażeń płuc prątkami niegruźliczymi
CA2989884A1 (en) * 2015-07-09 2017-01-12 Insmed Incorporated Compositions and methods for treating lung diseases and lung injury
CN108136023B (zh) 2015-08-12 2021-07-27 北卡罗莱纳州立大学 血小板膜包覆的药物递送系统
WO2017204896A1 (en) * 2016-05-26 2017-11-30 Becton, Dickinson And Company Methods and devices for liposome preparation by centrifugation
EP3773505A4 (en) 2018-03-30 2021-12-22 Insmed Incorporated PROCESS FOR THE CONTINUOUS MANUFACTURING OF LIPOSOMAL MEDICINAL PRODUCTS
US10736847B2 (en) 2018-07-03 2020-08-11 Becton, Dickinson And Company Inverting device for liposome preparation by centrifugation
EP4312536A1 (en) 2021-04-01 2024-02-07 Vestaron Corporation Liposome formulations for pesticide delivery and methods for producing and using the same

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1173179A (en) * 1967-09-29 1969-12-03 Samuel Ruben Method of Producing Micro-Perforated Stainless Steel Sheets
US3136695A (en) * 1961-03-10 1964-06-09 Strong Cobb Arner Inc Anhydrous thixotropic gel sustained release therapeutic compositions and method of preparation
US3719690A (en) * 1969-11-13 1973-03-06 Eisai Co Ltd Basic amino-acid salts of tocopherylsuccinate
US3993754A (en) * 1974-10-09 1976-11-23 The United States Of America As Represented By The United States Energy Research And Development Administration Liposome-encapsulated actinomycin for cancer chemotherapy
US4086257A (en) * 1976-10-12 1978-04-25 Sears Barry D Phosphatidyl quaternary ammonium compounds
US4088576A (en) * 1976-12-13 1978-05-09 Mott Lambert H Method of manufacture of tubular inertial filter
CH624011A5 (xx) * 1977-08-05 1981-07-15 Battelle Memorial Institute
US4235871A (en) * 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
US4263428A (en) * 1978-03-24 1981-04-21 The Regents Of The University Of California Bis-anthracycline nucleic acid function inhibitors and improved method for administering the same
US4193983A (en) * 1978-05-16 1980-03-18 Syva Company Labeled liposome particle compositions and immunoassays therewith
FR2438481A1 (fr) * 1978-10-11 1980-05-09 Bugard Pierre Complexe lipoproteique normalisant l'efficacite de la vitamine e et des antioxydants de synthese
GR73668B (xx) * 1978-11-21 1984-03-28 Hoffmann La Roche
DE3000483A1 (de) * 1979-01-09 1980-07-17 Fuji Photo Film Co Ltd Mikrokapseln fuer immunologische bestimmungen
CA1173360A (en) * 1979-06-22 1984-08-28 Jurg Schrank Pharmaceutical preparations
EP0032578B1 (de) * 1980-01-16 1984-07-25 Hans Georg Prof. Dr. Weder Verfahren und Dialysiereinrichtung zur Herstellung von Bilayer-Vesikeln und Verwendung der Bilayer-Vesikel
US4376118A (en) * 1980-10-06 1983-03-08 Miles Laboratories, Inc. Stable nonaqueous solution of tetracycline salt
GR77320B (xx) * 1980-12-22 1984-09-11 Procter & Gamble
US4522803A (en) * 1983-02-04 1985-06-11 The Liposome Company, Inc. Stable plurilamellar vesicles, their preparation and use
WO1985000968A1 (en) * 1983-09-06 1985-03-14 Health Research, Inc. Liposome delivery method for decreasing the toxicity of an antitumor drug
US4721612A (en) * 1984-04-12 1988-01-26 The Liposome Company, Inc. Steroidal liposomes
US4891208A (en) * 1985-04-10 1990-01-02 The Liposome Company, Inc. Steroidal liposomes
US4665204A (en) * 1985-06-27 1987-05-12 Henkel Corporation Diester derivatives of tocopherol
JP2634047B2 (ja) * 1985-10-15 1997-07-23 ザ リポソ−ム カンパニ−,インコ−ポレイテツド アルファトコフェロールをベースとした小胞体
JP2894445B2 (ja) * 1997-02-12 1999-05-24 日本たばこ産業株式会社 Cetp活性阻害剤として有効な化合物

Also Published As

Publication number Publication date
DE3650556D1 (de) 1996-09-19
JP2848583B2 (ja) 1999-01-20
EP0243446B1 (en) 1995-04-19
EP0243446A4 (en) 1988-06-23
WO1987002219A1 (en) 1987-04-23
US4861580A (en) 1989-08-29
ATE141156T1 (de) 1996-08-15
EP0460720A2 (en) 1991-12-11
DE3650302D1 (de) 1995-05-24
EP0460720A3 (en) 1992-01-02
CA1315678C (en) 1993-04-06
DE3650302T2 (de) 1995-09-07
AU6543786A (en) 1987-05-05
EP0460720B1 (en) 1996-08-14
ATE121261T1 (de) 1995-05-15
EP0243446A1 (en) 1987-11-04
DE3650556T2 (de) 1997-02-13
JPH0834745A (ja) 1996-02-06

Similar Documents

Publication Publication Date Title
IL80267A0 (en) Alpha tocopherol-based vesicles
GB2197219B (en) Method of filtering
EP0130577A3 (en) Method for producing liposomes
EP0602980A3 (en) Process for perforating a borehole.
ZA841847B (en) Annular hole cutter
EP0248905A4 (en) PROCESS FOR PRODUCING A COLORED FILTER.
GB2172175B (en) Method for controlling ring network
PL260784A1 (en) The method of production of new hydroxy- and- alkoxypirimidine
EP0194524A3 (en) Winding method
GB8627947D0 (en) Bobbin changing method
GB8629511D0 (en) Filtering screens
EP0286685A4 (en) DISCHARGE MACHINING CONTROL PROCESS BY CUTTING WIRE.
GB8616702D0 (en) Filter assembly machine
PL266932A1 (en) The method of manufacture of new 1,4-benzodiasepine
EP0221755A3 (en) Process for producing polyamide
AU6738787A (en) Method for the assembly of polar-nonpolar-polar proteolipid membranes
GB2170535B (en) Annular safety assembly for an oil well
NZ215991A (en) Method of controlling wasps
AU580657B2 (en) Method of producing adiponitrile
IL68519A (en) Production of 3-phenylpyrrole derivatives,and novel 2,4-dichloro-3-phenylbutyraldehyde intermediates therefor
GB8611520D0 (en) Winding method
ZA86475B (en) Process for producing 1-substituted aryl-1,4-dihydro-4-oxonaphthyridine derivative,intermediates therefor and processes for producing the intermediates
CS275270B2 (en) Method of substituted 3-/n,n-dimethylamino/-6-x-7-y-8-z-2h-1-benzopyran-2-one compounds production
CS304788A1 (en) Method of selfcarrying air filtering choke production
CS279488A1 (en) Method of cyclohexane oxidation

Legal Events

Date Code Title Description
KB Patent renewed
EXP Patent expired