IL78963A0 - N-phenyl-1-piperazine carboxamidines and related compounds,their preparation and pharmaceutical compositions containing them - Google Patents

N-phenyl-1-piperazine carboxamidines and related compounds,their preparation and pharmaceutical compositions containing them

Info

Publication number
IL78963A0
IL78963A0 IL78963A IL7896386A IL78963A0 IL 78963 A0 IL78963 A0 IL 78963A0 IL 78963 A IL78963 A IL 78963A IL 7896386 A IL7896386 A IL 7896386A IL 78963 A0 IL78963 A0 IL 78963A0
Authority
IL
Israel
Prior art keywords
carboxamidines
piperazine
phenyl
preparation
pharmaceutical compositions
Prior art date
Application number
IL78963A
Other languages
English (en)
Original Assignee
Syntex Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntex Lab filed Critical Syntex Lab
Publication of IL78963A0 publication Critical patent/IL78963A0/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/215Radicals derived from nitrogen analogues of carbonic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/06Antiarrhythmics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IL78963A 1985-05-30 1986-05-29 N-phenyl-1-piperazine carboxamidines and related compounds,their preparation and pharmaceutical compositions containing them IL78963A0 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/739,393 US4713382A (en) 1985-05-30 1985-05-30 N-phenyl-4-phenyl-1-piperazinecarboxamidines and related compounds as antiarrhythmic agents

Publications (1)

Publication Number Publication Date
IL78963A0 true IL78963A0 (en) 1986-09-30

Family

ID=24972082

Family Applications (1)

Application Number Title Priority Date Filing Date
IL78963A IL78963A0 (en) 1985-05-30 1986-05-29 N-phenyl-1-piperazine carboxamidines and related compounds,their preparation and pharmaceutical compositions containing them

Country Status (16)

Country Link
US (1) US4713382A (fr)
EP (1) EP0204265A1 (fr)
JP (1) JPS61280486A (fr)
KR (1) KR860008999A (fr)
CN (1) CN86103798A (fr)
AU (1) AU5805086A (fr)
DD (1) DD247452A5 (fr)
DK (1) DK253586A (fr)
ES (1) ES8708132A1 (fr)
FI (1) FI862279A (fr)
GR (1) GR861370B (fr)
HU (1) HU195201B (fr)
IL (1) IL78963A0 (fr)
NO (1) NO862138L (fr)
PT (1) PT82675B (fr)
ZA (1) ZA864023B (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3040473B2 (ja) * 1991-08-14 2000-05-15 プロクター、エンド、ギャンブル、ファーマスーティカルズ、インコーポレーテッド 抗不整脈及び抗細動剤として有用な新規4−オキソ環式尿素類
AU2013292519B2 (en) * 2012-07-19 2017-12-07 Drexel University Sigma receptor ligands for modulating cellular protein homeostasis
US11117870B2 (en) 2017-11-01 2021-09-14 Drexel University Compounds, compositions, and methods for treating diseases

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA574981A (fr) * 1959-04-28 H. Brown Edwin Dispositif etanche et coussinet a pression de fluide pour pompe centrifuge
GB948766A (en) * 1959-10-20 1964-02-05 May & Baker Ltd Trifluoromethylphenylpiperazine derivatives
US3655667A (en) * 1968-04-04 1972-04-11 Smith Kline French Lab 1-(2-benzoylcyclopropylmethyl)-4-phenylpiperazines
PH12016A (en) * 1972-09-22 1978-10-06 Rorer Inc William H Amidinoureas
US3793322A (en) * 1972-12-15 1974-02-19 Usv Pharma Corp 1,4-disubstituted piperazines
US3976643A (en) * 1973-07-13 1976-08-24 William H. Rorer, Inc. Guanidines
US3961056A (en) * 1974-02-11 1976-06-01 The Upjohn Company Substituted morpholine guanidines for the treatment of arrhythmic conditions
GB1514907A (en) * 1975-05-30 1978-06-21 Rorer Inc William H Process for the preparation of substituted phenylguanidines and substituted phenylguanidines when thus prepared
US4211867A (en) * 1976-03-19 1980-07-08 Mcneil Laboratories, Incorporated Nitrogen heterocyclic carboximidamide compounds
US4138561A (en) * 1977-09-30 1979-02-06 Bristol-Myers Company Cyanocarboxamidines and quinazoline process
EP0005385B1 (fr) * 1978-04-27 1982-09-01 LAROCHE NAVARRON S.A. Société dite: Dérivés de la pipérazine méthanimine, leur procédé de préparation et leurs applications en thérapeutique
CH643549A5 (de) * 1979-08-25 1984-06-15 Merz & Co N-(trimethoxybenzyl)-n'-phenylpiperazine.
US4374835A (en) * 1980-01-31 1983-02-22 Laroche-Navarron, S.A. Piperazine derivatives of theophylline

Also Published As

Publication number Publication date
AU5805086A (en) 1986-12-04
FI862279A (fi) 1986-12-01
HUT41016A (en) 1987-03-30
EP0204265A1 (fr) 1986-12-10
DD247452A5 (de) 1987-07-08
DK253586A (da) 1986-12-01
FI862279A0 (fi) 1986-05-29
CN86103798A (zh) 1987-06-10
ES555440A0 (es) 1987-10-16
US4713382A (en) 1987-12-15
GR861370B (en) 1986-09-17
ES8708132A1 (es) 1987-10-16
NO862138L (no) 1986-12-01
PT82675B (en) 1987-09-29
ZA864023B (en) 1988-01-27
DK253586D0 (da) 1986-05-29
JPS61280486A (ja) 1986-12-11
PT82675A (en) 1986-06-01
HU195201B (en) 1988-04-28
KR860008999A (ko) 1986-12-19

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