IL75990A - Stable crystal modification of disodium 3-amino-1-hydroxypropane-1,1-diphosphonate,process for its manufacture and pharmaceutical compositions containing it - Google Patents

Stable crystal modification of disodium 3-amino-1-hydroxypropane-1,1-diphosphonate,process for its manufacture and pharmaceutical compositions containing it

Info

Publication number
IL75990A
IL75990A IL75990A IL7599085A IL75990A IL 75990 A IL75990 A IL 75990A IL 75990 A IL75990 A IL 75990A IL 7599085 A IL7599085 A IL 7599085A IL 75990 A IL75990 A IL 75990A
Authority
IL
Israel
Prior art keywords
diphosphonate
hydroxypropane
disodium
amino
manufacture
Prior art date
Application number
IL75990A
Other languages
English (en)
Original Assignee
Ciba Geigy Ag
Henkel Kgaa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=4263070&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL75990(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ciba Geigy Ag, Henkel Kgaa filed Critical Ciba Geigy Ag
Publication of IL75990A publication Critical patent/IL75990A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/16—Esters of thiophosphoric acids or thiophosphorous acids
    • C07F9/165—Esters of thiophosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Obesity (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IL75990A 1984-08-06 1985-08-01 Stable crystal modification of disodium 3-amino-1-hydroxypropane-1,1-diphosphonate,process for its manufacture and pharmaceutical compositions containing it IL75990A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH376884 1984-08-06

Publications (1)

Publication Number Publication Date
IL75990A true IL75990A (en) 1989-07-31

Family

ID=4263070

Family Applications (1)

Application Number Title Priority Date Filing Date
IL75990A IL75990A (en) 1984-08-06 1985-08-01 Stable crystal modification of disodium 3-amino-1-hydroxypropane-1,1-diphosphonate,process for its manufacture and pharmaceutical compositions containing it

Country Status (26)

Country Link
US (2) US4639338A (da)
EP (1) EP0177443B1 (da)
JP (1) JPS6143196A (da)
KR (1) KR940000817B1 (da)
AR (4) AR240832A1 (da)
AT (1) ATE47396T1 (da)
AU (1) AU591066B2 (da)
CA (1) CA1255694A (da)
CY (1) CY1570A (da)
DD (1) DD239597A5 (da)
DE (1) DE3573783D1 (da)
DK (1) DK167282B1 (da)
DO (1) DOP1990004769A (da)
ES (2) ES8701188A1 (da)
FI (1) FI79712C (da)
GR (1) GR851910B (da)
HK (1) HK42591A (da)
HU (1) HU193124B (da)
IE (1) IE58077B1 (da)
IL (1) IL75990A (da)
MX (1) MX9203373A (da)
NO (1) NO165401C (da)
PH (1) PH24854A (da)
PT (1) PT80916B (da)
SG (1) SG91390G (da)
ZA (1) ZA855892B (da)

Families Citing this family (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH664158A5 (fr) * 1984-07-18 1988-02-15 Symphar Sa Derives propylidenediphosphonates-1,3 substitues en position 2, leur procede de preparation et compositions pharmaceutiques les contenant.
DE3770982D1 (de) * 1986-04-24 1991-08-01 Fujisawa Pharmaceutical Co Diphosphonsaeure-verbindungen, verfahren zu deren herstellung und sie enthaltende arzneimittel.
US4963681A (en) * 1987-07-06 1990-10-16 Norwich Eaton Pharmaceuticals, Inc. Process for synthesis of aminomethylene phosphonoalkylphosphinates
IL86951A (en) * 1987-07-06 1996-07-23 Procter & Gamble Pharma Methylene phosphonoalkylphosphinates and pharmaceutical preparations containing them
IT1222734B (it) * 1987-09-25 1990-09-12 Scalvo S P A Formulaziopne farmaceutiche e forme di dosaggio per la somminaistarzione rettale di calcitonina
PH26923A (en) * 1989-03-08 1992-12-03 Ciba Geigy N-substituted amino alkanediphosphonic acids
US4922007A (en) * 1989-06-09 1990-05-01 Merck & Co., Inc. Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof
PH27186A (en) * 1989-09-07 1993-04-16 Ciba Geigy Ag Double-coated granules of disodium pamidronate
US5019651A (en) * 1990-06-20 1991-05-28 Merck & Co., Inc. Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid (ABP) or salts thereof
EP0541037A3 (en) * 1991-11-06 1997-02-26 Takeda Chemical Industries Ltd Squalene synthetase inhibitory composition and use thereof
US5270365A (en) * 1991-12-17 1993-12-14 Merck & Co., Inc. Prevention and treatment of periodontal disease with alendronate
TW237386B (da) 1992-04-15 1995-01-01 Ciba Geigy
US6406714B1 (en) 1992-12-02 2002-06-18 Merck & Co., Inc. Dry mix formulation for bisphosphonic acids
US5358941A (en) * 1992-12-02 1994-10-25 Merck & Co., Inc. Dry mix formulation for bisphosphonic acids with lactose
JP3266395B2 (ja) * 1993-11-24 2002-03-18 富士写真フイルム株式会社 有機薬品の晶析方法
US20010007863A1 (en) * 1998-06-18 2001-07-12 Merck & Co., Inc. Wet granulation formulation for bisphosphonic acids
TW390813B (en) * 1994-04-29 2000-05-21 Merck & Co Inc Wet granulation formulation for bisphosphonic acids
GB9408775D0 (en) * 1994-05-04 1994-06-22 Ciba Geigy Ag Use of certain methanebisphosphonic acid derivatives to prevent prothesis loosening and prothesis migration
DE19719680A1 (de) 1997-05-09 1998-11-19 Boehringer Mannheim Gmbh Verwendung von Diphosphonsäuren zur präventiven Behandlung von Spätfolgen bei Harnblasenerweiterung oder Harnblasenersatz
PT891979E (pt) * 1997-07-15 2005-02-28 Gador Sa Uma forma cristalina do mono-hidrato do sal monossodico do acido n,n-dimetil-3-amino-1-hidroxipropan-1,1-difosfonico e o procedimento para a sua preparacao
EP1702924A3 (en) * 1998-08-27 2007-07-18 Teva Pharmaceutical Industries Ltd Novel hydrate forms of alendronate sodium, processes for manufacture thereof, and pharmaceutical compositions thereof
DK1107974T3 (da) 1998-08-27 2006-10-30 Teva Pharma Nye hydratformer af alendronat natrium, processer til fremstilling deraf, og farmaceutiske sammensætninger deraf
EP0998933A1 (de) 1998-10-09 2000-05-10 Boehringer Mannheim Gmbh Verfahren zur Herstellung von bisphosphonathaltigen pharmazeutischen Zusammensetzungen zur oralen Applikation
EP0998932A1 (de) 1998-10-09 2000-05-10 Boehringer Mannheim Gmbh Feste pharmazeutische Darreichungsform enthaltend Diphosphonsäure oder deren Salze und Verfahren zu ihrer Herstellung
US6160165A (en) 1998-12-10 2000-12-12 Aesgen, Inc. Method for preparation of disodium pamidronate
AU764157B2 (en) * 1998-12-10 2003-08-14 Eisai Inc. Method for preparation of disodium pamidronate
US6794536B1 (en) 1998-12-10 2004-09-21 Aesqen, Inc. Method for preparation of disodium pamidronate
US6315566B1 (en) 1999-05-18 2001-11-13 3M Innovative Properties Company Dental materials
US6143919A (en) * 1999-05-18 2000-11-07 3M Innovative Properties Company Polymerizable acidic compounds and methods of preparation
US6963008B2 (en) * 1999-07-19 2005-11-08 Teva Pharmaceutical Industries Ltd. Hydrate forms of alendronate sodium, processes for manufacture thereof, and pharmaceutical compositions thereof
ES2153794B1 (es) * 1999-08-06 2001-10-16 Medichem Sa Procedimiento para la obtencion del acido 4-amino-1-hidroxibutiliden-1,1-bisfosfonico y de su sal monosodica trihidratada.
KR100343232B1 (ko) * 1999-12-10 2002-07-10 김재윤 결정성 파미드론산 이나트륨염 수화물과 그의 제조방법
US20040082545A1 (en) * 2000-09-18 2004-04-29 Handreck Gregory Paul Diphosphonate solutions
CA2431515C (en) * 2001-01-23 2008-01-22 Gador S.A. Composition comprising bisphosphonates for prevention and/or treatment of metabolic diseases of bones, process for preparing such composition, and use thereof
US6709674B2 (en) 2001-05-02 2004-03-23 Gensia Sicor Pharmaceuticals, Inc. Injectable pamidronate disodium
CA2347330C (en) * 2001-05-10 2002-03-12 Pharmaceutical Partners Of Canada Inc. Liquid injectable formulation of disodium pamidronate
ITMI20012751A1 (it) * 2001-12-21 2003-06-21 Lyogen Ltd Sale monosodico dell'acido pamidronico e procedimento per la sua preparazione
EP2172192A1 (en) * 2001-12-24 2010-04-07 Teva Pharmaceutical Industries Ltd. Dosage form with a core tablet of active ingredient sheathed in a compressed annular body of powder of granular material, and process and tooling for producing it
US20040052843A1 (en) * 2001-12-24 2004-03-18 Lerner E. Itzhak Controlled release dosage forms
EP2266590A3 (en) 2002-02-22 2011-04-20 Shire LLC Active agent delivery sytems and methods for protecting and administering active agents
US20040138180A1 (en) * 2002-10-03 2004-07-15 Barr Laboratories, Inc. Bisphosphonate composition and process for the preparation thereof
SI1596870T2 (sl) * 2002-12-20 2011-07-29 Hoffmann La Roche Formulacija z visokim odmerkom ibandronata
US20050119230A1 (en) * 2003-09-18 2005-06-02 Alexandra Glausch Pharmaceutical products comprising bisphosphonated
AU2003286309A1 (en) * 2003-12-04 2005-06-24 Mustafa Nevzat Ilac Sanayii A.S. Method for producing pure disodium pamidronate
WO2005115331A2 (en) 2004-05-24 2005-12-08 The Procter & Gamble Company Enteric solid oral dosage form of bisphosphonate containing a chelating agent
WO2006039721A2 (en) * 2004-10-08 2006-04-13 The Board Of Trustees Of The University Of Illinois Bisphosphonate compounds and methods for bone resorption diseases, cancer, bone pain, immune disorders, and infectious diseases
US8012949B2 (en) * 2004-10-08 2011-09-06 The Board Of Trustees Of The University Of Illinois Bisphosphonate compounds and methods with enhanced potency for multiple targets including FPPS, GGPPS, and DPPS
JP2009530414A (ja) * 2006-03-17 2009-08-27 ザ ボード オブ トラスティーズ オブ ザ ユニヴァーシティー オブ イリノイ ビスホスホネート化合物及び方法
US20100144679A1 (en) * 2007-03-21 2010-06-10 Duke University Medication kits and formulations for preventing, treating or reducing secondary fractures after previous fracture
JP2011517313A (ja) 2007-12-11 2011-06-02 ビアメト ファーマシューティカルズ，インク． 金属結合部分を標的化部分と組み合わせて使用する金属酵素阻害剤
PL2473172T3 (pl) 2009-09-01 2015-08-31 Univ Duke Kompozycje bisfosfonianowe i sposoby do leczenia niewydolności serca
FR2954320B1 (fr) 2009-12-17 2012-06-15 Cll Pharma Composition pharmaceutique orale suprabiodisponible contenant un acide biphosphonique ou un de ses sels
AU2011239935A1 (en) 2010-04-16 2012-11-08 Novartis Ag Methods and compositions for improving implant osseointegration
EP2780021A4 (en) 2011-11-16 2015-08-05 Univ Duke BISPHOSPHONATE COMPOSITIONS AND METHODS FOR TREATING AND / OR REDUCING HEART FAILURE
GB201200868D0 (en) 2012-01-19 2012-02-29 Depuy Int Ltd Bone filler composition
US11654152B2 (en) 2012-05-14 2023-05-23 Antecip Bioventures Ii Llc Compositions for oral administration of zoledronic acid or related compounds for treating disease
PT2849758T (pt) * 2012-05-14 2018-05-09 Antecip Bioventures Ii Llc Composições que compreendem o ácido zoledrónico ou compostos relacionados para o alívio da dor inflamatória e estados relacionados
KR101995432B1 (ko) * 2016-10-13 2019-07-02 엘지전자 주식회사 공기조화기 및 그 제어방법
EP3553067A1 (en) * 2018-04-10 2019-10-16 Abiogen Pharma S.p.A. Polymorph of sodium neridronate and preparation process thereof

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2130794C3 (de) * 1971-06-22 1974-07-11 Joh. A. Benckiser Gmbh, 6700 Ludwigshafen Verfahren zur Herstellung von l-Hydroxy-S-amino-propan-ljl-diphosphonsäure
DE2405254C2 (de) * 1974-02-04 1982-05-27 Henkel KGaA, 4000 Düsseldorf Verwendung von 3-Amino-1-Hydroxypropan-1, 1-diphosphonsäure oder ihrer wasserlöslichen Salze bei der Beeinflußung von Calciumstoffwechselstörungen im menschlichen oder tierischen Körper
US4134969A (en) * 1974-02-04 1979-01-16 Henkel Kommanditgesellschaft Auf Aktien (Henkel Kgaa) Method of treatment of calcium disorders using aminoalkane-diphosphonic acids
DE2534391C2 (de) * 1975-08-01 1983-01-13 Henkel KGaA, 4000 Düsseldorf 1-Hydroxy-3-aminoalkan-1,1-diphosphonsäuren
DE2553963A1 (de) * 1975-12-01 1977-06-08 Henkel & Cie Gmbh Pharmazeutische praeparate zur behandlung von stoerungen des calciumstoffwechsels
JPS5283957A (en) * 1975-12-01 1977-07-13 Henkel & Cie Gmbh Medicine for treating metabolic obstruction of calcium
SE7612534L (sv) * 1975-12-01 1977-06-02 Henkel & Cie Gmbh Forfarande for framstellning av farmaceutiska preparat for behandling av storningar i kalciumemnesomsettning
SE409706B (sv) * 1976-05-21 1979-09-03 Astra Pharma Prod Forfarande for framstellning av n,n-dimetyl-3-(4-bromfenyl)-3-3(3-pyridyl)-allylamin dihydroklorid monohydrat
DE2702631A1 (de) * 1977-01-22 1978-07-27 Henkel Kgaa Verfahren zur herstellung von 1-hydroxy-3-amino-propan-1,1-diphosphonsaeuren
DE2943498C2 (de) * 1979-10-27 1983-01-27 Henkel KGaA, 4000 Düsseldorf Verfahren zur Herstellung von 3-Amino-1-hydroxypropan-1,1-diphosphonsäure
DE3016289A1 (de) * 1980-04-28 1981-10-29 Henkel KGaA, 4000 Düsseldorf Verfahren zur herstellung von omega -amino-1-hydroxyalkyliden-1,1-bis-phosphonsaeuren
US4304734A (en) * 1980-10-16 1981-12-08 Vysoka Skola Chemicko-Technologicka 6-Amino-1-hydroxyhexylidene diphosphonic acid, salts and a process for production thereof
DE3151038A1 (de) * 1981-12-23 1983-07-28 Henkel KGaA, 4000 Düsseldorf Verfahren zur herstellung von 3-amino-1-hydroxypropan-1,1-diphosphonsaeure
US4446052A (en) * 1982-05-17 1984-05-01 The Procter & Gamble Company Aqueous gel containing tricalcium di(1-hydroxy-3-aminopropane-1,1-diphosphonate
CH664158A5 (fr) * 1984-07-18 1988-02-15 Symphar Sa Derives propylidenediphosphonates-1,3 substitues en position 2, leur procede de preparation et compositions pharmaceutiques les contenant.

Also Published As

Publication number Publication date
IE58077B1 (en) 1993-06-30
ATE47396T1 (de) 1989-11-15
ZA855892B (en) 1986-03-26
ES545899A0 (es) 1986-11-16
AR240832A1 (es) 1991-02-28
HU193124B (en) 1987-08-28
FI79712B (fi) 1989-10-31
CA1255694A (en) 1989-06-13
NO853087L (no) 1986-02-07
DE3573783D1 (en) 1989-11-23
FI79712C (fi) 1990-02-12
FI852986A0 (fi) 1985-08-02
AR244696A1 (es) 1993-11-30
EP0177443A1 (de) 1986-04-09
NO165401C (no) 1991-02-06
AR244697A1 (es) 1993-11-30
US4711880A (en) 1987-12-08
SG91390G (en) 1991-01-18
US4639338A (en) 1987-01-27
JPS6143196A (ja) 1986-03-01
KR860001821A (ko) 1986-03-22
DK167282B1 (da) 1993-10-04
MX9203373A (es) 1992-09-01
DK355485D0 (da) 1985-08-05
ES8701188A1 (es) 1986-11-16
IE851931L (en) 1986-02-06
NO165401B (no) 1990-10-29
PT80916B (pt) 1987-12-30
AR244698A1 (es) 1993-11-30
AU591066B2 (en) 1989-11-30
HK42591A (en) 1991-06-07
GR851910B (da) 1985-12-03
PT80916A (en) 1985-09-01
AU4577785A (en) 1986-02-13
CY1570A (en) 1991-12-20
JPH058717B2 (da) 1993-02-02
FI852986L (fi) 1986-02-07
ES555602A0 (es) 1987-07-01
DOP1990004769A (es) 1999-08-19
DD239597A5 (de) 1986-10-01
PH24854A (en) 1990-12-26
DK355485A (da) 1986-02-07
EP0177443B1 (de) 1989-10-18
AR240832A2 (es) 1991-02-28
KR940000817B1 (ko) 1994-02-02
ES8706707A1 (es) 1987-07-01
HUT38361A (en) 1986-05-28

Similar Documents

Publication Publication Date Title
IL75990A (en) Stable crystal modification of disodium 3-amino-1-hydroxypropane-1,1-diphosphonate,process for its manufacture and pharmaceutical compositions containing it
PT86366A (en) Process for the preparation of phosphinic acid derivatives and of pharmaceutical compositions containing the same
PT81746A (en) Process for the preparation of peptide-aldehydes and of pharmaceutical compositions containing them
HUT40453A (en) Process for producing 11-beta-phenyl-gonanes and pharmaceutical compositions containing them
HUT41772A (en) Process for producing /4-substituted-piperazinyl- and -homopiperazinyl/-pyridazines and pharmaceutical compositions containing them
PH24334A (en) Process for the preparation of a lyophilisate composition containing oxicam derivatives
PT82294A (en) Process for the preparation of arylethanolamine derivatives and of pharmaceutical compositions containing the same
GB2167746B (en) A process for the preparation of isosilybin-free silibinin and pharmaceutical compositions containing it
PT76523B (en) Process for preparing phenoxyalkylcarboxylic acid derivatives and of pharmaceutical compositions containing the same
PT81502A (en) Process for the preparation of cholecalciferol derivatives and of pharmaceutical compositions containing the same
PT80794A (en) Process for the preparation of novel isoindolinyl-alkyl-piperazines and of pharmaceutical compositions containing the same
PT81842B (en) Process for the manufacture of polycyclic and of pharmaceutical compositions containing the same
HUT38367A (en) Process for producing epoxy-steroides and pharmaceutical compositions containing them
PT79858B (en) Process for the preparation of azolyl-aryl-alcanol and pharmaceutical compositions therewith
PT75042B (en) Process for the preparation of apovincaminates and pharmaceutical compositions containing them
HUT39142A (en) Process for producing naphtyl-analogues of mevalolactone and derivatives and pharmaceutical compositions containing them
HUT41762A (en) Process for producing thieno-benzo-pyranes, -thiopyranes and naphtothiophenes and pharmaceutical compositions containing them
GB2081708B (en) Novel derivatives of (1-benzyl-1h-indazol-3-yl) oxyacetic acid and pharmaceutical composition containing it
PT80876A (en) Process for the preparation of phenyl nonatetraenoic acid deri-vatives and of pharmaceutical compositions containing the same
PT81083A (en) Process for the preparation of substituted 7-oxomitosanes and of pharmaceutical compositions containing the same
HUT39438A (en) Process for producing naphtoxazine derivatives and pharmaceutical compositions containing them
HUT37746A (en) Process for producing cycloalkane-indene-carboximide-amide derivatives and pharmaceutical compositions containing them
HUT37155A (en) Process for producing n-acylized 1-lakyl-amino-1-deoxy-ketoze derivatives and pharmaceutical compositions containing them
PT80799A (en) Aminoeburnanecarboxylic acid derivatives pharmaceutical compositions containing them and process for preparing same
PT80800A (en) Nitroapovincaminic acid derivatives pharmaceutical compositions containing them and process for preparing same

Legal Events

Date Code Title Description
KB Patent renewed
KB Patent renewed
EXP Patent expired