IL75549A - Long-chain alpha,omega dicarboxylic acids,their preparation and pharmaceutical compositions containing them - Google Patents

Long-chain alpha,omega dicarboxylic acids,their preparation and pharmaceutical compositions containing them

Info

Publication number
IL75549A
IL75549A IL75549A IL7554985A IL75549A IL 75549 A IL75549 A IL 75549A IL 75549 A IL75549 A IL 75549A IL 7554985 A IL7554985 A IL 7554985A IL 75549 A IL75549 A IL 75549A
Authority
IL
Israel
Prior art keywords
preparation
long
pharmaceutical compositions
compositions containing
dicarboxylic acids
Prior art date
Application number
IL75549A
Other languages
English (en)
Other versions
IL75549A0 (en
Original Assignee
Yissum Res Dev Co
Univ Jerusalem Hebrew
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yissum Res Dev Co, Univ Jerusalem Hebrew filed Critical Yissum Res Dev Co
Publication of IL75549A0 publication Critical patent/IL75549A0/xx
Publication of IL75549A publication Critical patent/IL75549A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
    • C07C57/42—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings having unsaturation outside the rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C55/00—Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms
    • C07C55/26—Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms containing rings other than aromatic rings
    • C07C55/28—Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms containing rings other than aromatic rings monocyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C55/00—Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms
    • C07C55/32—Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
    • C07C57/13—Dicarboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
    • C07C57/34—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings containing more than one carboxyl group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
    • C07C57/38—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/235—Saturated compounds containing more than one carboxyl group
    • C07C59/245—Saturated compounds containing more than one carboxyl group containing hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/235—Saturated compounds containing more than one carboxyl group
    • C07C59/305—Saturated compounds containing more than one carboxyl group containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/84—Unsaturated compounds containing keto groups containing six membered aromatic rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
IL75549A 1984-06-22 1985-06-18 Long-chain alpha,omega dicarboxylic acids,their preparation and pharmaceutical compositions containing them IL75549A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19843423166 DE3423166A1 (de) 1984-06-22 1984-06-22 Alpha-, omega-dicarbonsaeuren, verfahren zu ihrer herstellung und arzneimittel, die diese verbindungen enthalten

Publications (2)

Publication Number Publication Date
IL75549A0 IL75549A0 (en) 1985-10-31
IL75549A true IL75549A (en) 1989-03-31

Family

ID=6238954

Family Applications (1)

Application Number Title Priority Date Filing Date
IL75549A IL75549A (en) 1984-06-22 1985-06-18 Long-chain alpha,omega dicarboxylic acids,their preparation and pharmaceutical compositions containing them

Country Status (17)

Country Link
US (1) US4711896A (enExample)
EP (1) EP0185080B1 (enExample)
JP (1) JPH0780807B2 (enExample)
AU (1) AU4607185A (enExample)
CA (1) CA1262552A (enExample)
DD (1) DD240541A5 (enExample)
DE (2) DE3423166A1 (enExample)
DK (1) DK75986D0 (enExample)
ES (1) ES8604090A1 (enExample)
FI (1) FI860711A0 (enExample)
GR (1) GR851509B (enExample)
HU (1) HUT38892A (enExample)
IL (1) IL75549A (enExample)
NO (1) NO860661L (enExample)
PT (1) PT80681B (enExample)
WO (1) WO1986000298A1 (enExample)
ZA (1) ZA854684B (enExample)

Families Citing this family (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4876279A (en) * 1986-05-05 1989-10-24 Merck & Co., Inc. Antihypercholesterolemic compounds
US5602164A (en) * 1992-04-28 1997-02-11 Senyorina Ltd. Anti-obesity drugs
IL101708A (en) * 1992-04-28 1996-08-04 Senyorina Ltd Anti-fattening drugs comprising amino acid derivatives
TW322493B (enExample) * 1994-06-27 1997-12-11 Shell Int Research
US5648387A (en) * 1995-03-24 1997-07-15 Warner-Lambert Company Carboxyalkylethers, formulations, and treatment of vascular diseases
IL119971A (en) 1997-01-07 2003-02-12 Yissum Res Dev Co Pharmaceutical compositions containing dicarboxylic acids and derivatives thereof and some novel dicarboxylic acids
IL121165A0 (en) 1997-06-26 1997-11-20 Yissum Res Dev Co Pharmaceutical compositions containing carboxylic acids and derivatives thereof
US20020037876A1 (en) * 1998-06-25 2002-03-28 Yissum Research Development Company Of Hebrew University Of Jerusalem Carboxylic acids and derivatives thereof and pharmaceutical compositions containing them
ATE384035T1 (de) 1999-04-01 2008-02-15 Esperion Therapeutics Inc Ether-verbindungen, zusammensetzungen und ihre verwendung
WO2002030884A2 (en) 2000-10-11 2002-04-18 Esperion Therapeutics, Inc. Sulfide and disulfide compounds and compositions for cholesterol management and related uses
WO2002030860A2 (en) 2000-10-11 2002-04-18 Esperion Therapeutics, Inc. Ketone compounds and compositions for cholesterol management and related uses
EP1351916A2 (en) 2000-10-11 2003-10-15 Esperion Therapeutics Inc. Ether compounds and compositions for cholesterol management and related uses
US20040122091A1 (en) * 2000-10-11 2004-06-24 Esperion Therapeutics, Inc. Sulfoxide and bis-sulfoxide compounds and compositions for cholesterol management and related uses
MXPA03003024A (es) 2000-10-11 2003-07-14 Esperion Therapeutics Inc Compuestos de sulfoxido y bis-sulfoxido y composiciones para el control de colesterol y usos relacionados.
US7304093B2 (en) * 2000-10-11 2007-12-04 Esperion Therapeutics, Inc. Ketone compounds and compositions for cholesterol management and related uses
US20050020694A1 (en) * 2001-10-11 2005-01-27 Dasseux Jean-Louis Henri Sulfide and disulfide compounds and compositions for cholesterol management and related uses
US20040204502A1 (en) * 2001-10-11 2004-10-14 Dasseux Jean-Louis Henri Sulfoxide and bis-sulfoxide compounds and compositions for cholesterol management and related uses
US20040192771A1 (en) * 2001-10-11 2004-09-30 Dasseux Jean-Louis Henri Ether compounds and compositions for cholesterol management and related uses
JP2005522504A (ja) * 2002-04-10 2005-07-28 エスペリオン セラピューティクス，インコーポレイテッド パントラクトンおよびパントテン酸誘導体を含むアシル補酵素−ａのミミック、その組成物、ならびにコレステロール管理の方法および関連の使用
AU2003248786A1 (en) * 2002-07-03 2004-01-23 Esperion Therapeutics, Inc. Compositions comprising panthetine for the treatment of dyslipidemia
US20040048910A1 (en) * 2002-08-22 2004-03-11 Bove Susan Elizabeth Method of treating osteoarthritis
EP2404890B1 (en) 2003-01-23 2017-07-26 Esperion Therapeutics Inc. Hydroxyl compounds and compositions for cholesterol management and related uses
WO2005002557A1 (en) * 2003-07-03 2005-01-13 Warner-Lambert Company Llc Pharmaceutical compositions including an ether and selective cox-2 inhibitor and uses thereof
WO2005046662A2 (en) * 2003-11-07 2005-05-26 Jj Pharma, Inc. Hdl-boosting combination therapy complexes
US20050192347A1 (en) * 2003-12-23 2005-09-01 Dasseux Jean-Louis H. Urea and thiourea compounds and compositions for cholesterol management and related uses
WO2005068412A1 (en) * 2003-12-24 2005-07-28 Esperion Therapeutics, Inc. Ketone compounds and compositions for cholesterol management and related uses
KR20070015114A (ko) * 2003-12-30 2007-02-01 신드로멕스 리미티드 3,3,14,14 테트라메틸 헥사데칸 1,16 이산의 투여 방법
AU2005255011A1 (en) * 2004-06-09 2005-12-29 Avanir Pharmaceuticals Heterocyclic derivatives for treatment of hyperlipidemia and related diseases
TW200603795A (en) * 2004-06-09 2006-02-01 Avanir Pharmaceuticals Mediators of reverse cholesterol transport for the treatment of hypercholesterolemia
US20050277690A1 (en) * 2004-06-09 2005-12-15 Sircar Jagadish C Small molecules for treatment of hypercholesterolemia and related diseases
EP2332527A3 (en) * 2004-10-20 2011-11-16 Resverlogix Corp. Flavanoids and Isoflavanoids for the prevention and treatment of cardiovascular diseases
CN101365446B (zh) * 2005-07-29 2013-05-22 雷斯弗洛吉克斯公司 预防和治疗复杂疾病的药物组合物及其经由可植入医药装置的递送
NZ579355A (en) 2007-02-01 2012-03-30 Resverlogix Corp 2-(Aryl)-4-oxo-quinazoline derivatives
IL181577A0 (en) * 2007-02-26 2007-07-04 Jacob Bar Tana Combination therapy composition and methods for the treatment of cardiovascular disorders and immune-related disorders
WO2008147807A2 (en) 2007-05-23 2008-12-04 Amcol International Corporation Cholesterol-interacting layered phyllosilicates and methods of reducing hypercholesteremia in a mammal
SI2346837T1 (sl) 2008-06-26 2015-05-29 Resverlogix Corporation Postopki pripravljanja kinazolinonskih derivatov
NZ594332A (en) 2009-01-08 2013-09-27 Resverlogix Corp Compounds for the prevention and treatment of cardiovascular disease
CN105859639A (zh) 2009-03-18 2016-08-17 雷斯韦洛吉克斯公司 新的抗炎剂
JP5813626B2 (ja) 2009-04-22 2015-11-17 レスバーロジックス コーポレイション 新規抗炎症剤
MX2012002639A (es) 2009-09-03 2012-03-14 Pfizer Vaccines Llc Vacuna de pcsk9.
JP2013537240A (ja) 2010-09-20 2013-09-30 カリウス セラピューティクス エスエー 糖尿病および脂質異常症の処置のための方法および組成物
EP2680883B1 (en) 2011-03-02 2018-09-05 Pfizer Inc Pcsk9 vaccine
RU2640115C2 (ru) 2011-11-01 2017-12-26 Ресверлоджикс Корп. Фармацевтические композиции замещенных хиназолинонов
WO2013084237A1 (en) 2011-12-08 2013-06-13 Syndromex Ltd. Deuterated tetramethyl dioic acids, compositions comprising them and uses thereof
US9073878B2 (en) 2012-11-21 2015-07-07 Zenith Epigenetics Corp. Cyclic amines as bromodomain inhibitors
US9765039B2 (en) 2012-11-21 2017-09-19 Zenith Epigenetics Ltd. Biaryl derivatives as bromodomain inhibitors
CN105073744B (zh) 2012-12-21 2019-11-08 齐尼思表观遗传学有限公司 作为溴结构域抑制剂的新型杂环化合物
US10279019B2 (en) 2014-02-11 2019-05-07 Stc.Unm PCSK9 peptide vaccine conjugated to a Qbeta carrier and methods of using the same
SG11201707497UA (en) 2015-03-13 2017-10-30 Esperion Therapeutics Inc Fixed dose combinations and formulations comprising etc1002 and ezetimibe and methods of treating or reducing the risk of cardiovascular disease
EP3268007B1 (en) 2015-03-13 2022-11-09 Resverlogix Corp. Compositions and therapeutic methods for the treatment of complement-associated diseases
MA41793A (fr) 2015-03-16 2018-01-23 Esperion Therapeutics Inc Associations de doses fixes comprenant du etc1002 et une ou plusieurs statines permettant de traiter ou de réduire un risque cardiovasculaire
CN107118098B (zh) 2016-02-25 2020-07-14 中国科学院上海药物研究所 一类脂肪酸类化合物、其制备方法及其用途
US10512624B2 (en) 2016-11-30 2019-12-24 Syndromex Ltd. Long-chain amphipathic dicarboxylic acids for treatment of diabetes type-1
WO2020257571A1 (en) 2019-06-21 2020-12-24 Esperion Therapeutics, Inc. Methods of making bempedoic acid and compositions of the same
CA3143294C (en) 2019-07-26 2024-06-11 Espervita Therapeutics, Inc. Functionalized long-chain hydrocarbon mono- and di-carboxylic acids useful for the prevention or treatment of disease
TW202245804A (zh) 2021-01-25 2022-12-01 美商艾斯佩維他治療學公司 官能化長鏈烴單羧酸及二羧酸及其衍生物以及其於預防或治療疾病之用途
CA3209453A1 (en) * 2021-01-25 2022-07-28 Espervita Therapeutics, Inc. Functionalized long-chain hydrocarbon mono- and di-carboxylic acids and derivatives therof, and their use for the prevention or treatment of disease
CN115894220A (zh) * 2021-09-23 2023-04-04 中国科学院上海药物研究所 一类作用于acly的长链类化合物、其制备方法及其用途
CN115887435A (zh) * 2021-09-23 2023-04-04 博骥源（上海）生物医药有限公司 长链类化合物及其用途

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1210786B (de) * 1962-12-17 1966-02-17 Shell Int Research Verfahren zur Herstellung von p-Phenylen-bis (3, 3'-isovaleriansaeure) und 3-Phenylisovalerian-saeure
GB1556660A (en) * 1975-10-07 1979-11-28 Akzo Nv Di-carboxylic acid derivatives
IL64542A0 (en) * 1981-12-15 1982-03-31 Yissum Res Dev Co Long-chain alpha,omega-dicarboxylic acids and derivatives thereof and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
AU4607185A (en) 1986-01-24
FI860711A7 (fi) 1986-02-17
IL75549A0 (en) 1985-10-31
PT80681A (de) 1985-07-01
DD240541A5 (de) 1986-11-05
CA1262552A (en) 1989-10-31
JPS61502537A (ja) 1986-11-06
EP0185080B1 (de) 1989-11-08
DE3423166A1 (de) 1986-01-02
FI860711A0 (fi) 1986-02-17
DK75986A (da) 1986-02-18
GR851509B (enExample) 1985-06-25
ES8604090A1 (es) 1986-02-01
WO1986000298A1 (fr) 1986-01-16
PT80681B (de) 1987-05-08
ZA854684B (en) 1986-02-26
EP0185080A1 (enExample) 1986-06-25
US4711896A (en) 1987-12-08
DE3574130D1 (en) 1989-12-14
DK75986D0 (da) 1986-02-18
HUT38892A (en) 1986-07-28
ES544439A0 (es) 1986-02-01
NO860661L (no) 1986-02-21
JPH0780807B2 (ja) 1995-08-30

Similar Documents

Publication Publication Date Title
IL75549A (en) Long-chain alpha,omega dicarboxylic acids,their preparation and pharmaceutical compositions containing them
DE3272373D1 (en) Long-chain alpha, omega-dicarboxylic acids and derivatives thereof and pharmaceutical compositions containing them
IL78569A (en) Substituted carboxamido-benz-heterocyclyl-methyl-benzoic acids,process for their preparation and pharmaceutical compositions comprising them
IL74882A0 (en) Naphthyridine-,quinoline-and benzoxazine-carboxylic acids and derivatives thereof,their manufacture and pharmaceutical compositions containing them
IL79323A0 (en) Phenylethanolaminotetralines,their preparation and pharmaceutical compositions containing them
ZA878176B (en) Substituted alpha-amino acids,their preparation and pharmaceutical compositions containing them
NZ211822A (en) Phenethanolamine derivatives and pharmaceutical compositions
IL80933A (en) 1-cyclopropyl-7-piperazinoquinoline-(or naphthyridin)-4-one-3-carboxylic acids and pharmaceutical compositions containing them
IL75621A0 (en) Substituted benzamides,their preparation and pharmaceutical compositions containing them
IL88433A0 (en) Diarylstyrylquinoline diacids and pharmaceutical compositions containing them
NZ222345A (en) 4-amino-3-hydroxy-4-substituted butanoic acids and 5-amino-2,5-disubstituted-4-hydroxypentanoic acids and pharmaceutical compositions
GB2156818B (en) Substituted a-amino acids, their preparation and pharmaceutical compositions containing them
IL87800A0 (en) Dioxolane-2-carboxylic acids and pharmaceutical compositions comprising them
IL86244A0 (en) Substituted benzamides,their preparation and pharmaceutical compositions containing them
ZA877444B (en) Pharmaceutical compositions containing alpha-halogenated dicarboxylic acids
IL79469A0 (en) Substituted benzamides,their preparation and pharmaceutical compositions containing them
IL77849A0 (en) Aryldihydropyridinedicarboxylic acid ester derivatives,their preparation and pharmaceutical compositions containing them
IL79039A0 (en) 4-oxoquinolinesulfonamides,their preparation and pharmaceutical compositions containing them
IL76823A0 (en) 1,2,4-triazolo-carbamates,their preparation and pharmaceutical compositions containing them
NZ215753A (en) Phenethanolamine derivatives and pharmaceutical compositions
IL79181A0 (en) 3-(substituted)propenylaminothiazolylcephalosporanic acids and esters thereof,their preparation and pharmaceutical compositions containing them
IL84724A0 (en) Substituted aminomethyl-5,6,7,8-tetrahydronaphthyloxyacetic acids and esters and amides thereof,their preparation and pharmaceutical compositions containing them
IL80294A (en) Phenethanolamine derivatives,their preparation and pharmaceutical compositions containing them
IL80434A (en) 5-aryl-2,4-dialkyl-3h-1,2,4-triazole-3-thiones and antidepressant pharmaceutical compositions containing them
IL81010A0 (en) Substituted benzamides,their preparation and pharmaceutical compositions containing them

Legal Events

Date Code Title Description
KB Patent renewed
KB Patent renewed
EXP Patent expired