AU4607185A - Alpha-omega-dicarboxylic acids,process for their preparation and medicines composed thereof - Google Patents

Alpha-omega-dicarboxylic acids,process for their preparation and medicines composed thereof

Info

Publication number
AU4607185A
AU4607185A AU46071/85A AU4607185A AU4607185A AU 4607185 A AU4607185 A AU 4607185A AU 46071/85 A AU46071/85 A AU 46071/85A AU 4607185 A AU4607185 A AU 4607185A AU 4607185 A AU4607185 A AU 4607185A
Authority
AU
Australia
Prior art keywords
omega
alpha
preparation
dicarboxylic acids
medicines composed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU46071/85A
Other languages
English (en)
Inventor
Jacob Bar-Tana
Bernd Hagenbruch
Johannes Pill
Karlheinz Stegmeier
Ernst-Christian Witte
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Epis SA
Original Assignee
Epis SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Epis SA filed Critical Epis SA
Publication of AU4607185A publication Critical patent/AU4607185A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
    • C07C57/42—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings having unsaturation outside the rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C55/00—Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms
    • C07C55/26—Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms containing rings other than aromatic rings
    • C07C55/28—Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms containing rings other than aromatic rings monocyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C55/00—Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms
    • C07C55/32—Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
    • C07C57/13—Dicarboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
    • C07C57/34—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings containing more than one carboxyl group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
    • C07C57/38—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/235—Saturated compounds containing more than one carboxyl group
    • C07C59/245—Saturated compounds containing more than one carboxyl group containing hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/235—Saturated compounds containing more than one carboxyl group
    • C07C59/305—Saturated compounds containing more than one carboxyl group containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/84—Unsaturated compounds containing keto groups containing six membered aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Obesity (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AU46071/85A 1984-06-22 1985-06-15 Alpha-omega-dicarboxylic acids,process for their preparation and medicines composed thereof Abandoned AU4607185A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3423166 1984-06-22
DE19843423166 DE3423166A1 (de) 1984-06-22 1984-06-22 Alpha-, omega-dicarbonsaeuren, verfahren zu ihrer herstellung und arzneimittel, die diese verbindungen enthalten

Publications (1)

Publication Number Publication Date
AU4607185A true AU4607185A (en) 1986-01-24

Family

ID=6238954

Family Applications (1)

Application Number Title Priority Date Filing Date
AU46071/85A Abandoned AU4607185A (en) 1984-06-22 1985-06-15 Alpha-omega-dicarboxylic acids,process for their preparation and medicines composed thereof

Country Status (17)

Country Link
US (1) US4711896A (enExample)
EP (1) EP0185080B1 (enExample)
JP (1) JPH0780807B2 (enExample)
AU (1) AU4607185A (enExample)
CA (1) CA1262552A (enExample)
DD (1) DD240541A5 (enExample)
DE (2) DE3423166A1 (enExample)
DK (1) DK75986A (enExample)
ES (1) ES8604090A1 (enExample)
FI (1) FI860711A0 (enExample)
GR (1) GR851509B (enExample)
HU (1) HUT38892A (enExample)
IL (1) IL75549A (enExample)
NO (1) NO860661L (enExample)
PT (1) PT80681B (enExample)
WO (1) WO1986000298A1 (enExample)
ZA (1) ZA854684B (enExample)

Families Citing this family (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4876279A (en) * 1986-05-05 1989-10-24 Merck & Co., Inc. Antihypercholesterolemic compounds
US5602164A (en) * 1992-04-28 1997-02-11 Senyorina Ltd. Anti-obesity drugs
IL101708A (en) * 1992-04-28 1996-08-04 Senyorina Ltd Anti-fattening drugs comprising amino acid derivatives
TW322493B (enExample) * 1994-06-27 1997-12-11 Shell Int Research
US5648387A (en) * 1995-03-24 1997-07-15 Warner-Lambert Company Carboxyalkylethers, formulations, and treatment of vascular diseases
IL119971A (en) * 1997-01-07 2003-02-12 Yissum Res Dev Co Pharmaceutical compositions containing dicarboxylic acids and derivatives thereof and some novel dicarboxylic acids
US20020037876A1 (en) * 1998-06-25 2002-03-28 Yissum Research Development Company Of Hebrew University Of Jerusalem Carboxylic acids and derivatives thereof and pharmaceutical compositions containing them
IL121165A0 (en) 1997-06-26 1997-11-20 Yissum Res Dev Co Pharmaceutical compositions containing carboxylic acids and derivatives thereof
ATE384035T1 (de) 1999-04-01 2008-02-15 Esperion Therapeutics Inc Ether-verbindungen, zusammensetzungen und ihre verwendung
US6703422B2 (en) 2000-10-11 2004-03-09 Esperion Therapeutics, Inc. Sulfide and disulfide compounds and compositions for cholesterol management and related uses
IL155213A0 (en) 2000-10-11 2003-11-23 Esperion Therapeutics Inc Ketone compounds and compositions for cholesterol management and related uses
US20040122091A1 (en) * 2000-10-11 2004-06-24 Esperion Therapeutics, Inc. Sulfoxide and bis-sulfoxide compounds and compositions for cholesterol management and related uses
MXPA03003021A (es) 2000-10-11 2003-07-14 Esperion Therapeutics Inc Compuestos de eter y composiciones para el control del colesterol y usos relacionados.
US7304093B2 (en) * 2000-10-11 2007-12-04 Esperion Therapeutics, Inc. Ketone compounds and compositions for cholesterol management and related uses
IL155246A0 (en) 2000-10-11 2003-11-23 Esperion Therapeutics Inc Sulfoxide and bis-sulfoxide compounds and compositions for cholesterol management and related uses
US20040204502A1 (en) * 2001-10-11 2004-10-14 Dasseux Jean-Louis Henri Sulfoxide and bis-sulfoxide compounds and compositions for cholesterol management and related uses
US20040192771A1 (en) * 2001-10-11 2004-09-30 Dasseux Jean-Louis Henri Ether compounds and compositions for cholesterol management and related uses
US20050020694A1 (en) * 2001-10-11 2005-01-27 Dasseux Jean-Louis Henri Sulfide and disulfide compounds and compositions for cholesterol management and related uses
US20030236212A1 (en) * 2002-04-10 2003-12-25 Jean-Louis Dasseux Functionalized long chain derivatives as acyl coenzyme-A mimics, compositions thereof, and methods of cholesterol management and related uses
BR0312426A (pt) * 2002-07-03 2005-12-06 Esperion Therapeutics Inc Composição farmacêutica, métodos para tratar, prevenir ou controlar um colesterol, dislipidemia ou distúrbio relacionado, para reduzir ou evitar um efeito adverso associado com monoterapia de pantetina e para reduzir ou evitar um efeito adverso associado com monoterapia de segundo agente ativo, e, kit
US20040048910A1 (en) * 2002-08-22 2004-03-11 Bove Susan Elizabeth Method of treating osteoarthritis
DK2404890T3 (en) 2003-01-23 2017-10-16 Esperion Therapeutics Inc Hydroxyl compounds and compositions for controlling cholesterol and related uses
WO2005002557A1 (en) * 2003-07-03 2005-01-13 Warner-Lambert Company Llc Pharmaceutical compositions including an ether and selective cox-2 inhibitor and uses thereof
JP4839221B2 (ja) * 2003-11-07 2011-12-21 ジェイ ジェイ ファーマ，インコーポレイテッド Ｈｄｌを高める併用療法用複合物
US20050192347A1 (en) * 2003-12-23 2005-09-01 Dasseux Jean-Louis H. Urea and thiourea compounds and compositions for cholesterol management and related uses
US7705177B2 (en) 2003-12-24 2010-04-27 Esperion Therapuetics, Inc. Ketone compounds and compositions for cholesterol management and related uses
KR20070015114A (ko) * 2003-12-30 2007-02-01 신드로멕스 리미티드 3,3,14,14 테트라메틸 헥사데칸 1,16 이산의 투여 방법
UY28952A1 (es) * 2004-06-09 2006-01-31 Avanir Pharmaceuticals Mediadores del transporte inverso de colesterol para el tratamiento de la hipercolesterolemia
RU2006146479A (ru) * 2004-06-09 2008-07-20 Аванир Фармасьютикалс (Us) Небольшие молекулярные медиаторы для лечения гиперхолестеринемии и связанных заболеваний
US20060009487A1 (en) * 2004-06-09 2006-01-12 Sircar Jagadish C Heterocyclic derivatives for treatment of hyperlipidemia and related diseases
US7846915B2 (en) * 2004-10-20 2010-12-07 Resverlogix Corporation Stilbenes and chalcones for the prevention and treatment of cardiovascular diseases
NZ566180A (en) * 2005-07-29 2011-04-29 Resverlogix Corp Pharmaceutical compositions for the prevention and treatment of complex diseases and their delivery by insertable medical devices
MX2009008099A (es) * 2007-02-01 2009-12-14 Resverlogix Corp Compuestos para la prevencion y tratamiento de enfermedades cardiovasculares.
IL181577A0 (en) * 2007-02-26 2007-07-04 Jacob Bar Tana Combination therapy composition and methods for the treatment of cardiovascular disorders and immune-related disorders
ATE530178T1 (de) 2007-05-23 2011-11-15 Amcol International Corp Mit cholesterin interagierende phyllosilikate und verfahren zur reduktion von hypercholesterinämie bei einem säuger
JP5602728B2 (ja) 2008-06-26 2014-10-08 レスバーロジックス コーポレイション キナゾリノン誘導体の製造方法
EP2382194B1 (en) 2009-01-08 2014-03-12 Resverlogix Corp. Compounds for the prevention and treatment of cardiovascular disease
NZ595747A (en) 2009-03-18 2015-06-26 Resverlogix Corp Novel quinazolinones and related compounds for use as anti-inflammatory agents
EP2421533B1 (en) 2009-04-22 2018-10-17 Resverlogix Corp. Novel anti-inflammatory agents
SI2473605T1 (en) 2009-09-03 2018-06-29 Pfizer Vaccines Llc CEPIVO PCSK9
JP2013537240A (ja) 2010-09-20 2013-09-30 カリウス セラピューティクス エスエー 糖尿病および脂質異常症の処置のための方法および組成物
WO2012131504A1 (en) 2011-03-02 2012-10-04 Pfizer Inc. Pcsk9 vaccine
LT2773354T (lt) 2011-11-01 2019-08-12 Resverlogix Corp. Geriamosios greitai atsipalaiduojančios pakeistų chinozolinų vaisto formos
US10479752B2 (en) 2011-12-08 2019-11-19 Syndromex Ltd. Deuterated tetramethyl dioic acids, compositions comprising them and uses thereof
WO2014080291A2 (en) 2012-11-21 2014-05-30 Rvx Therapeutics Inc. Biaryl derivatives as bromodomain inhibitors
US9073878B2 (en) 2012-11-21 2015-07-07 Zenith Epigenetics Corp. Cyclic amines as bromodomain inhibitors
MX2015007921A (es) 2012-12-21 2016-03-03 Zenith Epigenetics Corp Compuestos heterociclicos novedosos como inhibidores de bromodominio.
US10279019B2 (en) 2014-02-11 2019-05-07 Stc.Unm PCSK9 peptide vaccine conjugated to a Qbeta carrier and methods of using the same
EP3268007B1 (en) 2015-03-13 2022-11-09 Resverlogix Corp. Compositions and therapeutic methods for the treatment of complement-associated diseases
SG10201908500UA (en) 2015-03-13 2019-11-28 Esperion Therapeutics Inc Fixed dose combinations and formulations comprising etc1002 and ezetimibe and methods of treating or reducing the risk of cardiovascular disease
MA41793A (fr) 2015-03-16 2018-01-23 Esperion Therapeutics Inc Associations de doses fixes comprenant du etc1002 et une ou plusieurs statines permettant de traiter ou de réduire un risque cardiovasculaire
CN107118098B (zh) 2016-02-25 2020-07-14 中国科学院上海药物研究所 一类脂肪酸类化合物、其制备方法及其用途
US10512624B2 (en) 2016-11-30 2019-12-24 Syndromex Ltd. Long-chain amphipathic dicarboxylic acids for treatment of diabetes type-1
AU2020296094B2 (en) 2019-06-21 2025-02-06 Esperion Therapeutics, Inc. Methods of making bempedoic acid and compositions of the same
MX2022000570A (es) * 2019-07-26 2022-03-11 Espervita Therapeutics Inc Acidos mono- y dicarboxilicos hidrocarbonados de cadena larga funcionalizados y su uso para la prevencion o el tratamiento de enfermedad.
KR20230152007A (ko) 2021-01-25 2023-11-02 에스퍼비타 테라퓨틱스, 인크. 작용화된 장쇄 카복실산, 및 질환의 치료를 위한 이의 용도
US11730712B2 (en) 2021-01-25 2023-08-22 Espervita Therapeutics, Inc. Functionalized long-chain hydrocarbon mono- and di-carboxylic acids and derivatives thereof, and their use for the prevention or treatment of disease
CN115887435A (zh) * 2021-09-23 2023-04-04 博骥源（上海）生物医药有限公司 长链类化合物及其用途
CN115894220A (zh) * 2021-09-23 2023-04-04 中国科学院上海药物研究所 一类作用于acly的长链类化合物、其制备方法及其用途

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1210786B (de) * 1962-12-17 1966-02-17 Shell Int Research Verfahren zur Herstellung von p-Phenylen-bis (3, 3'-isovaleriansaeure) und 3-Phenylisovalerian-saeure
GB1556660A (en) * 1975-10-07 1979-11-28 Akzo Nv Di-carboxylic acid derivatives
IL64542A0 (en) * 1981-12-15 1982-03-31 Yissum Res Dev Co Long-chain alpha,omega-dicarboxylic acids and derivatives thereof and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
EP0185080A1 (enExample) 1986-06-25
US4711896A (en) 1987-12-08
DK75986D0 (da) 1986-02-18
FI860711A7 (fi) 1986-02-17
DD240541A5 (de) 1986-11-05
GR851509B (enExample) 1985-06-25
IL75549A (en) 1989-03-31
DE3423166A1 (de) 1986-01-02
PT80681A (de) 1985-07-01
WO1986000298A1 (fr) 1986-01-16
ES544439A0 (es) 1986-02-01
JPH0780807B2 (ja) 1995-08-30
NO860661L (no) 1986-02-21
IL75549A0 (en) 1985-10-31
DK75986A (da) 1986-02-18
ZA854684B (en) 1986-02-26
FI860711A0 (fi) 1986-02-17
JPS61502537A (ja) 1986-11-06
PT80681B (de) 1987-05-08
EP0185080B1 (de) 1989-11-08
CA1262552A (en) 1989-10-31
DE3574130D1 (en) 1989-12-14
ES8604090A1 (es) 1986-02-01
HUT38892A (en) 1986-07-28

Similar Documents

Publication Publication Date Title
AU4607185A (en) Alpha-omega-dicarboxylic acids,process for their preparation and medicines composed thereof
AU578703B2 (en) Dialkoxypyridines, process for their preparation, their use and medicaments containing them
IL78569A (en) Substituted carboxamido-benz-heterocyclyl-methyl-benzoic acids,process for their preparation and pharmaceutical compositions comprising them
AU585561B2 (en) New peptide-aldehydes, process for the preparation thereof and pharmaceutical compositions containing the same
AU1252088A (en) Pharmaceutical composition, pharmaceutical granulate and process for their preparation
AU5988986A (en) Phenylethanolaminoeteralines, a process for their preparation and pharmaceutical compositions containing them
AU585209B2 (en) Pleuromutilin derivatives, processes for their preparation and their uses
AU7171787A (en) 1-hydroxy-2-pyridones, a process for their preparation, and medicaments which contain them, and intermediates formed in the preparation of the 1-hydroxy-2-pyridones
AU587648B2 (en) Process for the preparation of (2,2)- paracyclophane
AU587841B2 (en) Poly-4-aminopyrrole-2-carboxamido derivatives and process for their preparation
AU3088489A (en) Phenoxyalkylcarboxylic acid derivatives and process for their preparation
AU5095885A (en) Pharmaceutical preparations
AU1902488A (en) New preparation process
AU584337B2 (en) Novel lactones, process for their preparation and the use thereof in pest control
AU7807781A (en) Pharmaceutical product and preparation method thereof
AU580311B2 (en) Dihydroorotic acid derivative and processes for preparing the same
AU584547B2 (en) Pharmaceutical `` -aminoalkyl- `` -alkylphenylacetonitriles
CS382191A3 (en) Benzoxazol- and benzothiazolamine derivatives, process of their preparation and pharmaceuticals based thereon
AR242193A1 (es) Procedimiento para la preparacion de 4-/4,5-dihidro-2-imidazolil(o 2-oxazolil o 2-tiazolil)7-amino-5(o 3,5)-halogeno benzamida e intermediarios de sintesis utilizados segun dicho procedimiento.
AU7812287A (en) Bromofluoroethylhypofluorite and process for its preparation
ZA854519B (en) 5,6-dihydro-4h-cyclopenta(b)thiophene-6-carboxylic acids preparation processes and medicines containing them
DE3561058D1 (en) Hydroxy-thia-alcanes, process for their preparation and their uses
ZA856735B (en) Novel pseudooligosaccharides with an alpha-glucosidase-inhibiting action,a process for their preparation,their use and pharmaceutical products
AU579734B2 (en) New process for making polyesters, polyamides and poliketones
AU581499B2 (en) Novel ketosultams and process for their preparation