IL69126A0 - Digoxigenin immunogens,antibodies,labeled conjugates,and related derivatives - Google Patents
Digoxigenin immunogens,antibodies,labeled conjugates,and related derivativesInfo
- Publication number
- IL69126A0 IL69126A0 IL69126A IL6912683A IL69126A0 IL 69126 A0 IL69126 A0 IL 69126A0 IL 69126 A IL69126 A IL 69126A IL 6912683 A IL6912683 A IL 6912683A IL 69126 A0 IL69126 A0 IL 69126A0
- Authority
- IL
- Israel
- Prior art keywords
- antibodies
- related derivatives
- labeled conjugates
- digoxigenin
- immunogens
- Prior art date
Links
- SHIBSTMRCDJXLN-UHFFFAOYSA-N Digoxigenin Natural products C1CC(C2C(C3(C)CCC(O)CC3CC2)CC2O)(O)C2(C)C1C1=CC(=O)OC1 SHIBSTMRCDJXLN-UHFFFAOYSA-N 0.000 title 1
- QONQRTHLHBTMGP-UHFFFAOYSA-N digitoxigenin Natural products CC12CCC(C3(CCC(O)CC3CC3)C)C3C11OC1CC2C1=CC(=O)OC1 QONQRTHLHBTMGP-UHFFFAOYSA-N 0.000 title 1
- SHIBSTMRCDJXLN-KCZCNTNESA-N digoxigenin Chemical compound C1([C@@H]2[C@@]3([C@@](CC2)(O)[C@H]2[C@@H]([C@@]4(C)CC[C@H](O)C[C@H]4CC2)C[C@H]3O)C)=CC(=O)OC1 SHIBSTMRCDJXLN-KCZCNTNESA-N 0.000 title 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
- G01N33/9453—Cardioregulators, e.g. antihypotensives, antiarrhythmics
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/80—Fluorescent dyes, e.g. rhodamine
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/815—Test for named compound or class of compounds
- Y10S436/817—Steroids or hormones
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/806—Antigenic peptides or proteins
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Cell Biology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Physics & Mathematics (AREA)
- Microbiology (AREA)
- Organic Chemistry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/422,217 US4469797A (en) | 1982-09-23 | 1982-09-23 | Digoxigenin immunogens, antibodies, labeled conjugates, and related derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL69126A0 true IL69126A0 (en) | 1983-10-31 |
Family
ID=23673888
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL69126A IL69126A0 (en) | 1982-09-23 | 1983-06-30 | Digoxigenin immunogens,antibodies,labeled conjugates,and related derivatives |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US4469797A (cs) |
| EP (1) | EP0104527B1 (cs) |
| JP (1) | JPS5983056A (cs) |
| AU (1) | AU541321B2 (cs) |
| CA (1) | CA1213579A (cs) |
| DE (1) | DE3369887D1 (cs) |
| ES (1) | ES8601478A1 (cs) |
| IL (1) | IL69126A0 (cs) |
Families Citing this family (75)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2551758B1 (fr) * | 1983-08-16 | 1986-01-31 | Anvar | Derives de muramyl-peptides et de steroides ayant des proprietes d'activation des macrophages |
| US4650771A (en) * | 1983-11-04 | 1987-03-17 | Miles Laboratories, Inc. | Immunogens, antibodies, labeled conjugates, and related derivatives for lidocaine and analogs thereof |
| US4595656A (en) * | 1984-01-06 | 1986-06-17 | Becton Dickinson & Company | Coupling agents and products produced therefrom |
| US4654311A (en) * | 1984-06-15 | 1987-03-31 | Syntex (U.S.A.) Inc. | Serum pretreatment for digoxin assay |
| US4767720A (en) * | 1985-08-29 | 1988-08-30 | Hsc Research Development Corporation | Antidigoxin antibodies |
| US5013720A (en) * | 1986-05-06 | 1991-05-07 | Abbott Laboratories | SAP-6-Val proteins and methods |
| FR2601141A1 (fr) * | 1986-07-02 | 1988-01-08 | Centre Nat Rech Scient | Produit de couplage a base d'haptene, utile notamment comme substance immunogene, anticorps correspondants et applications |
| US5034317A (en) * | 1987-01-30 | 1991-07-23 | Polaroid Corporation | Enzyme controlled release system and organic conjugate reactant |
| US6326136B1 (en) * | 1988-04-01 | 2001-12-04 | Digene Corporation | Macromolecular conjugate made using unsaturated aldehydes |
| DE3836656A1 (de) * | 1988-10-27 | 1990-05-03 | Boehringer Mannheim Gmbh | Neue digoxigenin-derivate und ihre verwendung |
| CA2031109C (en) * | 1990-07-27 | 1992-01-28 | Susan J. Danielson | Ligand analogs for immunoassays derived from dicarboxylic acid oxidation products |
| US5650150A (en) * | 1990-11-09 | 1997-07-22 | Gillies; Stephen D. | Recombinant antibody cytokine fusion proteins |
| RU2132553C1 (ru) * | 1996-05-30 | 1999-06-27 | Ивановская Елена Алексеевна | Количественное определение дигоксина в сыворотке крови методом инверсионной вольтамперометрии |
| JP2001514741A (ja) * | 1997-02-18 | 2001-09-11 | オンカー インク. | 緑色蛍光蛋白質およびその蛍光変異体による標的の検出 |
| EP1037927B1 (en) | 1997-12-08 | 2004-05-19 | Lexigen Pharmaceuticals Corp. | Heterodimeric fusion proteins useful for targeted immune therapy and general immune stimulation |
| US20030105294A1 (en) * | 1998-02-25 | 2003-06-05 | Stephen Gillies | Enhancing the circulating half life of antibody-based fusion proteins |
| CN1318092C (zh) * | 1998-04-15 | 2007-05-30 | 利思进药品公司 | 含有抗体-细胞因子融合蛋白和血管生成抑制剂的免疫治疗用组合物 |
| ATE369384T1 (de) * | 1999-05-19 | 2007-08-15 | Emd Lexigen Res Ct Corp | Expression und export von interferon-alpha proteinen als fc fusionsproteine |
| SK782002A3 (en) | 1999-07-21 | 2003-08-05 | Lexigen Pharm Corp | FC fusion proteins for enhancing the immunogenicity of protein and peptide antigens |
| US7067110B1 (en) | 1999-07-21 | 2006-06-27 | Emd Lexigen Research Center Corp. | Fc fusion proteins for enhancing the immunogenicity of protein and peptide antigens |
| RU2263118C2 (ru) * | 1999-08-09 | 2005-10-27 | Лексиген Фармасьютикэлс Корп. | Комплексы антител с несколькими цитокинами |
| US20050202538A1 (en) * | 1999-11-12 | 2005-09-15 | Merck Patent Gmbh | Fc-erythropoietin fusion protein with improved pharmacokinetics |
| AU2154401A (en) | 1999-11-12 | 2001-05-30 | Merck Patent Gmbh | Erythropoietin forms with improved properties |
| JP5179689B2 (ja) * | 2000-02-11 | 2013-04-10 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング | 抗体ベース融合タンパク質の循環系内半減期の増強 |
| PT1294401E (pt) * | 2000-06-29 | 2007-11-09 | Merck Patent Gmbh | Aumento das respostas imunológicas mediadas por proteínas de fusão anticorpo-citoquina por tratamento combinado com agentes que aumentam a captação de imunocitoquinas |
| BR0207854A (pt) * | 2001-03-07 | 2004-08-24 | Merck Patent Gmbh | Tecnologia de expressão para proteìnas contendo uma porção de anticorpo de isotipo hìbrido |
| WO2002079415A2 (en) * | 2001-03-30 | 2002-10-10 | Lexigen Pharmaceuticals Corp. | Reducing the immunogenicity of fusion proteins |
| JP4309662B2 (ja) * | 2001-05-03 | 2009-08-05 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング | 腫瘍特異的組換え抗体およびその使用 |
| CA2469151C (en) * | 2001-12-04 | 2013-08-13 | Merck Patent Gesellschaft Mit Beschraenkter Haftung | Immunocytokines with modulated selectivity |
| DE60335428D1 (de) * | 2002-01-31 | 2011-02-03 | Randox Lab Ltd | Immunogene, Antikörper und Konjugate für Ketamin und dessen Metaboliten |
| US7794716B2 (en) | 2002-07-25 | 2010-09-14 | Glenveigh Pharmaceuticals, Llc | Antibody composition and passive immunization against pregnancy-induced hypertension |
| MXPA05006384A (es) * | 2002-12-17 | 2005-08-29 | Merck Patent Gmbh | Anticuerpo humanizado (h14.18) del anticuerpo 14.18 de raton enlazado a gd2 y su fusion con il-2. |
| US7935539B2 (en) * | 2003-02-14 | 2011-05-03 | Siemens Healthcare Diagnostics, Inc. | Generic method for latex agglutination assays |
| US20050069521A1 (en) * | 2003-08-28 | 2005-03-31 | Emd Lexigen Research Center Corp. | Enhancing the circulating half-life of interleukin-2 proteins |
| JP2005172694A (ja) * | 2003-12-12 | 2005-06-30 | Fuji Photo Film Co Ltd | タンパク質の検出方法 |
| CN100467488C (zh) | 2003-12-30 | 2009-03-11 | 默克专利有限公司 | Il-7融合蛋白 |
| KR20060124656A (ko) * | 2003-12-31 | 2006-12-05 | 메르크 파텐트 게엠베하 | 개선된 약물동태를 가지는 Fc-에리스로포이에틴 융합단백질 |
| JP2007517506A (ja) * | 2004-01-05 | 2007-07-05 | イーエムディー・レキシゲン・リサーチ・センター・コーポレーション | 標的化用化合物 |
| US7670595B2 (en) * | 2004-06-28 | 2010-03-02 | Merck Patent Gmbh | Fc-interferon-beta fusion proteins |
| CN101072793B (zh) * | 2004-12-09 | 2012-06-20 | 默克专利有限公司 | 具有降低的免疫原性的il-7变体 |
| US20070104689A1 (en) * | 2005-09-27 | 2007-05-10 | Merck Patent Gmbh | Compositions and methods for treating tumors presenting survivin antigens |
| US20080003230A1 (en) | 2006-07-03 | 2008-01-03 | Adair Charles D | Composition for modulating the expression of cell adhesion molecules |
| AU2007322261B2 (en) | 2006-11-01 | 2014-01-23 | Ventana Medical Systems, Inc. | Haptens, hapten conjugates, compositions thereof and method for their preparation and use |
| US7682789B2 (en) * | 2007-05-04 | 2010-03-23 | Ventana Medical Systems, Inc. | Method for quantifying biomolecules conjugated to a nanoparticle |
| DK2167963T3 (da) | 2007-05-23 | 2019-06-24 | Ventana Med Syst Inc | Polymerbærere til immunhistokemi og in situ-hybridisering |
| ES2906426T3 (es) | 2008-06-05 | 2022-04-18 | Ventana Med Syst Inc | Composición para procesamiento histoquímico |
| US20110287088A1 (en) | 2008-12-03 | 2011-11-24 | Research Development Foundation | Modulation of olfml-3 mediated angiogenesis |
| WO2010121766A1 (en) * | 2009-04-22 | 2010-10-28 | Merck Patent Gmbh | Antibody fusion proteins with modified fcrn binding sites |
| USPP22463P3 (en) * | 2010-02-16 | 2012-01-17 | Menachem Bornstein | Gypsophila plant named ‘Pearl Blossom’ |
| CA2800936A1 (en) | 2010-07-02 | 2012-01-05 | Ventana Medical Systems, Inc. | Hapten conjugates for target detection |
| EP2661282A1 (en) * | 2011-01-03 | 2013-11-13 | F.Hoffmann-La Roche Ag | A pharmaceutical composition of a complex of an anti-dig antibody and digoxigenin that is conjugated to a peptide |
| AU2012294814A1 (en) | 2011-08-05 | 2014-02-27 | Research Development Foundation | Improved methods and compositions for modulation of Olfml3 mediated angiogenesis |
| WO2014066590A1 (en) | 2012-10-24 | 2014-05-01 | Research Development Foundation | Jam-c antibodies and methods for treatment of cancer |
| EP3036005A4 (en) | 2013-08-21 | 2017-04-26 | The Board Of Regents Of The University Of Texas System | Compositions and methods for targeting connexin hemichannels |
| IL290309B2 (en) | 2015-11-06 | 2024-04-01 | Ventana Med Syst Inc | Representative diagnostics |
| KR20250065433A (ko) | 2015-12-02 | 2025-05-12 | 주식회사 에스티큐브앤컴퍼니 | Btn1a1에 면역특이적으로 결합하는 항체와 분자 및 그의 치료 용도 |
| CN108925136B (zh) | 2015-12-02 | 2022-02-01 | 斯特赛恩斯公司 | 特异于糖基化的btla(b和t淋巴细胞衰减因子)的抗体 |
| JP7098527B2 (ja) | 2016-02-26 | 2022-07-11 | ザ ボード オブ リージェンツ オブ ザ ユニバーシティー オブ テキサス システム | コネキシン(Cx)43ヘミチャネル結合抗体及びその使用 |
| CN109195991B (zh) | 2016-03-29 | 2023-10-31 | 斯特库比股份有限公司 | 对糖基化pd-l1特异的双重功能抗体及其使用方法 |
| CN109195990A (zh) | 2016-03-30 | 2019-01-11 | Musc研究发展基金会 | 通过靶向糖蛋白a重复优势蛋白(garp)治疗和诊断癌症以及单独或联合提供有效免疫疗法的方法 |
| JP2019528251A (ja) | 2016-07-20 | 2019-10-10 | エスティーキューブ,インコーポレイテッド | グリコシル化pd−l1に結合する抗体の組合せを使用するがんの処置および治療の方法 |
| CA3065301A1 (en) | 2017-05-31 | 2018-12-06 | Stcube & Co., Inc. | Antibodies and molecules that immunospecifically bind to btn1a1 and the therapeutic uses thereof |
| AU2018277545B2 (en) | 2017-05-31 | 2025-05-15 | Stcube & Co., Inc. | Methods of treating cancer using antibodies and molecules that immunospecifically bind to BTN1A1 |
| US11542331B2 (en) | 2017-06-06 | 2023-01-03 | Stcube & Co., Inc. | Methods of treating cancer using antibodies and molecules that bind to BTN1A1 or BTN1A1-ligands |
| DE112018005145T5 (de) | 2017-09-15 | 2020-07-23 | The Regents Of The University Of California | Hemmung von aminoacylase 3 (aa3) bei der behandlung von krebs |
| US20200290978A1 (en) | 2017-09-26 | 2020-09-17 | The Regents Of The University Of California | Compositions and methods for treating cancer |
| EP3710820B1 (en) | 2017-11-13 | 2025-06-11 | F. Hoffmann-La Roche AG | Devices for sample analysis using epitachophoresis |
| JP7455816B2 (ja) * | 2018-09-20 | 2024-03-26 | ヴェンタナ メディカル システムズ, インク. | クマリン系架橋試薬 |
| EP3864403A1 (en) | 2018-10-12 | 2021-08-18 | F. Hoffmann-La Roche AG | Detection methods for epitachophoresis workflow automation |
| CN110174363A (zh) * | 2019-01-09 | 2019-08-27 | 北京九强生物技术股份有限公司 | 6-磷酸葡萄糖脱氢酶突变体及其在制备检测试剂中的用途 |
| WO2020229437A1 (en) | 2019-05-14 | 2020-11-19 | F. Hoffmann-La Roche Ag | Devices and methods for sample analysis |
| WO2021062323A1 (en) | 2019-09-26 | 2021-04-01 | Stcube & Co. | Antibodies specific to glycosylated ctla-4 and methods of use thereof |
| CN114829404B (zh) | 2019-10-09 | 2025-09-09 | 斯特库比公司 | 对糖基化的lag3特异的抗体及其使用方法 |
| US20230106973A1 (en) | 2020-02-17 | 2023-04-06 | Board Of Regents, The University Of Texas System | Methods for expansion of tumor infiltrating lymphocytes and use thereof |
| CN113736744B (zh) * | 2021-10-14 | 2023-07-18 | 江南大学 | 洋地黄毒苷单克隆抗体杂交瘤细胞株及其应用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3953431A (en) * | 1971-05-24 | 1976-04-27 | Becton, Dickinson & Company | Derivatives of digoxigenin |
| US3855208A (en) * | 1971-05-24 | 1974-12-17 | Becton Dickinson Co | Derivatives of digoxigenin |
| GB1441101A (en) * | 1972-06-22 | 1976-06-30 | Wellcome Found | Reagents for the assay of cardenolide glycosides and aglycones |
| US4064227A (en) * | 1975-03-17 | 1977-12-20 | Mallinckrodt, Inc. | Radioimmunoassay method for the determination of cardiotonic glycosides |
| FR2310766A1 (fr) * | 1975-05-16 | 1976-12-10 | Nativelle Sa Ets | Derives de cardenolides, procede de preparation et application a titre de medicament |
| US4082747A (en) * | 1975-10-01 | 1978-04-04 | Mallinckrodt, Inc. | Chemical process |
| JPS53119873A (en) * | 1977-03-28 | 1978-10-19 | Rohm & Haas | Digoxigenin derivative |
| CA1119163A (en) * | 1977-09-01 | 1982-03-02 | Ravi K. Varma | Digoxigenin derivatives |
-
1982
- 1982-09-23 US US06/422,217 patent/US4469797A/en not_active Expired - Fee Related
-
1983
- 1983-06-30 CA CA000431573A patent/CA1213579A/en not_active Expired
- 1983-06-30 IL IL69126A patent/IL69126A0/xx unknown
- 1983-06-30 AU AU16416/83A patent/AU541321B2/en not_active Ceased
- 1983-09-12 EP EP83108977A patent/EP0104527B1/en not_active Expired
- 1983-09-12 DE DE8383108977T patent/DE3369887D1/de not_active Expired
- 1983-09-22 ES ES525861A patent/ES8601478A1/es not_active Expired
- 1983-09-22 JP JP58174442A patent/JPS5983056A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0231346B2 (cs) | 1990-07-12 |
| ES525861A0 (es) | 1985-11-01 |
| EP0104527A1 (en) | 1984-04-04 |
| EP0104527B1 (en) | 1987-02-25 |
| DE3369887D1 (en) | 1987-04-02 |
| ES8601478A1 (es) | 1985-11-01 |
| AU541321B2 (en) | 1985-01-03 |
| AU1641683A (en) | 1984-03-29 |
| JPS5983056A (ja) | 1984-05-14 |
| CA1213579A (en) | 1986-11-04 |
| US4469797A (en) | 1984-09-04 |
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