IL67206A0 - Bicyclic compounds,their preparation and pharmaceutical compositions containing them - Google Patents

Bicyclic compounds,their preparation and pharmaceutical compositions containing them

Info

Publication number
IL67206A0
IL67206A0 IL67206A IL6720682A IL67206A0 IL 67206 A0 IL67206 A0 IL 67206A0 IL 67206 A IL67206 A IL 67206A IL 6720682 A IL6720682 A IL 6720682A IL 67206 A0 IL67206 A0 IL 67206A0
Authority
IL
Israel
Prior art keywords
preparation
pharmaceutical compositions
compositions containing
bicyclic compounds
bicyclic
Prior art date
Application number
IL67206A
Other languages
English (en)
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Found filed Critical Wellcome Found
Publication of IL67206A0 publication Critical patent/IL67206A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
IL67206A 1981-11-10 1982-11-09 Bicyclic compounds,their preparation and pharmaceutical compositions containing them IL67206A0 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB8133930 1981-11-10
GB8133942 1981-11-10
GB8213846 1982-05-12

Publications (1)

Publication Number Publication Date
IL67206A0 true IL67206A0 (en) 1983-03-31

Family

ID=27261362

Family Applications (1)

Application Number Title Priority Date Filing Date
IL67206A IL67206A0 (en) 1981-11-10 1982-11-09 Bicyclic compounds,their preparation and pharmaceutical compositions containing them

Country Status (17)

Country Link
US (1) US4603139A (da)
EP (1) EP0079083B1 (da)
KR (1) KR890000022B1 (da)
AR (1) AR241247A1 (da)
AU (1) AU9030682A (da)
DD (1) DD205904A5 (da)
DK (1) DK161325C (da)
ES (2) ES8401486A1 (da)
FI (1) FI79312C (da)
GB (1) GB2113675B (da)
GR (1) GR76746B (da)
IE (1) IE56478B1 (da)
IL (1) IL67206A0 (da)
MC (1) MC1491A1 (da)
NO (1) NO158100C (da)
PH (1) PH22764A (da)
PT (1) PT75820B (da)

Families Citing this family (78)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0072926B1 (de) * 1981-08-19 1986-09-24 MERCK PATENT GmbH 2-Aryl-imidazopyridine
ZA832938B (en) * 1982-05-03 1984-12-24 Lilly Co Eli 2-phenylimidazo(4,5-c)pyridines
US4758574A (en) * 1982-05-03 1988-07-19 Eli Lilly And Company 2-phenylimidazio (4,5-c) pyridines
US4904785A (en) * 1982-05-03 1990-02-27 Eli Lilly And Company 2-phenylimidazo[4,5-c]pyridines
DE3224512A1 (de) * 1982-07-01 1984-01-05 Dr. Karl Thomae Gmbh, 7950 Biberach Neue imidazolderivate, ihre herstellung und diese verbindungen enthaltende arzneimittel
DE3324115A1 (de) * 1983-07-05 1985-01-17 Dr. Karl Thomae Gmbh, 7950 Biberach Neue imidazole, ihre herstellung und diese verbindungen enthaltende arzneimittel
US4515796A (en) * 1983-09-08 1985-05-07 Eli Lilly And Company Certain naphthalenyl imidazo compounds and their pharmaceutical use
US4533734A (en) * 1983-11-10 1985-08-06 Eli Lilly And Company Inotropic agents
DE3346602A1 (de) * 1983-12-23 1985-07-11 Dr. Karl Thomae Gmbh, 7950 Biberach Neue imidazo(4,5-c)pyridin-one, deren herstellung und diese verbindungen enthaltende arzneimittel
DE3347290A1 (de) * 1983-12-28 1985-07-11 Dr. Karl Thomae Gmbh, 7950 Biberach Neue 2-phenyl-imidazole, ihre herstellung und diese verbindungen enthaltende arzneimittel
ZA851236B (en) * 1984-02-24 1986-09-24 Lilly Co Eli 2-arylimidazo 4,5-cpyridines
US4578387A (en) * 1984-03-05 1986-03-25 Eli Lilly And Company Inotropic agents
DE3445299A1 (de) * 1984-12-12 1986-06-19 Dr. Karl Thomae Gmbh, 7950 Biberach Neue imidazoderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
CA1295330C (en) * 1985-03-29 1992-02-04 James M. Greene Synthesis of inotropic imidazo(4,5-c) pyridine
DE3522230A1 (de) * 1985-06-21 1987-01-02 Thomae Gmbh Dr K Neue 2-arylimidazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
US4740599A (en) * 1986-10-03 1988-04-26 Eli Lilly And Company Synthesis of alkylsulfinyl substituted 2-phenylimidazo(4,5-c)pyridines
ZA889365B (en) * 1987-12-22 1990-08-29 Lilly Co Eli Hydrates of andinotropic agent
GB8822170D0 (en) * 1988-09-21 1988-10-26 Pfizer Ltd Therapeutic agents
BR9106433A (pt) * 1990-05-09 1993-05-04 Pfizer Imidazo (4,5-c) piridinas com atividade antagonista ao paf
DE4324580A1 (de) * 1993-07-22 1995-01-26 Thomae Gmbh Dr K Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
AU2892397A (en) * 1996-05-15 1997-12-05 Byk Gulden Novel imidazopyridines
DK0937075T3 (da) * 1996-11-11 2004-04-13 Altana Pharma Ag Hidtil ukendte imidazo- og oxazolopyridiner som phosphodiesteraseinhibitorer
AU2001259707A1 (en) * 2000-06-14 2001-12-24 Warner Lambert Company 6,5-fused bicyclic heterocycles
BRPI0407573A (pt) * 2003-02-25 2006-02-14 Altana Pharma Ag derivados de imidazo(4,5-b)quinolina e seu emprego como inibidores de sintase de no
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RU2539568C2 (ru) 2008-10-31 2015-01-20 Дженентек, Инк. Пиразолопиримидиновые соединения-ингибиторы jak и способы
UA110324C2 (en) 2009-07-02 2015-12-25 Genentech Inc Jak inhibitory compounds based on pyrazolo pyrimidine
PL2464232T3 (pl) * 2009-08-10 2016-04-29 Samumed Llc Indazolowe inhibitory szlaku sygnałowego Wnt i ich zastosowania terapeutyczne
US8450340B2 (en) 2009-12-21 2013-05-28 Samumed, Llc 1H-pyrazolo[3,4-b]pyridines and therapeutic uses thereof
US20130096104A1 (en) * 2010-03-17 2013-04-18 Genentech, Inc. Imidazopyridine compounds, compositions and methods of use
RU2013114352A (ru) 2010-09-15 2014-10-20 Ф. Хоффманн-Ля Рош Аг Азабензотиазолы, композиции и способы применения
CA2817785A1 (en) 2010-11-19 2012-05-24 Toby Blench Pyrazolopyridines and pyrazolopyridines and their use as tyk2 inhibitors
EP3473099A1 (en) 2011-09-14 2019-04-24 Samumed, LLC Indazole-3-carboxamides and their use as wnt/b-catenin signaling pathway inhibitors
PH12017500997A1 (en) 2012-04-04 2018-02-19 Samumed Llc Indazole inhibitors of the wnt signal pathway and therapeutic uses thereof
CN107417707A (zh) 2012-05-04 2017-12-01 萨穆梅德有限公司 1H‑吡唑并[3,4‑b]吡啶及其治疗应用
WO2014110086A2 (en) 2013-01-08 2014-07-17 Samumed, Llc 3-(benzoimidazol-2-yl)-indazole inhibitors of the wnt signaling pathway and therapeutic uses thereof
EP2818472A1 (en) * 2013-06-27 2014-12-31 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Imidazo[4,5-c]pyridine and pyrrolo[3,2-c]pyridine compounds as G-protein-coupled receptor kinase 5 (GRK5) modulators
MX2015017821A (es) * 2013-07-02 2016-04-15 Syngenta Participations Ag Heterociclos bi-o triciclicos activos como plaguicidas con sustituyentes que contienen azufre.
CN105431433B (zh) * 2013-07-02 2018-04-06 先正达参股股份有限公司 有杀有害生物活性的具有含硫取代基的二环或三环杂环
US11229208B2 (en) 2013-07-02 2022-01-25 Syngenta Participations Ag Pesticidally active bi- or tricyclic heterocycles with sulfur containing substituents
PE20171645A1 (es) 2014-02-17 2017-11-13 Bayer Cropscience Ag Derivados de heterociclos biciclicos condensados sustituidos con 2-(het)arilo como agentes para combatir parasitos
PE20211782A1 (es) 2014-05-23 2021-09-08 Hoffmann La Roche Compuestos de 5-cloro-2-difluorometoxifenil pirazolopirimidina, composiciones y metodos de uso de los mismos
US10081641B2 (en) 2014-08-21 2018-09-25 Syngenta Participations Ag Pesticidally active heterocyclic derivatives with sulphur containing substituents
WO2016040185A1 (en) 2014-09-08 2016-03-17 Samumed, Llc 2-(1h-indazol-3-yl)-3h-imidazo[4,5-b]pyridine and therapeutic uses thereof
WO2016040184A1 (en) 2014-09-08 2016-03-17 Samumed, Llc 3-(3h-imidazo[4,5-b]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridine and therapeutic uses thereof
WO2016040190A1 (en) 2014-09-08 2016-03-17 Samumed, Llc 3-(3h-imidazo[4,5-b]pyridin-2-yl)-1h-pyrazolo[3,4-b]pyridine and therapeutic uses thereof
WO2016040181A1 (en) 2014-09-08 2016-03-17 Samumed, Llc 3-(1h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridine and therapeutic uses thereof
WO2016040180A1 (en) 2014-09-08 2016-03-17 Samumed, Llc 3-(1h-benzo[d]imidazol-2-yl)-1h-pyrazolo[3,4-c]pyridine and therapeutic uses thereof
WO2016040193A1 (en) 2014-09-08 2016-03-17 Samumed, Llc 3-(1h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[3,4-b]pyridine and therapeutic uses thereof
WO2016040188A1 (en) 2014-09-08 2016-03-17 Samumed, Llc 3-(3h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridine and therapeutic uses thereof
WO2016040182A1 (en) 2014-09-08 2016-03-17 Samumed, Llc 2-(1h-indazol-3-yl)-1h-imidazo[4,5-c]pyridine and therapeutic uses thereof
WO2016058928A1 (en) * 2014-10-14 2016-04-21 Syngenta Participations Ag Pesticidally active heterocyclic derivatives with sulphur containing substituents
CN107001365B (zh) * 2014-12-17 2019-09-24 先正达参股股份有限公司 具有含硫取代基的杀有害生物活性杂环衍生物
EP3240786B1 (en) * 2014-12-31 2019-03-27 Syngenta Participations AG Pesticidally active polycyclic derivatives with sulfur containing substituents
UY36547A (es) * 2015-02-05 2016-06-01 Bayer Cropscience Ag Derivados heterocíclicos condensados bicíclicos sustituidos por 2-(het)arilo como pesticidas
US10519169B2 (en) 2015-08-03 2019-12-31 Samumed, Llc 3-(1H-pyrrolo[2,3-C]pyridin-2-yl)-1 H-pyrazolo[4,3-B]pyridines and therapeutic uses thereof
WO2017024026A1 (en) 2015-08-03 2017-02-09 Samumed, Llc 3-(1h-indol-2-yl)-1h-pyrazolo[3,4-c]pyridines and therapeutic uses thereof
WO2017023988A1 (en) 2015-08-03 2017-02-09 Samumed, Llc. 3-(3h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[4,3-b]pyridines and therapeutic uses thereof
US10206908B2 (en) 2015-08-03 2019-02-19 Samumed, Llc 3-(1H-pyrrolo[3,2-C]pyridin-2-YL)-1H-pyrazolo[3,4-C]pyridines and therapeutic uses thereof
WO2017023996A1 (en) 2015-08-03 2017-02-09 Samumed, Llc. 3-(1h-pyrrolo[2,3-b]pyridin-2-yl)-1h-pyrazolo[3,4-b]pyridines and therapeutic uses thereof
WO2017023980A1 (en) 2015-08-03 2017-02-09 Samumed, Llc. 3-(1h-pyrrolo[2,3-b]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridines and therapeutic uses thereof
WO2017024003A1 (en) 2015-08-03 2017-02-09 Samumed, Llc 3-(1h-pyrrolo[3,2-c]pyridin-2-yl)-1h-pyrazolo[4,3-b]pyridines and therapeutic uses thereof
WO2017024010A1 (en) 2015-08-03 2017-02-09 Samumed, Llc. 3-(1h-pyrrolo[3,2-c]pyridin-2-yl)-1h-indazoles and therapeutic uses thereof
WO2017023989A1 (en) 2015-08-03 2017-02-09 Samumed, Llc. 3-(1h-benzo[d]imidazol-2-yl)-1h-pyrazolo[4,3-b]pyridines and therapeutic uses thereof
WO2017023993A1 (en) 2015-08-03 2017-02-09 Samumed, Llc. 3-(1h-indol-2-yl)-1h-pyrazolo[4,3-b]pyridines and therapeutic uses thereof
US10604512B2 (en) 2015-08-03 2020-03-31 Samumed, Llc 3-(1H-indol-2-yl)-1H-indazoles and therapeutic uses thereof
US10206909B2 (en) 2015-08-03 2019-02-19 Samumed, Llc 3-(1H-pyrrolo[2,3-B]pyridin-2-yl)-1H-pyrazolo[4,3-B]pyridines and therapeutic uses thereof
WO2017024021A1 (en) 2015-08-03 2017-02-09 Samumed, Llc 3-(1h-pyrrolo[2,3-b]pyridin-2-yl)-1h-indazoles and therapeutic uses thereof
WO2017024015A1 (en) 2015-08-03 2017-02-09 Samumed, Llc. 3-(3h-imidazo[4,5-b]pyridin-2-yl)-1h-pyrazolo[4,3-b]pyridines and therapeutic uses thereof
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EP3528808B1 (en) 2016-10-21 2021-10-06 BioSplice Therapeutics, Inc. Methods of using indazole-3-carboxamides and their use as wnt/b-catenin signaling pathway inhibitors
KR102558716B1 (ko) 2016-11-07 2023-07-21 사뮤메드, 엘엘씨 단일-투여량, 즉시-사용가능한 주사용 제제
RU2769696C2 (ru) 2017-05-22 2022-04-05 Ф. Хоффманн-Ля Рош Аг Терапевтические соединения и композиции и способы их применения

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CA820316A (en) * 1969-08-12 Fisons Pest Control Limited Substituted heterocyclic compounds
FI58126C (fi) * 1973-02-03 1980-12-10 Thomae Gmbh Dr K Foerfarande foer framstaellning av kardiotona och blodtryckssaenkande 2-fenyl-1h-imidatso(4,5-b)pyridiner
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US3891660A (en) * 1974-02-07 1975-06-24 Squibb & Sons Inc Derivatives of 1H-imidazo{8 4,5-c{9 pyridine-7-carboxylic acids and esters
SU566842A1 (ru) * 1976-01-06 1977-07-30 Донецкое Отделение Физико-Органической Химии Института Физической Химии Им.Л.В.Писаржевского Ан Украинской Сср Способ получени замещенных имидазопиридинов
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DE2927987A1 (de) * 1979-07-11 1981-02-05 Thomae Gmbh Dr K Neue 2-alkoxyphenyl-imidazo eckige klammer auf 4,5-b eckige klammer zu pyridine, deren herstellung und deren verwendung als arzneimittel
DE3037464A1 (de) * 1980-10-03 1982-05-19 Dr. Karl Thomae Gmbh, 7950 Biberach 6-hydroxy-2-phenyl-imidazo 4,5-b zu pyridine, ihre herstellung und diese sie enthaltende arzneimittel
EP0072926B1 (de) * 1981-08-19 1986-09-24 MERCK PATENT GmbH 2-Aryl-imidazopyridine
ZA832938B (en) * 1982-05-03 1984-12-24 Lilly Co Eli 2-phenylimidazo(4,5-c)pyridines
DE3224512A1 (de) * 1982-07-01 1984-01-05 Dr. Karl Thomae Gmbh, 7950 Biberach Neue imidazolderivate, ihre herstellung und diese verbindungen enthaltende arzneimittel

Also Published As

Publication number Publication date
KR890000022B1 (ko) 1989-03-06
EP0079083A1 (en) 1983-05-18
PT75820B (en) 1986-06-11
FI823846L (fi) 1983-05-11
IE56478B1 (en) 1991-08-14
IE822667L (en) 1983-05-10
GB2113675B (en) 1985-10-30
FI79312B (fi) 1989-08-31
ES523083A0 (es) 1985-02-16
US4603139A (en) 1986-07-29
ES8503351A1 (es) 1985-02-16
FI823846A0 (fi) 1982-11-09
NO158100B (no) 1988-04-05
ES517193A0 (es) 1983-12-01
PH22764A (en) 1988-12-12
KR840002398A (ko) 1984-07-02
DK499582A (da) 1983-05-11
ES8401486A1 (es) 1983-12-01
DK161325B (da) 1991-06-24
DD205904A5 (de) 1984-01-11
PT75820A (en) 1982-12-01
GR76746B (da) 1984-08-30
AU9030682A (en) 1983-05-19
EP0079083B1 (en) 1991-02-27
FI79312C (fi) 1989-12-11
GB2113675A (en) 1983-08-10
NO823732L (no) 1983-05-11
AR241247A1 (es) 1992-03-31
MC1491A1 (fr) 1983-09-12
NO158100C (no) 1988-07-13
DK161325C (da) 1991-12-02

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