IL63531A - 7-beta-(alpha-syn-methoxyiminoalpha-2(2-aminothiazol-4-yl)-acetamido)-3-((1,2,3-thiadiazol-5-ylthio)methyl)-3-cephem-4-carboxylic acids,their preparation and pharmaceutical compositions comprising them - Google Patents

7-beta-(alpha-syn-methoxyiminoalpha-2(2-aminothiazol-4-yl)-acetamido)-3-((1,2,3-thiadiazol-5-ylthio)methyl)-3-cephem-4-carboxylic acids,their preparation and pharmaceutical compositions comprising them

Info

Publication number
IL63531A
IL63531A IL63531A IL6353181A IL63531A IL 63531 A IL63531 A IL 63531A IL 63531 A IL63531 A IL 63531A IL 6353181 A IL6353181 A IL 6353181A IL 63531 A IL63531 A IL 63531A
Authority
IL
Israel
Prior art keywords
methoxyiminoalpha
aminothiazol
cephem
ylthio
thiadiazol
Prior art date
Application number
IL63531A
Other languages
English (en)
Other versions
IL63531A0 (en
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of IL63531A0 publication Critical patent/IL63531A0/xx
Publication of IL63531A publication Critical patent/IL63531A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/36—Methylene radicals, substituted by sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IL63531A 1980-08-11 1981-08-10 7-beta-(alpha-syn-methoxyiminoalpha-2(2-aminothiazol-4-yl)-acetamido)-3-((1,2,3-thiadiazol-5-ylthio)methyl)-3-cephem-4-carboxylic acids,their preparation and pharmaceutical compositions comprising them IL63531A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17688980A 1980-08-11 1980-08-11
US06/281,438 US4399132A (en) 1980-08-11 1981-07-08 7-Beta-[alpha-syn-methoxyimino-alpha-(2-aminothiazol-4-yl)-acetamido]-3-[(1,2,3-thiadiazol-5-ylthio)methyl]-3-cephem-4-carboxylic acid and C1 -C6 alkyl derivatives thereof

Publications (2)

Publication Number Publication Date
IL63531A0 IL63531A0 (en) 1981-11-30
IL63531A true IL63531A (en) 1985-07-31

Family

ID=26872715

Family Applications (1)

Application Number Title Priority Date Filing Date
IL63531A IL63531A (en) 1980-08-11 1981-08-10 7-beta-(alpha-syn-methoxyiminoalpha-2(2-aminothiazol-4-yl)-acetamido)-3-((1,2,3-thiadiazol-5-ylthio)methyl)-3-cephem-4-carboxylic acids,their preparation and pharmaceutical compositions comprising them

Country Status (25)

Country Link
US (1) US4399132A (nl)
JP (1) JPS5759895A (nl)
KR (1) KR840002163B1 (nl)
AR (1) AR228869A1 (nl)
AT (1) AT389639B (nl)
AU (1) AU545895B2 (nl)
BE (1) BE889913A (nl)
CA (1) CA1175417A (nl)
CH (1) CH648561A5 (nl)
DD (1) DD202164A5 (nl)
DE (1) DE3130404A1 (nl)
DK (1) DK155945C (nl)
FI (1) FI74020C (nl)
FR (1) FR2488258A1 (nl)
GB (1) GB2083461B (nl)
GR (1) GR75676B (nl)
HK (1) HK52089A (nl)
HU (1) HU185644B (nl)
IE (1) IE51486B1 (nl)
IL (1) IL63531A (nl)
NL (1) NL8103751A (nl)
NO (1) NO161566C (nl)
NZ (1) NZ197965A (nl)
PL (1) PL131457B1 (nl)
SE (1) SE452324B (nl)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60120886A (ja) * 1983-12-02 1985-06-28 Takeda Chem Ind Ltd セフェムカルボン酸のナトリウム塩の結晶
US4914091A (en) * 1984-04-02 1990-04-03 American Cyanamid Company Esters of cephalosporin derivitives
CA1296012C (en) 1986-03-19 1992-02-18 Susumu Nakagawa 6,7-dihydroxy-isoquinoline derivatives
US4927922A (en) * 1986-07-08 1990-05-22 American Cyanamid Company 7β-(substituted)amino-3-substituted cephalosporanic acids and esters
EP0252473A3 (en) * 1986-07-08 1989-07-05 American Cyanamid Company 7 beta-(substituted) amino-3-substituted cephalosporanic acids and esters
US5066799A (en) * 1986-07-28 1991-11-19 American Cyanamid Company Intermediates for the preparation of aminothiazoloximino cephalosporins
EP0257275A3 (en) * 1986-07-28 1990-05-23 American Cyanamid Company Cephalosporin and penicillin derivatives
JPH01230547A (ja) * 1988-01-14 1989-09-14 Takeda Chem Ind Ltd ３−オキソ酪酸第三ブチルの製造法及びその用途
AT394196B (de) * 1990-01-22 1992-02-10 Biochemie Gmbh (6r,7r)-7-((2-(2-amino-4-thiazolyl) -2oxoacetamido)-3-(1,2,3-thiadiazol-5-yl)thiomethyl-3-cephem-4-carbons|urenitrat
CN105646538B (zh) * 2016-03-09 2018-04-24 上海宁瑞生化技术有限公司 一种头孢唑南的制备工艺

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK154939C (da) * 1974-12-19 1989-06-12 Takeda Chemical Industries Ltd Analogifremgangsmaade til fremstilling af thiazolylacetamido-cephemforbindelser eller farmaceutisk acceptable salte eller estere deraf
JPS597717B2 (ja) * 1976-09-08 1984-02-20 武田薬品工業株式会社 セフアロスポリン誘導体およびその製造法
DE2760484C2 (nl) * 1976-04-14 1992-12-03 Takeda Chemical Industries, Ltd., Osaka, Jp
FR2381053A1 (fr) * 1977-02-18 1978-09-15 Roussel Uclaf Nouvelles oximes derivees de l'acide 3-thiadiazolyl thiomethyl 7-aminothiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments
DE2714880A1 (de) * 1977-04-02 1978-10-26 Hoechst Ag Cephemderivate und verfahren zu ihrer herstellung
DE2856404A1 (de) * 1978-12-28 1980-07-17 Dynamit Nobel Ag 1,2,3-thiadiazol-5-yl-thioglycolsaeure, deren derivate sowie verfahren zu deren herstellung

Also Published As

Publication number Publication date
IL63531A0 (en) 1981-11-30
DD202164A5 (de) 1983-08-31
AT389639B (de) 1990-01-10
SE452324B (sv) 1987-11-23
DE3130404A1 (de) 1982-06-16
US4399132A (en) 1983-08-16
AR228869A1 (es) 1983-04-29
NO161566B (no) 1989-05-22
AU545895B2 (en) 1985-08-08
NL8103751A (nl) 1982-03-01
GB2083461B (en) 1984-04-11
PL131457B1 (en) 1984-11-30
JPS5759895A (en) 1982-04-10
DK155945C (da) 1989-12-04
NO812701L (no) 1982-02-12
FI812470L (fi) 1982-02-12
BE889913A (fr) 1982-02-10
IE51486B1 (en) 1987-01-07
NZ197965A (en) 1984-03-16
FI74020C (fi) 1987-12-10
GR75676B (nl) 1984-08-02
KR840002163B1 (ko) 1984-11-24
NO161566C (no) 1989-08-30
HU185644B (en) 1985-03-28
SE8104771L (sv) 1982-02-12
DK355081A (da) 1982-02-12
FR2488258A1 (fr) 1982-02-12
DE3130404C2 (nl) 1990-07-19
IE811811L (en) 1982-02-11
GB2083461A (en) 1982-03-24
DK155945B (da) 1989-06-05
FI74020B (fi) 1987-08-31
FR2488258B1 (nl) 1984-08-24
AU7384881A (en) 1982-02-18
ATA307683A (de) 1989-06-15
KR830006311A (ko) 1983-09-20
HK52089A (en) 1989-07-07
PL232568A1 (en) 1983-06-06
CA1175417A (en) 1984-10-02
JPS6141517B2 (nl) 1986-09-16
CH648561A5 (nl) 1985-03-29

Similar Documents

Publication Publication Date Title
IL65737A (en) 7-(2-(2-aminothiazol-4-yl)-2-oxy-iminoacetamido)-3-(1-pyridinium)methyl)ceph-3-em-4-carboxylate derivatives and pharmaceutical compositions comprising them
DE3366393D1 (en) Phospholipid derivatives, process for preparation thereof and pharmaceutical composition of the same
IL57398A (en) 7((2-aminothiazol-4-yl)-(2-carboxyalkoxyimino and-cycloalkoxyimino)acetamido)-ceph-3-em carboxylic acids,their preparation and pharmaceutical compositions containing them
PH17338A (en) Substituted azabicyclo-octane-carboxylic acids,their preparation and pharmaceutical compositions containing them
IL68804A (en) 2-azetidinone-1-sulfonic acids,their manufacture and pharmaceutical compositions containing them
IL64035A (en) 2-guanidino-4-(4-thiazolyl or-5-1,2,4-triazolyl)thiazoles,certain intermediates for their preparation and pharmaceutical compositions containing them
IL66887A (en) 7-(2-(2-aminothiazol-4-yl)-2-methoxyiminoacetamido)-3-pyrazinium-1-ylmethyl)-3-cephem-4-carboxylates,their preparation and pharmaceutical preparations comprising them
IL63531A (en) 7-beta-(alpha-syn-methoxyiminoalpha-2(2-aminothiazol-4-yl)-acetamido)-3-((1,2,3-thiadiazol-5-ylthio)methyl)-3-cephem-4-carboxylic acids,their preparation and pharmaceutical compositions comprising them
IL65285A0 (en) Thiazole derivatives,their manufacture and pharmaceutical compositions containing them
ZA822571B (en) Derivatives of phenyl aliphatic carboxylic acids, their preparation, their use as medicaments and the compositions containing them
IL64506A (en) 7beta-(2-(2-amino-4-thiazolyl)-2-(syn)-methoxyiminoacetamido)-3-cephem-4-carboxylic acid esters,their production and pharmaceutical compositions containing them
ZA792044B (en) Substituted 1-phenyl-2,3,4,5-tetrahydro-1h-3-benzazepines,process for the preparation thereof,and pharmaceutical compositions containing them
IL63965A0 (en) Cephalosporin derivatives,their preparation and pharmaceutical compositions containing them
PT76870B (en) Process for the preparation of 1,4-dihydropiridine derivatives and pharmaceutical compositions containing them
EP0084053A4 (en) Medicines and the use of Sn or Cr protoporphyrin for its manufacture.
DE3162109D1 (en) Cephalosporin sulfoxides, process for their preparation and pharmaceutical compositions containing them
AU562822B2 (en) Pharmaceutical composition of clotrimazole
IL66814A0 (en) Cephalosporin derivatives,their manufacture and pharmaceutical compositions containing them
PT74400A (en) Process for the preparation of 17,18-dehydro-apovincaminol-3', 4',5'-trimethoxy-benzoate and of pharmaceutical compositions containing them
DE3267034D1 (en) Phospholipid derivatives, process for preparation thereof and pharmaceutical composition of the same
ZA821723B (en) Cephalosporin derivatives, pharmaceutical compositions containing the same, and production thereof
IL64806A0 (en) Cephalosporanic acid derivatives,their preparation and pharmaceutical compositions containing them
EP0048915A3 (en) New cephem compounds, processes for preparation thereof and pharmaceutical composition comprising the same
DE3170755D1 (en) Cephalosporins, process for their preparation and pharmaceutical compositions containing them
IL66465A0 (en) 1,2-dithiol-3-ylideneammonium derivatives,process for the preparation thereof and pharmaceutical compositions comprising the same