IL62258A - Hypoxanthine derivatives and their pharmaceutical use - Google Patents

Hypoxanthine derivatives and their pharmaceutical use

Info

Publication number
IL62258A
IL62258A IL62258A IL6225881A IL62258A IL 62258 A IL62258 A IL 62258A IL 62258 A IL62258 A IL 62258A IL 6225881 A IL6225881 A IL 6225881A IL 62258 A IL62258 A IL 62258A
Authority
IL
Israel
Prior art keywords
acid
sup
compounds
unsubstituted
pharmaceutical use
Prior art date
Application number
IL62258A
Other languages
English (en)
Original Assignee
Newport Pharmaceuticals
Sloan Kettering Inst Cancer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Newport Pharmaceuticals, Sloan Kettering Inst Cancer filed Critical Newport Pharmaceuticals
Publication of IL62258A publication Critical patent/IL62258A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/28—Oxygen atom
    • C07D473/30—Oxygen atom attached in position 6, e.g. hypoxanthine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
IL62258A 1980-03-14 1981-03-03 Hypoxanthine derivatives and their pharmaceutical use IL62258A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/130,334 US4340726A (en) 1980-03-14 1980-03-14 Esters

Publications (1)

Publication Number Publication Date
IL62258A true IL62258A (en) 1984-12-31

Family

ID=22444200

Family Applications (1)

Application Number Title Priority Date Filing Date
IL62258A IL62258A (en) 1980-03-14 1981-03-03 Hypoxanthine derivatives and their pharmaceutical use

Country Status (26)

Country Link
US (1) US4340726A (cg-RX-API-DMAC7.html)
EP (1) EP0036077B1 (cg-RX-API-DMAC7.html)
JP (1) JPS572287A (cg-RX-API-DMAC7.html)
KR (1) KR850000320B1 (cg-RX-API-DMAC7.html)
AT (1) ATE8995T1 (cg-RX-API-DMAC7.html)
AU (1) AU535052B2 (cg-RX-API-DMAC7.html)
CA (1) CA1159827A (cg-RX-API-DMAC7.html)
CS (1) CS235514B2 (cg-RX-API-DMAC7.html)
DD (1) DD156813A5 (cg-RX-API-DMAC7.html)
DE (1) DE3165476D1 (cg-RX-API-DMAC7.html)
DK (1) DK154768C (cg-RX-API-DMAC7.html)
ES (1) ES8202825A1 (cg-RX-API-DMAC7.html)
FI (1) FI67848C (cg-RX-API-DMAC7.html)
GR (1) GR74807B (cg-RX-API-DMAC7.html)
HU (1) HU187324B (cg-RX-API-DMAC7.html)
IE (1) IE51019B1 (cg-RX-API-DMAC7.html)
IL (1) IL62258A (cg-RX-API-DMAC7.html)
IN (1) IN155441B (cg-RX-API-DMAC7.html)
NO (1) NO155579C (cg-RX-API-DMAC7.html)
NZ (1) NZ196295A (cg-RX-API-DMAC7.html)
PH (1) PH19148A (cg-RX-API-DMAC7.html)
PL (1) PL129094B1 (cg-RX-API-DMAC7.html)
PT (1) PT72665B (cg-RX-API-DMAC7.html)
RO (1) RO82509A (cg-RX-API-DMAC7.html)
YU (1) YU41973B (cg-RX-API-DMAC7.html)
ZA (1) ZA811181B (cg-RX-API-DMAC7.html)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4423050A (en) * 1981-05-21 1983-12-27 Syntex (U.S.A.) Inc. 9-(1,3-Dihydroxy-2-propoxymethyl)guanine as antiviral agent
JPS58135878A (ja) * 1981-09-22 1983-08-12 Suntory Ltd 新規アイラントン誘導体及びその製造法
AU564576B2 (en) * 1981-09-24 1987-08-20 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Purine derivatives
US4451478A (en) * 1982-03-12 1984-05-29 Newport Pharmaceuticals International, Inc. Imidazole compounds
US4609662A (en) * 1982-10-14 1986-09-02 Burroughs Wellcome Co. Method for using purine derivatives
HUT36464A (en) * 1983-05-24 1985-09-30 Newport Pharmaceuticals Process for producing erythro-4-amino-3-/2-hydroxy-3-alkyl/-imidazol-5-carboxamide
JP3005959B2 (ja) * 1989-03-31 2000-02-07 ヤンマー農機株式会社 乗用田植機における植付部伝動構造
US5614504A (en) * 1990-08-01 1997-03-25 The University Of South Florida Method of making inosine monophosphate derivatives and immunopotentiating uses thereof
US6420374B1 (en) 1990-11-30 2002-07-16 Fred Hutchinson Cancer Research Center Use of xanthines as immunosuppressants and to inhibit allograft reactions
US6338963B1 (en) 1994-07-25 2002-01-15 Neotherapeutics, Inc. Use of carbon monoxide dependent guanylyl cyclase modifiers to stimulate neuritogenesis
BE1008977A5 (fr) * 1994-12-27 1996-10-01 Solvay Adjuvants pour vaccins.
US6303617B1 (en) 1998-05-04 2001-10-16 Neotherapeutics, Inc. Serotonin-like 9-substituted hypoxanthine and methods of use
US6297226B1 (en) 1999-10-15 2001-10-02 Neotherapeutics, Inc. Synthesis and methods of use of 9-substituted guanine derivatives
US6288069B1 (en) 1999-11-16 2001-09-11 Neotherapeutics, Inc. Use of 9-substituted hypoxanthine derivatives to stimulate regeneration of nervous tissue
US6407237B1 (en) 2001-02-21 2002-06-18 Neotherapeutics, Inc. Crystal forms of 9-substituted hypoxanthine derivatives
US6849735B1 (en) 2000-06-23 2005-02-01 Merck Eprova Ag Methods of synthesis for 9-substituted hypoxanthine derivatives
ATE499103T1 (de) 2000-07-07 2011-03-15 Spectrum Pharmaceuticals Inc Verfahren zur behandlung von arzneimittelinduzierter peripherer neuropathie und verwandten krankheitsformen
US6759427B2 (en) 2001-04-20 2004-07-06 Spectrum Pharmaceuticals, Inc. Synthesis and methods of use of tetrahydroindolone analogues and derivatives
US20030055249A1 (en) * 2001-07-17 2003-03-20 Fick David B. Synthesis and methods of use of pyrimidine analogues and derivatives
CA2540598C (en) * 2003-10-03 2013-09-24 3M Innovative Properties Company Pyrazolopyridines and analogs thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2940966A (en) * 1958-05-15 1960-06-14 Daniel R Bullard Glucoside of 2-amino-4-hydroxy-6-(1', 2'-dihydroxypropyl)-pteridine
US3862189A (en) * 1973-08-14 1975-01-21 Warner Lambert Co Aralkyl-substituted purines and pyrimidines as antianginal bronchodilator agents
US4138562A (en) * 1977-02-09 1979-02-06 The Regents Of The University Of Minnesota Adenosine deaminase resistant antiviral purine nucleosides and method of preparation
DE2714883A1 (de) * 1977-04-02 1978-10-12 Basf Ag Nicht-glykosidische theophyllin- zucker-derivate
JPS55113786A (en) * 1979-02-23 1980-09-02 Toyo Jozo Co Ltd Novel substance, nepranosin b or f and its preparation
US4221909A (en) * 1978-09-15 1980-09-09 Sloan-Kettering Institute For Cancer Research P-Acetamidobenzoic acid salts of 9-(hydroxyalkyl) purines
US4221910A (en) * 1978-09-15 1980-09-09 Newport Pharmaceuticals International, Inc. 9-(Hydroxy alkyl)purines
US4221794A (en) * 1979-06-21 1980-09-09 Newport Pharmaceuticals International, Inc. Method of imparting immunomodulating and antiviral activity

Also Published As

Publication number Publication date
KR850000320B1 (ko) 1985-03-20
NO810723L (no) 1981-09-15
IE810552L (en) 1981-09-14
DK154768B (da) 1988-12-19
AU6802581A (en) 1981-09-17
PH19148A (en) 1986-01-15
DE3165476D1 (en) 1984-09-20
EP0036077A3 (en) 1982-01-13
CS235514B2 (en) 1985-05-15
FI67848B (fi) 1985-02-28
ZA811181B (en) 1982-01-27
ES500321A0 (es) 1982-03-01
JPH031311B2 (cg-RX-API-DMAC7.html) 1991-01-10
RO82509A (ro) 1983-09-26
JPS572287A (en) 1982-01-07
EP0036077A2 (en) 1981-09-23
GR74807B (cg-RX-API-DMAC7.html) 1984-08-12
FI810774L (fi) 1981-09-15
CA1159827A (en) 1984-01-03
US4340726A (en) 1982-07-20
ATE8995T1 (de) 1984-09-15
YU41973B (en) 1988-04-30
ES8202825A1 (es) 1982-03-01
KR830005224A (ko) 1983-08-03
PT72665A (en) 1981-04-01
DK154768C (da) 1989-06-19
NZ196295A (en) 1983-09-02
HU187324B (en) 1985-12-28
NO155579C (no) 1987-04-22
NO155579B (no) 1987-01-12
EP0036077B1 (en) 1984-08-15
DK115081A (da) 1981-09-15
IN155441B (cg-RX-API-DMAC7.html) 1985-02-02
RO82509B (ro) 1983-08-30
PL129094B1 (en) 1984-03-31
PL230115A1 (cg-RX-API-DMAC7.html) 1981-11-13
IE51019B1 (en) 1986-09-03
AU535052B2 (en) 1984-03-01
DD156813A5 (de) 1982-09-22
PT72665B (en) 1982-06-08
YU65181A (en) 1984-02-29
FI67848C (fi) 1985-06-10

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