ATE43348T1 - Acylierte cytidin-diphosphat-choline, verfahren zu ihrer herstellung und ihre therapeutische verwendung. - Google Patents
Acylierte cytidin-diphosphat-choline, verfahren zu ihrer herstellung und ihre therapeutische verwendung.Info
- Publication number
- ATE43348T1 ATE43348T1 AT85100715T AT85100715T ATE43348T1 AT E43348 T1 ATE43348 T1 AT E43348T1 AT 85100715 T AT85100715 T AT 85100715T AT 85100715 T AT85100715 T AT 85100715T AT E43348 T1 ATE43348 T1 AT E43348T1
- Authority
- AT
- Austria
- Prior art keywords
- diphosphate
- choline
- cytidin
- cholines
- acylated
- Prior art date
Links
- 230000001225 therapeutic effect Effects 0.000 title abstract 2
- UHDGCWIWMRVCDJ-XVFCMESISA-N cytidine Chemical class O=C1N=C(N)C=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 UHDGCWIWMRVCDJ-XVFCMESISA-N 0.000 title 1
- 239000001177 diphosphate Substances 0.000 title 1
- XPPKVPWEQAFLFU-UHFFFAOYSA-J diphosphate(4-) Chemical compound [O-]P([O-])(=O)OP([O-])([O-])=O XPPKVPWEQAFLFU-UHFFFAOYSA-J 0.000 title 1
- 235000011180 diphosphates Nutrition 0.000 title 1
- RZZPDXZPRHQOCG-OJAKKHQRSA-M CDP-choline(1-) Chemical class O[C@@H]1[C@H](O)[C@@H](COP([O-])(=O)OP([O-])(=O)OCC[N+](C)(C)C)O[C@H]1N1C(=O)N=C(N)C=C1 RZZPDXZPRHQOCG-OJAKKHQRSA-M 0.000 abstract 3
- 230000010933 acylation Effects 0.000 abstract 1
- 238000005917 acylation reaction Methods 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000001735 carboxylic acids Chemical class 0.000 abstract 1
- 229960001231 choline Drugs 0.000 abstract 1
- 229960001284 citicoline Drugs 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 235000014113 dietary fatty acids Nutrition 0.000 abstract 1
- 229930195729 fatty acid Natural products 0.000 abstract 1
- 239000000194 fatty acid Substances 0.000 abstract 1
- 150000004665 fatty acids Chemical class 0.000 abstract 1
- 210000001035 gastrointestinal tract Anatomy 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP85100715A EP0188647B1 (de) | 1985-01-24 | 1985-01-24 | Acylierte Cytidin-Diphosphat-Choline, Verfahren zu ihrer Herstellung und ihre therapeutische Verwendung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE43348T1 true ATE43348T1 (de) | 1989-06-15 |
Family
ID=8193252
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT85100715T ATE43348T1 (de) | 1985-01-24 | 1985-01-24 | Acylierte cytidin-diphosphat-choline, verfahren zu ihrer herstellung und ihre therapeutische verwendung. |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP0188647B1 (de) |
| JP (1) | JPS61176598A (de) |
| AT (1) | ATE43348T1 (de) |
| AU (1) | AU576548B2 (de) |
| DE (1) | DE3570441D1 (de) |
| ZA (1) | ZA85578B (de) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0713036Y2 (ja) * | 1989-01-27 | 1995-03-29 | ヤマハ株式会社 | 電子鍵盤楽器 |
| US5958896A (en) * | 1997-08-08 | 1999-09-28 | The Mclean Hospital | Cytidine-containing and cytosine-containing compounds as treatments for stimulant exposure |
| ES2425114T3 (es) | 2000-03-16 | 2013-10-11 | The Mclean Hospital Corporation | CDP-colina y uridina para el tratamiento del abuso del acohol |
| AU2003291368A1 (en) | 2002-11-08 | 2004-06-03 | The Mclean Hospital Corporation | Compounds for the treatment of tobacco dependence and withdrawal |
| EP1765075A4 (de) | 2004-06-10 | 2010-11-10 | Mclean Hospital Corp | Pyrimidine, wie z.b. uridin; bei der behandlung von patienten mit manisch-depressiver psychose |
| EP1784199A4 (de) | 2004-08-11 | 2010-06-23 | Mclean Hospital Corp | Verbindungen zur behandlung von marihuana-abhängigkeit, entzug und konsum |
| WO2014060941A2 (en) * | 2012-10-17 | 2014-04-24 | Mahesh Kandula | Compositions and methods of neuroprotective agents for the treatment of neurological and neurodegenerative diseases |
| US10654882B2 (en) | 2015-12-21 | 2020-05-19 | Showa Denko K.K. | Nicotinamide mononucleotide derivative and salt thereof, method for producing same, topical skin preparation, cosmetic and food additive |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1219824A (en) * | 1981-04-17 | 1987-03-31 | David C. Ward | Modified nucleotides and methods of preparing and using same |
| JPS5843993A (ja) * | 1981-09-09 | 1983-03-14 | Yamasa Shoyu Co Ltd | １−β−Ｄ−アラビノフラノシル−（Ｅ）−５−（２−ハロゲノビニル）ウラシル−５′−りん酸およびその製造法 |
| CA1223831A (en) * | 1982-06-23 | 1987-07-07 | Dean Engelhardt | Modified nucleotides, methods of preparing and utilizing and compositions containing the same |
-
1985
- 1985-01-24 AT AT85100715T patent/ATE43348T1/de not_active IP Right Cessation
- 1985-01-24 EP EP85100715A patent/EP0188647B1/de not_active Expired
- 1985-01-24 DE DE8585100715T patent/DE3570441D1/de not_active Expired
- 1985-01-24 ZA ZA850578A patent/ZA85578B/xx unknown
- 1985-01-25 AU AU38102/85A patent/AU576548B2/en not_active Ceased
- 1985-01-26 JP JP60011806A patent/JPS61176598A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP0188647A1 (de) | 1986-07-30 |
| AU576548B2 (en) | 1988-09-01 |
| ZA85578B (en) | 1985-07-22 |
| AU3810285A (en) | 1986-07-31 |
| EP0188647B1 (de) | 1989-05-24 |
| JPS61176598A (ja) | 1986-08-08 |
| DE3570441D1 (en) | 1989-06-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |