ZA85578B - Acylated derivatives of cytidine-diphosphate-choline,process for their preparation and their therapeutic use - Google Patents
Acylated derivatives of cytidine-diphosphate-choline,process for their preparation and their therapeutic useInfo
- Publication number
- ZA85578B ZA85578B ZA850578A ZA85578A ZA85578B ZA 85578 B ZA85578 B ZA 85578B ZA 850578 A ZA850578 A ZA 850578A ZA 85578 A ZA85578 A ZA 85578A ZA 85578 B ZA85578 B ZA 85578B
- Authority
- ZA
- South Africa
- Prior art keywords
- choline
- cytidine
- diphosphate
- preparation
- derivatives
- Prior art date
Links
- RZZPDXZPRHQOCG-OJAKKHQRSA-M CDP-choline(1-) Chemical class O[C@@H]1[C@H](O)[C@@H](COP([O-])(=O)OP([O-])(=O)OCC[N+](C)(C)C)O[C@H]1N1C(=O)N=C(N)C=C1 RZZPDXZPRHQOCG-OJAKKHQRSA-M 0.000 title abstract 4
- 230000001225 therapeutic effect Effects 0.000 title abstract 2
- 230000010933 acylation Effects 0.000 abstract 1
- 238000005917 acylation reaction Methods 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000001735 carboxylic acids Chemical class 0.000 abstract 1
- 229960001231 choline Drugs 0.000 abstract 1
- 229960001284 citicoline Drugs 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 235000014113 dietary fatty acids Nutrition 0.000 abstract 1
- 229930195729 fatty acid Natural products 0.000 abstract 1
- 239000000194 fatty acid Substances 0.000 abstract 1
- 150000004665 fatty acids Chemical class 0.000 abstract 1
- 210000001035 gastrointestinal tract Anatomy 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP85100715A EP0188647B1 (de) | 1985-01-24 | 1985-01-24 | Acylierte Cytidin-Diphosphat-Choline, Verfahren zu ihrer Herstellung und ihre therapeutische Verwendung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA85578B true ZA85578B (en) | 1985-07-22 |
Family
ID=8193252
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA850578A ZA85578B (en) | 1985-01-24 | 1985-01-24 | Acylated derivatives of cytidine-diphosphate-choline,process for their preparation and their therapeutic use |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP0188647B1 (de) |
| JP (1) | JPS61176598A (de) |
| AT (1) | ATE43348T1 (de) |
| AU (1) | AU576548B2 (de) |
| DE (1) | DE3570441D1 (de) |
| ZA (1) | ZA85578B (de) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0713036Y2 (ja) * | 1989-01-27 | 1995-03-29 | ヤマハ株式会社 | 電子鍵盤楽器 |
| US5958896A (en) * | 1997-08-08 | 1999-09-28 | The Mclean Hospital | Cytidine-containing and cytosine-containing compounds as treatments for stimulant exposure |
| WO2001068104A1 (en) | 2000-03-16 | 2001-09-20 | The Mclean Hospital Corporation | Compounds for the treatment of psychiatric or substance abuse disorders |
| MXPA05004866A (es) | 2002-11-08 | 2005-11-04 | Mclean Hospital Corp | Compuestos para el tratamiento de la dependencia y la abstinencia de tabaco. |
| US7737128B2 (en) | 2004-06-10 | 2010-06-15 | The Mclean Hospital Corporation | Pyrimidines, such as uridine, in treatments for patients with bipolar disorder |
| WO2006020703A1 (en) | 2004-08-11 | 2006-02-23 | The Mclean Hospital Corporation | Compounds for the treatment of marihuana dependence, withdrawal, and usage |
| WO2014060941A2 (en) * | 2012-10-17 | 2014-04-24 | Mahesh Kandula | Compositions and methods of neuroprotective agents for the treatment of neurological and neurodegenerative diseases |
| WO2017110317A1 (ja) * | 2015-12-21 | 2017-06-29 | 昭和電工株式会社 | ニコチンアミドモノヌクレオチド誘導体、その塩、その製造方法、皮膚外用剤、化粧料、食品添加剤 |
| WO2025216249A1 (ja) * | 2024-04-08 | 2025-10-16 | 協和発酵バイオ株式会社 | シチジンジリン酸コリン配糖体、組成物、シチジン残基含有化合物の配糖体の製造方法、遺伝子組換え微生物、シチジン残基含有化合物の製造方法、及びシチジン残基含有化合物の配糖体の生成の抑制方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1219824A (en) * | 1981-04-17 | 1987-03-31 | David C. Ward | Modified nucleotides and methods of preparing and using same |
| JPS5843993A (ja) * | 1981-09-09 | 1983-03-14 | Yamasa Shoyu Co Ltd | １−β−Ｄ−アラビノフラノシル−（Ｅ）−５−（２−ハロゲノビニル）ウラシル−５′−りん酸およびその製造法 |
| CA1223831A (en) * | 1982-06-23 | 1987-07-07 | Dean Engelhardt | Modified nucleotides, methods of preparing and utilizing and compositions containing the same |
-
1985
- 1985-01-24 AT AT85100715T patent/ATE43348T1/de not_active IP Right Cessation
- 1985-01-24 ZA ZA850578A patent/ZA85578B/xx unknown
- 1985-01-24 DE DE8585100715T patent/DE3570441D1/de not_active Expired
- 1985-01-24 EP EP85100715A patent/EP0188647B1/de not_active Expired
- 1985-01-25 AU AU38102/85A patent/AU576548B2/en not_active Ceased
- 1985-01-26 JP JP60011806A patent/JPS61176598A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JPS61176598A (ja) | 1986-08-08 |
| ATE43348T1 (de) | 1989-06-15 |
| AU3810285A (en) | 1986-07-31 |
| DE3570441D1 (en) | 1989-06-29 |
| EP0188647B1 (de) | 1989-05-24 |
| AU576548B2 (en) | 1988-09-01 |
| EP0188647A1 (de) | 1986-07-30 |
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