IL60498A - Separation of d-(6-methoxy-2-naphthyl)propionic acid and salts thereof from their mixtures with the 1-enantiomer by n-substituted d-glucamine,salts of the d-enantiomer with n-substituted d-glucamine and pharmaceutical compositions containing them - Google Patents

Separation of d-(6-methoxy-2-naphthyl)propionic acid and salts thereof from their mixtures with the 1-enantiomer by n-substituted d-glucamine,salts of the d-enantiomer with n-substituted d-glucamine and pharmaceutical compositions containing them

Info

Publication number
IL60498A
IL60498A IL60498A IL6049880A IL60498A IL 60498 A IL60498 A IL 60498A IL 60498 A IL60498 A IL 60498A IL 6049880 A IL6049880 A IL 6049880A IL 60498 A IL60498 A IL 60498A
Authority
IL
Israel
Prior art keywords
glucamine
enantiomer
salts
substituted
naphthyl
Prior art date
Application number
IL60498A
Other languages
English (en)
Other versions
IL60498A0 (en
Original Assignee
Syntex Corp
Palo Alto Res Ass
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26734026&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL60498(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US06/097,118 external-priority patent/US4246193A/en
Application filed by Syntex Corp, Palo Alto Res Ass filed Critical Syntex Corp
Priority to IL70934A priority Critical patent/IL70934A/xx
Publication of IL60498A0 publication Critical patent/IL60498A0/xx
Priority to IL8470934A priority patent/IL70934A0/xx
Publication of IL60498A publication Critical patent/IL60498A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/42—Separation; Purification; Stabilisation; Use of additives
    • C07C51/50—Use of additives, e.g. for stabilisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/42—Separation; Purification; Stabilisation; Use of additives
    • C07C51/487—Separation; Purification; Stabilisation; Use of additives by treatment giving rise to chemical modification
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
    • C07C57/38—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings polycyclic
    • C07C57/40—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings polycyclic containing condensed ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IL60498A 1979-07-06 1980-07-04 Separation of d-(6-methoxy-2-naphthyl)propionic acid and salts thereof from their mixtures with the 1-enantiomer by n-substituted d-glucamine,salts of the d-enantiomer with n-substituted d-glucamine and pharmaceutical compositions containing them IL60498A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
IL70934A IL70934A (en) 1979-07-06 1980-07-04 Salts of d 2-(6-methoxy-2-naphthyl)propionic acid with n-substituted d-glucamine,their preparation and pharmaceutical compositions containing them
IL8470934A IL70934A0 (en) 1979-07-06 1984-02-13 Salts of d 2-(6-methoxy-2-naphthyl)propionic acid with n-substituted d-glucamine,their preparation and pharmaceutical compositions containing them

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5525879A 1979-07-06 1979-07-06
US06/097,118 US4246193A (en) 1979-11-26 1979-11-26 Process for the resolution of d,1 2-(6-methoxy-2-naphthyl)propionic acid

Publications (2)

Publication Number Publication Date
IL60498A0 IL60498A0 (en) 1980-09-16
IL60498A true IL60498A (en) 1984-06-29

Family

ID=26734026

Family Applications (1)

Application Number Title Priority Date Filing Date
IL60498A IL60498A (en) 1979-07-06 1980-07-04 Separation of d-(6-methoxy-2-naphthyl)propionic acid and salts thereof from their mixtures with the 1-enantiomer by n-substituted d-glucamine,salts of the d-enantiomer with n-substituted d-glucamine and pharmaceutical compositions containing them

Country Status (27)

Country Link
EP (1) EP0022529B1 (sr)
JP (2) JPS63313749A (sr)
KR (1) KR830000769B1 (sr)
AR (1) AR225927A1 (sr)
AU (1) AU544963B2 (sr)
CA (1) CA1135717A (sr)
CZ (1) CZ277725B6 (sr)
DD (1) DD153367A5 (sr)
DE (3) DE3063969D1 (sr)
DK (2) DK156051C (sr)
ES (1) ES8105691A1 (sr)
FR (2) FR2472557A1 (sr)
GB (1) GB2054579B (sr)
GR (1) GR68796B (sr)
HK (1) HK886A (sr)
IE (1) IE50000B1 (sr)
IL (1) IL60498A (sr)
IN (1) IN152737B (sr)
IT (1) IT1130490B (sr)
MY (1) MY8600452A (sr)
NZ (1) NZ194237A (sr)
PH (4) PH15674A (sr)
PL (1) PL133439B1 (sr)
PT (1) PT71486A (sr)
RO (1) RO80655B (sr)
SK (1) SK278340B6 (sr)
YU (1) YU42673B (sr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1168387B (it) * 1981-04-01 1987-05-20 Alfa Farmaceutici Spa Procedimento per la preparazione dell'acido 2-(6-metossi-2-naftil)-propionico
ZA828453B (en) * 1981-12-08 1983-12-28 Boots Co Plc Therapeutic agents
IT1196197B (it) * 1984-07-23 1988-11-10 Ravizza Spa Procedimento per la risoluzione dell'acido (+)(-) 2-(2'-(p-fluorofenil)--5'-benzossazolil)-propionico
GB9121279D0 (en) * 1991-10-08 1991-11-20 Cerestar Holding Bv Process for the production of aminopolyols
US5574183A (en) * 1995-01-24 1996-11-12 Albemarle Corporation Preparation of optically active aliphatic carboxylic acids
KR100678287B1 (ko) * 2005-06-23 2007-02-02 한미약품 주식회사 클로피도그렐의 제조방법 및 이에 사용되는 중간체
KR101170537B1 (ko) * 2010-01-11 2012-08-01 김창운 해수의 자연순환이 가능한 내륙 내 바다양식 수조

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3904682A (en) * 1967-01-13 1975-09-09 Syntex Corp 2-(6{40 -Methoxy-2{40 -naphthyl)acetic acid
DE1668654B2 (de) * 1967-01-13 1976-11-04 Syntex Corp., Panama 2-(6'-substituierte-2'-naphthyl)- propionsaeuren und -derivate, ihre herstellung und sie enthaltende arzneimittel
ZA70809B (en) * 1969-03-24 1971-09-29 Syntex Corp Amine salts of 2-(6'-methoxy-2'-naphthyl)propionic acids and processes for the preparation thereof
US3686183A (en) * 1969-03-24 1972-08-22 Syntex Corp Preparation of optical isomers of arylalkylacetic acids
US3904683A (en) * 1972-08-10 1975-09-09 Syntex Corp Process for the resolution of d- and 1-2-(6-methoxy-2-naphthyl) propionic acid
PT67743A (en) * 1977-03-08 1978-04-01 Boots Co Ltd Preparation of therapeutic agents
CH641432A5 (de) * 1978-07-19 1984-02-29 Syntex Pharma Int Verfahren zur aufspaltung von racemischer 6-methoxy-alpha-methyl-2-naphthalinessigsaeure in die optischen antipoden.

Also Published As

Publication number Publication date
FR2470108B1 (sr) 1984-04-20
CA1135717A (en) 1982-11-16
PH16431A (en) 1983-10-03
FR2472557B1 (sr) 1984-04-20
PL225474A1 (sr) 1981-03-27
IT8068053A0 (it) 1980-07-03
IE50000B1 (en) 1986-01-22
ES493126A0 (es) 1981-06-16
HK886A (en) 1986-01-10
DK289080A (da) 1981-01-07
GR68796B (sr) 1982-02-18
JPH0454B2 (sr) 1992-01-06
JPH0249749A (ja) 1990-02-20
GB2054579B (en) 1983-06-22
DK239988D0 (da) 1988-05-03
EP0022529A1 (en) 1981-01-21
CS477480A3 (en) 1992-11-18
DE3025448A1 (de) 1981-01-15
RO80655A (ro) 1983-04-29
PH16328A (en) 1983-09-05
JPS63313749A (ja) 1988-12-21
CZ277725B6 (en) 1993-04-14
IE801396L (en) 1981-01-06
MY8600452A (en) 1986-12-31
JPH0321535B2 (sr) 1991-03-22
DK156051C (da) 1989-11-06
EP0022529B1 (en) 1983-06-29
PT71486A (en) 1980-08-01
YU174380A (en) 1984-04-30
IT1130490B (it) 1986-06-11
KR830000769B1 (ko) 1983-04-11
YU42673B (en) 1988-10-31
PL133439B1 (en) 1985-06-29
IL60498A0 (en) 1980-09-16
DK239988A (da) 1988-05-03
ES8105691A1 (es) 1981-06-16
FR2470108A1 (fr) 1981-05-29
DK156051B (da) 1989-06-19
DD153367A5 (de) 1982-01-06
DE3025448C2 (sr) 1987-05-21
SK278340B6 (en) 1996-12-04
RO80655B (ro) 1983-04-30
PH15674A (en) 1983-03-11
AU544963B2 (en) 1985-06-27
AU6012180A (en) 1981-01-15
AR225927A1 (es) 1982-05-14
GB2054579A (en) 1981-02-18
PH16432A (en) 1983-10-03
FR2472557A1 (fr) 1981-07-03
NZ194237A (en) 1984-05-31
DE3063969D1 (en) 1983-08-04
DE3051036C2 (sr) 1988-03-31
IN152737B (sr) 1984-03-24

Similar Documents

Publication Publication Date Title
NZ189574A (en) Dehydrocyclicimino acid derivatives pharmaceutical compositions
SG61787G (en) 7-acylamino-3-vinylcephalosporanic acid derivatives, processes for their preparation, pharmaceutical compositions containing them, their starting compounds and their preparation
IL49095A (en) 1,4dihydropyridine-3,5-di-carboxylic acid aralkyl esters their preparation and pharmaceutical compositions containing them
IT1130184B (it) Composti 2 penem,metodo per la loro preparazione e composizioni farmaceutiche contenenti tali composti
GB2053909B (en) Pyrrolidinylalkycarboxylic acid amide derivatives their preparation and pharmaceutical compositions containing them
IL58080A0 (en) Acid addition salts of 16 -monoquaternary ammonium derivatives of 2 ,16 -bis-piperidino-and rostanes and pharmaceutical compositions containing them
DE3365829D1 (en) Pharmaceutical composition containing an aliphatic aminosulphonic acid
GR63213B (en) 4-trifluormethylbenzoic acid derivatives and process of making the same and pharmaceutical compositions containing thereof
IL52466A (en) 7(2-acyl-2-hydroxyiminoacetamido)-3-tetrazol-5-ylthiomethyl-3-cephem-4-carboxylic acid derivatives,their preparation and pharmaceutical compositions containing them
IL50507A0 (en) Phenoxyalkylcarboxylic acid derivatives processes for the preparation thereof and pharmaceutical compositions containing the same
IL52227A (en) Process for the preparation of 10,19-dihydro-vitamin d derivatives and some novel 10,19-dihydro-1alpha-hydroxy and 1 alpha,25-dihydroxy-vitamin d3 compounds and pharmaceutical compositions containing them
IL60498A (en) Separation of d-(6-methoxy-2-naphthyl)propionic acid and salts thereof from their mixtures with the 1-enantiomer by n-substituted d-glucamine,salts of the d-enantiomer with n-substituted d-glucamine and pharmaceutical compositions containing them
IL51267A (en) Clavulanic acid thioethers their preparation and pharmaceutical compositions containing them
IL49352A0 (en) New carboxylic acid amides,their preparation and pharmaceutical compositions containing them
HK13285A (en) Pharmaceutical compositions containing immunestimulating n-substituted aziridine-2-carboxylic acid derivatives
JPS5328136A (en) Phenoxyyphenoxyyalkane carboxylic acid derivatives*process for preparation thereof and herbicide containing said compound
IL57090A0 (en) Pharmaceutical compositions containing anthranilic acid deivatives and certain such novel compounds
DE2967551D1 (en) 5(6)-(2-amino-5-thiazoloyl)benzimidazole-2-carbamic acid esters and their salts, their preparation and use, and pharmaceutical compositions containing them
ZA793720B (en) Substituted 2-phenylamino-imidazoline-(2)derivatives,acid addition salts thereof,processes for their preparation,and pharmaceutical compositions thereof
IL52966A0 (en) Novel 2-(phenylalkylhydrazono)-propionic acid derivatives process for their preparation and pharmaceutical compositions containing the same
IL56959A0 (en) Pharmaceutical compositions containing an amino acid derivative
IL53549A (en) Process for the preparation of 1-aziridine-carboxylic acid ester derivatives,pharmaceutical compositions containing the same and certain such novel compounds
IL60444A (en) 2-amino-3-(alkylthiobenzoyl)-phenylacetic acid derivatives and pharmaceutical compositions containing them
IL51720A0 (en) A novel substituted propionic acid and its salts their preparation and pharmaceutical compositions containing them
IL50546A (en) 7-acyl-3-(1-(2-sulfaminoethyl)tetrazol-5-ylthiomethyl)-3-cephem-4-carboxylic acid derivatives and pharmaceutical compositions containing them

Legal Events

Date Code Title Description
KB Patent renewed