IL44163A - Isoindoline derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same - Google Patents
Isoindoline derivatives,processes for the preparation thereof and pharmaceutical compositions containing the sameInfo
- Publication number
- IL44163A IL44163A IL44163A IL4416374A IL44163A IL 44163 A IL44163 A IL 44163A IL 44163 A IL44163 A IL 44163A IL 4416374 A IL4416374 A IL 4416374A IL 44163 A IL44163 A IL 44163A
- Authority
- IL
- Israel
- Prior art keywords
- acid addition
- addition salts
- phenyl
- isoindoline
- isoindolin
- Prior art date
Links
- GWVMLCQWXVFZCN-UHFFFAOYSA-N isoindoline Chemical class C1=CC=C2CNCC2=C1 GWVMLCQWXVFZCN-UHFFFAOYSA-N 0.000 title claims 14
- 238000000034 method Methods 0.000 title claims 10
- 238000002360 preparation method Methods 0.000 title claims 5
- 239000008194 pharmaceutical composition Substances 0.000 title claims 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract 2
- 239000002253 acid Substances 0.000 claims 18
- 150000003839 salts Chemical class 0.000 claims 17
- -1 alkylene radical Chemical class 0.000 claims 6
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical group [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- 150000002148 esters Chemical class 0.000 claims 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 2
- 150000003254 radicals Chemical class 0.000 claims 2
- ACLDPLJKHMWQBY-UHFFFAOYSA-N 2-phenyl-3-[2-(propan-2-ylamino)ethoxy]-3h-isoindol-1-one Chemical compound O=C1C2=CC=CC=C2C(OCCNC(C)C)N1C1=CC=CC=C1 ACLDPLJKHMWQBY-UHFFFAOYSA-N 0.000 claims 1
- JAEAVUQPERLVRU-UHFFFAOYSA-N 2-phenyl-3-[3-(propan-2-ylamino)propoxy]-3h-isoindol-1-one Chemical compound O=C1C2=CC=CC=C2C(OCCCNC(C)C)N1C1=CC=CC=C1 JAEAVUQPERLVRU-UHFFFAOYSA-N 0.000 claims 1
- VJKNTWOPQHSCOZ-UHFFFAOYSA-N 2-phenyl-3-[4-(propan-2-ylamino)butoxy]-3h-isoindol-1-one Chemical compound O=C1C2=CC=CC=C2C(OCCCCNC(C)C)N1C1=CC=CC=C1 VJKNTWOPQHSCOZ-UHFFFAOYSA-N 0.000 claims 1
- SZSFJLFFZCQCIA-UHFFFAOYSA-N 2-phenyl-3-[5-(propan-2-ylamino)pentoxy]-3h-isoindol-1-one Chemical compound O=C1C2=CC=CC=C2C(OCCCCCNC(C)C)N1C1=CC=CC=C1 SZSFJLFFZCQCIA-UHFFFAOYSA-N 0.000 claims 1
- HNUALPPJLMYHDK-UHFFFAOYSA-N C[CH]C Chemical compound C[CH]C HNUALPPJLMYHDK-UHFFFAOYSA-N 0.000 claims 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 229910052783 alkali metal Inorganic materials 0.000 claims 1
- 150000001412 amines Chemical class 0.000 claims 1
- 239000002585 base Substances 0.000 claims 1
- 229910052801 chlorine Inorganic materials 0.000 claims 1
- 239000000460 chlorine Substances 0.000 claims 1
- 238000000576 coating method Methods 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 claims 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 231100000252 nontoxic Toxicity 0.000 claims 1
- 230000003000 nontoxic effect Effects 0.000 claims 1
- 239000008016 pharmaceutical coating Substances 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 239000003416 antiarrhythmic agent Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- PXZQEOJJUGGUIB-UHFFFAOYSA-N isoindolin-1-one Chemical class C1=CC=C2C(=O)NCC2=C1 PXZQEOJJUGGUIB-UHFFFAOYSA-N 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 230000003285 pharmacodynamic effect Effects 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7304460A FR2217000B1 (enrdf_load_stackoverflow) | 1973-02-08 | 1973-02-08 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL44163A0 IL44163A0 (en) | 1974-05-16 |
| IL44163A true IL44163A (en) | 1976-08-31 |
Family
ID=9114536
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL44163A IL44163A (en) | 1973-02-08 | 1974-02-07 | Isoindoline derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same |
Country Status (23)
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2607506B1 (fr) * | 1986-12-02 | 1989-01-06 | Rhone Poulenc Sante | Nouveaux derives de l'isoindolinone, leur preparation et les compositions pharmaceutiques qui les contiennent |
| KR100485748B1 (ko) * | 1997-09-18 | 2005-09-15 | 삼성전자주식회사 | (3-옥소이소인돌린-1-일리덴)프로판디니트릴유도체및그제조방법 |
| GB0419481D0 (en) * | 2004-09-02 | 2004-10-06 | Cancer Rec Tech Ltd | Isoindolin-1-one derivatives |
| GB0811643D0 (en) | 2008-06-25 | 2008-07-30 | Cancer Rec Tech Ltd | New therapeutic agents |
| GB201517216D0 (en) | 2015-09-29 | 2015-11-11 | Cancer Res Technology Ltd And Astex Therapeutics Ltd | Pharmaceutical compounds |
| GB201517217D0 (en) | 2015-09-29 | 2015-11-11 | Astex Therapeutics Ltd And Cancer Res Technology Ltd | Pharmaceutical compounds |
| GB201704966D0 (en) | 2017-03-28 | 2017-05-10 | Astex Therapeutics Ltd | Pharmaceutical compounds |
| GB201704965D0 (en) | 2017-03-28 | 2017-05-10 | Astex Therapeutics Ltd | Pharmaceutical compounds |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2117740B1 (enrdf_load_stackoverflow) * | 1970-12-14 | 1974-04-12 | Rhone Poulenc Sa | |
| AR203991A1 (es) * | 1972-03-16 | 1975-11-12 | Rhone Poulenc Sa | Procedimiento para preparar derivados de(hidroxi-2-amino-3-propoxi)-3-isoindolinona-1 |
-
1973
- 1973-02-08 FR FR7304460A patent/FR2217000B1/fr not_active Expired
-
1974
- 1974-01-28 OA OA55106A patent/OA04592A/xx unknown
- 1974-01-31 NL NL7401366A patent/NL7401366A/xx not_active Application Discontinuation
- 1974-02-06 HU HURO767A patent/HU166919B/hu unknown
- 1974-02-07 ZA ZA00740813A patent/ZA74813B/xx unknown
- 1974-02-07 IE IE236/74A patent/IE38831B1/xx unknown
- 1974-02-07 DK DK66974AA patent/DK137572B/da not_active IP Right Cessation
- 1974-02-07 CA CA192,146A patent/CA1012149A/fr not_active Expired
- 1974-02-07 GB GB572574A patent/GB1407953A/en not_active Expired
- 1974-02-07 US US05/440,548 patent/US4001271A/en not_active Expired - Lifetime
- 1974-02-07 JP JP49015022A patent/JPS49102667A/ja active Pending
- 1974-02-07 AR AR252230A patent/AR199829A1/es active
- 1974-02-07 NO NO740411A patent/NO141441C/no unknown
- 1974-02-07 SU SU1993952A patent/SU505359A3/ru active
- 1974-02-07 BE BE140672A patent/BE810748A/xx not_active IP Right Cessation
- 1974-02-07 CH CH1643476A patent/CH587818A5/xx not_active IP Right Cessation
- 1974-02-07 CH CH171874A patent/CH587817A5/xx not_active IP Right Cessation
- 1974-02-07 LU LU69350A patent/LU69350A1/xx unknown
- 1974-02-07 SE SE7401663A patent/SE385583B/xx unknown
- 1974-02-07 IL IL44163A patent/IL44163A/en unknown
- 1974-02-08 AT AT101474A patent/AT328434B/de not_active IP Right Cessation
- 1974-02-08 DE DE2406065A patent/DE2406065C2/de not_active Expired
- 1974-02-08 ES ES423058A patent/ES423058A1/es not_active Expired
- 1974-02-08 FI FI358/74A patent/FI57747C/fi active
- 1974-04-17 ES ES425407A patent/ES425407A1/es not_active Expired
- 1974-09-04 AR AR255459A patent/AR200357A1/es active
-
1975
- 1975-03-31 SU SU7502117225A patent/SU568364A3/ru active
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