IL42790A - 4a-aryl-trans-decahydroisoquinolines their preparation and pharmaceutical compositions containing them - Google Patents
4a-aryl-trans-decahydroisoquinolines their preparation and pharmaceutical compositions containing themInfo
- Publication number
- IL42790A IL42790A IL42790A IL4279073A IL42790A IL 42790 A IL42790 A IL 42790A IL 42790 A IL42790 A IL 42790A IL 4279073 A IL4279073 A IL 4279073A IL 42790 A IL42790 A IL 42790A
- Authority
- IL
- Israel
- Prior art keywords
- compound
- trans
- formula
- decahydroisoquinoline
- administering
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 title claims 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims 31
- 238000000034 method Methods 0.000 claims 10
- 230000036592 analgesia Effects 0.000 claims 8
- 239000001257 hydrogen Substances 0.000 claims 8
- 229910052739 hydrogen Inorganic materials 0.000 claims 8
- 125000000217 alkyl group Chemical group 0.000 claims 6
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 6
- -1 methoxyphenyl Chemical group 0.000 claims 5
- 150000002431 hydrogen Chemical group 0.000 claims 4
- 125000000094 2-phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 claims 3
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 3
- 125000004981 cycloalkylmethyl group Chemical group 0.000 claims 3
- 238000010438 heat treatment Methods 0.000 claims 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 3
- 239000004593 Epoxy Substances 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- 230000000202 analgesic effect Effects 0.000 claims 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 2
- 239000012280 lithium aluminium hydride Substances 0.000 claims 2
- ZVUPIZCQKCQXCR-HOTGVXAUSA-N (4ar,8ar)-2-methyl-4a-phenyl-1,3,4,5,6,7,8,8a-octahydroisoquinoline Chemical compound C1([C@]23CCN(C[C@@H]2CCCC3)C)=CC=CC=C1 ZVUPIZCQKCQXCR-HOTGVXAUSA-N 0.000 claims 1
- ULQQGOGMQRGFFR-UHFFFAOYSA-N 2-chlorobenzenecarboperoxoic acid Chemical compound OOC(=O)C1=CC=CC=C1Cl ULQQGOGMQRGFFR-UHFFFAOYSA-N 0.000 claims 1
- ZMMPBZMELZHMIT-HOCLYGCPSA-N 3-[(4aR,8aR)-2-methyl-1,3,4,5,6,7,8,8a-octahydroisoquinolin-4a-yl]phenol Chemical compound OC=1C=C(C=CC1)[C@@]12CCN(C[C@@H]2CCCC1)C ZMMPBZMELZHMIT-HOCLYGCPSA-N 0.000 claims 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- 239000003054 catalyst Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 150000004820 halides Chemical class 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 238000010992 reflux Methods 0.000 claims 1
- 229910000104 sodium hydride Inorganic materials 0.000 claims 1
- 239000012312 sodium hydride Substances 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
- C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US27380672A | 1972-07-20 | 1972-07-20 | |
| US36584373A | 1973-06-01 | 1973-06-01 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL42790A0 IL42790A0 (en) | 1973-10-25 |
| IL42790A true IL42790A (en) | 1976-11-30 |
Family
ID=26956443
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL42790A IL42790A (en) | 1972-07-20 | 1973-07-19 | 4a-aryl-trans-decahydroisoquinolines their preparation and pharmaceutical compositions containing them |
| IL48667A IL48667A (en) | 1972-07-20 | 1973-07-19 | 4a-aryl-1,3-diketo-trans-decahydroisoquinolines and 4a-aryl-1,3-diketo-1,2,3,4,4a,5,6,7-octahydroisoquinolines and their preparation |
| IL48667A IL48667A0 (en) | 1972-07-20 | 1975-12-15 | 4alpha-aryl-1,3-diketo-trans-decahydroisoquinolines and 4alpha-aryl-1,3-diketo-1,2,3,4,4alpha,5,6,7-octahydroisoquinolines and their preparation |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL48667A IL48667A (en) | 1972-07-20 | 1973-07-19 | 4a-aryl-1,3-diketo-trans-decahydroisoquinolines and 4a-aryl-1,3-diketo-1,2,3,4,4a,5,6,7-octahydroisoquinolines and their preparation |
| IL48667A IL48667A0 (en) | 1972-07-20 | 1975-12-15 | 4alpha-aryl-1,3-diketo-trans-decahydroisoquinolines and 4alpha-aryl-1,3-diketo-1,2,3,4,4alpha,5,6,7-octahydroisoquinolines and their preparation |
Country Status (13)
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE7509337L (sv) * | 1974-09-23 | 1976-03-24 | Du Pont | Smertstillande foreningar |
| PT68934A (en) * | 1977-12-27 | 1979-01-01 | Lilly Co Eli | Process for preparing 4a-aryl-octahydro-1h-2-pyrindines |
| ES2098357T3 (es) * | 1990-06-05 | 1997-05-01 | Toray Industries | Derivado de indol. |
| WO1993001186A1 (en) * | 1991-07-05 | 1993-01-21 | Smithkline Beecham Farmaceutici S.P.A. | Hydroisoquinoline derivatives |
| IT1307327B1 (it) * | 1995-09-12 | 2001-10-30 | Smithkline Beecham Spa | Derivati idroisochinolinici sostituiti |
-
1973
- 1973-07-18 CA CA176,763A patent/CA1024149A/en not_active Expired
- 1973-07-18 DE DE19732336559 patent/DE2336559A1/de active Pending
- 1973-07-18 DE DE19732351599 patent/DE2351599A1/de active Pending
- 1973-07-19 AR AR249168A patent/AR208650A1/es active
- 1973-07-19 IL IL42790A patent/IL42790A/en unknown
- 1973-07-19 IL IL48667A patent/IL48667A/en unknown
- 1973-07-19 FR FR7326508A patent/FR2193600B1/fr not_active Expired
- 1973-07-19 GB GB3938775A patent/GB1436377A/en not_active Expired
- 1973-07-19 IE IE1229/73A patent/IE37929B1/xx unknown
- 1973-07-19 HU HUDU206A patent/HU167738B/hu unknown
- 1973-07-19 GB GB3443873A patent/GB1436376A/en not_active Expired
- 1973-07-19 NL NL7310078A patent/NL7310078A/xx not_active Application Discontinuation
- 1973-07-20 ES ES417127A patent/ES417127A1/es not_active Expired
- 1973-07-20 JP JP48082484A patent/JPS4985075A/ja active Pending
- 1973-07-20 LU LU68066A patent/LU68066A1/xx unknown
-
1975
- 1975-12-15 IL IL48667A patent/IL48667A0/xx unknown
-
1976
- 1976-02-23 SE SE7602150A patent/SE7602150L/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| FR2193600B1 (enrdf_load_stackoverflow) | 1976-10-22 |
| IL48667A (en) | 1976-11-30 |
| ES417127A1 (es) | 1976-04-01 |
| HU167738B (enrdf_load_stackoverflow) | 1975-12-25 |
| GB1436377A (en) | 1976-05-19 |
| AU5820773A (en) | 1975-01-23 |
| FR2193600A1 (enrdf_load_stackoverflow) | 1974-02-22 |
| JPS4985075A (enrdf_load_stackoverflow) | 1974-08-15 |
| CA1024149A (en) | 1978-01-10 |
| SE7602150L (sv) | 1976-02-23 |
| GB1436376A (en) | 1976-05-19 |
| IE37929L (en) | 1974-01-20 |
| DE2351599A1 (de) | 1974-01-31 |
| AR208650A1 (es) | 1977-02-28 |
| LU68066A1 (enrdf_load_stackoverflow) | 1973-09-26 |
| IL48667A0 (en) | 1976-02-29 |
| DE2336559A1 (de) | 1974-01-31 |
| NL7310078A (enrdf_load_stackoverflow) | 1974-01-22 |
| IL42790A0 (en) | 1973-10-25 |
| IE37929B1 (en) | 1977-11-09 |
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