GB1436377A - Isoquinoline derivatives - Google Patents

Isoquinoline derivatives

Info

Publication number
GB1436377A
GB1436377A GB3938775A GB3938775A GB1436377A GB 1436377 A GB1436377 A GB 1436377A GB 3938775 A GB3938775 A GB 3938775A GB 3938775 A GB3938775 A GB 3938775A GB 1436377 A GB1436377 A GB 1436377A
Authority
GB
United Kingdom
Prior art keywords
formula
compounds
isoquinoline derivatives
formulμ
july
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3938775A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
EIDP Inc
Original Assignee
EI Du Pont de Nemours and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by EI Du Pont de Nemours and Co filed Critical EI Du Pont de Nemours and Co
Publication of GB1436377A publication Critical patent/GB1436377A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

1436377 Isoquinoline derivatives E I DU PONT DE NEMOURS & CO 19 July 1973 [20 July 1972 1 June 1973] 39387/75 Divided out of 1436376 Heading C2C The invention comprises compounds of the formulµ where R<SP>1</SP> is H, C 1 -C 6 alkyl, benzyl, phenethyl or cycloalkylmethyl of the formula -CH 2 CH(CH 2 ) n where n is 2-5, R<SP>5</SP> is or Ar<SP>1</SP> is a group of the formula where R<SP>7</SP> is H or methoxy, R<SP>8</SP> is methoxy or two of R<SP>7</SP> or of R<SP>8</SP> on adjacent carbons may together form a methylenedioxy group with the proviso that R<SP>1</SP> is not H in compounds of Formulµ II or III. Compounds of Formula I where R<SP>1</SP> is H are prepared by treating a compound of the formula with R<SP>6</SP>OH and HCl where R<SP>6</SP> is C 1 -C 4 alkyl. The compounds may be alkylated and subsequently reduced to give compounds of Formula II or epoxidized to give compounds of Formula III.
GB3938775A 1972-07-20 1973-07-19 Isoquinoline derivatives Expired GB1436377A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US27380672A 1972-07-20 1972-07-20
US36584373A 1973-06-01 1973-06-01

Publications (1)

Publication Number Publication Date
GB1436377A true GB1436377A (en) 1976-05-19

Family

ID=26956443

Family Applications (2)

Application Number Title Priority Date Filing Date
GB3938775A Expired GB1436377A (en) 1972-07-20 1973-07-19 Isoquinoline derivatives
GB3443873A Expired GB1436376A (en) 1972-07-20 1973-07-19 Isoquinoline derivatives isoquinoline derivatives

Family Applications After (1)

Application Number Title Priority Date Filing Date
GB3443873A Expired GB1436376A (en) 1972-07-20 1973-07-19 Isoquinoline derivatives isoquinoline derivatives

Country Status (13)

Country Link
JP (1) JPS4985075A (en)
AR (1) AR208650A1 (en)
CA (1) CA1024149A (en)
DE (2) DE2351599A1 (en)
ES (1) ES417127A1 (en)
FR (1) FR2193600B1 (en)
GB (2) GB1436377A (en)
HU (1) HU167738B (en)
IE (1) IE37929B1 (en)
IL (3) IL48667A (en)
LU (1) LU68066A1 (en)
NL (1) NL7310078A (en)
SE (1) SE7602150L (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE7509337L (en) * 1974-09-23 1976-03-24 Du Pont PAINING ASSOCIATIONS
PL117572B1 (en) * 1977-12-27 1981-08-31 Lilly Co Eli Process for preparing novel derivatives of trans-4a-phenyl-2,3,4,4a,5,6,7,7a-octahydro-1h-2-pyrindine3,4,4a,5,6,7,7a-oktagidro-1h-2-piridina
EP0735026A1 (en) * 1990-06-05 1996-10-02 Toray Industries, Inc. Method for the production of isoquinoline derivatives and their use as intermediates in the preparation of indole derivatives
EP0596897B1 (en) * 1991-07-05 2002-03-13 Smithkline Becham S.P.A. Hydroisoquinoline derivatives
IT1307327B1 (en) * 1995-09-12 2001-10-30 Smithkline Beecham Spa REPLACED HYDROISOKINOLINIC DERIVATIVES

Also Published As

Publication number Publication date
IL42790A0 (en) 1973-10-25
GB1436376A (en) 1976-05-19
ES417127A1 (en) 1976-04-01
NL7310078A (en) 1974-01-22
IL48667A0 (en) 1976-02-29
FR2193600A1 (en) 1974-02-22
IL48667A (en) 1976-11-30
AR208650A1 (en) 1977-02-28
IE37929B1 (en) 1977-11-09
IL42790A (en) 1976-11-30
JPS4985075A (en) 1974-08-15
LU68066A1 (en) 1973-09-26
AU5820773A (en) 1975-01-23
DE2351599A1 (en) 1974-01-31
IE37929L (en) 1974-01-20
FR2193600B1 (en) 1976-10-22
DE2336559A1 (en) 1974-01-31
SE7602150L (en) 1976-02-23
CA1024149A (en) 1978-01-10
HU167738B (en) 1975-12-25

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee