GB1436376A - Isoquinoline derivatives isoquinoline derivatives - Google Patents

Isoquinoline derivatives isoquinoline derivatives

Info

Publication number
GB1436376A
GB1436376A GB3443873A GB3443873A GB1436376A GB 1436376 A GB1436376 A GB 1436376A GB 3443873 A GB3443873 A GB 3443873A GB 3443873 A GB3443873 A GB 3443873A GB 1436376 A GB1436376 A GB 1436376A
Authority
GB
United Kingdom
Prior art keywords
compounds
isoquinoline derivatives
formula
diketo
acetoxyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3443873A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
EIDP Inc
Original Assignee
EI Du Pont de Nemours and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by EI Du Pont de Nemours and Co filed Critical EI Du Pont de Nemours and Co
Publication of GB1436376A publication Critical patent/GB1436376A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring

Abstract

1436376 Isoquinoline derivatives E I DU PONT DE NEMOURS & CO 19 July 1973 [20 July 1972 1 June 1973] 34438/73 Heading C2C The invention comprises compounds of the formula where R<SP>1</SP> is C 1 -C 6 alkyl, benzyl, phenethyl or cycloalkylmethy of the formula -CH 2 CH(CH 2 ) n where n is 2-5, R<SP>2</SP> is divalent oxygen, A is H or OH, Ar is a group of the formula where R<SP>3</SP> is H, OH, OCH 3 or acetoxyl, R<SP>4</SP> is OH, OCH 3 or acetoxyl or two of R<SP>3</SP> or of R<SP>4</SP> situated on adjacent carbons may be combined to form a divalent methylenedioxy group, and pharmaceutically acceptable acid addition salts thereof. Compounds wherein A is H and R<SP>2</SP> is or may be prepared by reducing the corresponding 1,3-diketo decahydroisoquinoline. Compounds wherein A is OH and R<SP>2</SP> is or may be prepared by reducing the corresponding 1, - diketo - 8,8a - epoxydecahydroisoquinoline. The products may be converted into compounds having different R<SP>2</SP> values by known methods.
GB3443873A 1972-07-20 1973-07-19 Isoquinoline derivatives isoquinoline derivatives Expired GB1436376A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US27380672A 1972-07-20 1972-07-20
US36584373A 1973-06-01 1973-06-01

Publications (1)

Publication Number Publication Date
GB1436376A true GB1436376A (en) 1976-05-19

Family

ID=26956443

Family Applications (2)

Application Number Title Priority Date Filing Date
GB3443873A Expired GB1436376A (en) 1972-07-20 1973-07-19 Isoquinoline derivatives isoquinoline derivatives
GB3938775A Expired GB1436377A (en) 1972-07-20 1973-07-19 Isoquinoline derivatives

Family Applications After (1)

Application Number Title Priority Date Filing Date
GB3938775A Expired GB1436377A (en) 1972-07-20 1973-07-19 Isoquinoline derivatives

Country Status (13)

Country Link
JP (1) JPS4985075A (en)
AR (1) AR208650A1 (en)
CA (1) CA1024149A (en)
DE (2) DE2351599A1 (en)
ES (1) ES417127A1 (en)
FR (1) FR2193600B1 (en)
GB (2) GB1436376A (en)
HU (1) HU167738B (en)
IE (1) IE37929B1 (en)
IL (3) IL48667A (en)
LU (1) LU68066A1 (en)
NL (1) NL7310078A (en)
SE (1) SE7602150L (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993001186A1 (en) * 1991-07-05 1993-01-21 Smithkline Beecham Farmaceutici S.P.A. Hydroisoquinoline derivatives

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE7509337L (en) * 1974-09-23 1976-03-24 Du Pont PAINING ASSOCIATIONS
PT68934A (en) * 1977-12-27 1979-01-01 Lilly Co Eli Process for preparing 4a-aryl-octahydro-1h-2-pyrindines
US5244904A (en) * 1990-06-05 1993-09-14 Toray Industries, Inc. Indole derivatives
IT1307327B1 (en) * 1995-09-12 2001-10-30 Smithkline Beecham Spa REPLACED HYDROISOKINOLINIC DERIVATIVES

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993001186A1 (en) * 1991-07-05 1993-01-21 Smithkline Beecham Farmaceutici S.P.A. Hydroisoquinoline derivatives
US5441956A (en) * 1991-07-05 1995-08-15 Smithkline Beecham Farmaceutici S.P.A. Hydroisoquinoline derivatives

Also Published As

Publication number Publication date
IL42790A (en) 1976-11-30
CA1024149A (en) 1978-01-10
HU167738B (en) 1975-12-25
ES417127A1 (en) 1976-04-01
FR2193600B1 (en) 1976-10-22
IE37929L (en) 1974-01-20
DE2351599A1 (en) 1974-01-31
DE2336559A1 (en) 1974-01-31
AR208650A1 (en) 1977-02-28
IL42790A0 (en) 1973-10-25
JPS4985075A (en) 1974-08-15
IL48667A (en) 1976-11-30
IE37929B1 (en) 1977-11-09
FR2193600A1 (en) 1974-02-22
NL7310078A (en) 1974-01-22
SE7602150L (en) 1976-02-23
LU68066A1 (en) 1973-09-26
IL48667A0 (en) 1976-02-29
AU5820773A (en) 1975-01-23
GB1436377A (en) 1976-05-19

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee